Incidental Mutation 'R8878:Ceacam16'
ID 676690
Institutional Source Beutler Lab
Gene Symbol Ceacam16
Ensembl Gene ENSMUSG00000014686
Gene Name CEA cell adhesion molecule 16
Synonyms LOC330483
MMRRC Submission 068746-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8878 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 19586022-19595224 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 19592656 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 84 (T84K)
Ref Sequence ENSEMBL: ENSMUSP00000014830 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000014830] [ENSMUST00000172815] [ENSMUST00000208198]
AlphaFold E9QA28
Predicted Effect possibly damaging
Transcript: ENSMUST00000014830
AA Change: T84K

PolyPhen 2 Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000014830
Gene: ENSMUSG00000014686
AA Change: T84K

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
IG 28 129 4.04e0 SMART
IG 140 221 2.5e-4 SMART
IGc2 244 301 4.43e-5 SMART
IG 324 423 1.12e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000172815
Predicted Effect probably benign
Transcript: ENSMUST00000208198
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 99% (73/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired hearing at low and high frequencies. Mice homozygous for a different knock-out allele show altered tectorial membrane structure and enhanced spontaneous, stimulus-frequency, and transiently evoked otoacoustic emissions. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acss2 C A 2: 155,398,324 (GRCm39) H348Q probably benign Het
Ago1 T A 4: 126,357,516 (GRCm39) Y53F probably benign Het
Arrdc5 A G 17: 56,601,342 (GRCm39) L261P probably benign Het
Asb2 C A 12: 103,290,138 (GRCm39) W551L possibly damaging Het
Atl2 T C 17: 80,160,232 (GRCm39) I452V probably benign Het
Atxn7l3 T C 11: 102,183,545 (GRCm39) S203G probably benign Het
Bche A G 3: 73,608,506 (GRCm39) F307L probably benign Het
C6 T C 15: 4,826,454 (GRCm39) V679A probably benign Het
Cd163 A T 6: 124,297,469 (GRCm39) N872Y probably damaging Het
Cdkal1 C A 13: 29,658,607 (GRCm39) V380F probably damaging Het
Ceacam11 A T 7: 17,709,536 (GRCm39) I245L probably benign Het
Ceacam2 T A 7: 25,227,351 (GRCm39) Q172L probably benign Het
Chga T G 12: 102,527,720 (GRCm39) S125A possibly damaging Het
Col9a1 T C 1: 24,236,048 (GRCm39) probably null Het
Crybg3 C A 16: 59,380,547 (GRCm39) A236S probably benign Het
Csmd1 A G 8: 15,960,528 (GRCm39) Y3296H probably damaging Het
Cyp2j8 C A 4: 96,358,807 (GRCm39) V371L possibly damaging Het
Des C A 1: 75,337,137 (GRCm39) L26M unknown Het
Edc3 A G 9: 57,623,484 (GRCm39) S140G possibly damaging Het
Fam161a C T 11: 22,970,092 (GRCm39) T90I probably benign Het
Fancm T C 12: 65,173,522 (GRCm39) Y1945H probably damaging Het
Fbn2 C T 18: 58,257,318 (GRCm39) V350I probably benign Het
Git2 A G 5: 114,899,649 (GRCm39) C235R possibly damaging Het
Gk2 T C 5: 97,604,341 (GRCm39) K166E probably benign Het
Gm12258 G A 11: 58,750,112 (GRCm39) R429H unknown Het
Gm7247 T G 14: 51,666,210 (GRCm39) probably benign Het
Gmppa A G 1: 75,414,932 (GRCm39) Y59C probably damaging Het
Has1 G T 17: 18,070,321 (GRCm39) A200E possibly damaging Het
Hbs1l T C 10: 21,234,711 (GRCm39) I588T possibly damaging Het
Helz2 A G 2: 180,874,560 (GRCm39) V1978A possibly damaging Het
Hoxb9 T C 11: 96,165,557 (GRCm39) Y209H probably damaging Het
Hps5 T C 7: 46,421,345 (GRCm39) D706G probably benign Het
Hydin T C 8: 111,035,720 (GRCm39) V137A probably benign Het
Ifngr2 T C 16: 91,359,847 (GRCm39) I318T probably benign Het
Iqgap3 C T 3: 88,020,532 (GRCm39) T1290I probably damaging Het
Jrk A T 15: 74,578,988 (GRCm39) V99E probably benign Het
Kalrn G A 16: 34,025,696 (GRCm39) T931M probably damaging Het
Kalrn G A 16: 34,018,830 (GRCm39) P1311S probably benign Het
Kirrel3 A G 9: 34,850,561 (GRCm39) probably benign Het
Klk1b9 T C 7: 43,443,782 (GRCm39) F99L possibly damaging Het
Lamb3 T C 1: 193,013,124 (GRCm39) C450R probably damaging Het
Lyst T A 13: 13,815,661 (GRCm39) S1182T probably benign Het
Map1a T C 2: 121,138,125 (GRCm39) V2933A probably damaging Het
Map2k5 A T 9: 63,250,667 (GRCm39) probably null Het
Mcm6 A G 1: 128,283,248 (GRCm39) probably null Het
Mmp17 G A 5: 129,683,378 (GRCm39) V505M probably damaging Het
Mpped2 A G 2: 106,575,065 (GRCm39) D50G probably damaging Het
Mtf1 T A 4: 124,715,023 (GRCm39) L216* probably null Het
Niban2 A T 2: 32,811,105 (GRCm39) M372L probably benign Het
Obscn T C 11: 58,890,638 (GRCm39) E7298G unknown Het
Or52ab7 A T 7: 102,978,212 (GRCm39) H173L possibly damaging Het
Or56a3 T C 7: 104,735,763 (GRCm39) L280P probably damaging Het
Or6c205 T C 10: 129,086,883 (GRCm39) L160P probably benign Het
Or7d9 A G 9: 20,197,358 (GRCm39) D129G probably damaging Het
Otulinl T A 15: 27,664,884 (GRCm39) H24L probably benign Het
Pax2 G A 19: 44,777,215 (GRCm39) probably null Het
Pcnt T A 10: 76,244,675 (GRCm39) E1135V probably damaging Het
Pgap3 A T 11: 98,281,924 (GRCm39) V129D probably benign Het
Polq A G 16: 36,860,869 (GRCm39) N497S probably benign Het
Ppfia4 T C 1: 134,227,122 (GRCm39) T1138A Het
Prickle4 A G 17: 48,001,587 (GRCm39) L32P Het
Prl2c2 C T 13: 13,171,896 (GRCm39) G158R probably damaging Het
Psd3 A G 8: 68,210,750 (GRCm39) I752T probably benign Het
Sag A T 1: 87,756,158 (GRCm39) Y255F probably benign Het
Scn7a A T 2: 66,506,199 (GRCm39) D1563E probably damaging Het
Secisbp2 A G 13: 51,837,404 (GRCm39) N855S probably benign Het
Setd2 T C 9: 110,421,467 (GRCm39) V2011A probably benign Het
Slc30a6 T C 17: 74,730,112 (GRCm39) V334A probably damaging Het
Spen A G 4: 141,204,520 (GRCm39) V1369A unknown Het
Stac2 T C 11: 97,932,373 (GRCm39) T207A probably benign Het
Syne2 T C 12: 75,952,067 (GRCm39) V445A probably benign Het
Tas2r131 C A 6: 132,934,467 (GRCm39) W114L probably damaging Het
Tgfbrap1 G A 1: 43,088,959 (GRCm39) R815* probably null Het
Trpv2 A T 11: 62,481,112 (GRCm39) I404L probably benign Het
Zfp236 G A 18: 82,617,122 (GRCm39) T1791M probably damaging Het
Other mutations in Ceacam16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01401:Ceacam16 APN 7 19,595,054 (GRCm39) missense probably benign
IGL02643:Ceacam16 APN 7 19,595,086 (GRCm39) unclassified probably benign
BB006:Ceacam16 UTSW 7 19,587,556 (GRCm39) missense probably damaging 1.00
BB016:Ceacam16 UTSW 7 19,587,556 (GRCm39) missense probably damaging 1.00
R1793:Ceacam16 UTSW 7 19,590,041 (GRCm39) missense probably damaging 1.00
R1830:Ceacam16 UTSW 7 19,592,803 (GRCm39) missense possibly damaging 0.90
R2153:Ceacam16 UTSW 7 19,595,066 (GRCm39) missense probably benign
R3975:Ceacam16 UTSW 7 19,587,537 (GRCm39) missense probably damaging 1.00
R3980:Ceacam16 UTSW 7 19,592,558 (GRCm39) missense probably benign
R4433:Ceacam16 UTSW 7 19,587,514 (GRCm39) missense possibly damaging 0.65
R4634:Ceacam16 UTSW 7 19,592,531 (GRCm39) missense probably benign
R5839:Ceacam16 UTSW 7 19,590,008 (GRCm39) nonsense probably null
R5973:Ceacam16 UTSW 7 19,590,262 (GRCm39) missense probably damaging 1.00
R6167:Ceacam16 UTSW 7 19,595,182 (GRCm39) unclassified probably benign
R6969:Ceacam16 UTSW 7 19,586,230 (GRCm39) makesense probably null
R7648:Ceacam16 UTSW 7 19,586,203 (GRCm39) missense unknown
R7929:Ceacam16 UTSW 7 19,587,556 (GRCm39) missense probably damaging 1.00
R8506:Ceacam16 UTSW 7 19,586,195 (GRCm39) missense unknown
R9583:Ceacam16 UTSW 7 19,587,803 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGTCCCGGAGATGTCAGAG -3'
(R):5'- GAGGTCAATTCTGCCCCTTC -3'

Sequencing Primer
(F):5'- TCAGAGGGGGTGGCTCAC -3'
(R):5'- TCAGCCTGGATCCTGAACACTG -3'
Posted On 2021-07-15