Mutagenetix > Incidental Mutation

Incidental Mutation 'R8879:Zfp202'

676774

Institutional Source

Beutler Lab

Gene Symbol

Zfp202

Ensembl Gene

ENSMUSG00000025602

Gene Name

zinc finger protein 202

Synonyms

C130037E22Rik

MMRRC Submission

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8879 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

40192316-40213604 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 40211757 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glutamine at position 605 (R605Q)

Ref Sequence

ENSEMBL: ENSMUSP00000026693 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000026693] [ENSMUST00000168691] [ENSMUST00000168832]

AlphaFold

Q8C879

Predicted Effect

probably damaging
Transcript: ENSMUST00000026693
AA Change: R605Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000026693
Gene: ENSMUSG00000025602
AA Change: R605Q

Domain	Start	End	E-Value	Type
SCAN	42	154	1.19e-75	SMART
KRAB	237	297	1.7e-17	SMART
ZnF_C2H2	391	413	9.44e-2	SMART
ZnF_C2H2	419	441	6.42e-4	SMART
ZnF_C2H2	473	495	3.44e-4	SMART
ZnF_C2H2	501	523	1.47e-3	SMART
ZnF_C2H2	529	551	1.64e-1	SMART
ZnF_C2H2	557	579	3.11e-2	SMART
ZnF_C2H2	585	607	8.47e-4	SMART
ZnF_C2H2	613	635	3.39e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000168691

SMART Domains

Protein: ENSMUSP00000130163
Gene: ENSMUSG00000025602

Domain	Start	End	E-Value	Type
SCAN	42	132	1.03e-56	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000168832

SMART Domains

Protein: ENSMUSP00000132131
Gene: ENSMUSG00000025602

Domain	Start	End	E-Value	Type
SCAN	42	154	1.19e-75	SMART
KRAB	237	277	5.32e-2	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (69/69)

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9130401M01Rik	C	T	15: 58,022,509	V326M	probably damaging	Het
Adap2	T	A	11: 80,156,959	H80Q	probably benign	Het
Ang4	T	C	14: 51,764,486	T2A	probably benign	Het
Arf2	T	C	11: 103,979,759		probably null	Het
B3gnt4	A	G	5: 123,511,148	D192G	probably damaging	Het
BC034090	T	C	1: 155,226,357	I54V	probably benign	Het
Catsper3	A	G	13: 55,804,895	T202A	probably benign	Het
Cenpe	T	A	3: 135,260,101	D2113E	probably damaging	Het
Clasp2	T	C	9: 113,773,705	V191A	probably benign	Het
Col5a1	G	T	2: 28,014,158	A1356S	unknown	Het
Cuzd1	A	G	7: 131,308,848	S573P	probably damaging	Het
Cyp1a2	C	A	9: 57,681,885	M215I	possibly damaging	Het
Dcaf17	T	A	2: 71,063,402	I122K	possibly damaging	Het
Dhcr24	A	G	4: 106,573,809	I232V	probably benign	Het
Dnah10	A	G	5: 124,818,117	E3570G	probably damaging	Het
Dnaja4	A	T	9: 54,714,704		probably benign	Het
Ehd1	A	G	19: 6,298,324	D444G	probably damaging	Het
Ehmt1	T	A	2: 24,836,476	M766L	possibly damaging	Het
Eno4	A	G	19: 58,970,722	I613M	probably benign	Het
Exoc3l	A	T	8: 105,290,549	M602K		Het
Fam107a	C	T	14: 8,301,352		probably null	Het
Frem3	A	T	8: 80,613,148	D690V	probably damaging	Het
Gm11639	T	C	11: 104,690,955	I41T	probably benign	Het
Gm19410	A	T	8: 35,771,868	D97V	probably damaging	Het
Grik5	T	A	7: 25,023,064	D540V	possibly damaging	Het
Hint1	T	A	11: 54,869,943	D69E	probably benign	Het
Krt13	T	C	11: 100,119,385	T257A	probably benign	Het
Lpin2	T	C	17: 71,242,754	L676P	probably damaging	Het
Lrguk	A	G	6: 34,029,683	E76G	probably benign	Het
Lrrc8a	A	G	2: 30,256,298	M375V	probably benign	Het
Lrrtm3	T	C	10: 64,089,238	Q50R	possibly damaging	Het
Mmrn1	T	A	6: 60,976,529	L598Q	probably damaging	Het
Mrs2	A	G	13: 25,001,784	I135T	probably damaging	Het
Neb	T	C	2: 52,235,580	D475G		Het
Notch2	A	G	3: 98,135,599	S1427G	possibly damaging	Het
Olfr118	C	A	17: 37,672,411	Y129*	probably null	Het
Olfr682-ps1	A	G	7: 105,126,686	V195A	probably benign	Het
Olfr694	A	T	7: 106,689,089	I214N	probably damaging	Het
Olfr816	A	G	10: 129,911,862	C139R	probably damaging	Het
Olfr952	A	C	9: 39,426,219	V284G	possibly damaging	Het
Opcml	T	C	9: 28,902,151	F246S	probably damaging	Het
Pdzd2	C	A	15: 12,402,319	V729F	probably damaging	Het
Pias2	C	T	18: 77,146,768	Q565*	probably null	Het
Pnp	T	A	14: 50,950,720		probably null	Het
Ptpn18	T	C	1: 34,463,130	S76P	probably benign	Het
Qtrt2	A	T	16: 43,863,197	L304Q	probably damaging	Het
Rad51ap2	A	T	12: 11,457,400	E441V	possibly damaging	Het
Ranbp2	T	A	10: 58,477,889	V1477E	probably benign	Het
Repin1	C	T	6: 48,597,433	T432I	possibly damaging	Het
Rest	G	A	5: 77,282,511	G926R	probably benign	Het
Rnft1	T	A	11: 86,486,690	F143L	possibly damaging	Het
Sema3e	A	T	5: 14,232,094	I415L	probably benign	Het
Slc10a1	T	A	12: 80,967,595	N117I	probably damaging	Het
Slc25a23	G	A	17: 57,059,709		probably benign	Het
Slc2a2	T	C	3: 28,713,802	S160P	possibly damaging	Het
Srrd	A	G	5: 112,338,456	V178A	possibly damaging	Het
Tmigd3	G	T	3: 105,921,961	G198C	probably benign	Het
Trbv29	G	A	6: 41,271,405	M1I	probably null	Het
Tril	A	G	6: 53,819,584	S218P	probably damaging	Het
Trip11	T	C	12: 101,862,598	K1749R	probably benign	Het
Ttc25	G	T	11: 100,566,926	E452*	probably null	Het
Ttn	A	G	2: 76,830,651	V12011A		Het
Ubr4	T	G	4: 139,410,518	F1093V	probably benign	Het
Urb2	C	A	8: 124,028,403	A283E	probably benign	Het
Usp43	T	A	11: 67,898,881		probably benign	Het
Vmn1r28	A	T	6: 58,265,684	I171F	probably benign	Het
Vps33a	G	A	5: 123,533,899	R469W	probably damaging	Het
Zpbp2	A	T	11: 98,554,620	H158L	probably benign	Het

Other mutations in Zfp202

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00662:Zfp202	APN	9	40211043	missense	probably benign	0.02
IGL01862:Zfp202	APN	9	40211828	missense	probably benign	0.39
IGL03069:Zfp202	APN	9	40211399	missense	probably damaging	1.00
R0028:Zfp202	UTSW	9	40211752	missense	probably damaging	1.00
R0158:Zfp202	UTSW	9	40208916	nonsense	probably null
R0278:Zfp202	UTSW	9	40208482	missense	probably benign	0.15
R1132:Zfp202	UTSW	9	40211022	missense	probably benign	0.00
R1404:Zfp202	UTSW	9	40211496	missense	probably damaging	1.00
R1404:Zfp202	UTSW	9	40211496	missense	probably damaging	1.00
R1764:Zfp202	UTSW	9	40210466	missense	probably benign	0.00
R1928:Zfp202	UTSW	9	40209787	missense	probably damaging	1.00
R2929:Zfp202	UTSW	9	40211688	missense	possibly damaging	0.94
R3153:Zfp202	UTSW	9	40208438	missense	probably benign	0.00
R3948:Zfp202	UTSW	9	40208425	missense	probably benign	0.43
R4190:Zfp202	UTSW	9	40211337	missense	probably benign	0.00
R4273:Zfp202	UTSW	9	40207494	nonsense	probably null
R6181:Zfp202	UTSW	9	40207342	missense	probably damaging	1.00
R6182:Zfp202	UTSW	9	40207342	missense	probably damaging	1.00
R6816:Zfp202	UTSW	9	40211813	missense	probably damaging	1.00
R6835:Zfp202	UTSW	9	40210235	splice site	probably null
R7382:Zfp202	UTSW	9	40211505	missense	probably damaging	1.00
R7493:Zfp202	UTSW	9	40207344	missense	possibly damaging	0.57
R7542:Zfp202	UTSW	9	40211147	missense	probably benign	0.12
R7689:Zfp202	UTSW	9	40210533	missense	probably benign	0.02
R7832:Zfp202	UTSW	9	40210462	missense	possibly damaging	0.92
R8084:Zfp202	UTSW	9	40211242	missense	probably benign	0.19
R8349:Zfp202	UTSW	9	40207680	nonsense	probably null
R8449:Zfp202	UTSW	9	40207680	nonsense	probably null
R9135:Zfp202	UTSW	9	40208941	missense	possibly damaging	0.85
R9411:Zfp202	UTSW	9	40207582	missense	probably damaging	1.00
R9785:Zfp202	UTSW	9	40208937	missense	probably benign	0.00
X0012:Zfp202	UTSW	9	40211184	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CTGTGGCGAGAACTTCAGTG -3'
(R):5'- TTCTCAGGTTGAACACAGAACC -3'

Sequencing Primer
(F):5'- CTTCAGTGAGCAGAAGCAGTATCTG -3'
(R):5'- AGAACCCATCCGTCTCAGTTGG -3'

Posted On

2021-07-15