Incidental Mutation 'R8880:Lrrc7'
| ID |
676822 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrc7
|
| Ensembl Gene |
ENSMUSG00000028176 |
| Gene Name |
leucine rich repeat containing 7 |
| Synonyms |
densin |
| MMRRC Submission |
068748-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.798)
|
| Stock # |
R8880 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
157788528-158267858 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 157867381 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Lysine
at position 787
(E787K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142498
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106044]
[ENSMUST00000199890]
[ENSMUST00000200137]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106044
AA Change: E787K
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000101659
Gene: ENSMUSG00000028176
AA Change: E787K
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
53 |
73 |
3.65e0 |
SMART |
|
LRR
|
96 |
118 |
2.2e1 |
SMART |
|
LRR
|
142 |
164 |
4.21e1 |
SMART |
|
LRR
|
165 |
187 |
7.36e0 |
SMART |
|
LRR
|
188 |
210 |
7.05e-1 |
SMART |
|
LRR
|
211 |
233 |
3.09e1 |
SMART |
|
LRR
|
234 |
257 |
4.21e1 |
SMART |
|
LRR
|
258 |
279 |
2.61e2 |
SMART |
|
LRR
|
280 |
303 |
3.52e-1 |
SMART |
|
LRR
|
326 |
349 |
1.99e0 |
SMART |
|
LRR
|
372 |
394 |
2.63e0 |
SMART |
|
low complexity region
|
466 |
476 |
N/A |
INTRINSIC |
|
low complexity region
|
692 |
705 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
708 |
736 |
1e-5 |
BLAST |
|
low complexity region
|
787 |
797 |
N/A |
INTRINSIC |
|
low complexity region
|
864 |
878 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
1349 |
1378 |
2e-11 |
BLAST |
|
PDZ
|
1460 |
1540 |
1.33e-19 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000199890
AA Change: E787K
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000142440
Gene: ENSMUSG00000028176
AA Change: E787K
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
53 |
73 |
3.65e0 |
SMART |
|
LRR
|
96 |
118 |
2.2e1 |
SMART |
|
LRR
|
142 |
164 |
4.21e1 |
SMART |
|
LRR
|
165 |
187 |
7.36e0 |
SMART |
|
LRR
|
188 |
210 |
7.05e-1 |
SMART |
|
LRR
|
211 |
233 |
3.09e1 |
SMART |
|
LRR
|
234 |
257 |
4.21e1 |
SMART |
|
LRR
|
258 |
279 |
2.61e2 |
SMART |
|
LRR
|
280 |
303 |
3.52e-1 |
SMART |
|
LRR
|
326 |
349 |
1.99e0 |
SMART |
|
LRR
|
372 |
394 |
2.63e0 |
SMART |
|
low complexity region
|
466 |
476 |
N/A |
INTRINSIC |
|
low complexity region
|
692 |
705 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
708 |
736 |
9e-6 |
BLAST |
|
low complexity region
|
787 |
797 |
N/A |
INTRINSIC |
|
low complexity region
|
864 |
878 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
1328 |
1364 |
1e-15 |
BLAST |
|
low complexity region
|
1374 |
1387 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000200137
AA Change: E787K
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000142498
Gene: ENSMUSG00000028176
AA Change: E787K
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
52 |
69 |
7.6e-1 |
SMART |
|
LRR
|
73 |
92 |
4.2e-1 |
SMART |
|
LRR
|
96 |
115 |
3.4e-1 |
SMART |
|
LRR
|
142 |
164 |
1.8e-1 |
SMART |
|
LRR
|
165 |
184 |
1.5e-1 |
SMART |
|
LRR
|
188 |
207 |
2e-2 |
SMART |
|
LRR
|
211 |
233 |
1.3e-1 |
SMART |
|
LRR
|
234 |
257 |
1.7e-1 |
SMART |
|
LRR
|
257 |
276 |
1e0 |
SMART |
|
LRR
|
280 |
299 |
3.1e-2 |
SMART |
|
LRR
|
303 |
322 |
6.6e-1 |
SMART |
|
LRR
|
326 |
345 |
2.1e-1 |
SMART |
|
LRR
|
372 |
391 |
1.2e-1 |
SMART |
|
low complexity region
|
466 |
476 |
N/A |
INTRINSIC |
|
low complexity region
|
692 |
705 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
708 |
736 |
1e-5 |
BLAST |
|
low complexity region
|
787 |
797 |
N/A |
INTRINSIC |
|
low complexity region
|
864 |
878 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
1302 |
1331 |
2e-11 |
BLAST |
|
PDZ
|
1413 |
1493 |
6.4e-22 |
SMART |
|
| Predicted Effect |
|
| Meta Mutation Damage Score |
0.0978 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
100% (82/82) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit limb grasping, reduced long term depression, increased anxiety, increased aggression towards other mice, impaired spatial memory, decreased prepulse inhibition, decreased nesting building behavior, and abnormal dendritic spines. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(2) : Gene trapped(2) |
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3425401B19Rik |
C |
T |
14: 32,382,837 (GRCm39) |
V1043I |
probably benign |
Het |
| 5031439G07Rik |
T |
A |
15: 84,839,867 (GRCm39) |
I176F |
possibly damaging |
Het |
| Adam6b |
T |
A |
12: 113,454,764 (GRCm39) |
M527K |
probably benign |
Het |
| Atp10b |
C |
T |
11: 43,106,811 (GRCm39) |
T615I |
probably benign |
Het |
| Atxn2 |
A |
G |
5: 121,948,973 (GRCm39) |
T1117A |
probably benign |
Het |
| AU021092 |
A |
T |
16: 5,032,585 (GRCm39) |
|
probably benign |
Het |
| Bcam |
C |
T |
7: 19,492,671 (GRCm39) |
V505M |
probably damaging |
Het |
| Bco2 |
A |
T |
9: 50,461,962 (GRCm39) |
L14Q |
probably damaging |
Het |
| Caps2 |
T |
G |
10: 112,030,824 (GRCm39) |
|
probably benign |
Het |
| Cblb |
T |
C |
16: 51,986,368 (GRCm39) |
V537A |
probably benign |
Het |
| Ccdc141 |
A |
T |
2: 76,845,556 (GRCm39) |
N1170K |
probably benign |
Het |
| Ccdc154 |
T |
G |
17: 25,389,129 (GRCm39) |
D442E |
probably benign |
Het |
| Col24a1 |
A |
G |
3: 145,019,798 (GRCm39) |
I60V |
probably null |
Het |
| Crb1 |
A |
T |
1: 139,164,886 (GRCm39) |
N1140K |
probably benign |
Het |
| Ddhd1 |
G |
A |
14: 45,846,430 (GRCm39) |
P621S |
probably benign |
Het |
| Ddx46 |
A |
T |
13: 55,814,033 (GRCm39) |
N663I |
probably benign |
Het |
| Dgki |
C |
T |
6: 37,011,652 (GRCm39) |
|
probably benign |
Het |
| Disp2 |
T |
C |
2: 118,621,239 (GRCm39) |
F657S |
probably damaging |
Het |
| Dnajc2 |
T |
C |
5: 21,973,670 (GRCm39) |
E262G |
probably damaging |
Het |
| Dvl2 |
T |
A |
11: 69,898,761 (GRCm39) |
L408Q |
possibly damaging |
Het |
| Egflam |
T |
C |
15: 7,267,249 (GRCm39) |
D712G |
probably damaging |
Het |
| Entpd7 |
A |
G |
19: 43,692,846 (GRCm39) |
|
probably benign |
Het |
| Epb41 |
A |
T |
4: 131,695,104 (GRCm39) |
W28R |
|
Het |
| Fabp9 |
C |
T |
3: 10,262,231 (GRCm39) |
|
probably benign |
Het |
| Fkbp15 |
T |
A |
4: 62,232,602 (GRCm39) |
M657L |
probably benign |
Het |
| Gfy |
A |
C |
7: 44,827,784 (GRCm39) |
L104R |
possibly damaging |
Het |
| Gm4884 |
A |
T |
7: 40,693,911 (GRCm39) |
I627F |
probably damaging |
Het |
| Gm9195 |
A |
T |
14: 72,691,320 (GRCm39) |
S1643T |
unknown |
Het |
| Gpsm2 |
C |
T |
3: 108,610,335 (GRCm39) |
A42T |
possibly damaging |
Het |
| Gvin2 |
T |
C |
7: 105,551,120 (GRCm39) |
K644R |
probably benign |
Het |
| Gys2 |
T |
C |
6: 142,402,113 (GRCm39) |
Y242C |
probably damaging |
Het |
| Hbs1l |
A |
G |
10: 21,185,868 (GRCm39) |
N430S |
probably damaging |
Het |
| Idh3b |
A |
T |
2: 130,126,004 (GRCm39) |
|
probably benign |
Het |
| Igdcc3 |
C |
T |
9: 65,088,550 (GRCm39) |
A384V |
probably benign |
Het |
| Ighv3-4 |
C |
T |
12: 114,217,535 (GRCm39) |
D19N |
possibly damaging |
Het |
| Igkv19-93 |
G |
T |
6: 68,713,494 (GRCm39) |
A45E |
probably damaging |
Het |
| Il10ra |
G |
A |
9: 45,175,631 (GRCm39) |
T230M |
probably damaging |
Het |
| Kalrn |
A |
G |
16: 34,038,305 (GRCm39) |
V1009A |
probably damaging |
Het |
| Kcnma1 |
G |
T |
14: 23,417,718 (GRCm39) |
A837D |
probably damaging |
Het |
| Kif7 |
T |
A |
7: 79,348,650 (GRCm39) |
R1231S |
probably benign |
Het |
| Klhdc1 |
A |
G |
12: 69,298,817 (GRCm39) |
D134G |
possibly damaging |
Het |
| Klk14 |
T |
C |
7: 43,343,459 (GRCm39) |
V97A |
probably damaging |
Het |
| Lamb3 |
G |
A |
1: 193,003,363 (GRCm39) |
V101M |
possibly damaging |
Het |
| Mep1a |
A |
G |
17: 43,808,808 (GRCm39) |
I94T |
possibly damaging |
Het |
| Mtrex |
T |
A |
13: 113,051,034 (GRCm39) |
K180N |
probably benign |
Het |
| Ncr1 |
C |
T |
7: 4,341,336 (GRCm39) |
S109L |
probably benign |
Het |
| Nell2 |
A |
T |
15: 95,129,329 (GRCm39) |
M678K |
probably damaging |
Het |
| Or12j5 |
C |
A |
7: 140,084,172 (GRCm39) |
A67S |
probably benign |
Het |
| Or14c42-ps1 |
G |
A |
7: 86,211,549 (GRCm39) |
C203Y |
unknown |
Het |
| Or2m13 |
A |
T |
16: 19,226,396 (GRCm39) |
Y123* |
probably null |
Het |
| Or8g19 |
T |
A |
9: 39,055,899 (GRCm39) |
F168I |
probably damaging |
Het |
| Pnpla1 |
A |
C |
17: 29,098,438 (GRCm39) |
Y248S |
probably damaging |
Het |
| Pramel27 |
T |
C |
4: 143,573,140 (GRCm39) |
|
probably null |
Het |
| Prdm10 |
T |
C |
9: 31,264,742 (GRCm39) |
F726L |
probably damaging |
Het |
| Prdm16 |
T |
C |
4: 154,613,370 (GRCm39) |
N19S |
probably damaging |
Het |
| Prss44 |
A |
G |
9: 110,643,263 (GRCm39) |
R53G |
probably benign |
Het |
| Rasgrp1 |
C |
T |
2: 117,115,425 (GRCm39) |
R721Q |
probably benign |
Het |
| Rassf1 |
A |
T |
9: 107,434,740 (GRCm39) |
N149I |
probably damaging |
Het |
| Rbp3 |
A |
C |
14: 33,678,796 (GRCm39) |
T915P |
probably benign |
Het |
| Reg3g |
A |
T |
6: 78,444,788 (GRCm39) |
D63E |
probably benign |
Het |
| Relch |
T |
C |
1: 105,592,220 (GRCm39) |
Y130H |
probably damaging |
Het |
| Rgs3 |
C |
A |
4: 62,543,373 (GRCm39) |
T236K |
probably damaging |
Het |
| Rin2 |
T |
C |
2: 145,690,772 (GRCm39) |
F147L |
probably damaging |
Het |
| Slc17a1 |
T |
C |
13: 24,062,732 (GRCm39) |
I266T |
probably benign |
Het |
| Slc34a3 |
A |
T |
2: 25,119,267 (GRCm39) |
N534K |
probably benign |
Het |
| Smc2 |
A |
T |
4: 52,462,856 (GRCm39) |
E615D |
probably benign |
Het |
| Snx16 |
A |
C |
3: 10,484,193 (GRCm39) |
D343E |
probably benign |
Het |
| St18 |
T |
A |
1: 6,865,619 (GRCm39) |
Y32* |
probably null |
Het |
| Svep1 |
C |
T |
4: 58,064,204 (GRCm39) |
V3260I |
possibly damaging |
Het |
| Synm |
C |
T |
7: 67,386,456 (GRCm39) |
R402H |
possibly damaging |
Het |
| Tacc2 |
A |
T |
7: 130,318,564 (GRCm39) |
E67V |
possibly damaging |
Het |
| Tarbp1 |
G |
T |
8: 127,198,044 (GRCm39) |
N302K |
probably damaging |
Het |
| Tenm2 |
A |
G |
11: 35,942,788 (GRCm39) |
S1294P |
probably damaging |
Het |
| Ttk |
T |
C |
9: 83,751,304 (GRCm39) |
S794P |
probably damaging |
Het |
| Ulk1 |
G |
A |
5: 110,934,288 (GRCm39) |
A999V |
probably damaging |
Het |
| Upf2 |
A |
G |
2: 6,030,983 (GRCm39) |
I808V |
unknown |
Het |
| Ush2a |
A |
G |
1: 188,460,733 (GRCm39) |
T2665A |
probably benign |
Het |
| Usp8 |
A |
G |
2: 126,590,229 (GRCm39) |
K672E |
probably damaging |
Het |
| Vmn2r105 |
T |
A |
17: 20,429,229 (GRCm39) |
I616F |
probably damaging |
Het |
| Vps33a |
T |
C |
5: 123,707,506 (GRCm39) |
M154V |
probably damaging |
Het |
| Wdfy4 |
A |
C |
14: 32,795,492 (GRCm39) |
Y2083* |
probably null |
Het |
| Zc3hav1 |
A |
G |
6: 38,288,212 (GRCm39) |
F875L |
probably benign |
Het |
| Zfp979 |
T |
C |
4: 147,697,836 (GRCm39) |
N291S |
probably benign |
Het |
| Zp2 |
T |
A |
7: 119,742,835 (GRCm39) |
Y99F |
possibly damaging |
Het |
|
| Other mutations in Lrrc7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00594:Lrrc7
|
APN |
3 |
157,892,647 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL00644:Lrrc7
|
APN |
3 |
157,908,005 (GRCm39) |
nonsense |
probably null |
|
|
IGL00822:Lrrc7
|
APN |
3 |
157,891,111 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00927:Lrrc7
|
APN |
3 |
157,866,727 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL00946:Lrrc7
|
APN |
3 |
157,866,993 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL00948:Lrrc7
|
APN |
3 |
157,867,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01838:Lrrc7
|
APN |
3 |
157,891,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01874:Lrrc7
|
APN |
3 |
157,946,080 (GRCm39) |
splice site |
probably benign |
|
|
IGL02514:Lrrc7
|
APN |
3 |
157,865,929 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02545:Lrrc7
|
APN |
3 |
157,891,011 (GRCm39) |
splice site |
probably benign |
|
|
IGL02665:Lrrc7
|
APN |
3 |
157,866,742 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03129:Lrrc7
|
APN |
3 |
157,866,696 (GRCm39) |
missense |
probably benign |
0.02 |
|
N/A:Lrrc7
|
UTSW |
3 |
157,865,977 (GRCm39) |
missense |
probably benign |
|
|
R0021:Lrrc7
|
UTSW |
3 |
157,866,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0041:Lrrc7
|
UTSW |
3 |
157,869,897 (GRCm39) |
splice site |
probably benign |
|
|
R0255:Lrrc7
|
UTSW |
3 |
157,866,475 (GRCm39) |
nonsense |
probably null |
|
|
R0278:Lrrc7
|
UTSW |
3 |
157,885,432 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0409:Lrrc7
|
UTSW |
3 |
157,867,063 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R0612:Lrrc7
|
UTSW |
3 |
157,869,990 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0866:Lrrc7
|
UTSW |
3 |
157,869,903 (GRCm39) |
splice site |
probably benign |
|
|
R1077:Lrrc7
|
UTSW |
3 |
157,866,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1103:Lrrc7
|
UTSW |
3 |
157,854,343 (GRCm39) |
splice site |
probably benign |
|
|
R1157:Lrrc7
|
UTSW |
3 |
157,865,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1187:Lrrc7
|
UTSW |
3 |
157,866,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1301:Lrrc7
|
UTSW |
3 |
157,840,968 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1433:Lrrc7
|
UTSW |
3 |
157,882,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1450:Lrrc7
|
UTSW |
3 |
157,892,681 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1595:Lrrc7
|
UTSW |
3 |
157,882,914 (GRCm39) |
nonsense |
probably null |
|
|
R1659:Lrrc7
|
UTSW |
3 |
157,867,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1693:Lrrc7
|
UTSW |
3 |
157,790,170 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1774:Lrrc7
|
UTSW |
3 |
157,865,929 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2273:Lrrc7
|
UTSW |
3 |
157,892,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2276:Lrrc7
|
UTSW |
3 |
157,885,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2302:Lrrc7
|
UTSW |
3 |
157,840,881 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2326:Lrrc7
|
UTSW |
3 |
157,876,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2371:Lrrc7
|
UTSW |
3 |
157,866,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2383:Lrrc7
|
UTSW |
3 |
157,869,593 (GRCm39) |
missense |
probably benign |
|
|
R2679:Lrrc7
|
UTSW |
3 |
157,880,745 (GRCm39) |
nonsense |
probably null |
|
|
R2698:Lrrc7
|
UTSW |
3 |
157,841,028 (GRCm39) |
missense |
probably benign |
0.22 |
|
R2858:Lrrc7
|
UTSW |
3 |
157,867,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3758:Lrrc7
|
UTSW |
3 |
157,869,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3791:Lrrc7
|
UTSW |
3 |
157,869,593 (GRCm39) |
missense |
probably benign |
|
|
R3805:Lrrc7
|
UTSW |
3 |
157,891,130 (GRCm39) |
missense |
probably benign |
0.10 |
|
R3806:Lrrc7
|
UTSW |
3 |
157,891,130 (GRCm39) |
missense |
probably benign |
0.10 |
|
R3807:Lrrc7
|
UTSW |
3 |
157,891,130 (GRCm39) |
missense |
probably benign |
0.10 |
|
R3892:Lrrc7
|
UTSW |
3 |
157,866,333 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3912:Lrrc7
|
UTSW |
3 |
157,997,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3913:Lrrc7
|
UTSW |
3 |
157,997,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3963:Lrrc7
|
UTSW |
3 |
157,866,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4665:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4666:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4671:Lrrc7
|
UTSW |
3 |
157,908,132 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4688:Lrrc7
|
UTSW |
3 |
157,854,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4725:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4726:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4728:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4783:Lrrc7
|
UTSW |
3 |
157,832,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4867:Lrrc7
|
UTSW |
3 |
157,866,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4907:Lrrc7
|
UTSW |
3 |
157,866,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5032:Lrrc7
|
UTSW |
3 |
157,887,217 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5107:Lrrc7
|
UTSW |
3 |
157,867,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5295:Lrrc7
|
UTSW |
3 |
157,876,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5348:Lrrc7
|
UTSW |
3 |
157,880,963 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5468:Lrrc7
|
UTSW |
3 |
158,024,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5778:Lrrc7
|
UTSW |
3 |
157,876,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5897:Lrrc7
|
UTSW |
3 |
157,869,990 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6179:Lrrc7
|
UTSW |
3 |
158,059,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6312:Lrrc7
|
UTSW |
3 |
157,866,246 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6313:Lrrc7
|
UTSW |
3 |
157,866,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6366:Lrrc7
|
UTSW |
3 |
157,841,012 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6389:Lrrc7
|
UTSW |
3 |
157,891,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6638:Lrrc7
|
UTSW |
3 |
157,840,940 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6956:Lrrc7
|
UTSW |
3 |
157,994,668 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6969:Lrrc7
|
UTSW |
3 |
157,862,550 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7073:Lrrc7
|
UTSW |
3 |
157,832,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7313:Lrrc7
|
UTSW |
3 |
157,866,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7365:Lrrc7
|
UTSW |
3 |
157,903,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7398:Lrrc7
|
UTSW |
3 |
157,997,595 (GRCm39) |
nonsense |
probably null |
|
|
R7403:Lrrc7
|
UTSW |
3 |
157,854,311 (GRCm39) |
nonsense |
probably null |
|
|
R7407:Lrrc7
|
UTSW |
3 |
157,840,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7427:Lrrc7
|
UTSW |
3 |
157,903,778 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7453:Lrrc7
|
UTSW |
3 |
157,891,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7461:Lrrc7
|
UTSW |
3 |
157,892,657 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7807:Lrrc7
|
UTSW |
3 |
157,866,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7872:Lrrc7
|
UTSW |
3 |
158,059,099 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8215:Lrrc7
|
UTSW |
3 |
157,915,387 (GRCm39) |
missense |
probably benign |
|
|
R8367:Lrrc7
|
UTSW |
3 |
157,908,007 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8867:Lrrc7
|
UTSW |
3 |
157,867,521 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8941:Lrrc7
|
UTSW |
3 |
157,869,593 (GRCm39) |
missense |
probably benign |
|
|
R8958:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9068:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9069:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9180:Lrrc7
|
UTSW |
3 |
157,867,011 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9193:Lrrc7
|
UTSW |
3 |
158,059,011 (GRCm39) |
nonsense |
probably null |
|
|
R9309:Lrrc7
|
UTSW |
3 |
157,915,361 (GRCm39) |
nonsense |
probably null |
|
|
R9418:Lrrc7
|
UTSW |
3 |
157,908,023 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9474:Lrrc7
|
UTSW |
3 |
157,841,028 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9515:Lrrc7
|
UTSW |
3 |
157,867,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9635:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9639:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9682:Lrrc7
|
UTSW |
3 |
157,882,954 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9731:Lrrc7
|
UTSW |
3 |
157,880,888 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CAAATGGACTGGGAGTTCTGG -3'
(R):5'- CCTGCTTGTGTTCACAGGATTG -3'
Sequencing Primer
(F):5'- TCCAATTCTGCCAGGGATTG -3'
(R):5'- GTGTTCACAGGATTGCACCAC -3'
|
| Posted On |
2021-07-15 |
Incidental Mutation