Incidental Mutation 'R8882:Ulk2'
ID 676995
Institutional Source Beutler Lab
Gene Symbol Ulk2
Ensembl Gene ENSMUSG00000004798
Gene Name unc-51 like kinase 2
Synonyms A830085I22Rik, Unc51.2
MMRRC Submission 068750-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.219) question?
Stock # R8882 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 61666475-61745899 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 61698887 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000004920 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004920]
AlphaFold Q9QY01
Predicted Effect probably null
Transcript: ENSMUST00000004920
SMART Domains Protein: ENSMUSP00000004920
Gene: ENSMUSG00000004798

DomainStartEndE-ValueType
S_TKc 9 271 1.1e-93 SMART
low complexity region 274 309 N/A INTRINSIC
Blast:S_TKc 310 413 9e-28 BLAST
Blast:S_TKc 433 738 1e-29 BLAST
low complexity region 751 766 N/A INTRINSIC
low complexity region 771 791 N/A INTRINSIC
Pfam:DUF3543 821 1032 1.8e-31 PFAM
Meta Mutation Damage Score 0.9497 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008]
PHENOTYPE: Homozygous mutation of this gene results in an increased anxiety-like response in males. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actbl2 A T 13: 111,392,033 (GRCm39) I123L probably benign Het
Adam18 T C 8: 25,136,438 (GRCm39) D361G probably benign Het
Adcyap1r1 G A 6: 55,468,219 (GRCm39) V352M possibly damaging Het
Ahnak T C 19: 8,978,106 (GRCm39) L75P probably damaging Het
Arhgap23 T C 11: 97,355,949 (GRCm39) S856P probably benign Het
Asprv1 G T 6: 86,605,349 (GRCm39) C65F probably benign Het
Atp2b4 A T 1: 133,654,193 (GRCm39) probably null Het
Cd55 A G 1: 130,387,501 (GRCm39) V99A probably benign Het
Cit G A 5: 116,001,089 (GRCm39) A163T probably benign Het
Dnah6 A T 6: 73,155,481 (GRCm39) D711E probably benign Het
Dnajc15 A T 14: 78,094,411 (GRCm39) V41E probably damaging Het
Dock2 GCACACACACA GCACACACACACA 11: 34,595,436 (GRCm39) 453 probably null Het
Dst T C 1: 34,240,005 (GRCm39) S1785P probably damaging Het
Efhb A G 17: 53,769,712 (GRCm39) V199A probably damaging Het
Esyt3 C T 9: 99,202,909 (GRCm39) G498D probably damaging Het
Fbxo11 A G 17: 88,304,957 (GRCm39) I562T Het
Fh1 C T 1: 175,437,353 (GRCm39) V249I possibly damaging Het
Gdpgp1 T C 7: 79,888,704 (GRCm39) I245T possibly damaging Het
Hinfp A G 9: 44,209,629 (GRCm39) probably null Het
Hip1r A G 5: 124,140,025 (GRCm39) K1043E probably damaging Het
Htt G A 5: 34,979,061 (GRCm39) V815I probably benign Het
Jrk A G 15: 74,579,004 (GRCm39) Y94H probably damaging Het
Krit1 T A 5: 3,886,864 (GRCm39) N704K possibly damaging Het
Mmp17 A G 5: 129,679,008 (GRCm39) D331G probably benign Het
Nlrp9a T A 7: 26,257,703 (GRCm39) Y440* probably null Het
Nphp3 A G 9: 103,882,793 (GRCm39) T216A possibly damaging Het
Or1e1f T G 11: 73,855,940 (GRCm39) C169G probably damaging Het
Or4a79 G T 2: 89,551,740 (GRCm39) C238* probably null Het
Or5ae2 T C 7: 84,505,681 (GRCm39) Y37H probably damaging Het
Or7e176 T C 9: 20,171,256 (GRCm39) F40S probably benign Het
Or8c15 T A 9: 38,120,461 (GRCm39) Y35* probably null Het
Parva T C 7: 112,027,211 (GRCm39) S14P probably benign Het
Pax6 A C 2: 105,521,963 (GRCm39) N207H possibly damaging Het
Pde6a A G 18: 61,378,619 (GRCm39) N314S Het
Phlpp1 T A 1: 106,320,372 (GRCm39) S1456T probably benign Het
Plxnc1 A G 10: 94,677,428 (GRCm39) V933A probably damaging Het
Rasgef1b A G 5: 99,524,860 (GRCm39) S100P probably benign Het
Rpn2 A G 2: 157,136,102 (GRCm39) H170R probably benign Het
Sbds A G 5: 130,282,778 (GRCm39) probably null Het
Scube2 G C 7: 109,451,680 (GRCm39) L158V probably damaging Het
Slc16a12 C A 19: 34,649,854 (GRCm39) V394L probably benign Het
Slc23a2 A T 2: 131,933,159 (GRCm39) Y100N possibly damaging Het
Slc30a9 G T 5: 67,473,044 (GRCm39) E43* probably null Het
Specc1l A T 10: 75,065,689 (GRCm39) M1L unknown Het
Sspo T A 6: 48,452,390 (GRCm39) C2785S probably damaging Het
Star T C 8: 26,302,897 (GRCm39) S280P probably benign Het
Strip1 A T 3: 107,534,341 (GRCm39) M127K probably benign Het
Tbx19 C T 1: 164,966,780 (GRCm39) V365M probably benign Het
Tex2 T C 11: 106,435,062 (GRCm39) D788G unknown Het
Tspyl1 A G 10: 34,158,494 (GRCm39) E73G possibly damaging Het
Vmn2r120 A T 17: 57,852,229 (GRCm39) M29K probably benign Het
Vmn2r60 C A 7: 41,790,518 (GRCm39) Q502K probably benign Het
Xpo5 A G 17: 46,538,666 (GRCm39) D624G possibly damaging Het
Zfp119b T C 17: 56,246,923 (GRCm39) R88G possibly damaging Het
Zfp879 C A 11: 50,724,763 (GRCm39) E98* probably null Het
Other mutations in Ulk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01599:Ulk2 APN 11 61,682,262 (GRCm39) nonsense probably null
IGL02044:Ulk2 APN 11 61,672,465 (GRCm39) missense probably damaging 1.00
IGL02185:Ulk2 APN 11 61,672,886 (GRCm39) missense probably damaging 1.00
IGL03036:Ulk2 APN 11 61,725,660 (GRCm39) missense probably damaging 1.00
BB007:Ulk2 UTSW 11 61,682,258 (GRCm39) critical splice donor site probably null
BB009:Ulk2 UTSW 11 61,698,916 (GRCm39) missense probably benign
BB017:Ulk2 UTSW 11 61,682,258 (GRCm39) critical splice donor site probably null
BB019:Ulk2 UTSW 11 61,698,916 (GRCm39) missense probably benign
R0207:Ulk2 UTSW 11 61,668,611 (GRCm39) missense probably benign 0.42
R0362:Ulk2 UTSW 11 61,678,412 (GRCm39) missense probably benign
R0657:Ulk2 UTSW 11 61,698,880 (GRCm39) splice site probably benign
R1076:Ulk2 UTSW 11 61,710,135 (GRCm39) missense probably damaging 1.00
R1144:Ulk2 UTSW 11 61,690,886 (GRCm39) missense possibly damaging 0.80
R1573:Ulk2 UTSW 11 61,670,581 (GRCm39) missense probably damaging 1.00
R1583:Ulk2 UTSW 11 61,674,371 (GRCm39) missense possibly damaging 0.95
R1619:Ulk2 UTSW 11 61,672,572 (GRCm39) missense probably damaging 1.00
R1757:Ulk2 UTSW 11 61,732,165 (GRCm39) splice site probably benign
R1845:Ulk2 UTSW 11 61,703,564 (GRCm39) missense probably benign 0.04
R1883:Ulk2 UTSW 11 61,721,438 (GRCm39) missense probably damaging 1.00
R1966:Ulk2 UTSW 11 61,710,297 (GRCm39) splice site probably null
R2177:Ulk2 UTSW 11 61,682,335 (GRCm39) missense probably benign 0.01
R2416:Ulk2 UTSW 11 61,672,865 (GRCm39) missense probably damaging 1.00
R2509:Ulk2 UTSW 11 61,678,340 (GRCm39) missense probably benign 0.00
R2847:Ulk2 UTSW 11 61,715,555 (GRCm39) critical splice acceptor site probably null
R4736:Ulk2 UTSW 11 61,724,261 (GRCm39) missense probably damaging 1.00
R4997:Ulk2 UTSW 11 61,689,982 (GRCm39) missense probably benign 0.00
R5081:Ulk2 UTSW 11 61,694,488 (GRCm39) missense probably damaging 1.00
R5190:Ulk2 UTSW 11 61,672,537 (GRCm39) missense probably benign
R5346:Ulk2 UTSW 11 61,725,740 (GRCm39) missense probably damaging 1.00
R5348:Ulk2 UTSW 11 61,674,439 (GRCm39) missense probably benign
R5520:Ulk2 UTSW 11 61,698,970 (GRCm39) missense probably damaging 1.00
R5954:Ulk2 UTSW 11 61,694,622 (GRCm39) splice site probably benign
R6153:Ulk2 UTSW 11 61,672,572 (GRCm39) missense probably damaging 1.00
R6223:Ulk2 UTSW 11 61,678,330 (GRCm39) nonsense probably null
R7204:Ulk2 UTSW 11 61,674,457 (GRCm39) missense probably benign 0.11
R7205:Ulk2 UTSW 11 61,725,657 (GRCm39) missense possibly damaging 0.84
R7259:Ulk2 UTSW 11 61,672,909 (GRCm39) missense probably damaging 1.00
R7353:Ulk2 UTSW 11 61,710,174 (GRCm39) missense probably damaging 1.00
R7734:Ulk2 UTSW 11 61,744,127 (GRCm39) nonsense probably null
R7797:Ulk2 UTSW 11 61,672,928 (GRCm39) missense probably benign 0.06
R7808:Ulk2 UTSW 11 61,745,378 (GRCm39) missense probably damaging 1.00
R7930:Ulk2 UTSW 11 61,682,258 (GRCm39) critical splice donor site probably null
R7932:Ulk2 UTSW 11 61,698,916 (GRCm39) missense probably benign
R8909:Ulk2 UTSW 11 61,690,380 (GRCm39) missense probably benign
R9704:Ulk2 UTSW 11 61,716,694 (GRCm39) missense probably damaging 1.00
X0028:Ulk2 UTSW 11 61,690,394 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CACATTCTGCCATTCAGTACTATAC -3'
(R):5'- TAAAAGTGATCATGTGCCTTTCTGG -3'

Sequencing Primer
(F):5'- CAGCACAGCGTATACAGTGTTTGC -3'
(R):5'- ACAGCCCCAATTCCAGTT -3'
Posted On 2021-07-15