Incidental Mutation 'R8887:Dlc1'
| ID |
677407 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dlc1
|
| Ensembl Gene |
ENSMUSG00000031523 |
| Gene Name |
deleted in liver cancer 1 |
| Synonyms |
p122-RhoGAP, Arhgap7, A730069N07Rik, STARD12 |
| MMRRC Submission |
068752-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R8887 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
37034905-37420297 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 37051481 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 299
(V299E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000033923
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000033923]
[ENSMUST00000098826]
[ENSMUST00000163663]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000033923
AA Change: V299E
PolyPhen 2
Score 0.341 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000033923
Gene: ENSMUSG00000031523
AA Change: V299E
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:SAM_2
|
15 |
76 |
2.2e-7 |
PFAM |
|
low complexity region
|
154 |
174 |
N/A |
INTRINSIC |
|
low complexity region
|
238 |
250 |
N/A |
INTRINSIC |
|
low complexity region
|
298 |
325 |
N/A |
INTRINSIC |
|
low complexity region
|
427 |
441 |
N/A |
INTRINSIC |
|
RhoGAP
|
653 |
845 |
8.82e-59 |
SMART |
|
START
|
887 |
1088 |
3.93e-59 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000098826
AA Change: V333E
PolyPhen 2
Score 0.468 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000096425
Gene: ENSMUSG00000031523
AA Change: V333E
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:SAM_2
|
49 |
110 |
5.9e-8 |
PFAM |
|
low complexity region
|
188 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
284 |
N/A |
INTRINSIC |
|
low complexity region
|
332 |
359 |
N/A |
INTRINSIC |
|
low complexity region
|
461 |
475 |
N/A |
INTRINSIC |
|
RhoGAP
|
687 |
879 |
8.82e-59 |
SMART |
|
START
|
921 |
1122 |
3.93e-59 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000163663
AA Change: V750E
PolyPhen 2
Score 0.906 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000132812
Gene: ENSMUSG00000031523
AA Change: V750E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
353 |
369 |
N/A |
INTRINSIC |
|
low complexity region
|
388 |
403 |
N/A |
INTRINSIC |
|
Pfam:SAM_2
|
466 |
527 |
1.2e-7 |
PFAM |
|
low complexity region
|
605 |
625 |
N/A |
INTRINSIC |
|
low complexity region
|
689 |
701 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
776 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
892 |
N/A |
INTRINSIC |
|
RhoGAP
|
1104 |
1296 |
8.82e-59 |
SMART |
|
START
|
1338 |
1539 |
3.93e-59 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.5%
|
| Validation Efficiency |
98% (93/95) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]
PHENOTYPE: Homozygous mutants die by E10.5 with variable defects in the neural tube, heart, brain and placenta. Mouse embryonic fibroblasts homozygous for an activated conditional allele exhibti increased sensitivity to Ras-induced transformation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsbg2 |
T |
C |
17: 57,175,285 (GRCm39) |
T76A |
probably benign |
Het |
| Actn1 |
A |
G |
12: 80,215,197 (GRCm39) |
C860R |
probably damaging |
Het |
| Adam23 |
T |
A |
1: 63,554,744 (GRCm39) |
L170Q |
probably damaging |
Het |
| Afdn |
C |
T |
17: 14,116,401 (GRCm39) |
R1620* |
probably null |
Het |
| Agfg1 |
A |
G |
1: 82,848,525 (GRCm39) |
|
probably benign |
Het |
| Aire |
A |
G |
10: 77,870,298 (GRCm39) |
S476P |
probably damaging |
Het |
| Arhgef26 |
A |
G |
3: 62,247,401 (GRCm39) |
T162A |
probably benign |
Het |
| Atp1a2 |
T |
C |
1: 172,113,222 (GRCm39) |
Q487R |
probably null |
Het |
| BC048507 |
T |
A |
13: 68,011,628 (GRCm39) |
C2S |
probably benign |
Het |
| Bltp1 |
G |
T |
3: 37,087,503 (GRCm39) |
A615S |
possibly damaging |
Het |
| Bnc2 |
A |
C |
4: 84,209,707 (GRCm39) |
|
probably benign |
Het |
| Bop1 |
C |
T |
15: 76,338,524 (GRCm39) |
G473R |
probably damaging |
Het |
| C1galt1 |
A |
G |
6: 7,866,379 (GRCm39) |
E75G |
probably benign |
Het |
| Cacna1i |
T |
C |
15: 80,258,894 (GRCm39) |
V1201A |
possibly damaging |
Het |
| Cecr2 |
C |
A |
6: 120,715,162 (GRCm39) |
T249K |
probably damaging |
Het |
| Clca3a2 |
C |
A |
3: 144,790,810 (GRCm39) |
G421* |
probably null |
Het |
| Clec1b |
A |
T |
6: 129,378,703 (GRCm39) |
|
probably null |
Het |
| Cnksr3 |
C |
T |
10: 7,104,467 (GRCm39) |
D79N |
probably damaging |
Het |
| Col15a1 |
A |
G |
4: 47,287,091 (GRCm39) |
Q843R |
probably damaging |
Het |
| Col6a3 |
T |
C |
1: 90,755,948 (GRCm39) |
S114G |
probably benign |
Het |
| Corin |
A |
T |
5: 72,486,953 (GRCm39) |
|
probably null |
Het |
| Cyp2u1 |
A |
G |
3: 131,096,503 (GRCm39) |
Y92H |
probably damaging |
Het |
| Dcbld2 |
T |
C |
16: 58,229,270 (GRCm39) |
L51P |
probably damaging |
Het |
| Dip2c |
T |
A |
13: 9,673,989 (GRCm39) |
|
probably benign |
Het |
| Dlgap2 |
G |
A |
8: 14,229,682 (GRCm39) |
|
probably null |
Het |
| Dnah1 |
A |
G |
14: 31,032,997 (GRCm39) |
L346P |
probably damaging |
Het |
| Dnah9 |
T |
C |
11: 65,746,210 (GRCm39) |
T3968A |
probably benign |
Het |
| Duox2 |
A |
C |
2: 122,120,044 (GRCm39) |
M822R |
probably null |
Het |
| E2f7 |
A |
T |
10: 110,610,674 (GRCm39) |
Q433L |
probably benign |
Het |
| Eif3k |
A |
C |
7: 28,679,901 (GRCm39) |
Y42* |
probably null |
Het |
| Elmod3 |
A |
G |
6: 72,563,494 (GRCm39) |
S45P |
probably damaging |
Het |
| Emilin3 |
C |
A |
2: 160,751,108 (GRCm39) |
V214F |
possibly damaging |
Het |
| Fbxo10 |
A |
T |
4: 45,058,887 (GRCm39) |
F283L |
probably benign |
Het |
| Fbxw7 |
T |
C |
3: 84,876,549 (GRCm39) |
Y358H |
|
Het |
| G430095P16Rik |
A |
G |
8: 85,453,043 (GRCm39) |
N10S |
unknown |
Het |
| Gldc |
A |
G |
19: 30,111,156 (GRCm39) |
V540A |
possibly damaging |
Het |
| Gm3667 |
T |
A |
14: 18,271,553 (GRCm39) |
E67D |
probably benign |
Het |
| Golga3 |
T |
A |
5: 110,353,626 (GRCm39) |
|
probably benign |
Het |
| H60c |
T |
C |
10: 3,217,255 (GRCm39) |
E38G |
probably benign |
Het |
| Hectd4 |
A |
G |
5: 121,433,541 (GRCm39) |
D952G |
probably benign |
Het |
| Hoxb8 |
T |
A |
11: 96,175,223 (GRCm39) |
L220Q |
probably damaging |
Het |
| Ice1 |
A |
T |
13: 70,751,050 (GRCm39) |
L1679M |
probably damaging |
Het |
| Ifi202b |
T |
A |
1: 173,802,480 (GRCm39) |
Y118F |
probably damaging |
Het |
| Ift122 |
A |
T |
6: 115,868,880 (GRCm39) |
T456S |
probably benign |
Het |
| Ighg3 |
G |
A |
12: 113,323,845 (GRCm39) |
T181I |
|
Het |
| Ighv1-66 |
C |
A |
12: 115,557,032 (GRCm39) |
V17F |
probably damaging |
Het |
| Ighv5-12-4 |
A |
G |
12: 113,726,130 (GRCm39) |
V31A |
possibly damaging |
Het |
| Ints12 |
T |
A |
3: 132,815,003 (GRCm39) |
N403K |
probably damaging |
Het |
| Itpr3 |
G |
A |
17: 27,337,651 (GRCm39) |
|
probably benign |
Het |
| Kalrn |
A |
C |
16: 34,047,496 (GRCm39) |
N908K |
probably benign |
Het |
| Kctd9 |
G |
A |
14: 67,962,016 (GRCm39) |
V20I |
unknown |
Het |
| Krt78 |
G |
T |
15: 101,861,746 (GRCm39) |
L167M |
probably damaging |
Het |
| Ldb1 |
T |
C |
19: 46,023,294 (GRCm39) |
E206G |
probably damaging |
Het |
| Lig1 |
A |
G |
7: 13,030,713 (GRCm39) |
Y455C |
probably damaging |
Het |
| Ltbp1 |
T |
G |
17: 75,486,077 (GRCm39) |
I34S |
probably damaging |
Het |
| Map2 |
T |
C |
1: 66,454,758 (GRCm39) |
I1216T |
possibly damaging |
Het |
| Mex3c |
T |
C |
18: 73,706,800 (GRCm39) |
V229A |
probably damaging |
Het |
| Mfsd11 |
T |
C |
11: 116,745,526 (GRCm39) |
|
probably null |
Het |
| Mroh1 |
A |
G |
15: 76,331,474 (GRCm39) |
T1233A |
probably benign |
Het |
| Myct1 |
C |
T |
10: 5,554,208 (GRCm39) |
T25I |
probably damaging |
Het |
| Nipbl |
A |
T |
15: 8,391,271 (GRCm39) |
H234Q |
probably damaging |
Het |
| Npc1l1 |
G |
A |
11: 6,175,665 (GRCm39) |
P549S |
probably damaging |
Het |
| Or12d2 |
A |
T |
17: 37,624,642 (GRCm39) |
L211Q |
probably damaging |
Het |
| Or4c3 |
A |
G |
2: 89,852,269 (GRCm39) |
V47A |
probably benign |
Het |
| Or5h22 |
A |
T |
16: 58,894,846 (GRCm39) |
V199D |
possibly damaging |
Het |
| Or5w22 |
A |
G |
2: 87,363,187 (GRCm39) |
D270G |
possibly damaging |
Het |
| Or6c3b |
A |
T |
10: 129,527,372 (GRCm39) |
Y179* |
probably null |
Het |
| Padi3 |
A |
T |
4: 140,523,795 (GRCm39) |
C228* |
probably null |
Het |
| Palld |
T |
A |
8: 61,986,512 (GRCm39) |
D1015V |
unknown |
Het |
| Pcna-ps2 |
A |
T |
19: 9,261,488 (GRCm39) |
Y249F |
probably benign |
Het |
| Pelo |
C |
T |
13: 115,225,451 (GRCm39) |
C258Y |
probably benign |
Het |
| Ppp1r13b |
A |
T |
12: 111,803,430 (GRCm39) |
|
probably benign |
Het |
| Pramel26 |
A |
G |
4: 143,539,257 (GRCm39) |
F79L |
probably damaging |
Het |
| Prdm2 |
A |
G |
4: 142,860,771 (GRCm39) |
W840R |
probably damaging |
Het |
| Prkcg |
A |
G |
7: 3,370,857 (GRCm39) |
D428G |
possibly damaging |
Het |
| Pus7 |
G |
A |
5: 23,948,476 (GRCm39) |
R571* |
probably null |
Het |
| Rab11fip3 |
A |
G |
17: 26,286,927 (GRCm39) |
C409R |
possibly damaging |
Het |
| Rdh13 |
T |
C |
7: 4,434,522 (GRCm39) |
D186G |
probably damaging |
Het |
| Rslcan18 |
T |
A |
13: 67,246,793 (GRCm39) |
H273L |
probably damaging |
Het |
| Rxfp1 |
T |
A |
3: 79,559,289 (GRCm39) |
|
probably benign |
Het |
| Sh3bp1 |
T |
A |
15: 78,788,540 (GRCm39) |
|
probably null |
Het |
| Siglecg |
T |
A |
7: 43,058,008 (GRCm39) |
S9T |
probably benign |
Het |
| Slc9a1 |
T |
C |
4: 133,139,258 (GRCm39) |
F159L |
probably benign |
Het |
| Slc9a2 |
A |
G |
1: 40,758,009 (GRCm39) |
I183V |
probably benign |
Het |
| St6galnac4 |
A |
G |
2: 32,484,110 (GRCm39) |
M103V |
probably damaging |
Het |
| Tbc1d30 |
T |
C |
10: 121,187,059 (GRCm39) |
D42G |
possibly damaging |
Het |
| Tlr5 |
C |
A |
1: 182,801,332 (GRCm39) |
T212K |
probably benign |
Het |
| Trim43b |
T |
G |
9: 88,969,642 (GRCm39) |
I269L |
probably benign |
Het |
| Ttll6 |
T |
C |
11: 96,047,492 (GRCm39) |
L697P |
possibly damaging |
Het |
| Ttn |
T |
G |
2: 76,549,239 (GRCm39) |
T31813P |
probably damaging |
Het |
| Ttn |
A |
T |
2: 76,571,932 (GRCm39) |
D26320E |
probably damaging |
Het |
| Uba6 |
A |
G |
5: 86,307,061 (GRCm39) |
|
probably null |
Het |
| Usp1 |
C |
G |
4: 98,819,185 (GRCm39) |
Q216E |
probably benign |
Het |
| Vcan |
T |
C |
13: 89,853,026 (GRCm39) |
T645A |
probably benign |
Het |
| Wdr64 |
C |
A |
1: 175,599,850 (GRCm39) |
P559H |
probably benign |
Het |
| Zfat |
T |
C |
15: 68,056,315 (GRCm39) |
Y247C |
probably damaging |
Het |
| Zfp979 |
A |
T |
4: 147,698,219 (GRCm39) |
N163K |
probably damaging |
Het |
|
| Other mutations in Dlc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00493:Dlc1
|
APN |
8 |
37,037,436 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL00807:Dlc1
|
APN |
8 |
37,040,002 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00924:Dlc1
|
APN |
8 |
37,405,368 (GRCm39) |
missense |
probably benign |
|
|
IGL01349:Dlc1
|
APN |
8 |
37,050,978 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01419:Dlc1
|
APN |
8 |
37,317,371 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01871:Dlc1
|
APN |
8 |
37,317,334 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01937:Dlc1
|
APN |
8 |
37,317,345 (GRCm39) |
missense |
probably benign |
0.25 |
|
IGL02525:Dlc1
|
APN |
8 |
37,046,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02696:Dlc1
|
APN |
8 |
37,041,326 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02826:Dlc1
|
APN |
8 |
37,037,429 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL03029:Dlc1
|
APN |
8 |
37,038,416 (GRCm39) |
splice site |
probably null |
|
|
BB001:Dlc1
|
UTSW |
8 |
37,038,570 (GRCm39) |
missense |
probably benign |
0.03 |
|
BB011:Dlc1
|
UTSW |
8 |
37,038,570 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02835:Dlc1
|
UTSW |
8 |
37,051,055 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0068:Dlc1
|
UTSW |
8 |
37,404,875 (GRCm39) |
missense |
probably benign |
|
|
R0068:Dlc1
|
UTSW |
8 |
37,404,875 (GRCm39) |
missense |
probably benign |
|
|
R0164:Dlc1
|
UTSW |
8 |
37,066,594 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0164:Dlc1
|
UTSW |
8 |
37,066,594 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0218:Dlc1
|
UTSW |
8 |
37,317,383 (GRCm39) |
missense |
probably benign |
|
|
R0419:Dlc1
|
UTSW |
8 |
37,050,740 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0513:Dlc1
|
UTSW |
8 |
37,051,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0645:Dlc1
|
UTSW |
8 |
37,041,203 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R0646:Dlc1
|
UTSW |
8 |
37,325,205 (GRCm39) |
missense |
probably benign |
|
|
R0727:Dlc1
|
UTSW |
8 |
37,039,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0792:Dlc1
|
UTSW |
8 |
37,405,702 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1061:Dlc1
|
UTSW |
8 |
37,325,205 (GRCm39) |
missense |
probably benign |
|
|
R1221:Dlc1
|
UTSW |
8 |
37,051,985 (GRCm39) |
missense |
probably benign |
|
|
R1440:Dlc1
|
UTSW |
8 |
37,060,617 (GRCm39) |
splice site |
probably benign |
|
|
R1501:Dlc1
|
UTSW |
8 |
37,405,302 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1606:Dlc1
|
UTSW |
8 |
37,317,406 (GRCm39) |
missense |
probably benign |
|
|
R1707:Dlc1
|
UTSW |
8 |
37,404,763 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1750:Dlc1
|
UTSW |
8 |
37,325,244 (GRCm39) |
splice site |
probably null |
|
|
R1762:Dlc1
|
UTSW |
8 |
37,404,739 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2041:Dlc1
|
UTSW |
8 |
37,049,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2055:Dlc1
|
UTSW |
8 |
37,060,535 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2091:Dlc1
|
UTSW |
8 |
37,404,763 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2987:Dlc1
|
UTSW |
8 |
37,041,306 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4285:Dlc1
|
UTSW |
8 |
37,041,282 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4294:Dlc1
|
UTSW |
8 |
37,051,907 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4631:Dlc1
|
UTSW |
8 |
37,404,712 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4828:Dlc1
|
UTSW |
8 |
37,317,400 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4867:Dlc1
|
UTSW |
8 |
37,051,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4902:Dlc1
|
UTSW |
8 |
37,044,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5067:Dlc1
|
UTSW |
8 |
37,051,647 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5068:Dlc1
|
UTSW |
8 |
37,405,184 (GRCm39) |
missense |
probably benign |
|
|
R5198:Dlc1
|
UTSW |
8 |
37,405,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5471:Dlc1
|
UTSW |
8 |
37,051,879 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5668:Dlc1
|
UTSW |
8 |
37,404,655 (GRCm39) |
unclassified |
probably benign |
|
|
R5915:Dlc1
|
UTSW |
8 |
37,405,829 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R6323:Dlc1
|
UTSW |
8 |
37,405,537 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6655:Dlc1
|
UTSW |
8 |
37,039,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6908:Dlc1
|
UTSW |
8 |
37,404,841 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6914:Dlc1
|
UTSW |
8 |
37,405,364 (GRCm39) |
missense |
probably benign |
|
|
R6942:Dlc1
|
UTSW |
8 |
37,405,364 (GRCm39) |
missense |
probably benign |
|
|
R7269:Dlc1
|
UTSW |
8 |
37,046,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7271:Dlc1
|
UTSW |
8 |
37,049,954 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7462:Dlc1
|
UTSW |
8 |
37,405,118 (GRCm39) |
missense |
unknown |
|
|
R7548:Dlc1
|
UTSW |
8 |
37,051,809 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7649:Dlc1
|
UTSW |
8 |
37,049,894 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7924:Dlc1
|
UTSW |
8 |
37,038,570 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7960:Dlc1
|
UTSW |
8 |
37,404,989 (GRCm39) |
missense |
probably benign |
|
|
R7984:Dlc1
|
UTSW |
8 |
37,405,472 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8227:Dlc1
|
UTSW |
8 |
37,039,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8491:Dlc1
|
UTSW |
8 |
37,052,000 (GRCm39) |
missense |
probably benign |
|
|
R8526:Dlc1
|
UTSW |
8 |
37,404,968 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8715:Dlc1
|
UTSW |
8 |
37,405,795 (GRCm39) |
start gained |
probably benign |
|
|
R8972:Dlc1
|
UTSW |
8 |
37,405,394 (GRCm39) |
nonsense |
probably null |
|
|
R8988:Dlc1
|
UTSW |
8 |
37,039,997 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9031:Dlc1
|
UTSW |
8 |
37,405,055 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9080:Dlc1
|
UTSW |
8 |
37,052,006 (GRCm39) |
missense |
probably benign |
|
|
R9092:Dlc1
|
UTSW |
8 |
37,199,860 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9096:Dlc1
|
UTSW |
8 |
37,080,721 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9097:Dlc1
|
UTSW |
8 |
37,080,721 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9166:Dlc1
|
UTSW |
8 |
37,066,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9187:Dlc1
|
UTSW |
8 |
37,405,786 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
R9240:Dlc1
|
UTSW |
8 |
37,052,005 (GRCm39) |
missense |
probably benign |
|
|
R9276:Dlc1
|
UTSW |
8 |
37,046,558 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9325:Dlc1
|
UTSW |
8 |
37,038,518 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1176:Dlc1
|
UTSW |
8 |
37,051,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTAGAACACCGTGTCCTCTG -3'
(R):5'- TCAAACGCATGGAGAGCCTG -3'
Sequencing Primer
(F):5'- AACACCGTGTCCTCTGGGTAG -3'
(R):5'- TGAAGCTCAAGGGCTCCCAC -3'
|
| Posted On |
2021-08-02 |
Incidental Mutation