Incidental Mutation 'R8880:Vmn2r105'
ID 676882
Institutional Source Beutler Lab
Gene Symbol Vmn2r105
Ensembl Gene ENSMUSG00000091670
Gene Name vomeronasal 2, receptor 105
Synonyms EG627743
MMRRC Submission 068748-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8880 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 20428492-20455134 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 20429229 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 616 (I616F)
Ref Sequence ENSEMBL: ENSMUSP00000129762 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167382]
AlphaFold E9Q3A5
Predicted Effect probably damaging
Transcript: ENSMUST00000167382
AA Change: I616F

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000129762
Gene: ENSMUSG00000091670
AA Change: I616F

DomainStartEndE-ValueType
Pfam:ANF_receptor 85 469 6.5e-42 PFAM
Pfam:NCD3G 512 565 3.2e-21 PFAM
Pfam:7tm_3 598 833 2.5e-51 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (82/82)
Allele List at MGI
Other mutations in this stock
Total: 84 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik C T 14: 32,382,837 (GRCm39) V1043I probably benign Het
5031439G07Rik T A 15: 84,839,867 (GRCm39) I176F possibly damaging Het
Adam6b T A 12: 113,454,764 (GRCm39) M527K probably benign Het
Atp10b C T 11: 43,106,811 (GRCm39) T615I probably benign Het
Atxn2 A G 5: 121,948,973 (GRCm39) T1117A probably benign Het
AU021092 A T 16: 5,032,585 (GRCm39) probably benign Het
Bcam C T 7: 19,492,671 (GRCm39) V505M probably damaging Het
Bco2 A T 9: 50,461,962 (GRCm39) L14Q probably damaging Het
Caps2 T G 10: 112,030,824 (GRCm39) probably benign Het
Cblb T C 16: 51,986,368 (GRCm39) V537A probably benign Het
Ccdc141 A T 2: 76,845,556 (GRCm39) N1170K probably benign Het
Ccdc154 T G 17: 25,389,129 (GRCm39) D442E probably benign Het
Col24a1 A G 3: 145,019,798 (GRCm39) I60V probably null Het
Crb1 A T 1: 139,164,886 (GRCm39) N1140K probably benign Het
Ddhd1 G A 14: 45,846,430 (GRCm39) P621S probably benign Het
Ddx46 A T 13: 55,814,033 (GRCm39) N663I probably benign Het
Dgki C T 6: 37,011,652 (GRCm39) probably benign Het
Disp2 T C 2: 118,621,239 (GRCm39) F657S probably damaging Het
Dnajc2 T C 5: 21,973,670 (GRCm39) E262G probably damaging Het
Dvl2 T A 11: 69,898,761 (GRCm39) L408Q possibly damaging Het
Egflam T C 15: 7,267,249 (GRCm39) D712G probably damaging Het
Entpd7 A G 19: 43,692,846 (GRCm39) probably benign Het
Epb41 A T 4: 131,695,104 (GRCm39) W28R Het
Fabp9 C T 3: 10,262,231 (GRCm39) probably benign Het
Fkbp15 T A 4: 62,232,602 (GRCm39) M657L probably benign Het
Gfy A C 7: 44,827,784 (GRCm39) L104R possibly damaging Het
Gm4884 A T 7: 40,693,911 (GRCm39) I627F probably damaging Het
Gm9195 A T 14: 72,691,320 (GRCm39) S1643T unknown Het
Gpsm2 C T 3: 108,610,335 (GRCm39) A42T possibly damaging Het
Gvin2 T C 7: 105,551,120 (GRCm39) K644R probably benign Het
Gys2 T C 6: 142,402,113 (GRCm39) Y242C probably damaging Het
Hbs1l A G 10: 21,185,868 (GRCm39) N430S probably damaging Het
Idh3b A T 2: 130,126,004 (GRCm39) probably benign Het
Igdcc3 C T 9: 65,088,550 (GRCm39) A384V probably benign Het
Ighv3-4 C T 12: 114,217,535 (GRCm39) D19N possibly damaging Het
Igkv19-93 G T 6: 68,713,494 (GRCm39) A45E probably damaging Het
Il10ra G A 9: 45,175,631 (GRCm39) T230M probably damaging Het
Kalrn A G 16: 34,038,305 (GRCm39) V1009A probably damaging Het
Kcnma1 G T 14: 23,417,718 (GRCm39) A837D probably damaging Het
Kif7 T A 7: 79,348,650 (GRCm39) R1231S probably benign Het
Klhdc1 A G 12: 69,298,817 (GRCm39) D134G possibly damaging Het
Klk14 T C 7: 43,343,459 (GRCm39) V97A probably damaging Het
Lamb3 G A 1: 193,003,363 (GRCm39) V101M possibly damaging Het
Lrrc7 C T 3: 157,867,381 (GRCm39) E787K probably damaging Het
Mep1a A G 17: 43,808,808 (GRCm39) I94T possibly damaging Het
Mtrex T A 13: 113,051,034 (GRCm39) K180N probably benign Het
Ncr1 C T 7: 4,341,336 (GRCm39) S109L probably benign Het
Nell2 A T 15: 95,129,329 (GRCm39) M678K probably damaging Het
Or12j5 C A 7: 140,084,172 (GRCm39) A67S probably benign Het
Or14c42-ps1 G A 7: 86,211,549 (GRCm39) C203Y unknown Het
Or2m13 A T 16: 19,226,396 (GRCm39) Y123* probably null Het
Or8g19 T A 9: 39,055,899 (GRCm39) F168I probably damaging Het
Pnpla1 A C 17: 29,098,438 (GRCm39) Y248S probably damaging Het
Pramel27 T C 4: 143,573,140 (GRCm39) probably null Het
Prdm10 T C 9: 31,264,742 (GRCm39) F726L probably damaging Het
Prdm16 T C 4: 154,613,370 (GRCm39) N19S probably damaging Het
Prss44 A G 9: 110,643,263 (GRCm39) R53G probably benign Het
Rasgrp1 C T 2: 117,115,425 (GRCm39) R721Q probably benign Het
Rassf1 A T 9: 107,434,740 (GRCm39) N149I probably damaging Het
Rbp3 A C 14: 33,678,796 (GRCm39) T915P probably benign Het
Reg3g A T 6: 78,444,788 (GRCm39) D63E probably benign Het
Relch T C 1: 105,592,220 (GRCm39) Y130H probably damaging Het
Rgs3 C A 4: 62,543,373 (GRCm39) T236K probably damaging Het
Rin2 T C 2: 145,690,772 (GRCm39) F147L probably damaging Het
Slc17a1 T C 13: 24,062,732 (GRCm39) I266T probably benign Het
Slc34a3 A T 2: 25,119,267 (GRCm39) N534K probably benign Het
Smc2 A T 4: 52,462,856 (GRCm39) E615D probably benign Het
Snx16 A C 3: 10,484,193 (GRCm39) D343E probably benign Het
St18 T A 1: 6,865,619 (GRCm39) Y32* probably null Het
Svep1 C T 4: 58,064,204 (GRCm39) V3260I possibly damaging Het
Synm C T 7: 67,386,456 (GRCm39) R402H possibly damaging Het
Tacc2 A T 7: 130,318,564 (GRCm39) E67V possibly damaging Het
Tarbp1 G T 8: 127,198,044 (GRCm39) N302K probably damaging Het
Tenm2 A G 11: 35,942,788 (GRCm39) S1294P probably damaging Het
Ttk T C 9: 83,751,304 (GRCm39) S794P probably damaging Het
Ulk1 G A 5: 110,934,288 (GRCm39) A999V probably damaging Het
Upf2 A G 2: 6,030,983 (GRCm39) I808V unknown Het
Ush2a A G 1: 188,460,733 (GRCm39) T2665A probably benign Het
Usp8 A G 2: 126,590,229 (GRCm39) K672E probably damaging Het
Vps33a T C 5: 123,707,506 (GRCm39) M154V probably damaging Het
Wdfy4 A C 14: 32,795,492 (GRCm39) Y2083* probably null Het
Zc3hav1 A G 6: 38,288,212 (GRCm39) F875L probably benign Het
Zfp979 T C 4: 147,697,836 (GRCm39) N291S probably benign Het
Zp2 T A 7: 119,742,835 (GRCm39) Y99F possibly damaging Het
Other mutations in Vmn2r105
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01433:Vmn2r105 APN 17 20,448,817 (GRCm39) missense probably benign 0.01
IGL01909:Vmn2r105 APN 17 20,444,918 (GRCm39) missense probably damaging 1.00
IGL01925:Vmn2r105 APN 17 20,428,973 (GRCm39) missense possibly damaging 0.94
IGL02021:Vmn2r105 APN 17 20,448,157 (GRCm39) missense possibly damaging 0.49
IGL02828:Vmn2r105 APN 17 20,429,345 (GRCm39) missense possibly damaging 0.80
IGL02838:Vmn2r105 APN 17 20,447,847 (GRCm39) missense probably damaging 1.00
IGL03343:Vmn2r105 APN 17 20,446,631 (GRCm39) nonsense probably null
R0096:Vmn2r105 UTSW 17 20,447,741 (GRCm39) missense possibly damaging 0.49
R0096:Vmn2r105 UTSW 17 20,447,741 (GRCm39) missense possibly damaging 0.49
R0212:Vmn2r105 UTSW 17 20,428,827 (GRCm39) missense possibly damaging 0.90
R0268:Vmn2r105 UTSW 17 20,428,938 (GRCm39) missense probably benign 0.18
R0271:Vmn2r105 UTSW 17 20,454,965 (GRCm39) missense probably damaging 0.96
R0613:Vmn2r105 UTSW 17 20,428,578 (GRCm39) missense probably damaging 1.00
R0765:Vmn2r105 UTSW 17 20,448,119 (GRCm39) missense probably damaging 0.98
R0765:Vmn2r105 UTSW 17 20,447,973 (GRCm39) missense probably benign 0.20
R1162:Vmn2r105 UTSW 17 20,447,973 (GRCm39) missense probably benign 0.20
R1263:Vmn2r105 UTSW 17 20,428,584 (GRCm39) missense probably damaging 1.00
R1363:Vmn2r105 UTSW 17 20,428,932 (GRCm39) missense probably benign 0.00
R1464:Vmn2r105 UTSW 17 20,449,004 (GRCm39) splice site probably benign
R2029:Vmn2r105 UTSW 17 20,444,840 (GRCm39) missense probably damaging 0.99
R2420:Vmn2r105 UTSW 17 20,448,097 (GRCm39) missense probably benign 0.15
R2421:Vmn2r105 UTSW 17 20,448,097 (GRCm39) missense probably benign 0.15
R2422:Vmn2r105 UTSW 17 20,448,097 (GRCm39) missense probably benign 0.15
R2570:Vmn2r105 UTSW 17 20,447,585 (GRCm39) missense probably damaging 1.00
R3847:Vmn2r105 UTSW 17 20,428,952 (GRCm39) missense possibly damaging 0.85
R3848:Vmn2r105 UTSW 17 20,428,952 (GRCm39) missense possibly damaging 0.85
R4030:Vmn2r105 UTSW 17 20,429,016 (GRCm39) missense probably damaging 0.99
R4275:Vmn2r105 UTSW 17 20,448,902 (GRCm39) missense probably damaging 1.00
R4551:Vmn2r105 UTSW 17 20,446,613 (GRCm39) missense probably benign
R4801:Vmn2r105 UTSW 17 20,447,556 (GRCm39) missense probably benign 0.00
R4802:Vmn2r105 UTSW 17 20,447,556 (GRCm39) missense probably benign 0.00
R4816:Vmn2r105 UTSW 17 20,428,953 (GRCm39) missense probably benign 0.27
R4929:Vmn2r105 UTSW 17 20,448,280 (GRCm39) missense probably benign 0.44
R5022:Vmn2r105 UTSW 17 20,428,676 (GRCm39) missense probably damaging 0.99
R5475:Vmn2r105 UTSW 17 20,455,044 (GRCm39) missense probably benign
R5576:Vmn2r105 UTSW 17 20,444,836 (GRCm39) critical splice donor site probably null
R5795:Vmn2r105 UTSW 17 20,448,998 (GRCm39) missense probably benign 0.00
R5895:Vmn2r105 UTSW 17 20,448,929 (GRCm39) missense probably benign 0.10
R6017:Vmn2r105 UTSW 17 20,428,889 (GRCm39) missense probably damaging 0.97
R6210:Vmn2r105 UTSW 17 20,448,758 (GRCm39) missense probably damaging 1.00
R6491:Vmn2r105 UTSW 17 20,447,992 (GRCm39) nonsense probably null
R6542:Vmn2r105 UTSW 17 20,448,803 (GRCm39) missense probably benign 0.03
R6729:Vmn2r105 UTSW 17 20,428,605 (GRCm39) missense probably damaging 0.99
R7020:Vmn2r105 UTSW 17 20,429,336 (GRCm39) missense probably damaging 1.00
R7033:Vmn2r105 UTSW 17 20,428,874 (GRCm39) missense probably damaging 0.97
R7488:Vmn2r105 UTSW 17 20,429,045 (GRCm39) missense probably damaging 1.00
R7491:Vmn2r105 UTSW 17 20,448,827 (GRCm39) missense probably benign 0.02
R7555:Vmn2r105 UTSW 17 20,447,937 (GRCm39) missense probably damaging 0.98
R7863:Vmn2r105 UTSW 17 20,428,937 (GRCm39) missense probably benign 0.18
R8137:Vmn2r105 UTSW 17 20,454,966 (GRCm39) missense probably benign 0.02
R8166:Vmn2r105 UTSW 17 20,428,904 (GRCm39) missense probably benign 0.07
R8186:Vmn2r105 UTSW 17 20,444,880 (GRCm39) nonsense probably null
R8214:Vmn2r105 UTSW 17 20,448,775 (GRCm39) missense probably benign 0.02
R8497:Vmn2r105 UTSW 17 20,455,134 (GRCm39) start codon destroyed probably null 0.75
R8850:Vmn2r105 UTSW 17 20,428,872 (GRCm39) missense probably damaging 1.00
R9272:Vmn2r105 UTSW 17 20,447,685 (GRCm39) missense probably damaging 1.00
R9506:Vmn2r105 UTSW 17 20,429,404 (GRCm39) missense probably benign 0.00
R9549:Vmn2r105 UTSW 17 20,448,023 (GRCm39) missense probably benign 0.12
Predicted Primers PCR Primer
(F):5'- TATTCTCCCTGGAAAAGTGGC -3'
(R):5'- ATGTATGAAGTGTCCAGACAGTC -3'

Sequencing Primer
(F):5'- GTGGCCTTGAATGCAATAACC -3'
(R):5'- GAAGTGTCCAGACAGTCATTATGC -3'
Posted On 2021-07-15