Mutagenetix > Incidental Mutation

Incidental Mutation 'R8880:Tenm2'

676861

Institutional Source

Beutler Lab

Gene Symbol

Tenm2

Ensembl Gene

ENSMUSG00000049336

Gene Name

teneurin transmembrane protein 2

Synonyms

D3Bwg1534e, Odz2, 9330187F13Rik, Ten-m2, 2610040L17Rik

MMRRC Submission

068748-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.569) question?

Stock #

R8880 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

35897483-37126791 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 35942788 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 1294 (S1294P)

Ref Sequence

ENSEMBL: ENSMUSP00000052014 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057207] [ENSMUST00000102801] [ENSMUST00000163524]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000057207
AA Change: S1294P

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000052014
Gene: ENSMUSG00000049336
AA Change: S1294P

Domain	Start	End	E-Value	Type
Pfam:Ten_N	10	374	4.9e-177	PFAM
transmembrane domain	375	397	N/A	INTRINSIC
EGF	575	603	5.62e0	SMART
EGF_like	606	634	4.93e1	SMART
EGF	639	668	1.76e1	SMART
EGF	671	700	1.43e-1	SMART
EGF	705	735	1.2e1	SMART
EGF	738	766	9.63e0	SMART
EGF	769	797	1.25e1	SMART
EGF	800	832	1.4e0	SMART
low complexity region	1459	1475	N/A	INTRINSIC
low complexity region	2219	2230	N/A	INTRINSIC
Pfam:Tox-GHH	2681	2758	1.4e-34	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000102801
AA Change: S1293P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000099865
Gene: ENSMUSG00000049336
AA Change: S1293P

Domain	Start	End	E-Value	Type
Pfam:Ten_N	9	374	2e-186	PFAM
transmembrane domain	375	397	N/A	INTRINSIC
EGF	575	603	5.62e0	SMART
EGF_like	606	634	4.93e1	SMART
EGF	639	668	1.76e1	SMART
EGF	671	700	1.43e-1	SMART
EGF	705	735	1.2e1	SMART
EGF	737	765	9.63e0	SMART
EGF	768	796	1.25e1	SMART
EGF	799	831	1.4e0	SMART
low complexity region	1458	1474	N/A	INTRINSIC
low complexity region	2218	2229	N/A	INTRINSIC
Pfam:Tox-GHH	2679	2757	2e-34	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000163524
AA Change: S1293P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000129951
Gene: ENSMUSG00000049336
AA Change: S1293P

Domain	Start	End	E-Value	Type
Pfam:Ten_N	9	374	2e-186	PFAM
transmembrane domain	375	397	N/A	INTRINSIC
EGF	575	603	5.62e0	SMART
EGF_like	606	634	4.93e1	SMART
EGF	639	668	1.76e1	SMART
EGF	671	700	1.43e-1	SMART
EGF	705	735	1.2e1	SMART
EGF	737	765	9.63e0	SMART
EGF	768	796	1.25e1	SMART
EGF	799	831	1.4e0	SMART
low complexity region	1458	1474	N/A	INTRINSIC
low complexity region	2218	2229	N/A	INTRINSIC
Pfam:Tox-GHH	2679	2757	2e-34	PFAM

Meta Mutation Damage Score

0.6591

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

100% (82/82)

MGI Phenotype

PHENOTYPE: Mice homozygous for a null allele show abnormalities in the laterality and mapping of ipsilateral retinal projections that lead to loss of ipsilateral drive, defects in binocular vision, and impaired performance on a visual discrimination task. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 84 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3425401B19Rik	C	T	14: 32,382,837 (GRCm39)	V1043I	probably benign	Het
5031439G07Rik	T	A	15: 84,839,867 (GRCm39)	I176F	possibly damaging	Het
Adam6b	T	A	12: 113,454,764 (GRCm39)	M527K	probably benign	Het
Atp10b	C	T	11: 43,106,811 (GRCm39)	T615I	probably benign	Het
Atxn2	A	G	5: 121,948,973 (GRCm39)	T1117A	probably benign	Het
AU021092	A	T	16: 5,032,585 (GRCm39)		probably benign	Het
Bcam	C	T	7: 19,492,671 (GRCm39)	V505M	probably damaging	Het
Bco2	A	T	9: 50,461,962 (GRCm39)	L14Q	probably damaging	Het
Caps2	T	G	10: 112,030,824 (GRCm39)		probably benign	Het
Cblb	T	C	16: 51,986,368 (GRCm39)	V537A	probably benign	Het
Ccdc141	A	T	2: 76,845,556 (GRCm39)	N1170K	probably benign	Het
Ccdc154	T	G	17: 25,389,129 (GRCm39)	D442E	probably benign	Het
Col24a1	A	G	3: 145,019,798 (GRCm39)	I60V	probably null	Het
Crb1	A	T	1: 139,164,886 (GRCm39)	N1140K	probably benign	Het
Ddhd1	G	A	14: 45,846,430 (GRCm39)	P621S	probably benign	Het
Ddx46	A	T	13: 55,814,033 (GRCm39)	N663I	probably benign	Het
Dgki	C	T	6: 37,011,652 (GRCm39)		probably benign	Het
Disp2	T	C	2: 118,621,239 (GRCm39)	F657S	probably damaging	Het
Dnajc2	T	C	5: 21,973,670 (GRCm39)	E262G	probably damaging	Het
Dvl2	T	A	11: 69,898,761 (GRCm39)	L408Q	possibly damaging	Het
Egflam	T	C	15: 7,267,249 (GRCm39)	D712G	probably damaging	Het
Entpd7	A	G	19: 43,692,846 (GRCm39)		probably benign	Het
Epb41	A	T	4: 131,695,104 (GRCm39)	W28R		Het
Fabp9	C	T	3: 10,262,231 (GRCm39)		probably benign	Het
Fkbp15	T	A	4: 62,232,602 (GRCm39)	M657L	probably benign	Het
Gfy	A	C	7: 44,827,784 (GRCm39)	L104R	possibly damaging	Het
Gm4884	A	T	7: 40,693,911 (GRCm39)	I627F	probably damaging	Het
Gm9195	A	T	14: 72,691,320 (GRCm39)	S1643T	unknown	Het
Gpsm2	C	T	3: 108,610,335 (GRCm39)	A42T	possibly damaging	Het
Gvin2	T	C	7: 105,551,120 (GRCm39)	K644R	probably benign	Het
Gys2	T	C	6: 142,402,113 (GRCm39)	Y242C	probably damaging	Het
Hbs1l	A	G	10: 21,185,868 (GRCm39)	N430S	probably damaging	Het
Idh3b	A	T	2: 130,126,004 (GRCm39)		probably benign	Het
Igdcc3	C	T	9: 65,088,550 (GRCm39)	A384V	probably benign	Het
Ighv3-4	C	T	12: 114,217,535 (GRCm39)	D19N	possibly damaging	Het
Igkv19-93	G	T	6: 68,713,494 (GRCm39)	A45E	probably damaging	Het
Il10ra	G	A	9: 45,175,631 (GRCm39)	T230M	probably damaging	Het
Kalrn	A	G	16: 34,038,305 (GRCm39)	V1009A	probably damaging	Het
Kcnma1	G	T	14: 23,417,718 (GRCm39)	A837D	probably damaging	Het
Kif7	T	A	7: 79,348,650 (GRCm39)	R1231S	probably benign	Het
Klhdc1	A	G	12: 69,298,817 (GRCm39)	D134G	possibly damaging	Het
Klk14	T	C	7: 43,343,459 (GRCm39)	V97A	probably damaging	Het
Lamb3	G	A	1: 193,003,363 (GRCm39)	V101M	possibly damaging	Het
Lrrc7	C	T	3: 157,867,381 (GRCm39)	E787K	probably damaging	Het
Mep1a	A	G	17: 43,808,808 (GRCm39)	I94T	possibly damaging	Het
Mtrex	T	A	13: 113,051,034 (GRCm39)	K180N	probably benign	Het
Ncr1	C	T	7: 4,341,336 (GRCm39)	S109L	probably benign	Het
Nell2	A	T	15: 95,129,329 (GRCm39)	M678K	probably damaging	Het
Or12j5	C	A	7: 140,084,172 (GRCm39)	A67S	probably benign	Het
Or14c42-ps1	G	A	7: 86,211,549 (GRCm39)	C203Y	unknown	Het
Or2m13	A	T	16: 19,226,396 (GRCm39)	Y123*	probably null	Het
Or8g19	T	A	9: 39,055,899 (GRCm39)	F168I	probably damaging	Het
Pnpla1	A	C	17: 29,098,438 (GRCm39)	Y248S	probably damaging	Het
Pramel27	T	C	4: 143,573,140 (GRCm39)		probably null	Het
Prdm10	T	C	9: 31,264,742 (GRCm39)	F726L	probably damaging	Het
Prdm16	T	C	4: 154,613,370 (GRCm39)	N19S	probably damaging	Het
Prss44	A	G	9: 110,643,263 (GRCm39)	R53G	probably benign	Het
Rasgrp1	C	T	2: 117,115,425 (GRCm39)	R721Q	probably benign	Het
Rassf1	A	T	9: 107,434,740 (GRCm39)	N149I	probably damaging	Het
Rbp3	A	C	14: 33,678,796 (GRCm39)	T915P	probably benign	Het
Reg3g	A	T	6: 78,444,788 (GRCm39)	D63E	probably benign	Het
Relch	T	C	1: 105,592,220 (GRCm39)	Y130H	probably damaging	Het
Rgs3	C	A	4: 62,543,373 (GRCm39)	T236K	probably damaging	Het
Rin2	T	C	2: 145,690,772 (GRCm39)	F147L	probably damaging	Het
Slc17a1	T	C	13: 24,062,732 (GRCm39)	I266T	probably benign	Het
Slc34a3	A	T	2: 25,119,267 (GRCm39)	N534K	probably benign	Het
Smc2	A	T	4: 52,462,856 (GRCm39)	E615D	probably benign	Het
Snx16	A	C	3: 10,484,193 (GRCm39)	D343E	probably benign	Het
St18	T	A	1: 6,865,619 (GRCm39)	Y32*	probably null	Het
Svep1	C	T	4: 58,064,204 (GRCm39)	V3260I	possibly damaging	Het
Synm	C	T	7: 67,386,456 (GRCm39)	R402H	possibly damaging	Het
Tacc2	A	T	7: 130,318,564 (GRCm39)	E67V	possibly damaging	Het
Tarbp1	G	T	8: 127,198,044 (GRCm39)	N302K	probably damaging	Het
Ttk	T	C	9: 83,751,304 (GRCm39)	S794P	probably damaging	Het
Ulk1	G	A	5: 110,934,288 (GRCm39)	A999V	probably damaging	Het
Upf2	A	G	2: 6,030,983 (GRCm39)	I808V	unknown	Het
Ush2a	A	G	1: 188,460,733 (GRCm39)	T2665A	probably benign	Het
Usp8	A	G	2: 126,590,229 (GRCm39)	K672E	probably damaging	Het
Vmn2r105	T	A	17: 20,429,229 (GRCm39)	I616F	probably damaging	Het
Vps33a	T	C	5: 123,707,506 (GRCm39)	M154V	probably damaging	Het
Wdfy4	A	C	14: 32,795,492 (GRCm39)	Y2083*	probably null	Het
Zc3hav1	A	G	6: 38,288,212 (GRCm39)	F875L	probably benign	Het
Zfp979	T	C	4: 147,697,836 (GRCm39)	N291S	probably benign	Het
Zp2	T	A	7: 119,742,835 (GRCm39)	Y99F	possibly damaging	Het

Other mutations in Tenm2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00161:Tenm2	APN	11	36,097,726 (GRCm39)	splice site	probably benign
IGL00834:Tenm2	APN	11	35,915,085 (GRCm39)	missense	probably damaging	1.00
IGL00911:Tenm2	APN	11	35,899,560 (GRCm39)	nonsense	probably null
IGL00937:Tenm2	APN	11	35,915,450 (GRCm39)	missense	probably damaging	1.00
IGL01154:Tenm2	APN	11	35,932,371 (GRCm39)	missense	probably damaging	1.00
IGL01313:Tenm2	APN	11	35,915,075 (GRCm39)	missense	probably damaging	0.98
IGL01346:Tenm2	APN	11	35,918,232 (GRCm39)	nonsense	probably null
IGL01539:Tenm2	APN	11	35,997,654 (GRCm39)	missense	possibly damaging	0.89
IGL01629:Tenm2	APN	11	36,755,711 (GRCm39)	missense	probably damaging	0.98
IGL01780:Tenm2	APN	11	35,937,768 (GRCm39)	missense	probably benign
IGL01821:Tenm2	APN	11	35,914,710 (GRCm39)	missense	probably damaging	0.98
IGL01988:Tenm2	APN	11	35,918,078 (GRCm39)	missense	probably damaging	1.00
IGL02002:Tenm2	APN	11	36,097,922 (GRCm39)	missense	probably benign
IGL02449:Tenm2	APN	11	35,914,449 (GRCm39)	missense	probably damaging	0.99
IGL02505:Tenm2	APN	11	35,942,743 (GRCm39)	nonsense	probably null
IGL02649:Tenm2	APN	11	36,097,912 (GRCm39)	missense	possibly damaging	0.85
IGL02688:Tenm2	APN	11	35,959,285 (GRCm39)	missense	probably benign	0.05
IGL02801:Tenm2	APN	11	35,937,857 (GRCm39)	nonsense	probably null
IGL02928:Tenm2	APN	11	35,917,997 (GRCm39)	missense	possibly damaging	0.69
IGL02940:Tenm2	APN	11	35,932,471 (GRCm39)	missense	probably damaging	1.00
IGL03202:Tenm2	APN	11	35,915,375 (GRCm39)	missense	probably damaging	1.00
IGL03213:Tenm2	APN	11	35,914,157 (GRCm39)	missense	probably benign	0.05
IGL03276:Tenm2	APN	11	35,963,603 (GRCm39)	missense	possibly damaging	0.95
IGL03296:Tenm2	APN	11	35,942,852 (GRCm39)	splice site	probably null
IGL03381:Tenm2	APN	11	35,959,238 (GRCm39)	missense	probably benign	0.01
IGL03398:Tenm2	APN	11	35,915,370 (GRCm39)	missense	probably damaging	1.00
browser	UTSW	11	35,937,592 (GRCm39)	critical splice donor site	probably null
mosaic	UTSW	11	35,954,602 (GRCm39)	critical splice donor site	probably null
IGL02799:Tenm2	UTSW	11	36,164,235 (GRCm39)	missense	probably damaging	1.00
PIT4260001:Tenm2	UTSW	11	36,054,557 (GRCm39)	missense	probably damaging	1.00
PIT4382001:Tenm2	UTSW	11	35,954,729 (GRCm39)	missense	probably damaging	0.99
R0004:Tenm2	UTSW	11	35,914,184 (GRCm39)	missense	probably damaging	1.00
R0420:Tenm2	UTSW	11	36,097,951 (GRCm39)	splice site	probably benign
R0537:Tenm2	UTSW	11	36,054,557 (GRCm39)	missense	probably damaging	1.00
R0599:Tenm2	UTSW	11	35,915,607 (GRCm39)	missense	possibly damaging	0.93
R0636:Tenm2	UTSW	11	36,834,803 (GRCm39)	missense	probably damaging	1.00
R0693:Tenm2	UTSW	11	35,915,636 (GRCm39)	missense	probably damaging	1.00
R0991:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R0992:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1167:Tenm2	UTSW	11	36,755,511 (GRCm39)	missense	probably benign	0.30
R1177:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1178:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1179:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1180:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1181:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1193:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1194:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1195:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1195:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1195:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1259:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1265:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1267:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1268:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1269:Tenm2	UTSW	11	35,899,185 (GRCm39)	missense	possibly damaging	0.64
R1270:Tenm2	UTSW	11	35,932,486 (GRCm39)	missense	probably damaging	1.00
R1272:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1273:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1311:Tenm2	UTSW	11	35,959,421 (GRCm39)	splice site	probably benign
R1374:Tenm2	UTSW	11	35,899,281 (GRCm39)	missense	probably benign	0.00
R1542:Tenm2	UTSW	11	36,191,047 (GRCm39)	missense	probably damaging	0.99
R1573:Tenm2	UTSW	11	35,937,896 (GRCm39)	missense	probably damaging	1.00
R1579:Tenm2	UTSW	11	35,997,610 (GRCm39)	missense	probably damaging	1.00
R1697:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1722:Tenm2	UTSW	11	35,898,930 (GRCm39)	missense	probably damaging	1.00
R1756:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1793:Tenm2	UTSW	11	35,914,209 (GRCm39)	missense	probably damaging	0.99
R1950:Tenm2	UTSW	11	35,954,004 (GRCm39)	missense	possibly damaging	0.94
R1954:Tenm2	UTSW	11	35,938,374 (GRCm39)	missense	possibly damaging	0.87
R2025:Tenm2	UTSW	11	35,938,091 (GRCm39)	nonsense	probably null
R2117:Tenm2	UTSW	11	35,915,681 (GRCm39)	missense	probably damaging	1.00
R2244:Tenm2	UTSW	11	36,755,689 (GRCm39)	missense	probably damaging	0.98
R2298:Tenm2	UTSW	11	35,937,604 (GRCm39)	missense	possibly damaging	0.62
R2432:Tenm2	UTSW	11	35,918,018 (GRCm39)	missense	probably damaging	1.00
R3014:Tenm2	UTSW	11	35,914,800 (GRCm39)	missense	probably damaging	1.00
R3115:Tenm2	UTSW	11	35,914,193 (GRCm39)	missense	probably damaging	1.00
R3684:Tenm2	UTSW	11	35,942,644 (GRCm39)	missense	probably benign	0.00
R3685:Tenm2	UTSW	11	35,942,644 (GRCm39)	missense	probably benign	0.00
R3705:Tenm2	UTSW	11	35,959,153 (GRCm39)	missense	probably damaging	0.97
R3820:Tenm2	UTSW	11	35,915,147 (GRCm39)	missense	probably damaging	0.98
R3821:Tenm2	UTSW	11	35,915,147 (GRCm39)	missense	probably damaging	0.98
R3822:Tenm2	UTSW	11	35,915,147 (GRCm39)	missense	probably damaging	0.98
R3844:Tenm2	UTSW	11	35,938,365 (GRCm39)	missense	probably damaging	0.98
R3878:Tenm2	UTSW	11	36,030,401 (GRCm39)	critical splice donor site	probably null
R4019:Tenm2	UTSW	11	35,937,901 (GRCm39)	missense	probably benign	0.04
R4062:Tenm2	UTSW	11	35,899,482 (GRCm39)	missense	probably damaging	1.00
R4367:Tenm2	UTSW	11	35,918,225 (GRCm39)	missense	probably benign
R4395:Tenm2	UTSW	11	35,915,451 (GRCm39)	missense	probably benign	0.23
R4508:Tenm2	UTSW	11	35,899,172 (GRCm39)	missense	possibly damaging	0.82
R4534:Tenm2	UTSW	11	35,953,931 (GRCm39)	missense	possibly damaging	0.64
R4539:Tenm2	UTSW	11	35,937,607 (GRCm39)	missense	probably damaging	1.00
R4644:Tenm2	UTSW	11	35,937,963 (GRCm39)	missense	probably benign	0.00
R4661:Tenm2	UTSW	11	35,915,275 (GRCm39)	missense	probably damaging	0.99
R4669:Tenm2	UTSW	11	35,901,314 (GRCm39)	missense	probably damaging	1.00
R4687:Tenm2	UTSW	11	35,939,924 (GRCm39)	missense	probably benign
R4711:Tenm2	UTSW	11	36,191,039 (GRCm39)	missense	probably damaging	0.98
R4816:Tenm2	UTSW	11	35,918,117 (GRCm39)	missense	probably damaging	1.00
R4843:Tenm2	UTSW	11	35,914,847 (GRCm39)	missense	probably damaging	1.00
R4850:Tenm2	UTSW	11	35,914,315 (GRCm39)	nonsense	probably null
R4870:Tenm2	UTSW	11	35,969,396 (GRCm39)	missense	probably damaging	1.00
R5058:Tenm2	UTSW	11	36,097,907 (GRCm39)	missense	possibly damaging	0.80
R5071:Tenm2	UTSW	11	35,959,208 (GRCm39)	missense	probably damaging	0.99
R5073:Tenm2	UTSW	11	35,959,208 (GRCm39)	missense	probably damaging	0.99
R5074:Tenm2	UTSW	11	35,959,208 (GRCm39)	missense	probably damaging	0.99
R5081:Tenm2	UTSW	11	35,915,460 (GRCm39)	missense	possibly damaging	0.95
R5093:Tenm2	UTSW	11	36,834,989 (GRCm39)	missense	probably damaging	1.00
R5170:Tenm2	UTSW	11	35,915,633 (GRCm39)	missense	probably damaging	0.98
R5253:Tenm2	UTSW	11	35,938,028 (GRCm39)	nonsense	probably null
R5343:Tenm2	UTSW	11	35,960,330 (GRCm39)	missense	probably benign	0.00
R5493:Tenm2	UTSW	11	36,755,503 (GRCm39)	missense	probably benign	0.01
R5600:Tenm2	UTSW	11	36,054,541 (GRCm39)	splice site	probably null
R5677:Tenm2	UTSW	11	36,032,510 (GRCm39)	missense	probably damaging	0.98
R5703:Tenm2	UTSW	11	35,914,626 (GRCm39)	missense	probably benign	0.34
R5707:Tenm2	UTSW	11	35,938,009 (GRCm39)	missense	possibly damaging	0.79
R6026:Tenm2	UTSW	11	35,963,556 (GRCm39)	critical splice donor site	probably null
R6063:Tenm2	UTSW	11	36,054,544 (GRCm39)	critical splice donor site	probably null
R6086:Tenm2	UTSW	11	35,899,473 (GRCm39)	missense	possibly damaging	0.64
R6151:Tenm2	UTSW	11	35,899,610 (GRCm39)	missense	probably damaging	1.00
R6169:Tenm2	UTSW	11	36,030,517 (GRCm39)	missense	probably damaging	0.99
R6193:Tenm2	UTSW	11	35,937,621 (GRCm39)	missense	probably damaging	1.00
R6405:Tenm2	UTSW	11	36,755,686 (GRCm39)	missense	probably benign	0.44
R6477:Tenm2	UTSW	11	35,901,334 (GRCm39)	critical splice acceptor site	probably null
R6607:Tenm2	UTSW	11	35,954,602 (GRCm39)	critical splice donor site	probably null
R6668:Tenm2	UTSW	11	35,937,592 (GRCm39)	critical splice donor site	probably null
R6825:Tenm2	UTSW	11	35,937,711 (GRCm39)	missense	probably benign	0.02
R6885:Tenm2	UTSW	11	35,914,407 (GRCm39)	missense	possibly damaging	0.95
R7017:Tenm2	UTSW	11	36,062,236 (GRCm39)	missense	probably damaging	0.98
R7115:Tenm2	UTSW	11	36,054,644 (GRCm39)	missense	probably damaging	0.99
R7153:Tenm2	UTSW	11	35,915,009 (GRCm39)	missense	probably damaging	0.98
R7173:Tenm2	UTSW	11	35,932,378 (GRCm39)	missense	probably damaging	0.99
R7199:Tenm2	UTSW	11	36,062,263 (GRCm39)	missense	probably damaging	1.00
R7205:Tenm2	UTSW	11	35,939,956 (GRCm39)	missense	probably damaging	0.99
R7250:Tenm2	UTSW	11	35,963,625 (GRCm39)	missense	probably damaging	1.00
R7290:Tenm2	UTSW	11	35,914,298 (GRCm39)	missense	probably damaging	1.00
R7366:Tenm2	UTSW	11	35,960,241 (GRCm39)	missense	probably benign	0.09
R7432:Tenm2	UTSW	11	36,755,768 (GRCm39)	missense	probably benign
R7504:Tenm2	UTSW	11	36,030,570 (GRCm39)	missense	probably damaging	1.00
R7513:Tenm2	UTSW	11	35,942,727 (GRCm39)	missense	probably benign	0.34
R7523:Tenm2	UTSW	11	35,969,408 (GRCm39)	splice site	probably null
R7527:Tenm2	UTSW	11	36,097,803 (GRCm39)	missense	probably damaging	1.00
R7648:Tenm2	UTSW	11	35,997,563 (GRCm39)	missense	probably damaging	1.00
R7653:Tenm2	UTSW	11	35,938,174 (GRCm39)	missense	probably benign	0.09
R7717:Tenm2	UTSW	11	36,755,762 (GRCm39)	missense	probably damaging	0.97
R7739:Tenm2	UTSW	11	35,960,388 (GRCm39)	missense	possibly damaging	0.50
R7762:Tenm2	UTSW	11	35,914,133 (GRCm39)	missense	possibly damaging	0.74
R7786:Tenm2	UTSW	11	35,901,276 (GRCm39)	missense	probably damaging	0.99
R7803:Tenm2	UTSW	11	35,937,943 (GRCm39)	missense	probably damaging	0.98
R7834:Tenm2	UTSW	11	35,915,681 (GRCm39)	missense	probably damaging	1.00
R7838:Tenm2	UTSW	11	35,997,626 (GRCm39)	missense	probably benign	0.02
R8073:Tenm2	UTSW	11	36,030,471 (GRCm39)	missense	possibly damaging	0.56
R8076:Tenm2	UTSW	11	35,918,048 (GRCm39)	missense	probably benign	0.23
R8109:Tenm2	UTSW	11	35,899,137 (GRCm39)	missense	probably benign
R8306:Tenm2	UTSW	11	35,960,196 (GRCm39)	missense	possibly damaging	0.52
R8352:Tenm2	UTSW	11	35,914,428 (GRCm39)	missense	probably damaging	0.98
R8452:Tenm2	UTSW	11	35,914,428 (GRCm39)	missense	probably damaging	0.98
R8864:Tenm2	UTSW	11	35,918,022 (GRCm39)	missense	possibly damaging	0.95
R8943:Tenm2	UTSW	11	36,834,861 (GRCm39)	missense	probably damaging	0.98
R8969:Tenm2	UTSW	11	35,942,688 (GRCm39)	missense	probably damaging	0.99
R9168:Tenm2	UTSW	11	35,930,722 (GRCm39)	missense	probably damaging	1.00
R9279:Tenm2	UTSW	11	35,959,303 (GRCm39)	missense	probably benign	0.00
R9294:Tenm2	UTSW	11	35,915,327 (GRCm39)	missense	probably damaging	0.98
R9320:Tenm2	UTSW	11	35,914,474 (GRCm39)	missense	probably damaging	0.99
R9373:Tenm2	UTSW	11	35,930,713 (GRCm39)	missense	probably damaging	1.00
R9408:Tenm2	UTSW	11	35,960,246 (GRCm39)	missense	probably damaging	1.00
R9410:Tenm2	UTSW	11	36,032,396 (GRCm39)	missense	probably damaging	0.99
R9454:Tenm2	UTSW	11	36,112,286 (GRCm39)	missense	probably benign
R9489:Tenm2	UTSW	11	36,834,791 (GRCm39)	missense	probably damaging	0.99
R9711:Tenm2	UTSW	11	35,915,341 (GRCm39)	missense	probably damaging	0.99
RF021:Tenm2	UTSW	11	35,915,030 (GRCm39)	missense	possibly damaging	0.95
X0018:Tenm2	UTSW	11	35,915,027 (GRCm39)	missense	probably damaging	1.00
X0063:Tenm2	UTSW	11	35,915,557 (GRCm39)	missense	probably benign
Z1088:Tenm2	UTSW	11	36,164,094 (GRCm39)	missense	probably damaging	1.00
Z1177:Tenm2	UTSW	11	36,191,162 (GRCm39)	missense	probably damaging	0.98
Z1177:Tenm2	UTSW	11	35,899,061 (GRCm39)	missense	possibly damaging	0.95
Z1177:Tenm2	UTSW	11	36,275,957 (GRCm39)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- GTCTTTACCTCTGGGGCTCATG -3'
(R):5'- AATCATGAGATGAGTATCTGGAAGC -3'

Sequencing Primer
(F):5'- TCATGAGGGTGGCGTCC -3'
(R):5'- AGTATCTGGAAGCCATGATGTG -3'

Posted On

2021-07-15