Incidental Mutation 'R8886:Vmn2r3'
| ID |
677313 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r3
|
| Ensembl Gene |
ENSMUSG00000091572 |
| Gene Name |
vomeronasal 2, receptor 3 |
| Synonyms |
EG637004 |
| MMRRC Submission |
068691-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8886 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
64166225-64197130 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 64194892 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 9
(I9F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134891
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170244]
[ENSMUST00000176328]
|
| AlphaFold |
H3BJ88 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170244
|
| SMART Domains |
Protein: ENSMUSP00000126165
Gene: ENSMUSG00000091572
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
64 |
479 |
4e-64 |
PFAM |
|
Pfam:NCD3G
|
521 |
574 |
1.1e-17 |
PFAM |
|
Pfam:7tm_3
|
605 |
842 |
2.9e-75 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000176328
AA Change: I9F
PolyPhen 2
Score 0.465 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000134891
Gene: ENSMUSG00000091572
AA Change: I9F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
92 |
507 |
9.5e-66 |
PFAM |
|
Pfam:NCD3G
|
549 |
602 |
8.8e-17 |
PFAM |
|
Pfam:7tm_3
|
635 |
869 |
8.5e-48 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
99% (72/73) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700025G04Rik |
T |
A |
1: 151,882,349 (GRCm39) |
N14I |
possibly damaging |
Het |
| 1700066M21Rik |
T |
A |
1: 57,422,008 (GRCm39) |
I128N |
probably damaging |
Het |
| 4930407I10Rik |
G |
T |
15: 81,950,051 (GRCm39) |
S1316I |
probably damaging |
Het |
| Abcc9 |
T |
C |
6: 142,546,420 (GRCm39) |
|
probably benign |
Het |
| Adgrb3 |
A |
G |
1: 25,150,928 (GRCm39) |
S1102P |
probably damaging |
Het |
| BC061237 |
A |
C |
14: 44,741,691 (GRCm39) |
I145L |
probably benign |
Het |
| Birc7 |
A |
T |
2: 180,574,786 (GRCm39) |
|
probably benign |
Het |
| Boc |
C |
T |
16: 44,319,806 (GRCm39) |
G393S |
|
Het |
| Ccdc112 |
C |
T |
18: 46,444,826 (GRCm39) |
G18R |
unknown |
Het |
| Cryzl1 |
T |
A |
16: 91,492,188 (GRCm39) |
T213S |
possibly damaging |
Het |
| Cttnbp2 |
T |
C |
6: 18,414,298 (GRCm39) |
N916D |
probably benign |
Het |
| Cyp4v3 |
A |
T |
8: 45,774,785 (GRCm39) |
L123* |
probably null |
Het |
| Dmpk |
C |
A |
7: 18,825,886 (GRCm39) |
|
probably benign |
Het |
| Dnah9 |
A |
T |
11: 65,943,840 (GRCm39) |
V1932E |
probably damaging |
Het |
| Ect2 |
T |
C |
3: 27,200,126 (GRCm39) |
|
probably benign |
Het |
| Eif4a3 |
A |
G |
11: 119,179,705 (GRCm39) |
Y361H |
probably damaging |
Het |
| Fkbp10 |
A |
G |
11: 100,312,862 (GRCm39) |
E336G |
probably damaging |
Het |
| Gnptg |
T |
C |
17: 25,453,628 (GRCm39) |
S305G |
probably benign |
Het |
| Greb1l |
A |
T |
18: 10,553,843 (GRCm39) |
I1615F |
probably benign |
Het |
| Gse1 |
G |
A |
8: 121,297,470 (GRCm39) |
R561Q |
unknown |
Het |
| Igkv9-129 |
T |
A |
6: 67,817,221 (GRCm39) |
Y108* |
probably null |
Het |
| Igsf10 |
T |
A |
3: 59,237,410 (GRCm39) |
T924S |
probably benign |
Het |
| Itgb6 |
A |
T |
2: 60,458,324 (GRCm39) |
C476* |
probably null |
Het |
| Itih4 |
C |
T |
14: 30,617,482 (GRCm39) |
Q601* |
probably null |
Het |
| Itpk1 |
G |
A |
12: 102,550,604 (GRCm39) |
|
probably benign |
Het |
| Itpr3 |
G |
A |
17: 27,337,651 (GRCm39) |
|
probably benign |
Het |
| Jakmip3 |
G |
A |
7: 138,609,171 (GRCm39) |
E92K |
probably benign |
Het |
| Klhl29 |
A |
T |
12: 5,187,542 (GRCm39) |
L274H |
possibly damaging |
Het |
| Klk1b5 |
T |
A |
7: 43,869,192 (GRCm39) |
M122K |
probably damaging |
Het |
| Krt84 |
A |
G |
15: 101,437,221 (GRCm39) |
I314T |
possibly damaging |
Het |
| Lama2 |
A |
T |
10: 27,245,157 (GRCm39) |
|
probably benign |
Het |
| Lmntd1 |
T |
C |
6: 145,363,152 (GRCm39) |
T270A |
probably damaging |
Het |
| Mindy4 |
T |
C |
6: 55,255,223 (GRCm39) |
L567P |
probably benign |
Het |
| Mt2 |
A |
T |
8: 94,899,476 (GRCm39) |
M1L |
probably damaging |
Het |
| Myct1 |
C |
T |
10: 5,554,208 (GRCm39) |
T25I |
probably damaging |
Het |
| Myh11 |
A |
G |
16: 14,052,278 (GRCm39) |
I396T |
|
Het |
| Naprt |
T |
C |
15: 75,765,433 (GRCm39) |
T136A |
probably damaging |
Het |
| Nbea |
T |
C |
3: 55,966,148 (GRCm39) |
N438S |
probably damaging |
Het |
| Nckap1 |
C |
A |
2: 80,339,055 (GRCm39) |
|
probably null |
Het |
| Nop56 |
G |
T |
2: 130,117,902 (GRCm39) |
R126L |
probably damaging |
Het |
| Nts |
C |
T |
10: 102,320,868 (GRCm39) |
A74T |
probably benign |
Het |
| Ogfr |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
2: 180,237,059 (GRCm39) |
|
probably benign |
Het |
| Or8b49 |
T |
G |
9: 38,506,446 (GRCm39) |
F310V |
possibly damaging |
Het |
| Pcp2 |
A |
G |
8: 3,675,208 (GRCm39) |
|
probably null |
Het |
| Pdgfra |
T |
C |
5: 75,343,734 (GRCm39) |
S752P |
probably benign |
Het |
| Pign |
C |
T |
1: 105,512,779 (GRCm39) |
V635I |
probably benign |
Het |
| Plekhg3 |
C |
A |
12: 76,611,748 (GRCm39) |
H342Q |
possibly damaging |
Het |
| Ppp4c |
A |
T |
7: 126,386,466 (GRCm39) |
I177N |
probably damaging |
Het |
| Psmd5 |
A |
G |
2: 34,747,755 (GRCm39) |
F301L |
possibly damaging |
Het |
| Rad52 |
C |
T |
6: 119,890,041 (GRCm39) |
R56C |
probably damaging |
Het |
| Rbm20 |
A |
T |
19: 53,801,767 (GRCm39) |
I92L |
probably benign |
Het |
| Rnf213 |
A |
G |
11: 119,364,264 (GRCm39) |
D4522G |
|
Het |
| Robo3 |
T |
C |
9: 37,328,768 (GRCm39) |
E1276G |
probably damaging |
Het |
| Rxrb |
T |
C |
17: 34,256,428 (GRCm39) |
F500L |
probably damaging |
Het |
| Sar1a |
A |
T |
10: 61,522,172 (GRCm39) |
N88I |
possibly damaging |
Het |
| Scd3 |
A |
G |
19: 44,230,276 (GRCm39) |
D353G |
probably damaging |
Het |
| Sh2d4b |
T |
C |
14: 40,595,946 (GRCm39) |
|
probably benign |
Het |
| Ski |
A |
T |
4: 155,244,016 (GRCm39) |
L498Q |
probably null |
Het |
| Spocd1 |
T |
A |
4: 129,845,631 (GRCm39) |
M497K |
|
Het |
| Sspo |
A |
G |
6: 48,458,201 (GRCm39) |
E3299G |
possibly damaging |
Het |
| St14 |
C |
A |
9: 31,008,420 (GRCm39) |
V507F |
possibly damaging |
Het |
| Tcf24 |
G |
A |
1: 10,037,388 (GRCm39) |
T108I |
probably benign |
Het |
| Tecta |
T |
C |
9: 42,278,359 (GRCm39) |
T1050A |
probably benign |
Het |
| Ttc17 |
T |
C |
2: 94,205,473 (GRCm39) |
D291G |
probably benign |
Het |
| Tubgcp2 |
G |
T |
7: 139,584,882 (GRCm39) |
R518S |
probably benign |
Het |
| Ugt2a3 |
T |
C |
5: 87,484,358 (GRCm39) |
Y222C |
probably damaging |
Het |
| Unc5c |
C |
G |
3: 141,509,581 (GRCm39) |
A687G |
probably benign |
Het |
| Usp42 |
T |
C |
5: 143,700,714 (GRCm39) |
D1103G |
probably damaging |
Het |
| Vmn1r83 |
A |
C |
7: 12,055,843 (GRCm39) |
D71E |
probably benign |
Het |
| Zfand1 |
T |
C |
3: 10,409,862 (GRCm39) |
Q160R |
probably null |
Het |
| Zhx3 |
T |
C |
2: 160,623,216 (GRCm39) |
N317S |
probably damaging |
Het |
|
| Other mutations in Vmn2r3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01019:Vmn2r3
|
APN |
3 |
64,167,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01468:Vmn2r3
|
APN |
3 |
64,182,382 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
IGL02032:Vmn2r3
|
APN |
3 |
64,182,476 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02405:Vmn2r3
|
APN |
3 |
64,178,620 (GRCm39) |
splice site |
probably benign |
|
|
IGL02640:Vmn2r3
|
APN |
3 |
64,194,816 (GRCm39) |
missense |
probably benign |
|
|
IGL02719:Vmn2r3
|
APN |
3 |
64,183,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02746:Vmn2r3
|
APN |
3 |
64,167,239 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL02952:Vmn2r3
|
APN |
3 |
64,186,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03390:Vmn2r3
|
APN |
3 |
64,182,767 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
G1citation:Vmn2r3
|
UTSW |
3 |
64,194,876 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0023:Vmn2r3
|
UTSW |
3 |
64,182,787 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0433:Vmn2r3
|
UTSW |
3 |
64,183,054 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R0647:Vmn2r3
|
UTSW |
3 |
64,183,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1071:Vmn2r3
|
UTSW |
3 |
64,182,697 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1536:Vmn2r3
|
UTSW |
3 |
64,182,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1806:Vmn2r3
|
UTSW |
3 |
64,194,810 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1806:Vmn2r3
|
UTSW |
3 |
64,182,893 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1852:Vmn2r3
|
UTSW |
3 |
64,166,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1868:Vmn2r3
|
UTSW |
3 |
64,166,537 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2072:Vmn2r3
|
UTSW |
3 |
64,182,493 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2240:Vmn2r3
|
UTSW |
3 |
64,166,483 (GRCm39) |
missense |
probably benign |
0.44 |
|
R2446:Vmn2r3
|
UTSW |
3 |
64,182,733 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4133:Vmn2r3
|
UTSW |
3 |
64,183,138 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4159:Vmn2r3
|
UTSW |
3 |
64,194,850 (GRCm39) |
nonsense |
probably null |
|
|
R4494:Vmn2r3
|
UTSW |
3 |
64,182,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4860:Vmn2r3
|
UTSW |
3 |
64,183,022 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4895:Vmn2r3
|
UTSW |
3 |
64,167,182 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4912:Vmn2r3
|
UTSW |
3 |
64,166,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5018:Vmn2r3
|
UTSW |
3 |
64,178,774 (GRCm39) |
missense |
probably benign |
|
|
R5033:Vmn2r3
|
UTSW |
3 |
64,167,220 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5126:Vmn2r3
|
UTSW |
3 |
64,166,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5148:Vmn2r3
|
UTSW |
3 |
64,186,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5414:Vmn2r3
|
UTSW |
3 |
64,166,978 (GRCm39) |
nonsense |
probably null |
|
|
R5785:Vmn2r3
|
UTSW |
3 |
64,166,444 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5905:Vmn2r3
|
UTSW |
3 |
64,182,698 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5992:Vmn2r3
|
UTSW |
3 |
64,167,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6028:Vmn2r3
|
UTSW |
3 |
64,182,698 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6331:Vmn2r3
|
UTSW |
3 |
64,186,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Vmn2r3
|
UTSW |
3 |
64,182,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6775:Vmn2r3
|
UTSW |
3 |
64,183,039 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6822:Vmn2r3
|
UTSW |
3 |
64,194,876 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6826:Vmn2r3
|
UTSW |
3 |
64,182,327 (GRCm39) |
nonsense |
probably null |
|
|
R6886:Vmn2r3
|
UTSW |
3 |
64,166,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6971:Vmn2r3
|
UTSW |
3 |
64,166,668 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7154:Vmn2r3
|
UTSW |
3 |
64,194,732 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7192:Vmn2r3
|
UTSW |
3 |
64,167,364 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7282:Vmn2r3
|
UTSW |
3 |
64,168,825 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7472:Vmn2r3
|
UTSW |
3 |
64,182,953 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7563:Vmn2r3
|
UTSW |
3 |
64,182,770 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R7726:Vmn2r3
|
UTSW |
3 |
64,182,939 (GRCm39) |
nonsense |
probably null |
|
|
R7966:Vmn2r3
|
UTSW |
3 |
64,186,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8025:Vmn2r3
|
UTSW |
3 |
64,182,871 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8050:Vmn2r3
|
UTSW |
3 |
64,178,714 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8300:Vmn2r3
|
UTSW |
3 |
64,182,347 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8402:Vmn2r3
|
UTSW |
3 |
64,178,617 (GRCm39) |
splice site |
probably benign |
|
|
R8486:Vmn2r3
|
UTSW |
3 |
64,186,370 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8523:Vmn2r3
|
UTSW |
3 |
64,182,311 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8678:Vmn2r3
|
UTSW |
3 |
64,166,896 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8885:Vmn2r3
|
UTSW |
3 |
64,182,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8905:Vmn2r3
|
UTSW |
3 |
64,166,695 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8937:Vmn2r3
|
UTSW |
3 |
64,166,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8955:Vmn2r3
|
UTSW |
3 |
64,168,803 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9172:Vmn2r3
|
UTSW |
3 |
64,186,403 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9485:Vmn2r3
|
UTSW |
3 |
64,183,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9575:Vmn2r3
|
UTSW |
3 |
64,178,735 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9618:Vmn2r3
|
UTSW |
3 |
64,178,724 (GRCm39) |
missense |
probably damaging |
0.98 |
|
X0022:Vmn2r3
|
UTSW |
3 |
64,182,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0022:Vmn2r3
|
UTSW |
3 |
64,178,669 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCATCAGAGTCACTTGTTGGG -3'
(R):5'- TGAGAGGATTGCTCAGCTCC -3'
Sequencing Primer
(F):5'- TGGGATGGTCCTATAGTGAACAG -3'
(R):5'- CCAGATCCAGAAATTGCAACTGATTG -3'
|
| Posted On |
2021-08-02 |
Incidental Mutation