Mutagenetix > Incidental Mutation

Incidental Mutation 'R8888:Naip2'

677510

Institutional Source

Beutler Lab

Gene Symbol

Naip2

Ensembl Gene

ENSMUSG00000078945

Gene Name

NLR family, apoptosis inhibitory protein 2

Synonyms

Birc1b, Naip2, Naip-rs6

MMRRC Submission

068692-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

R8888 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

100144063-100202092 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 100189136 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Arginine at position 88 (H88R)

Ref Sequence

ENSEMBL: ENSMUSP00000070827 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067975] [ENSMUST00000117913] [ENSMUST00000167986]

AlphaFold

Q9QUK4

Predicted Effect

probably benign
Transcript: ENSMUST00000067975
AA Change: H88R

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000070827
Gene: ENSMUSG00000078945
AA Change: H88R

Domain	Start	End	E-Value	Type
BIR	58	129	7.95e-18	SMART
BIR	157	229	5.31e-37	SMART
BIR	276	347	4.22e-31	SMART
Pfam:NACHT	508	662	1.9e-36	PFAM
low complexity region	954	964	N/A	INTRINSIC
low complexity region	1116	1126	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000117913
AA Change: H88R

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000113890
Gene: ENSMUSG00000078945
AA Change: H88R

Domain	Start	End	E-Value	Type
BIR	58	129	7.95e-18	SMART
BIR	157	229	5.31e-37	SMART
BIR	276	347	4.22e-31	SMART
Pfam:NACHT	508	662	1.9e-36	PFAM
low complexity region	954	964	N/A	INTRINSIC
low complexity region	1116	1126	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000167986
AA Change: H88R

PolyPhen 2 Score 0.520 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000125852
Gene: ENSMUSG00000078945
AA Change: H88R

Domain	Start	End	E-Value	Type
BIR	58	129	7.95e-18	SMART
BIR	157	229	5.31e-37	SMART
BIR	276	347	4.22e-31	SMART
Pfam:NACHT	508	662	8.6e-35	PFAM
low complexity region	954	964	N/A	INTRINSIC
low complexity region	1116	1126	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

100% (78/78)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Nov 2016]

Allele List at MGI

Other mutations in this stock

Total: 78 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931409K22Rik	T	C	5: 24,550,630 (GRCm38)	D298G	probably benign	Het
5830411N06Rik	C	T	7: 140,261,619 (GRCm38)	P279S	possibly damaging	Het
Akr1a1	A	G	4: 116,641,063 (GRCm38)	L95P	probably damaging	Het
Amigo2	G	T	15: 97,245,508 (GRCm38)	N344K	probably damaging	Het
Ankrd11	T	C	8: 122,894,275 (GRCm38)	D946G	possibly damaging	Het
Ankrd12	T	C	17: 66,031,573 (GRCm38)		probably null	Het
Atp8b5	A	G	4: 43,304,687 (GRCm38)	N66S		Het
Bean1	CT	C	8: 104,182,032 (GRCm38)		probably null	Het
Birc6	G	A	17: 74,528,538 (GRCm38)	S24N	probably null	Het
Bzw2	A	T	12: 36,123,983 (GRCm38)	C97*	probably null	Het
C530008M17Rik	GCGCGAGGCCGAGAGGCAGGAGGAGGAAGCAAGACAACGCGAGGCCGAGAGGCAGG	GCGCGAGGCCGAGAGGCAGG	5: 76,856,954 (GRCm38)		probably benign	Het
Capn12	T	A	7: 28,886,524 (GRCm38)		probably benign	Het
Cdh1	T	A	8: 106,604,339 (GRCm38)	F34Y	probably damaging	Het
Cdh5	T	C	8: 104,125,460 (GRCm38)	I69T	possibly damaging	Het
Celsr2	G	A	3: 108,413,564 (GRCm38)	T644I	possibly damaging	Het
Cep85l	A	T	10: 53,348,815 (GRCm38)	L226Q	possibly damaging	Het
Clasp2	T	A	9: 113,903,868 (GRCm38)	M924K	possibly damaging	Het
Col3a1	G	A	1: 45,339,979 (GRCm38)	A850T	unknown	Het
Cped1	C	T	6: 22,016,963 (GRCm38)	P104S	possibly damaging	Het
Cyp2c69	T	C	19: 39,881,466 (GRCm38)	D104G	possibly damaging	Het
Daw1	T	A	1: 83,209,290 (GRCm38)	C274S	probably damaging	Het
Dmtn	T	C	14: 70,612,704 (GRCm38)	T267A	probably benign	Het
Dock5	A	G	14: 67,817,663 (GRCm38)	Y585H	possibly damaging	Het
Dopey1	A	G	9: 86,521,534 (GRCm38)	I132V	probably benign	Het
Dpysl5	C	T	5: 30,745,343 (GRCm38)	R40C	probably benign	Het
Dsg2	T	G	18: 20,590,069 (GRCm38)	V384G	probably damaging	Het
Elmo1	C	T	13: 20,564,460 (GRCm38)	L492F	probably damaging	Het
Epg5	C	A	18: 78,012,871 (GRCm38)	D1753E	possibly damaging	Het
Ext1	T	C	15: 53,092,327 (GRCm38)	Y458C	probably damaging	Het
Folr2	C	T	7: 101,840,201 (GRCm38)	V244M	unknown	Het
Frmd6	C	A	12: 70,893,872 (GRCm38)	H430Q	possibly damaging	Het
Galnt18	T	C	7: 111,779,502 (GRCm38)	I16V	possibly damaging	Het
Gm10036	C	A	18: 15,833,150 (GRCm38)	Y119*	probably null	Het
Gm853	T	C	4: 130,211,430 (GRCm38)	K316E	probably benign	Het
Gm884	T	A	11: 103,618,830 (GRCm38)	T771S	unknown	Het
Gria4	A	G	9: 4,664,951 (GRCm38)	S102P	probably damaging	Het
Hc	A	T	2: 35,000,849 (GRCm38)	N1318K	probably benign	Het
Htr2a	C	T	14: 74,645,177 (GRCm38)	T201I	possibly damaging	Het
Ifitm1	T	C	7: 140,969,586 (GRCm38)	L94P	probably damaging	Het
Itpr3	G	A	17: 27,118,677 (GRCm38)		probably benign	Het
Kank4	C	T	4: 98,765,510 (GRCm38)	V894I	possibly damaging	Het
Kcnip2	T	A	19: 45,796,661 (GRCm38)		probably benign	Het
Klhl29	A	T	12: 5,137,542 (GRCm38)	L274H	possibly damaging	Het
Lamb1	A	G	12: 31,302,954 (GRCm38)	T885A	possibly damaging	Het
Lipi	A	T	16: 75,555,822 (GRCm38)	L376I	probably benign	Het
Malrd1	A	T	2: 15,845,227 (GRCm38)	N1219I	unknown	Het
Mrc1	A	C	2: 14,307,949 (GRCm38)	N894T	probably damaging	Het
Mrpl35	C	T	6: 71,816,287 (GRCm38)	A127T	possibly damaging	Het
Nek5	C	T	8: 22,090,479 (GRCm38)		probably null	Het
Nlrc5	G	A	8: 94,525,490 (GRCm38)	V1880I	probably benign	Het
Noc3l	T	A	19: 38,810,307 (GRCm38)	K282N	probably damaging	Het
Nwd2	T	C	5: 63,805,898 (GRCm38)	Y942H	probably damaging	Het
Olfr1123	T	C	2: 87,418,315 (GRCm38)	V87A	probably benign	Het
Olfr1318	G	A	2: 112,156,629 (GRCm38)	R226H	probably benign	Het
Olfr646	T	A	7: 104,107,095 (GRCm38)	I272N	probably damaging	Het
Osbpl9	C	A	4: 109,073,136 (GRCm38)	A221S	probably benign	Het
Paip1	T	C	13: 119,430,265 (GRCm38)	L45S	probably benign	Het
Pccb	A	T	9: 101,023,252 (GRCm38)		probably benign	Het
Pgap3	A	G	11: 98,390,776 (GRCm38)	F199L	possibly damaging	Het
Pik3c2g	A	T	6: 139,730,366 (GRCm38)	K79*	probably null	Het
Pou3f1	C	G	4: 124,658,359 (GRCm38)	A218G	possibly damaging	Het
Ptk2b	T	A	14: 66,174,793 (GRCm38)	N383I	probably benign	Het
Rad52	C	T	6: 119,913,080 (GRCm38)	R56C	probably damaging	Het
Rdh7	A	T	10: 127,888,561 (GRCm38)	F18Y	probably benign	Het
Sept5	A	G	16: 18,623,111 (GRCm38)	M315T	possibly damaging	Het
Slc27a6	A	G	18: 58,582,234 (GRCm38)	Y303C	probably damaging	Het
Slc7a7	T	A	14: 54,369,836 (GRCm38)	M495L	probably benign	Het
Sntg1	T	A	1: 8,677,850 (GRCm38)		probably null	Het
Spdye4a	T	G	5: 143,225,663 (GRCm38)	S49R	probably benign	Het
Spred2	T	A	11: 20,001,019 (GRCm38)	I72N	probably benign	Het
Stox1	A	T	10: 62,659,607 (GRCm38)	H962Q	probably benign	Het
Susd2	G	T	10: 75,639,618 (GRCm38)	A484D	possibly damaging	Het
Syt14	A	G	1: 192,897,558 (GRCm38)	S473P	probably damaging	Het
Tpx2	T	C	2: 152,882,335 (GRCm38)	Y344H	probably damaging	Het
Ttc17	T	C	2: 94,326,704 (GRCm38)	N411S	probably benign	Het
Ttf2	A	T	3: 100,962,712 (GRCm38)	F348L	probably benign	Het
Ttn	A	T	2: 76,833,306 (GRCm38)	V11675E	unknown	Het
Usp2	G	T	9: 44,075,597 (GRCm38)	R64L	probably benign	Het

Other mutations in Naip2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00515:Naip2	APN	13	100,154,887 (GRCm38)	missense	probably benign	0.00
IGL00676:Naip2	APN	13	100,152,632 (GRCm38)	missense	probably damaging	1.00
IGL00870:Naip2	APN	13	100,152,060 (GRCm38)	splice site	probably benign
IGL00908:Naip2	APN	13	100,160,649 (GRCm38)	missense	probably benign	0.01
IGL00916:Naip2	APN	13	100,161,431 (GRCm38)	missense	probably damaging	0.97
IGL00949:Naip2	APN	13	100,161,591 (GRCm38)	missense	probably damaging	1.00
IGL01010:Naip2	APN	13	100,154,938 (GRCm38)	missense	probably damaging	0.99
IGL01642:Naip2	APN	13	100,160,937 (GRCm38)	missense	probably damaging	0.97
IGL01884:Naip2	APN	13	100,188,821 (GRCm38)	splice site	probably benign
IGL01917:Naip2	APN	13	100,162,083 (GRCm38)	missense	probably benign	0.00
IGL02015:Naip2	APN	13	100,161,607 (GRCm38)	missense	possibly damaging	0.57
IGL02315:Naip2	APN	13	100,161,236 (GRCm38)	missense	probably damaging	1.00
IGL02328:Naip2	APN	13	100,161,369 (GRCm38)	missense	probably damaging	1.00
IGL02735:Naip2	APN	13	100,160,214 (GRCm38)	missense	probably damaging	0.99
IGL02738:Naip2	APN	13	100,189,177 (GRCm38)	missense	probably benign	0.01
IGL02887:Naip2	APN	13	100,161,512 (GRCm38)	missense	possibly damaging	0.90
IGL02894:Naip2	APN	13	100,183,789 (GRCm38)	missense	probably benign
IGL02894:Naip2	APN	13	100,160,997 (GRCm38)	missense	probably damaging	1.00
IGL02974:Naip2	APN	13	100,161,678 (GRCm38)	missense	probably damaging	1.00
IGL03024:Naip2	APN	13	100,189,354 (GRCm38)	missense	possibly damaging	0.50
IGL03056:Naip2	APN	13	100,162,287 (GRCm38)	missense	possibly damaging	0.90
IGL03281:Naip2	APN	13	100,161,620 (GRCm38)	missense	probably damaging	0.99
R0131:Naip2	UTSW	13	100,183,788 (GRCm38)	missense	probably benign	0.01
R0131:Naip2	UTSW	13	100,183,788 (GRCm38)	missense	probably benign	0.01
R0132:Naip2	UTSW	13	100,183,788 (GRCm38)	missense	probably benign	0.01
R0310:Naip2	UTSW	13	100,148,842 (GRCm38)	missense	probably damaging	1.00
R0367:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0368:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0422:Naip2	UTSW	13	100,161,113 (GRCm38)	missense	probably benign	0.10
R0441:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0445:Naip2	UTSW	13	100,161,887 (GRCm38)	missense	possibly damaging	0.91
R0446:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0464:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0466:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0467:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0486:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0533:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R0853:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R0853:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R0855:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R0855:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R0904:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R0904:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R0906:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R0906:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R0908:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R0908:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R0959:Naip2	UTSW	13	100,154,911 (GRCm38)	missense	probably benign	0.03
R0959:Naip2	UTSW	13	100,154,878 (GRCm38)	missense	probably benign	0.01
R0962:Naip2	UTSW	13	100,179,385 (GRCm38)	missense	probably damaging	1.00
R1024:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1024:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1186:Naip2	UTSW	13	100,162,037 (GRCm38)	frame shift	probably null
R1186:Naip2	UTSW	13	100,161,981 (GRCm38)	missense	possibly damaging	0.63
R1217:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1217:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1340:Naip2	UTSW	13	100,189,122 (GRCm38)	missense	possibly damaging	0.80
R1342:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1342:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1404:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1423:Naip2	UTSW	13	100,154,847 (GRCm38)	intron	probably benign
R1423:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1423:Naip2	UTSW	13	100,154,878 (GRCm38)	missense	probably benign	0.01
R1423:Naip2	UTSW	13	100,154,872 (GRCm38)	missense	possibly damaging	0.59
R1426:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1426:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1472:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1575:Naip2	UTSW	13	100,155,029 (GRCm38)	intron	probably benign
R1575:Naip2	UTSW	13	100,155,021 (GRCm38)	missense	probably benign	0.00
R1576:Naip2	UTSW	13	100,155,021 (GRCm38)	missense	probably benign	0.00
R1576:Naip2	UTSW	13	100,155,029 (GRCm38)	intron	probably benign
R1599:Naip2	UTSW	13	100,161,981 (GRCm38)	missense	possibly damaging	0.63
R1640:Naip2	UTSW	13	100,161,981 (GRCm38)	missense	possibly damaging	0.63
R1641:Naip2	UTSW	13	100,161,981 (GRCm38)	missense	possibly damaging	0.63
R1642:Naip2	UTSW	13	100,161,981 (GRCm38)	missense	possibly damaging	0.63
R1643:Naip2	UTSW	13	100,161,981 (GRCm38)	missense	possibly damaging	0.63
R1644:Naip2	UTSW	13	100,182,929 (GRCm38)	missense	possibly damaging	0.83
R1681:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1681:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1891:Naip2	UTSW	13	100,154,887 (GRCm38)	missense	probably benign	0.00
R1913:Naip2	UTSW	13	100,152,157 (GRCm38)	critical splice acceptor site	probably null
R1937:Naip2	UTSW	13	100,161,860 (GRCm38)	missense	probably benign	0.00
R1937:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign
R1993:Naip2	UTSW	13	100,162,007 (GRCm38)	missense	probably benign	0.03
R2001:Naip2	UTSW	13	100,144,588 (GRCm38)	missense	probably damaging	1.00
R2055:Naip2	UTSW	13	100,179,372 (GRCm38)	missense	probably benign	0.07
R2198:Naip2	UTSW	13	100,152,592 (GRCm38)	missense	probably damaging	1.00
R2906:Naip2	UTSW	13	100,161,996 (GRCm38)	missense	probably damaging	1.00
R2931:Naip2	UTSW	13	100,155,021 (GRCm38)	missense	probably benign	0.00
R3014:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R3016:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R3037:Naip2	UTSW	13	100,154,949 (GRCm38)	missense	probably benign	0.08
R3414:Naip2	UTSW	13	100,189,263 (GRCm38)	nonsense	probably null
R3437:Naip2	UTSW	13	100,154,911 (GRCm38)	missense	probably benign	0.03
R3713:Naip2	UTSW	13	100,161,902 (GRCm38)	missense	probably damaging	1.00
R3806:Naip2	UTSW	13	100,152,634 (GRCm38)	missense	possibly damaging	0.92
R3847:Naip2	UTSW	13	100,179,432 (GRCm38)	missense	probably damaging	1.00
R3847:Naip2	UTSW	13	100,179,433 (GRCm38)	missense	probably damaging	1.00
R3848:Naip2	UTSW	13	100,179,432 (GRCm38)	missense	probably damaging	1.00
R3848:Naip2	UTSW	13	100,179,433 (GRCm38)	missense	probably damaging	1.00
R3849:Naip2	UTSW	13	100,179,432 (GRCm38)	missense	probably damaging	1.00
R3849:Naip2	UTSW	13	100,179,433 (GRCm38)	missense	probably damaging	1.00
R3850:Naip2	UTSW	13	100,179,432 (GRCm38)	missense	probably damaging	1.00
R3850:Naip2	UTSW	13	100,179,433 (GRCm38)	missense	probably damaging	1.00
R3891:Naip2	UTSW	13	100,161,098 (GRCm38)	missense	probably damaging	0.99
R4419:Naip2	UTSW	13	100,160,625 (GRCm38)	missense	probably benign	0.03
R4456:Naip2	UTSW	13	100,154,911 (GRCm38)	missense	probably benign	0.03
R4458:Naip2	UTSW	13	100,154,911 (GRCm38)	missense	probably benign	0.03
R4689:Naip2	UTSW	13	100,148,812 (GRCm38)	missense	probably damaging	1.00
R4797:Naip2	UTSW	13	100,161,735 (GRCm38)	missense	probably damaging	1.00
R4852:Naip2	UTSW	13	100,161,536 (GRCm38)	missense	probably benign
R4922:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R5135:Naip2	UTSW	13	100,179,440 (GRCm38)	missense	probably damaging	0.98
R5185:Naip2	UTSW	13	100,189,351 (GRCm38)	missense	probably damaging	1.00
R5265:Naip2	UTSW	13	100,152,560 (GRCm38)	missense	probably damaging	1.00
R5451:Naip2	UTSW	13	100,188,860 (GRCm38)	missense	probably benign	0.12
R5521:Naip2	UTSW	13	100,154,914 (GRCm38)	missense	probably damaging	1.00
R5737:Naip2	UTSW	13	100,161,854 (GRCm38)	missense	probably benign	0.38
R6244:Naip2	UTSW	13	100,152,137 (GRCm38)	missense	probably damaging	1.00
R6478:Naip2	UTSW	13	100,162,041 (GRCm38)	missense	probably benign
R6480:Naip2	UTSW	13	100,162,041 (GRCm38)	missense	probably benign
R6481:Naip2	UTSW	13	100,162,041 (GRCm38)	missense	probably benign
R6490:Naip2	UTSW	13	100,160,685 (GRCm38)	missense	probably benign
R6653:Naip2	UTSW	13	100,152,136 (GRCm38)	missense	probably benign	0.00
R6653:Naip2	UTSW	13	100,161,844 (GRCm38)	missense	probably benign
R6768:Naip2	UTSW	13	100,178,324 (GRCm38)	nonsense	probably null
R6791:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R6793:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R6890:Naip2	UTSW	13	100,162,041 (GRCm38)	missense	probably benign
R7036:Naip2	UTSW	13	100,155,021 (GRCm38)	missense	probably benign	0.00
R7213:Naip2	UTSW	13	100,187,483 (GRCm38)	missense	probably damaging	1.00
R7342:Naip2	UTSW	13	100,189,356 (GRCm38)	missense	probably benign	0.09
R7445:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R7572:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R7699:Naip2	UTSW	13	100,160,369 (GRCm38)	missense	probably benign	0.00
R7840:Naip2	UTSW	13	100,144,409 (GRCm38)	missense	probably benign	0.14
R7874:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R7874:Naip2	UTSW	13	100,154,951 (GRCm38)	missense	probably benign	0.00
R8038:Naip2	UTSW	13	100,162,062 (GRCm38)	missense	probably benign	0.00
R8065:Naip2	UTSW	13	100,189,222 (GRCm38)	missense	probably damaging	1.00
R8094:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R8166:Naip2	UTSW	13	100,162,007 (GRCm38)	missense	probably benign	0.03
R8378:Naip2	UTSW	13	100,161,782 (GRCm38)	missense	probably benign	0.01
R8669:Naip2	UTSW	13	100,188,969 (GRCm38)	missense	probably benign	0.05
R8691:Naip2	UTSW	13	100,161,168 (GRCm38)	missense	probably damaging	1.00
R8716:Naip2	UTSW	13	100,144,406 (GRCm38)	missense	probably benign
R8720:Naip2	UTSW	13	100,162,122 (GRCm38)	missense	probably benign	0.04
R8895:Naip2	UTSW	13	100,189,136 (GRCm38)	missense	probably benign	0.01
R9031:Naip2	UTSW	13	100,178,268 (GRCm38)	missense	possibly damaging	0.55
R9072:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R9072:Naip2	UTSW	13	100,154,951 (GRCm38)	missense	probably benign	0.00
R9074:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R9074:Naip2	UTSW	13	100,154,951 (GRCm38)	missense	probably benign	0.00
R9077:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
R9077:Naip2	UTSW	13	100,154,951 (GRCm38)	missense	probably benign	0.00
R9176:Naip2	UTSW	13	100,162,199 (GRCm38)	missense	probably damaging	1.00
R9219:Naip2	UTSW	13	100,160,705 (GRCm38)	missense	probably benign	0.06
R9358:Naip2	UTSW	13	100,161,572 (GRCm38)	missense	probably damaging	1.00
R9371:Naip2	UTSW	13	100,161,846 (GRCm38)	nonsense	probably null
R9414:Naip2	UTSW	13	100,161,735 (GRCm38)	missense	probably damaging	1.00
R9415:Naip2	UTSW	13	100,161,735 (GRCm38)	missense	probably damaging	1.00
R9416:Naip2	UTSW	13	100,161,735 (GRCm38)	missense	probably damaging	1.00
R9708:Naip2	UTSW	13	100,161,579 (GRCm38)	missense	probably damaging	0.99
V5622:Naip2	UTSW	13	100,155,029 (GRCm38)	intron	probably benign
V5622:Naip2	UTSW	13	100,155,021 (GRCm38)	missense	probably benign	0.00
V5622:Naip2	UTSW	13	100,155,021 (GRCm38)	missense	probably benign	0.00
X0063:Naip2	UTSW	13	100,161,758 (GRCm38)	missense	probably damaging	1.00
Y5405:Naip2	UTSW	13	100,154,960 (GRCm38)	missense	probably benign
Z1088:Naip2	UTSW	13	100,161,909 (GRCm38)	missense	probably benign
Z1176:Naip2	UTSW	13	100,161,909 (GRCm38)	missense	probably benign
Z1176:Naip2	UTSW	13	100,161,593 (GRCm38)	missense	probably benign	0.02
Z1177:Naip2	UTSW	13	100,161,909 (GRCm38)	missense	probably benign
Z1177:Naip2	UTSW	13	100,152,629 (GRCm38)	missense	possibly damaging	0.65
Z1177:Naip2	UTSW	13	100,162,865 (GRCm38)	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- AAGGACTCCAGTCTTGCCTC -3'
(R):5'- GTGGATGCACTTTCAGTCTTGAAG -3'

Sequencing Primer
(F):5'- AGCATCTTCTCTGGACTCTTAAC -3'
(R):5'- CTTGAAGAGACAACAAGAAGAAGACC -3'

Posted On

2021-08-02