Mutagenetix > Incidental Mutation

Incidental Mutation 'R8885:Lama1'

677289

Institutional Source

Beutler Lab

Gene Symbol

Lama1

Ensembl Gene

ENSMUSG00000032796

Gene Name

laminin, alpha 1

Synonyms

Lama

MMRRC Submission

068751-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R8885 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

67697265-67822645 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 67773784 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Glutamic Acid at position 1269 (G1269E)

Ref Sequence

ENSEMBL: ENSMUSP00000043957 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035471]

AlphaFold

no structure available at present

Predicted Effect

SMART Domains

Protein: ENSMUSP00000043957
Gene: ENSMUSG00000032796
AA Change: G1269E

Domain	Start	End	E-Value	Type
low complexity region	3	22	N/A	INTRINSIC
LamNT	23	275	1.2e-131	SMART
EGF_Lam	277	331	1e-5	SMART
EGF_Lam	334	401	6.6e-6	SMART
EGF_Lam	404	458	9.11e-9	SMART
EGF_Lam	461	507	8.12e-6	SMART
LamB	570	702	2.09e-57	SMART
EGF_like	715	746	3.36e0	SMART
EGF_Lam	749	795	7.01e-10	SMART
EGF_Lam	798	853	3.59e-7	SMART
EGF_Lam	856	906	1.53e-10	SMART
EGF_Lam	909	955	1.13e-13	SMART
EGF_Lam	958	1002	1.36e-7	SMART
EGF_Lam	1005	1048	7.29e-8	SMART
EGF_like	1034	1082	4.83e1	SMART
EGF_Lam	1051	1094	1.67e-7	SMART
EGF_Lam	1097	1154	1.32e-5	SMART
LamB	1220	1352	8.7e-46	SMART
Pfam:Laminin_EGF	1367	1397	1.7e-6	PFAM
EGF_Lam	1410	1456	7.12e-11	SMART
EGF_Lam	1459	1513	3.25e-5	SMART
EGF_like	1497	1547	6.41e1	SMART
EGF_Lam	1516	1560	1.71e-13	SMART
Pfam:Laminin_I	1574	1838	1.7e-91	PFAM
low complexity region	2012	2031	N/A	INTRINSIC
low complexity region	2087	2098	N/A	INTRINSIC
LamG	2145	2287	3.66e-30	SMART
LamG	2332	2473	5.98e-35	SMART
LamG	2513	2661	1.11e-29	SMART
low complexity region	2695	2708	N/A	INTRINSIC
LamG	2743	2877	9.72e-35	SMART
LamG	2920	3056	4.63e-41	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (104/104)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]
PHENOTYPE: Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 106 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	A	T	13: 77,323,406	S977C	possibly damaging	Het
4921507P07Rik	A	T	6: 50,574,048	Y474N	possibly damaging	Het
Abca8a	T	A	11: 110,069,479	D646V	probably damaging	Het
Adss	T	A	1: 177,769,960	Y378F	probably damaging	Het
Akap6	C	T	12: 53,141,536	A1911V	probably benign	Het
Alg2	T	C	4: 47,474,159	Y43C	probably benign	Het
Alk	A	C	17: 71,895,763	V1159G	probably damaging	Het
Alx3	A	T	3: 107,600,694	Q173L	probably damaging	Het
Aqp9	A	G	9: 71,162,311		probably benign	Het
Atf7ip	C	A	6: 136,587,143	L787I	probably benign	Het
Bbs9	A	T	9: 22,678,938	E657D	possibly damaging	Het
Bean1	G	A	8: 104,182,120		probably null	Het
Cactin	G	T	10: 81,321,248	R13L	unknown	Het
Ccdc178	T	C	18: 22,067,664	E412G	probably damaging	Het
Ccdc30	A	G	4: 119,324,562	I583T	probably damaging	Het
Ccl8	T	C	11: 82,116,107	Y49H	probably damaging	Het
Clptm1	T	A	7: 19,639,007	K199N	probably damaging	Het
Cnbp	G	A	6: 87,845,664	S39L	probably benign	Het
Cnih3	T	A	1: 181,409,872		probably benign	Het
Cnksr3	A	T	10: 7,140,201		probably benign	Het
Cntn1	A	G	15: 92,261,499	I512V	probably benign	Het
Col20a1	A	G	2: 180,998,503		probably benign	Het
Col28a1	A	T	6: 8,127,360		probably benign	Het
Col6a2	A	T	10: 76,614,907	Y63*	probably null	Het
Copa	T	G	1: 172,097,745	F190V	probably damaging	Het
Crisp4	A	C	1: 18,136,924		probably benign	Het
Cxcl2	C	T	5: 90,904,226	Q64*	probably null	Het
Cxcr5	T	C	9: 44,514,252	D36G	probably benign	Het
Cyp20a1	T	A	1: 60,372,606	V271E	possibly damaging	Het
D430041D05Rik	T	C	2: 104,241,193	Y570C	probably damaging	Het
Ddi1	T	G	9: 6,266,198	D57A	probably benign	Het
Ddx11	T	A	17: 66,143,465	S492T	probably benign	Het
Dhx34	C	T	7: 16,216,451	R264H	probably damaging	Het
Dnah3	T	A	7: 119,962,152	I328F		Het
Dnah5	C	T	15: 28,327,740	R2087C	probably damaging	Het
Dnah8	C	G	17: 30,708,312	S1314W	possibly damaging	Het
Dock2	T	C	11: 34,310,396	N982D	probably benign	Het
Dync1h1	A	G	12: 110,616,738	D423G	probably damaging	Het
Ect2l	A	C	10: 18,172,835	L213V	probably damaging	Het
Fam210a	T	C	18: 68,276,144	I32V	probably benign	Het
Fancg	A	G	4: 43,007,266		probably null	Het
Fastkd5	T	C	2: 130,615,191	E493G	probably benign	Het
Fbxo38	T	C	18: 62,526,201	M342V	probably damaging	Het
Flnc	A	C	6: 29,455,411	K2020Q	probably damaging	Het
Flt4	A	G	11: 49,636,333		probably benign	Het
Frmd4b	G	T	6: 97,412,519	P129T	probably benign	Het
Galnt13	C	A	2: 54,880,126	A310E	probably benign	Het
Gm4884	T	A	7: 41,044,684	Y692*	probably null	Het
Gm6309	T	A	5: 146,168,293	D270V	probably damaging	Het
Grip1	G	T	10: 119,454,287		probably benign	Het
Itpr3	G	A	17: 27,118,677		probably benign	Het
Kdf1	G	T	4: 133,528,194	C74F	probably damaging	Het
Kdm1b	T	A	13: 47,053,708	C169*	probably null	Het
Kmt2c	G	T	5: 25,315,079	T2011K	probably benign	Het
Lamb3	C	T	1: 193,334,874	A791V	probably benign	Het
Leng9	G	T	7: 4,148,775	R301S	possibly damaging	Het
Lgr6	C	A	1: 134,987,604	V746L	probably benign	Het
Lrp5	T	A	19: 3,652,170	S216C	probably damaging	Het
Ltn1	T	C	16: 87,381,545	T1599A	probably damaging	Het
Map2k1	G	T	9: 64,187,324	N345K	probably damaging	Het
Map4k1	T	A	7: 28,989,437	D304E	probably benign	Het
Mcpt1	C	T	14: 56,019,065	T86I	probably damaging	Het
Mcpt9	T	C	14: 56,027,696	K116R	probably benign	Het
Morc2a	G	T	11: 3,678,584	A346S	probably damaging	Het
Mybpc3	A	T	2: 91,123,892	Q370L	probably benign	Het
Nars2	T	C	7: 97,002,888	S229P	probably damaging	Het
Ndufa10	A	T	1: 92,469,971	Y118N	probably damaging	Het
Nek11	A	T	9: 105,295,372		probably null	Het
Notch4	T	C	17: 34,584,496	V1463A	possibly damaging	Het
Nrcam	T	C	12: 44,564,125	I536T	probably benign	Het
Olfr771	T	C	10: 129,160,465	Y173C	probably benign	Het
Pbld1	A	T	10: 63,076,447	T285S	probably benign	Het
Pcdhgb8	A	T	18: 37,763,124	T416S	possibly damaging	Het
Plekhg6	T	C	6: 125,374,560	D242G	probably damaging	Het
Pnmt	T	A	11: 98,387,754	V182D	probably benign	Het
Ppp1r13b	G	T	12: 111,833,437	N758K	probably damaging	Het
Prex2	A	G	1: 11,170,575		probably benign	Het
Prss3	A	T	6: 41,377,578	L7Q	probably damaging	Het
Prss43	T	A	9: 110,830,978	L370Q	probably damaging	Het
Rac1	A	T	5: 143,508,130	V104E	probably damaging	Het
Rgs9	T	C	11: 109,275,623	Y107C	probably damaging	Het
Rnase13	C	T	14: 51,922,483	W66*	probably null	Het
Rrp1b	G	A	17: 32,051,714	V216I	possibly damaging	Het
Serinc1	A	G	10: 57,519,768	S309P	probably benign	Het
Serpine3	T	A	14: 62,665,138	L66Q	probably damaging	Het
Smc5	C	T	19: 23,213,870	V924M	probably damaging	Het
Srgap1	A	T	10: 121,925,640		probably benign	Het
Stab1	T	C	14: 31,161,814	E262G	possibly damaging	Het
Ston2	A	G	12: 91,639,724	*896R	probably null	Het
Syt6	A	G	3: 103,625,625	M442V	probably benign	Het
Tap1	T	C	17: 34,189,562		probably null	Het
Tbx3	A	C	5: 119,680,559	S420R	probably benign	Het
Tespa1	A	T	10: 130,362,447	Q446L	probably benign	Het
Tifab	T	C	13: 56,176,295	M112V	probably benign	Het
Trpv5	A	T	6: 41,653,258	S633T	possibly damaging	Het
Ttn	A	T	2: 76,914,466	V5413E	probably damaging	Het
Ttn	T	C	2: 76,853,892	K838R	unknown	Het
Tub	C	A	7: 109,029,586	N415K		Het
Vmn2r3	T	C	3: 64,274,962	M439V	probably benign	Het
Vps13c	A	G	9: 67,943,454	D2231G	probably benign	Het
Wbp1	C	T	6: 83,119,932	C118Y	unknown	Het
Zdhhc20	C	T	14: 57,890,214		probably benign	Het
Zfp217	T	A	2: 170,114,471	N869I	probably benign	Het
Zfp677	T	C	17: 21,398,088	I469T	probably benign	Het
Zmym2	T	A	14: 56,947,872		probably benign	Het
Zzef1	T	G	11: 72,796,576	S94A	probably benign	Het

Other mutations in Lama1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Lama1	APN	17	67,815,928 (GRCm38)	missense	probably benign
IGL00336:Lama1	APN	17	67,813,948 (GRCm38)	missense	probably benign	0.07
IGL01066:Lama1	APN	17	67,743,326 (GRCm38)	missense	probably damaging	1.00
IGL01140:Lama1	APN	17	67,802,933 (GRCm38)	missense	probably benign	0.14
IGL01291:Lama1	APN	17	67,738,870 (GRCm38)	missense	probably damaging	1.00
IGL01296:Lama1	APN	17	67,745,051 (GRCm38)	missense	probably benign	0.27
IGL01317:Lama1	APN	17	67,818,701 (GRCm38)	missense	probably damaging	1.00
IGL01490:Lama1	APN	17	67,750,584 (GRCm38)	missense	possibly damaging	0.54
IGL01506:Lama1	APN	17	67,785,070 (GRCm38)	missense	probably benign	0.01
IGL01508:Lama1	APN	17	67,809,361 (GRCm38)	splice site	probably benign
IGL01522:Lama1	APN	17	67,752,774 (GRCm38)	splice site	probably benign
IGL01530:Lama1	APN	17	67,796,790 (GRCm38)	missense	probably benign	0.02
IGL01541:Lama1	APN	17	67,785,070 (GRCm38)	missense	probably benign	0.01
IGL01677:Lama1	APN	17	67,779,148 (GRCm38)	missense	probably benign	0.15
IGL01886:Lama1	APN	17	67,807,797 (GRCm38)	missense	probably benign	0.36
IGL01994:Lama1	APN	17	67,752,439 (GRCm38)	missense	probably benign	0.05
IGL02017:Lama1	APN	17	67,764,725 (GRCm38)	missense	probably benign	0.00
IGL02021:Lama1	APN	17	67,821,626 (GRCm38)	missense	probably damaging	1.00
IGL02026:Lama1	APN	17	67,809,292 (GRCm38)	missense	possibly damaging	0.82
IGL02044:Lama1	APN	17	67,811,490 (GRCm38)	missense	probably benign	0.01
IGL02120:Lama1	APN	17	67,716,789 (GRCm38)	missense	probably damaging	1.00
IGL02425:Lama1	APN	17	67,811,485 (GRCm38)	missense	probably benign	0.45
IGL02549:Lama1	APN	17	67,790,835 (GRCm38)	missense	possibly damaging	0.93
IGL02642:Lama1	APN	17	67,812,366 (GRCm38)	missense	probably benign	0.00
IGL02795:Lama1	APN	17	67,738,894 (GRCm38)	splice site	probably null
IGL02798:Lama1	APN	17	67,795,191 (GRCm38)	splice site	probably benign
IGL02863:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL02870:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL02876:Lama1	APN	17	67,750,692 (GRCm38)	critical splice donor site	probably null
IGL02885:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL02891:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL02978:Lama1	APN	17	67,786,081 (GRCm38)	nonsense	probably null
IGL03064:Lama1	APN	17	67,779,104 (GRCm38)	missense	probably benign	0.01
IGL03076:Lama1	APN	17	67,716,799 (GRCm38)	missense	possibly damaging	0.95
IGL03110:Lama1	APN	17	67,798,986 (GRCm38)	missense	probably benign	0.04
IGL03143:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL03159:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
IGL03268:Lama1	APN	17	67,804,536 (GRCm38)	missense	probably damaging	0.99
ANU05:Lama1	UTSW	17	67,738,870 (GRCm38)	missense	probably damaging	1.00
PIT4472001:Lama1	UTSW	17	67,764,704 (GRCm38)	missense
R0047:Lama1	UTSW	17	67,795,186 (GRCm38)	splice site	probably benign
R0047:Lama1	UTSW	17	67,795,186 (GRCm38)	splice site	probably benign
R0050:Lama1	UTSW	17	67,782,056 (GRCm38)	missense	possibly damaging	0.66
R0096:Lama1	UTSW	17	67,805,413 (GRCm38)	missense	probably benign	0.12
R0096:Lama1	UTSW	17	67,805,413 (GRCm38)	missense	probably benign	0.12
R0111:Lama1	UTSW	17	67,737,498 (GRCm38)	missense	probably damaging	0.98
R0116:Lama1	UTSW	17	67,776,923 (GRCm38)	missense	probably benign	0.10
R0121:Lama1	UTSW	17	67,798,513 (GRCm38)	splice site	probably benign
R0278:Lama1	UTSW	17	67,810,183 (GRCm38)	missense	probably null	0.98
R0281:Lama1	UTSW	17	67,817,569 (GRCm38)	missense	probably damaging	1.00
R0312:Lama1	UTSW	17	67,775,851 (GRCm38)	missense	possibly damaging	0.45
R0419:Lama1	UTSW	17	67,791,610 (GRCm38)	critical splice donor site	probably null
R0512:Lama1	UTSW	17	67,779,134 (GRCm38)	missense	possibly damaging	0.67
R0514:Lama1	UTSW	17	67,764,698 (GRCm38)	missense	probably benign	0.40
R0562:Lama1	UTSW	17	67,815,959 (GRCm38)	missense	probably damaging	1.00
R0632:Lama1	UTSW	17	67,752,368 (GRCm38)	splice site	probably benign
R0645:Lama1	UTSW	17	67,773,712 (GRCm38)	missense	probably benign	0.01
R0712:Lama1	UTSW	17	67,779,042 (GRCm38)	splice site	probably null
R0763:Lama1	UTSW	17	67,772,818 (GRCm38)	missense	probably damaging	0.97
R0941:Lama1	UTSW	17	67,775,865 (GRCm38)	missense	probably benign	0.10
R1025:Lama1	UTSW	17	67,752,898 (GRCm38)	missense	probably benign	0.00
R1084:Lama1	UTSW	17	67,804,469 (GRCm38)	missense	probably benign	0.12
R1103:Lama1	UTSW	17	67,790,947 (GRCm38)	missense	probably damaging	0.98
R1420:Lama1	UTSW	17	67,790,947 (GRCm38)	missense	probably damaging	0.98
R1430:Lama1	UTSW	17	67,782,155 (GRCm38)	missense	possibly damaging	0.95
R1569:Lama1	UTSW	17	67,780,618 (GRCm38)	splice site	probably null
R1575:Lama1	UTSW	17	67,810,409 (GRCm38)	missense	possibly damaging	0.96
R1613:Lama1	UTSW	17	67,807,923 (GRCm38)	missense	probably benign	0.42
R1620:Lama1	UTSW	17	67,767,033 (GRCm38)	missense	probably benign	0.01
R1629:Lama1	UTSW	17	67,805,428 (GRCm38)	missense	probably benign	0.00
R1645:Lama1	UTSW	17	67,737,682 (GRCm38)	missense	probably benign	0.14
R1652:Lama1	UTSW	17	67,807,846 (GRCm38)	missense	probably damaging	0.97
R1674:Lama1	UTSW	17	67,791,244 (GRCm38)	missense	probably benign
R1678:Lama1	UTSW	17	67,810,155 (GRCm38)	missense	possibly damaging	0.56
R1710:Lama1	UTSW	17	67,753,791 (GRCm38)	missense	probably benign	0.00
R1712:Lama1	UTSW	17	67,717,186 (GRCm38)	missense	possibly damaging	0.95
R1737:Lama1	UTSW	17	67,802,921 (GRCm38)	missense	probably benign	0.36
R1757:Lama1	UTSW	17	67,697,383 (GRCm38)	missense	unknown
R1757:Lama1	UTSW	17	67,763,836 (GRCm38)	missense	probably benign	0.40
R1813:Lama1	UTSW	17	67,791,223 (GRCm38)	missense	probably benign
R1896:Lama1	UTSW	17	67,791,223 (GRCm38)	missense	probably benign
R1945:Lama1	UTSW	17	67,745,853 (GRCm38)	missense	probably benign	0.14
R2086:Lama1	UTSW	17	67,817,623 (GRCm38)	missense	probably damaging	1.00
R2149:Lama1	UTSW	17	67,773,865 (GRCm38)	missense	possibly damaging	0.95
R2178:Lama1	UTSW	17	67,769,515 (GRCm38)	missense	probably benign	0.07
R2183:Lama1	UTSW	17	67,791,009 (GRCm38)	missense	probably damaging	0.98
R2197:Lama1	UTSW	17	67,752,941 (GRCm38)	missense	probably benign	0.02
R2213:Lama1	UTSW	17	67,777,034 (GRCm38)	nonsense	probably null
R2260:Lama1	UTSW	17	67,737,507 (GRCm38)	missense	probably damaging	0.96
R2356:Lama1	UTSW	17	67,810,114 (GRCm38)	missense	probably damaging	1.00
R2420:Lama1	UTSW	17	67,750,553 (GRCm38)	missense	probably benign	0.00
R2421:Lama1	UTSW	17	67,750,553 (GRCm38)	missense	probably benign	0.00
R2422:Lama1	UTSW	17	67,750,553 (GRCm38)	missense	probably benign	0.00
R2424:Lama1	UTSW	17	67,798,665 (GRCm38)	missense	probably benign	0.09
R2442:Lama1	UTSW	17	67,768,317 (GRCm38)	missense	probably benign	0.04
R3147:Lama1	UTSW	17	67,737,658 (GRCm38)	missense	probably damaging	0.98
R3414:Lama1	UTSW	17	67,737,603 (GRCm38)	missense	probably damaging	1.00
R3683:Lama1	UTSW	17	67,768,333 (GRCm38)	missense	probably benign	0.40
R3820:Lama1	UTSW	17	67,779,046 (GRCm38)	splice site	probably null
R3821:Lama1	UTSW	17	67,779,046 (GRCm38)	splice site	probably null
R3822:Lama1	UTSW	17	67,779,046 (GRCm38)	splice site	probably null
R4012:Lama1	UTSW	17	67,812,373 (GRCm38)	nonsense	probably null
R4113:Lama1	UTSW	17	67,764,703 (GRCm38)	missense	probably benign	0.01
R4133:Lama1	UTSW	17	67,812,486 (GRCm38)	missense	probably damaging	1.00
R4133:Lama1	UTSW	17	67,750,655 (GRCm38)	missense	probably damaging	0.98
R4259:Lama1	UTSW	17	67,752,418 (GRCm38)	missense	possibly damaging	0.95
R4278:Lama1	UTSW	17	67,791,517 (GRCm38)	missense	probably null	0.00
R4321:Lama1	UTSW	17	67,771,083 (GRCm38)	missense	probably benign	0.03
R4374:Lama1	UTSW	17	67,804,518 (GRCm38)	missense	probably benign	0.00
R4386:Lama1	UTSW	17	67,773,712 (GRCm38)	missense	probably benign	0.01
R4463:Lama1	UTSW	17	67,761,700 (GRCm38)	missense	probably damaging	1.00
R4629:Lama1	UTSW	17	67,805,360 (GRCm38)	critical splice acceptor site	probably null
R4630:Lama1	UTSW	17	67,794,300 (GRCm38)	missense	probably benign	0.00
R4633:Lama1	UTSW	17	67,798,584 (GRCm38)	missense	probably damaging	0.96
R4668:Lama1	UTSW	17	67,752,434 (GRCm38)	missense	probably benign	0.27
R4684:Lama1	UTSW	17	67,773,778 (GRCm38)	missense	possibly damaging	0.88
R4745:Lama1	UTSW	17	67,738,780 (GRCm38)	missense	probably damaging	1.00
R4786:Lama1	UTSW	17	67,773,859 (GRCm38)	missense	possibly damaging	0.77
R4797:Lama1	UTSW	17	67,716,775 (GRCm38)	missense	probably benign	0.04
R4803:Lama1	UTSW	17	67,809,271 (GRCm38)	missense	probably damaging	1.00
R4925:Lama1	UTSW	17	67,794,314 (GRCm38)	missense	probably benign	0.02
R4939:Lama1	UTSW	17	67,737,475 (GRCm38)	missense	possibly damaging	0.91
R4952:Lama1	UTSW	17	67,767,566 (GRCm38)	critical splice donor site	probably null
R4975:Lama1	UTSW	17	67,738,834 (GRCm38)	missense	possibly damaging	0.95
R4977:Lama1	UTSW	17	67,737,682 (GRCm38)	missense	probably damaging	1.00
R5039:Lama1	UTSW	17	67,745,893 (GRCm38)	missense	possibly damaging	0.66
R5047:Lama1	UTSW	17	67,743,281 (GRCm38)	nonsense	probably null
R5195:Lama1	UTSW	17	67,764,800 (GRCm38)	missense	probably benign	0.13
R5230:Lama1	UTSW	17	67,745,083 (GRCm38)	nonsense	probably null
R5236:Lama1	UTSW	17	67,804,492 (GRCm38)	missense	probably benign	0.24
R5254:Lama1	UTSW	17	67,756,716 (GRCm38)	missense	probably benign	0.01
R5345:Lama1	UTSW	17	67,817,563 (GRCm38)	missense	probably benign
R5438:Lama1	UTSW	17	67,800,774 (GRCm38)	missense	possibly damaging	0.92
R5521:Lama1	UTSW	17	67,780,894 (GRCm38)	nonsense	probably null
R5568:Lama1	UTSW	17	67,768,298 (GRCm38)	critical splice acceptor site	probably null
R5645:Lama1	UTSW	17	67,802,948 (GRCm38)	missense	probably damaging	1.00
R5665:Lama1	UTSW	17	67,770,987 (GRCm38)	missense	probably damaging	1.00
R5727:Lama1	UTSW	17	67,815,224 (GRCm38)	missense	possibly damaging	0.81
R5757:Lama1	UTSW	17	67,738,787 (GRCm38)	missense	possibly damaging	0.59
R5795:Lama1	UTSW	17	67,796,727 (GRCm38)	missense	probably benign	0.02
R5857:Lama1	UTSW	17	67,807,843 (GRCm38)	missense	probably damaging	0.99
R5894:Lama1	UTSW	17	67,779,047 (GRCm38)	critical splice acceptor site	probably null
R5974:Lama1	UTSW	17	67,773,727 (GRCm38)	missense	probably benign	0.31
R6032:Lama1	UTSW	17	67,750,643 (GRCm38)	missense	probably benign	0.01
R6032:Lama1	UTSW	17	67,750,643 (GRCm38)	missense	probably benign	0.01
R6120:Lama1	UTSW	17	67,780,617 (GRCm38)	critical splice donor site	probably null
R6219:Lama1	UTSW	17	67,790,856 (GRCm38)	missense	probably benign	0.08
R6224:Lama1	UTSW	17	67,802,987 (GRCm38)	missense	possibly damaging	0.56
R6249:Lama1	UTSW	17	67,798,604 (GRCm38)	missense	probably benign
R6265:Lama1	UTSW	17	67,750,655 (GRCm38)	missense	probably damaging	0.98
R6276:Lama1	UTSW	17	67,784,088 (GRCm38)	splice site	probably null
R6284:Lama1	UTSW	17	67,810,096 (GRCm38)	missense	probably damaging	0.99
R6337:Lama1	UTSW	17	67,786,019 (GRCm38)	missense	probably benign	0.27
R6414:Lama1	UTSW	17	67,746,910 (GRCm38)	critical splice donor site	probably null
R6631:Lama1	UTSW	17	67,774,482 (GRCm38)	missense	probably benign	0.21
R6659:Lama1	UTSW	17	67,818,635 (GRCm38)	missense	probably damaging	1.00
R6660:Lama1	UTSW	17	67,804,500 (GRCm38)	missense	probably benign	0.05
R6677:Lama1	UTSW	17	67,795,233 (GRCm38)	missense	probably benign	0.14
R6763:Lama1	UTSW	17	67,746,873 (GRCm38)	missense	unknown
R6787:Lama1	UTSW	17	67,784,025 (GRCm38)	missense	unknown
R6831:Lama1	UTSW	17	67,756,754 (GRCm38)	missense	possibly damaging	0.89
R6855:Lama1	UTSW	17	67,782,155 (GRCm38)	missense	possibly damaging	0.95
R6910:Lama1	UTSW	17	67,791,464 (GRCm38)	missense	possibly damaging	0.60
R6934:Lama1	UTSW	17	67,774,543 (GRCm38)	missense	probably benign	0.04
R6945:Lama1	UTSW	17	67,813,866 (GRCm38)	missense
R6984:Lama1	UTSW	17	67,779,112 (GRCm38)	missense
R6989:Lama1	UTSW	17	67,753,758 (GRCm38)	missense
R6994:Lama1	UTSW	17	67,753,825 (GRCm38)	missense
R6995:Lama1	UTSW	17	67,753,825 (GRCm38)	missense
R7035:Lama1	UTSW	17	67,781,049 (GRCm38)	missense
R7133:Lama1	UTSW	17	67,782,146 (GRCm38)	missense
R7172:Lama1	UTSW	17	67,804,545 (GRCm38)	missense
R7197:Lama1	UTSW	17	67,737,705 (GRCm38)	nonsense	probably null
R7217:Lama1	UTSW	17	67,764,673 (GRCm38)	missense
R7229:Lama1	UTSW	17	67,752,446 (GRCm38)	missense
R7264:Lama1	UTSW	17	67,743,297 (GRCm38)	missense
R7311:Lama1	UTSW	17	67,767,385 (GRCm38)	missense
R7394:Lama1	UTSW	17	67,717,261 (GRCm38)	missense
R7419:Lama1	UTSW	17	67,717,174 (GRCm38)	missense
R7460:Lama1	UTSW	17	67,767,018 (GRCm38)	missense
R7492:Lama1	UTSW	17	67,817,651 (GRCm38)	missense
R7494:Lama1	UTSW	17	67,811,446 (GRCm38)	missense
R7552:Lama1	UTSW	17	67,737,667 (GRCm38)	missense
R7576:Lama1	UTSW	17	67,782,041 (GRCm38)	missense
R7583:Lama1	UTSW	17	67,761,621 (GRCm38)	missense
R7649:Lama1	UTSW	17	67,737,554 (GRCm38)	missense
R7663:Lama1	UTSW	17	67,780,880 (GRCm38)	missense
R7667:Lama1	UTSW	17	67,780,597 (GRCm38)	missense
R7688:Lama1	UTSW	17	67,761,628 (GRCm38)	missense
R7693:Lama1	UTSW	17	67,817,031 (GRCm38)	missense
R7748:Lama1	UTSW	17	67,750,590 (GRCm38)	missense
R7778:Lama1	UTSW	17	67,804,473 (GRCm38)	missense
R7824:Lama1	UTSW	17	67,804,473 (GRCm38)	missense
R7861:Lama1	UTSW	17	67,809,221 (GRCm38)	missense
R7884:Lama1	UTSW	17	67,769,435 (GRCm38)	missense
R8029:Lama1	UTSW	17	67,817,594 (GRCm38)	missense
R8078:Lama1	UTSW	17	67,791,294 (GRCm38)	missense
R8101:Lama1	UTSW	17	67,745,922 (GRCm38)	missense
R8313:Lama1	UTSW	17	67,750,520 (GRCm38)	missense
R8356:Lama1	UTSW	17	67,737,496 (GRCm38)	missense
R8366:Lama1	UTSW	17	67,818,704 (GRCm38)	missense
R8403:Lama1	UTSW	17	67,745,923 (GRCm38)	missense
R8456:Lama1	UTSW	17	67,737,496 (GRCm38)	missense
R8466:Lama1	UTSW	17	67,813,953 (GRCm38)	missense
R8678:Lama1	UTSW	17	67,817,103 (GRCm38)	missense
R8728:Lama1	UTSW	17	67,818,668 (GRCm38)	missense
R8796:Lama1	UTSW	17	67,810,151 (GRCm38)	missense
R8893:Lama1	UTSW	17	67,805,372 (GRCm38)	missense
R8898:Lama1	UTSW	17	67,821,615 (GRCm38)	missense
R8909:Lama1	UTSW	17	67,772,741 (GRCm38)	missense
R9025:Lama1	UTSW	17	67,812,496 (GRCm38)	missense
R9045:Lama1	UTSW	17	67,753,843 (GRCm38)	missense
R9098:Lama1	UTSW	17	67,804,513 (GRCm38)	missense
R9114:Lama1	UTSW	17	67,821,674 (GRCm38)	missense
R9173:Lama1	UTSW	17	67,769,602 (GRCm38)	missense
R9190:Lama1	UTSW	17	67,804,519 (GRCm38)	missense
R9381:Lama1	UTSW	17	67,737,484 (GRCm38)	missense
R9429:Lama1	UTSW	17	67,811,454 (GRCm38)	missense
R9504:Lama1	UTSW	17	67,821,666 (GRCm38)	missense
R9558:Lama1	UTSW	17	67,817,009 (GRCm38)	missense
R9647:Lama1	UTSW	17	67,717,175 (GRCm38)	missense
R9651:Lama1	UTSW	17	67,794,220 (GRCm38)	missense
R9654:Lama1	UTSW	17	67,794,271 (GRCm38)	missense
R9710:Lama1	UTSW	17	67,822,409 (GRCm38)	missense
R9733:Lama1	UTSW	17	67,809,945 (GRCm38)	missense
RF001:Lama1	UTSW	17	67,752,902 (GRCm38)	missense
RF013:Lama1	UTSW	17	67,781,062 (GRCm38)	missense
V8831:Lama1	UTSW	17	67,752,883 (GRCm38)	missense	probably benign	0.00
X0024:Lama1	UTSW	17	67,738,888 (GRCm38)	missense	probably damaging	1.00
X0028:Lama1	UTSW	17	67,794,310 (GRCm38)	missense	probably benign	0.06
X0028:Lama1	UTSW	17	67,767,422 (GRCm38)	missense	probably benign	0.00
X0066:Lama1	UTSW	17	67,811,566 (GRCm38)	missense	probably damaging	1.00
Z1088:Lama1	UTSW	17	67,810,171 (GRCm38)	missense	probably damaging	1.00
Z1088:Lama1	UTSW	17	67,771,082 (GRCm38)	missense	probably benign	0.25
Z1088:Lama1	UTSW	17	67,752,883 (GRCm38)	missense	probably benign	0.00
Z1176:Lama1	UTSW	17	67,752,883 (GRCm38)	missense	probably benign	0.00
Z1177:Lama1	UTSW	17	67,752,883 (GRCm38)	missense	probably benign	0.00
Z1191:Lama1	UTSW	17	67,798,644 (GRCm38)	missense

Predicted Primers

PCR Primer
(F):5'- GACAAGCTTTGCATAAAGTGGC -3'
(R):5'- TGAAGCCATGAAATATGAATCGCTC -3'

Sequencing Primer
(F):5'- GCTTTGCATAAAGTGGCCTTAAAC -3'
(R):5'- AGAACTCTCTGTCAGCTGGCTG -3'

Posted On

2021-08-02