Mutagenetix > Incidental Mutation

Incidental Mutation 'R8885:Dock2'

677260

Institutional Source

Beutler Lab

Gene Symbol

Dock2

Ensembl Gene

ENSMUSG00000020143

Gene Name

dedicator of cyto-kinesis 2

Synonyms

CED-5, MBC, Hch

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8885 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

34226815-34783892 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 34310396 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Aspartic acid at position 982 (N982D)

Ref Sequence

ENSEMBL: ENSMUSP00000090884 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093192] [ENSMUST00000093193] [ENSMUST00000101365] [ENSMUST00000165963]

AlphaFold

Q8C3J5

Predicted Effect

probably benign
Transcript: ENSMUST00000093192

SMART Domains

Protein: ENSMUSP00000090883
Gene: ENSMUSG00000069911

Domain	Start	End	E-Value	Type
Pfam:FAM196	1	535	3.6e-196	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000093193
AA Change: N982D

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000090884
Gene: ENSMUSG00000020143
AA Change: N982D

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	2e-113	PFAM
Pfam:DOCK-C2	419	616	1e-60	PFAM
Pfam:DHR-2	1114	1614	6.3e-96	PFAM
low complexity region	1691	1706	N/A	INTRINSIC
low complexity region	1793	1800	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000101365
AA Change: N982D

PolyPhen 2 Score 0.312 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000098916
Gene: ENSMUSG00000020143
AA Change: N982D

Domain	Start	End	E-Value	Type
SH3	11	68	1.22e-11	SMART
Pfam:DOCK_N	71	414	1.4e-113	PFAM
Pfam:DOCK-C2	419	616	5.5e-61	PFAM
low complexity region	1163	1171	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000165963

SMART Domains

Protein: ENSMUSP00000129183
Gene: ENSMUSG00000069911

Domain	Start	End	E-Value	Type
Pfam:FAM196	3	535	1.3e-168	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (104/104)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygous mutants are defective in the migration of T and B lympohcytes in response to chemokines, and thus display immune defects such as lymphocytopenia, atrophy of lymphoid follicles and loss of marginal-zone B cells. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 106 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	A	T	13: 77,323,406	S977C	possibly damaging	Het
4921507P07Rik	A	T	6: 50,574,048	Y474N	possibly damaging	Het
Abca8a	T	A	11: 110,069,479	D646V	probably damaging	Het
Adss	T	A	1: 177,769,960	Y378F	probably damaging	Het
Akap6	C	T	12: 53,141,536	A1911V	probably benign	Het
Alg2	T	C	4: 47,474,159	Y43C	probably benign	Het
Alk	A	C	17: 71,895,763	V1159G	probably damaging	Het
Alx3	A	T	3: 107,600,694	Q173L	probably damaging	Het
Aqp9	A	G	9: 71,162,311		probably benign	Het
Atf7ip	C	A	6: 136,587,143	L787I	probably benign	Het
Bbs9	A	T	9: 22,678,938	E657D	possibly damaging	Het
Bean1	G	A	8: 104,182,120		probably null	Het
Cactin	G	T	10: 81,321,248	R13L	unknown	Het
Ccdc178	T	C	18: 22,067,664	E412G	probably damaging	Het
Ccdc30	A	G	4: 119,324,562	I583T	probably damaging	Het
Ccl8	T	C	11: 82,116,107	Y49H	probably damaging	Het
Clptm1	T	A	7: 19,639,007	K199N	probably damaging	Het
Cnbp	G	A	6: 87,845,664	S39L	probably benign	Het
Cnih3	T	A	1: 181,409,872		probably benign	Het
Cnksr3	A	T	10: 7,140,201		probably benign	Het
Cntn1	A	G	15: 92,261,499	I512V	probably benign	Het
Col20a1	A	G	2: 180,998,503		probably benign	Het
Col28a1	A	T	6: 8,127,360		probably benign	Het
Col6a2	A	T	10: 76,614,907	Y63*	probably null	Het
Copa	T	G	1: 172,097,745	F190V	probably damaging	Het
Crisp4	A	C	1: 18,136,924		probably benign	Het
Cxcl2	C	T	5: 90,904,226	Q64*	probably null	Het
Cxcr5	T	C	9: 44,514,252	D36G	probably benign	Het
Cyp20a1	T	A	1: 60,372,606	V271E	possibly damaging	Het
D430041D05Rik	T	C	2: 104,241,193	Y570C	probably damaging	Het
Ddi1	T	G	9: 6,266,198	D57A	probably benign	Het
Ddx11	T	A	17: 66,143,465	S492T	probably benign	Het
Dhx34	C	T	7: 16,216,451	R264H	probably damaging	Het
Dnah3	T	A	7: 119,962,152	I328F		Het
Dnah5	C	T	15: 28,327,740	R2087C	probably damaging	Het
Dnah8	C	G	17: 30,708,312	S1314W	possibly damaging	Het
Dync1h1	A	G	12: 110,616,738	D423G	probably damaging	Het
Ect2l	A	C	10: 18,172,835	L213V	probably damaging	Het
Fam210a	T	C	18: 68,276,144	I32V	probably benign	Het
Fancg	A	G	4: 43,007,266		probably null	Het
Fastkd5	T	C	2: 130,615,191	E493G	probably benign	Het
Fbxo38	T	C	18: 62,526,201	M342V	probably damaging	Het
Flnc	A	C	6: 29,455,411	K2020Q	probably damaging	Het
Flt4	A	G	11: 49,636,333		probably benign	Het
Frmd4b	G	T	6: 97,412,519	P129T	probably benign	Het
Galnt13	C	A	2: 54,880,126	A310E	probably benign	Het
Gm4884	T	A	7: 41,044,684	Y692*	probably null	Het
Gm6309	T	A	5: 146,168,293	D270V	probably damaging	Het
Grip1	G	T	10: 119,454,287		probably benign	Het
Itpr3	G	A	17: 27,118,677		probably benign	Het
Kdf1	G	T	4: 133,528,194	C74F	probably damaging	Het
Kdm1b	T	A	13: 47,053,708	C169*	probably null	Het
Kmt2c	G	T	5: 25,315,079	T2011K	probably benign	Het
Lama1	G	A	17: 67,773,784	G1269E		Het
Lamb3	C	T	1: 193,334,874	A791V	probably benign	Het
Leng9	G	T	7: 4,148,775	R301S	possibly damaging	Het
Lgr6	C	A	1: 134,987,604	V746L	probably benign	Het
Lrp5	T	A	19: 3,652,170	S216C	probably damaging	Het
Ltn1	T	C	16: 87,381,545	T1599A	probably damaging	Het
Map2k1	G	T	9: 64,187,324	N345K	probably damaging	Het
Map4k1	T	A	7: 28,989,437	D304E	probably benign	Het
Mcpt1	C	T	14: 56,019,065	T86I	probably damaging	Het
Mcpt9	T	C	14: 56,027,696	K116R	probably benign	Het
Morc2a	G	T	11: 3,678,584	A346S	probably damaging	Het
Mybpc3	A	T	2: 91,123,892	Q370L	probably benign	Het
Nars2	T	C	7: 97,002,888	S229P	probably damaging	Het
Ndufa10	A	T	1: 92,469,971	Y118N	probably damaging	Het
Nek11	A	T	9: 105,295,372		probably null	Het
Notch4	T	C	17: 34,584,496	V1463A	possibly damaging	Het
Nrcam	T	C	12: 44,564,125	I536T	probably benign	Het
Olfr771	T	C	10: 129,160,465	Y173C	probably benign	Het
Pbld1	A	T	10: 63,076,447	T285S	probably benign	Het
Pcdhgb8	A	T	18: 37,763,124	T416S	possibly damaging	Het
Plekhg6	T	C	6: 125,374,560	D242G	probably damaging	Het
Pnmt	T	A	11: 98,387,754	V182D	probably benign	Het
Ppp1r13b	G	T	12: 111,833,437	N758K	probably damaging	Het
Prex2	A	G	1: 11,170,575		probably benign	Het
Prss3	A	T	6: 41,377,578	L7Q	probably damaging	Het
Prss43	T	A	9: 110,830,978	L370Q	probably damaging	Het
Rac1	A	T	5: 143,508,130	V104E	probably damaging	Het
Rgs9	T	C	11: 109,275,623	Y107C	probably damaging	Het
Rnase13	C	T	14: 51,922,483	W66*	probably null	Het
Rrp1b	G	A	17: 32,051,714	V216I	possibly damaging	Het
Serinc1	A	G	10: 57,519,768	S309P	probably benign	Het
Serpine3	T	A	14: 62,665,138	L66Q	probably damaging	Het
Smc5	C	T	19: 23,213,870	V924M	probably damaging	Het
Srgap1	A	T	10: 121,925,640		probably benign	Het
Stab1	T	C	14: 31,161,814	E262G	possibly damaging	Het
Ston2	A	G	12: 91,639,724	*896R	probably null	Het
Syt6	A	G	3: 103,625,625	M442V	probably benign	Het
Tap1	T	C	17: 34,189,562		probably null	Het
Tbx3	A	C	5: 119,680,559	S420R	probably benign	Het
Tespa1	A	T	10: 130,362,447	Q446L	probably benign	Het
Tifab	T	C	13: 56,176,295	M112V	probably benign	Het
Trpv5	A	T	6: 41,653,258	S633T	possibly damaging	Het
Ttn	T	C	2: 76,853,892	K838R	unknown	Het
Ttn	A	T	2: 76,914,466	V5413E	probably damaging	Het
Tub	C	A	7: 109,029,586	N415K		Het
Vmn2r3	T	C	3: 64,274,962	M439V	probably benign	Het
Vps13c	A	G	9: 67,943,454	D2231G	probably benign	Het
Wbp1	C	T	6: 83,119,932	C118Y	unknown	Het
Zdhhc20	C	T	14: 57,890,214		probably benign	Het
Zfp217	T	A	2: 170,114,471	N869I	probably benign	Het
Zfp677	T	C	17: 21,398,088	I469T	probably benign	Het
Zmym2	T	A	14: 56,947,872		probably benign	Het
Zzef1	T	G	11: 72,796,576	S94A	probably benign	Het

Other mutations in Dock2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Dock2	APN	11	34704661	missense	probably damaging	1.00
IGL00469:Dock2	APN	11	34229603	splice site	probably benign
IGL01061:Dock2	APN	11	34705826	missense	probably damaging	1.00
IGL01319:Dock2	APN	11	34698790	missense	possibly damaging	0.61
IGL01451:Dock2	APN	11	34310390	missense	probably damaging	1.00
IGL01490:Dock2	APN	11	34705781	missense	probably damaging	0.97
IGL01601:Dock2	APN	11	34239528	critical splice donor site	probably null
IGL01800:Dock2	APN	11	34756273	missense	probably damaging	1.00
IGL01804:Dock2	APN	11	34262433	missense	probably benign	0.01
IGL01823:Dock2	APN	11	34262391	missense	probably damaging	1.00
IGL01829:Dock2	APN	11	34705841	missense	probably damaging	0.98
IGL01830:Dock2	APN	11	34691917	nonsense	probably null
IGL01835:Dock2	APN	11	34310435	missense	possibly damaging	0.51
IGL01845:Dock2	APN	11	34708865	missense	probably benign	0.02
IGL01953:Dock2	APN	11	34732356	missense	probably benign	0.28
IGL01989:Dock2	APN	11	34268053	missense	probably benign
IGL02081:Dock2	APN	11	34254355	missense	probably benign
IGL02105:Dock2	APN	11	34714525	missense	probably damaging	1.00
IGL02153:Dock2	APN	11	34230670	missense	probably benign	0.01
IGL02170:Dock2	APN	11	34267949	missense	probably damaging	1.00
IGL02344:Dock2	APN	11	34731510	missense	probably damaging	0.98
IGL02389:Dock2	APN	11	34698740	splice site	probably benign
IGL02409:Dock2	APN	11	34501204	missense	probably benign	0.00
IGL02472:Dock2	APN	11	34249801	missense	probably benign	0.00
IGL02625:Dock2	APN	11	34501168	critical splice donor site	probably null
IGL02929:Dock2	APN	11	34268048	missense	probably damaging	1.00
IGL02951:Dock2	APN	11	34310448	unclassified	probably benign
IGL02999:Dock2	APN	11	34692259	missense	probably damaging	0.99
IGL03165:Dock2	APN	11	34687533	missense	probably damaging	0.99
Arches	UTSW	11	34689760	missense	probably damaging	1.00
capitol_reef	UTSW	11	34294170	critical splice acceptor site	probably null
Croesus	UTSW	11	34721027	missense	probably damaging	1.00
denali	UTSW	11	34229472	critical splice donor site	probably null
dew	UTSW	11	34248636	nonsense	probably null
Dinghy	UTSW	11	34262460	missense	possibly damaging	0.70
Dry	UTSW	11	34231652	missense	possibly damaging	0.79
frazz	UTSW	11	34248572	critical splice donor site	probably benign
frizz	UTSW	11	34258184	splice site	probably benign
gildenstern	UTSW	11	34732339	critical splice donor site	probably null
godsgrace	UTSW	11	34695453	missense	probably damaging	1.00
Harborside	UTSW	11	34262445	missense	probably benign
Landing	UTSW	11	34714501	missense	possibly damaging	0.83
latest	UTSW	11	34756222	missense	probably damaging	1.00
Launch	UTSW	11	34256562	missense	probably damaging	1.00
liaoning	UTSW	11	34708793	missense	probably damaging	1.00
lucre	UTSW	11	34704609	frame shift	probably null
midas	UTSW	11	34294323	missense	probably damaging	0.99
muelle	UTSW	11	34687538	missense	probably damaging	1.00
narrowest	UTSW	11	34282652	missense	probably damaging	0.98
pier	UTSW	11	34689766	missense	probably damaging	1.00
Plank	UTSW	11	34783795	missense	possibly damaging	0.51
resplendent	UTSW	11	34727460	nonsense	probably null
riches	UTSW	11	34688452	critical splice donor site	probably null
skiff	UTSW	11	34262388	missense	probably null	0.80
Slip	UTSW	11	34294286	missense	probably benign	0.25
toothskin	UTSW	11	34464922	missense	probably damaging	1.00
Touch	UTSW	11	34273750	missense	possibly damaging	0.95
wassup	UTSW	11	34503413	missense	probably damaging	1.00
Wharf	UTSW	11	34732371	missense	possibly damaging	0.81
BB009:Dock2	UTSW	11	34267998	missense	probably benign	0.00
BB019:Dock2	UTSW	11	34267998	missense	probably benign	0.00
IGL03052:Dock2	UTSW	11	34232853	missense	probably benign	0.01
PIT4377001:Dock2	UTSW	11	34721008	missense	probably benign	0.02
R0006:Dock2	UTSW	11	34312453	unclassified	probably benign
R0012:Dock2	UTSW	11	34783795	missense	possibly damaging	0.51
R0063:Dock2	UTSW	11	34756284	critical splice acceptor site	probably null
R0063:Dock2	UTSW	11	34756284	critical splice acceptor site	probably null
R0116:Dock2	UTSW	11	34688565	intron	probably benign
R0149:Dock2	UTSW	11	34438327	missense	probably damaging	1.00
R0361:Dock2	UTSW	11	34438327	missense	probably damaging	1.00
R0462:Dock2	UTSW	11	34268052	missense	possibly damaging	0.74
R0471:Dock2	UTSW	11	34688553	missense	probably benign	0.30
R0538:Dock2	UTSW	11	34704718	splice site	probably benign
R0543:Dock2	UTSW	11	34294325	missense	probably damaging	1.00
R0660:Dock2	UTSW	11	34248621	missense	probably damaging	1.00
R0676:Dock2	UTSW	11	34695236	missense	probably damaging	0.99
R0722:Dock2	UTSW	11	34464970	splice site	probably benign
R0801:Dock2	UTSW	11	34708793	missense	probably damaging	1.00
R1110:Dock2	UTSW	11	34256535	missense	possibly damaging	0.78
R1171:Dock2	UTSW	11	34695241	missense	probably damaging	1.00
R1387:Dock2	UTSW	11	34273309	splice site	probably benign
R1445:Dock2	UTSW	11	34239705	missense	probably benign
R1494:Dock2	UTSW	11	34282761	nonsense	probably null
R1589:Dock2	UTSW	11	34706461	missense	probably damaging	0.99
R1597:Dock2	UTSW	11	34704647	missense	probably benign	0.00
R1629:Dock2	UTSW	11	34262480	splice site	probably null
R1749:Dock2	UTSW	11	34232767	critical splice donor site	probably null
R1888:Dock2	UTSW	11	34707342	missense	probably damaging	1.00
R1888:Dock2	UTSW	11	34707342	missense	probably damaging	1.00
R1899:Dock2	UTSW	11	34294286	missense	probably benign	0.25
R1924:Dock2	UTSW	11	34464934	missense	possibly damaging	0.69
R2031:Dock2	UTSW	11	34727470	splice site	probably benign
R2045:Dock2	UTSW	11	34294106	splice site	probably null
R2098:Dock2	UTSW	11	34266279	missense	probably benign	0.16
R2098:Dock2	UTSW	11	34719005	missense	probably damaging	0.99
R2129:Dock2	UTSW	11	34727415	missense	probably damaging	1.00
R2147:Dock2	UTSW	11	34229472	critical splice donor site	probably null
R2149:Dock2	UTSW	11	34229472	critical splice donor site	probably null
R2150:Dock2	UTSW	11	34229472	critical splice donor site	probably null
R2176:Dock2	UTSW	11	34695217	missense	probably benign	0.00
R2230:Dock2	UTSW	11	34294323	missense	probably damaging	0.99
R2508:Dock2	UTSW	11	34312485	missense	probably benign	0.04
R2875:Dock2	UTSW	11	34718885	missense	probably damaging	1.00
R2885:Dock2	UTSW	11	34689766	missense	probably damaging	1.00
R2910:Dock2	UTSW	11	34232910	splice site	probably benign
R3081:Dock2	UTSW	11	34231610	missense	probably benign
R3418:Dock2	UTSW	11	34689760	missense	probably damaging	1.00
R3552:Dock2	UTSW	11	34720960	missense	probably benign	0.22
R3731:Dock2	UTSW	11	34708895	missense	probably damaging	1.00
R3846:Dock2	UTSW	11	34732371	missense	possibly damaging	0.81
R4135:Dock2	UTSW	11	34714501	missense	possibly damaging	0.83
R4598:Dock2	UTSW	11	34239536	missense	probably damaging	1.00
R4599:Dock2	UTSW	11	34239536	missense	probably damaging	1.00
R4715:Dock2	UTSW	11	34294118	missense	probably damaging	1.00
R4722:Dock2	UTSW	11	34695471	missense	probably damaging	1.00
R4742:Dock2	UTSW	11	34294170	critical splice acceptor site	probably null
R4830:Dock2	UTSW	11	34273767	splice site	probably null
R4884:Dock2	UTSW	11	34266248	missense	probably damaging	1.00
R4990:Dock2	UTSW	11	34695251	missense	probably damaging	1.00
R5334:Dock2	UTSW	11	34228643	missense	probably benign	0.00
R5570:Dock2	UTSW	11	34727406	missense	probably damaging	1.00
R5602:Dock2	UTSW	11	34254391	missense	probably benign	0.16
R5681:Dock2	UTSW	11	34249836	missense	probably benign	0.06
R5809:Dock2	UTSW	11	34262445	missense	probably benign
R5860:Dock2	UTSW	11	34256562	missense	probably damaging	1.00
R6111:Dock2	UTSW	11	34708787	missense	probably damaging	0.99
R6155:Dock2	UTSW	11	34294123	missense	probably benign	0.06
R6156:Dock2	UTSW	11	34247789	missense	possibly damaging	0.51
R6173:Dock2	UTSW	11	34262388	missense	probably null	0.80
R6182:Dock2	UTSW	11	34229476	missense	probably damaging	0.97
R6188:Dock2	UTSW	11	34503396	missense	probably damaging	0.98
R6191:Dock2	UTSW	11	34231652	missense	possibly damaging	0.79
R6283:Dock2	UTSW	11	34707325	missense	probably damaging	0.99
R6395:Dock2	UTSW	11	34232874	missense	probably damaging	1.00
R6465:Dock2	UTSW	11	34503413	missense	probably damaging	1.00
R6500:Dock2	UTSW	11	34362822	missense	possibly damaging	0.76
R6561:Dock2	UTSW	11	34687538	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34705842	missense	probably damaging	1.00
R6745:Dock2	UTSW	11	34705843	missense	probably damaging	1.00
R6880:Dock2	UTSW	11	34688452	critical splice donor site	probably null
R6913:Dock2	UTSW	11	34756222	missense	probably damaging	1.00
R6997:Dock2	UTSW	11	34464922	missense	probably damaging	1.00
R7057:Dock2	UTSW	11	34227684	missense	probably benign	0.10
R7057:Dock2	UTSW	11	34695217	missense	probably benign	0.00
R7134:Dock2	UTSW	11	34310363	missense	probably benign	0.03
R7188:Dock2	UTSW	11	34239675	missense	possibly damaging	0.87
R7239:Dock2	UTSW	11	34231677	missense	probably benign	0.00
R7247:Dock2	UTSW	11	34714513	nonsense	probably null
R7250:Dock2	UTSW	11	34695205	missense	probably benign	0.01
R7250:Dock2	UTSW	11	34695293	missense	probably damaging	1.00
R7271:Dock2	UTSW	11	34273750	missense	possibly damaging	0.95
R7284:Dock2	UTSW	11	34230672	missense	probably benign	0.01
R7397:Dock2	UTSW	11	34718989	missense	probably benign	0.00
R7464:Dock2	UTSW	11	34695278	missense	probably damaging	0.99
R7512:Dock2	UTSW	11	34312542	missense	possibly damaging	0.95
R7556:Dock2	UTSW	11	34720951	missense	probably benign	0.43
R7663:Dock2	UTSW	11	34721027	missense	probably damaging	1.00
R7779:Dock2	UTSW	11	34714455	missense	probably benign	0.38
R7797:Dock2	UTSW	11	34282652	missense	probably damaging	0.98
R7855:Dock2	UTSW	11	34273698	missense	probably damaging	1.00
R7922:Dock2	UTSW	11	34707327	missense	probably benign	0.29
R7932:Dock2	UTSW	11	34267998	missense	probably benign	0.00
R8013:Dock2	UTSW	11	34705850	missense	probably damaging	0.96
R8192:Dock2	UTSW	11	34732339	critical splice donor site	probably null
R8244:Dock2	UTSW	11	34695453	missense	probably damaging	1.00
R8307:Dock2	UTSW	11	34310362	missense	possibly damaging	0.95
R8418:Dock2	UTSW	11	34718968	missense	probably benign	0.01
R8460:Dock2	UTSW	11	34230825	critical splice acceptor site	probably null
R8495:Dock2	UTSW	11	34231622	missense	probably benign	0.14
R8556:Dock2	UTSW	11	34262457	missense	possibly damaging	0.84
R8690:Dock2	UTSW	11	34727460	nonsense	probably null
R8743:Dock2	UTSW	11	34273252	nonsense	probably null
R8757:Dock2	UTSW	11	34695240	missense	probably benign	0.13
R8759:Dock2	UTSW	11	34695240	missense	probably benign	0.13
R8793:Dock2	UTSW	11	34501215	missense	probably benign	0.00
R8882:Dock2	UTSW	11	34704609	frame shift	probably null
R8943:Dock2	UTSW	11	34708819	missense	possibly damaging	0.63
R9171:Dock2	UTSW	11	34698843	missense	probably benign	0.12
R9182:Dock2	UTSW	11	34310398	missense	possibly damaging	0.51
R9203:Dock2	UTSW	11	34731539	missense	possibly damaging	0.92
R9310:Dock2	UTSW	11	34294139	missense	possibly damaging	0.71
R9388:Dock2	UTSW	11	34262460	missense	possibly damaging	0.70
R9490:Dock2	UTSW	11	34698755	missense	possibly damaging	0.90
R9568:Dock2	UTSW	11	34708811	missense	possibly damaging	0.83
R9593:Dock2	UTSW	11	34228607	missense	probably benign	0.34
R9694:Dock2	UTSW	11	34268054	missense	probably benign
R9697:Dock2	UTSW	11	34254417	missense	probably benign
R9753:Dock2	UTSW	11	34273673	missense	possibly damaging	0.68
R9783:Dock2	UTSW	11	34258128	missense	possibly damaging	0.83
X0017:Dock2	UTSW	11	34266271	missense	probably benign	0.08
X0018:Dock2	UTSW	11	34232833	missense	possibly damaging	0.65
X0058:Dock2	UTSW	11	34256564	missense	probably damaging	1.00
X0066:Dock2	UTSW	11	34310357	missense	possibly damaging	0.95
Z1088:Dock2	UTSW	11	34438300	missense	probably benign	0.14
Z1088:Dock2	UTSW	11	34692382	missense	probably damaging	1.00
Z1088:Dock2	UTSW	11	34695212	nonsense	probably null
Z1176:Dock2	UTSW	11	34718924	missense	probably benign	0.04
Z1177:Dock2	UTSW	11	34312553	missense	possibly damaging	0.68

Predicted Primers

PCR Primer
(F):5'- TGTGTTTGTGCACAGAAAGG -3'
(R):5'- TGAGGCAGAATCTTAGTAGCGG -3'

Sequencing Primer
(F):5'- TTTGTGCACAGAAAGGAAGGGC -3'
(R):5'- CCATTTCTAACTGGTTGTGATGAC -3'

Posted On

2021-08-02