Incidental Mutation 'R8890:Fhad1'
ID 677621
Institutional Source Beutler Lab
Gene Symbol Fhad1
Ensembl Gene ENSMUSG00000051435
Gene Name forkhead-associated phosphopeptide binding domain 1
Synonyms 2900090M10Rik
MMRRC Submission 068694-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R8890 (G1)
Quality Score 143.008
Status Validated
Chromosome 4
Chromosomal Location 141617749-141742393 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 141656902 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 84 (M84K)
Ref Sequence ENSEMBL: ENSMUSP00000036224 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036701] [ENSMUST00000105779] [ENSMUST00000105780]
AlphaFold A6PWD2
Predicted Effect probably benign
Transcript: ENSMUST00000036701
AA Change: M84K

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000036224
Gene: ENSMUSG00000051435
AA Change: M84K

DomainStartEndE-ValueType
coiled coil region 31 250 N/A INTRINSIC
Predicted Effect
SMART Domains Protein: ENSMUSP00000101405
Gene: ENSMUSG00000051435
AA Change: M749K

DomainStartEndE-ValueType
FHA 17 69 8.41e-8 SMART
low complexity region 111 124 N/A INTRINSIC
coiled coil region 307 434 N/A INTRINSIC
coiled coil region 640 915 N/A INTRINSIC
low complexity region 1091 1102 N/A INTRINSIC
coiled coil region 1111 1140 N/A INTRINSIC
coiled coil region 1255 1339 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105780
AA Change: M749K

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000101406
Gene: ENSMUSG00000051435
AA Change: M749K

DomainStartEndE-ValueType
FHA 17 69 8.41e-8 SMART
low complexity region 111 124 N/A INTRINSIC
coiled coil region 307 434 N/A INTRINSIC
coiled coil region 640 915 N/A INTRINSIC
low complexity region 1091 1102 N/A INTRINSIC
coiled coil region 1111 1140 N/A INTRINSIC
coiled coil region 1255 1339 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 100% (59/59)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930567H17Rik G A X: 69,437,994 (GRCm39) R100W possibly damaging Het
Acrv1 A T 9: 36,604,608 (GRCm39) M1L probably benign Het
Adam23 G A 1: 63,624,524 (GRCm39) G784D possibly damaging Het
Astl A T 2: 127,198,479 (GRCm39) M365L probably benign Het
C1ql3 T A 2: 13,015,184 (GRCm39) T159S Het
Ccser2 T G 14: 36,601,352 (GRCm39) D344A probably damaging Het
Cox11 A C 11: 90,534,599 (GRCm39) I214L probably damaging Het
Cramp1 C T 17: 25,202,114 (GRCm39) G456D probably damaging Het
Ctsq T A 13: 61,185,502 (GRCm39) Y213F probably damaging Het
Cyp2j5 T A 4: 96,522,555 (GRCm39) I340F probably damaging Het
Efcab6 A G 15: 83,829,349 (GRCm39) F664L probably damaging Het
Eif3j2 A G 18: 43,610,276 (GRCm39) L179P probably benign Het
Gabbr1 T C 17: 37,358,436 (GRCm39) V58A probably benign Het
Gabra1 T A 11: 42,024,553 (GRCm39) Y374F probably benign Het
Glt28d2 A T 3: 85,779,359 (GRCm39) V38D possibly damaging Het
Grid2 A T 6: 63,233,923 (GRCm39) H28L probably benign Het
Hat1 G A 2: 71,269,137 (GRCm39) R355K probably damaging Het
Hivep3 T C 4: 119,953,657 (GRCm39) Y658H possibly damaging Het
Hsh2d T C 8: 72,951,690 (GRCm39) F108S probably damaging Het
Il17rc G T 6: 113,456,031 (GRCm39) C292F probably damaging Het
Il31ra T C 13: 112,660,861 (GRCm39) D576G possibly damaging Het
Iqsec3 T C 6: 121,389,515 (GRCm39) D652G probably damaging Het
Kdm5a T A 6: 120,366,624 (GRCm39) S420R probably damaging Het
Klhdc7b A G 15: 89,272,888 (GRCm39) T599A probably benign Het
Lrrc8c A T 5: 105,754,954 (GRCm39) E243V probably damaging Het
Mecom A G 3: 30,006,882 (GRCm39) S714P probably damaging Het
Mindy4 T C 6: 55,255,223 (GRCm39) L567P probably benign Het
Mipep G T 14: 61,109,506 (GRCm39) A628S probably damaging Het
Mmp1a TG TGG 9: 7,465,083 (GRCm38) probably null Het
Mterf3 C T 13: 67,064,676 (GRCm39) probably null Het
Myh15 C A 16: 48,959,130 (GRCm39) L1001I probably damaging Het
Myom3 G A 4: 135,541,565 (GRCm39) M1385I probably benign Het
Nbea T C 3: 55,926,784 (GRCm39) probably benign Het
Nphs1 C T 7: 30,162,080 (GRCm39) R270W probably damaging Het
Nwd1 T A 8: 73,438,484 (GRCm39) S1552T probably benign Het
Or10ag60 A T 2: 87,438,412 (GRCm39) I227F probably damaging Het
Or10j5 G A 1: 172,785,045 (GRCm39) V228M probably benign Het
Or52ae9 G T 7: 103,389,675 (GRCm39) F257L probably damaging Het
Or52r1 A T 7: 102,536,699 (GRCm39) Y220* probably null Het
Pcdh7 A T 5: 57,876,717 (GRCm39) I91F probably damaging Het
Pheta2 G T 15: 82,227,618 (GRCm39) V46F probably damaging Het
Piezo1 T C 8: 123,216,330 (GRCm39) R1394G Het
Pramel28 G T 4: 143,691,494 (GRCm39) Q410K probably benign Het
Psmd1 G A 1: 86,012,914 (GRCm39) R361Q probably damaging Het
Ralb G A 1: 119,411,246 (GRCm39) T31M probably damaging Het
Rassf4 T A 6: 116,617,305 (GRCm39) K233N probably damaging Het
Rif1 T C 2: 51,988,875 (GRCm39) F756S probably damaging Het
Rpgrip1 G A 14: 52,382,501 (GRCm39) D556N possibly damaging Het
Scai T C 2: 39,040,400 (GRCm39) probably benign Het
Scfd1 A G 12: 51,474,678 (GRCm39) T478A probably benign Het
Spag17 T A 3: 99,911,994 (GRCm39) I288N possibly damaging Het
Sult1e1 C T 5: 87,727,719 (GRCm39) V188I probably benign Het
Tmco1 A G 1: 167,143,814 (GRCm39) R82G Het
Tmem109 T C 19: 10,849,235 (GRCm39) S207G probably benign Het
Vmn2r115 A G 17: 23,578,497 (GRCm39) T657A probably damaging Het
Whamm A G 7: 81,243,640 (GRCm39) T621A probably benign Het
Zbtb40 A G 4: 136,725,897 (GRCm39) L554P probably damaging Het
Zfp131 A T 13: 120,244,338 (GRCm39) M114K probably damaging Het
Zfp532 C T 18: 65,757,404 (GRCm39) P446S probably damaging Het
Other mutations in Fhad1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01065:Fhad1 APN 4 141,632,923 (GRCm39) missense probably benign 0.02
IGL01478:Fhad1 APN 4 141,678,949 (GRCm39) missense possibly damaging 0.84
IGL01752:Fhad1 APN 4 141,700,210 (GRCm39) missense possibly damaging 0.82
IGL01788:Fhad1 APN 4 141,660,113 (GRCm39) missense probably benign 0.00
IGL01919:Fhad1 APN 4 141,691,906 (GRCm39) missense probably damaging 0.96
IGL02489:Fhad1 APN 4 141,684,931 (GRCm39) missense probably damaging 0.97
IGL02568:Fhad1 APN 4 141,660,105 (GRCm39) missense probably null 1.00
IGL02583:Fhad1 APN 4 141,738,955 (GRCm39) utr 5 prime probably benign
IGL02716:Fhad1 APN 4 141,645,642 (GRCm39) missense possibly damaging 0.89
IGL02819:Fhad1 APN 4 141,646,069 (GRCm39) missense probably benign 0.23
IGL02820:Fhad1 APN 4 141,646,069 (GRCm39) missense probably benign 0.23
IGL03038:Fhad1 APN 4 141,729,805 (GRCm39) missense probably benign 0.38
IGL03167:Fhad1 APN 4 141,700,108 (GRCm39) missense probably benign 0.00
IGL03255:Fhad1 APN 4 141,700,191 (GRCm39) missense possibly damaging 0.79
R4466_Fhad1_343 UTSW 4 141,684,969 (GRCm39) missense probably damaging 1.00
R4831_Fhad1_494 UTSW 4 141,643,378 (GRCm39) splice site probably null
R5504_Fhad1_818 UTSW 4 141,712,846 (GRCm39) missense probably benign
BB002:Fhad1 UTSW 4 141,681,498 (GRCm39) missense probably damaging 0.97
BB012:Fhad1 UTSW 4 141,681,498 (GRCm39) missense probably damaging 0.97
PIT1430001:Fhad1 UTSW 4 141,637,060 (GRCm39) missense probably damaging 0.99
R0014:Fhad1 UTSW 4 141,655,719 (GRCm39) missense probably damaging 1.00
R0116:Fhad1 UTSW 4 141,667,406 (GRCm39) missense probably benign 0.06
R0143:Fhad1 UTSW 4 141,656,957 (GRCm39) splice site probably benign
R0178:Fhad1 UTSW 4 141,682,651 (GRCm39) missense probably benign 0.31
R0308:Fhad1 UTSW 4 141,712,904 (GRCm39) splice site probably benign
R0384:Fhad1 UTSW 4 141,729,737 (GRCm39) missense probably benign
R0583:Fhad1 UTSW 4 141,631,301 (GRCm39) missense probably benign 0.37
R1501:Fhad1 UTSW 4 141,691,936 (GRCm39) missense probably benign
R1584:Fhad1 UTSW 4 141,712,822 (GRCm39) missense probably benign 0.22
R1615:Fhad1 UTSW 4 141,649,634 (GRCm39) missense probably damaging 0.99
R1991:Fhad1 UTSW 4 141,709,473 (GRCm39) missense possibly damaging 0.75
R2060:Fhad1 UTSW 4 141,626,560 (GRCm39) missense probably benign 0.08
R2079:Fhad1 UTSW 4 141,718,513 (GRCm39) nonsense probably null
R2133:Fhad1 UTSW 4 141,655,711 (GRCm39) missense probably damaging 1.00
R2337:Fhad1 UTSW 4 141,649,655 (GRCm39) missense possibly damaging 0.84
R2843:Fhad1 UTSW 4 141,632,279 (GRCm39) missense probably benign 0.06
R2844:Fhad1 UTSW 4 141,632,279 (GRCm39) missense probably benign 0.06
R2845:Fhad1 UTSW 4 141,632,279 (GRCm39) missense probably benign 0.06
R2846:Fhad1 UTSW 4 141,632,279 (GRCm39) missense probably benign 0.06
R2866:Fhad1 UTSW 4 141,648,099 (GRCm39) missense probably benign 0.00
R3119:Fhad1 UTSW 4 141,645,618 (GRCm39) frame shift probably null
R3760:Fhad1 UTSW 4 141,637,124 (GRCm39) missense probably damaging 1.00
R4180:Fhad1 UTSW 4 141,712,854 (GRCm39) missense possibly damaging 0.69
R4466:Fhad1 UTSW 4 141,684,969 (GRCm39) missense probably damaging 1.00
R4627:Fhad1 UTSW 4 141,623,779 (GRCm39) missense possibly damaging 0.47
R4680:Fhad1 UTSW 4 141,738,858 (GRCm39) nonsense probably null
R4725:Fhad1 UTSW 4 141,655,689 (GRCm39) critical splice donor site probably null
R4755:Fhad1 UTSW 4 141,655,794 (GRCm39) missense probably damaging 1.00
R4831:Fhad1 UTSW 4 141,643,378 (GRCm39) splice site probably null
R4909:Fhad1 UTSW 4 141,712,822 (GRCm39) missense probably benign 0.01
R4968:Fhad1 UTSW 4 141,645,618 (GRCm39) missense probably damaging 1.00
R5004:Fhad1 UTSW 4 141,729,910 (GRCm39) critical splice acceptor site probably null
R5036:Fhad1 UTSW 4 141,648,052 (GRCm39) missense probably benign 0.03
R5048:Fhad1 UTSW 4 141,691,987 (GRCm39) critical splice acceptor site probably null
R5416:Fhad1 UTSW 4 141,646,113 (GRCm39) missense probably benign 0.39
R5504:Fhad1 UTSW 4 141,712,846 (GRCm39) missense probably benign
R5586:Fhad1 UTSW 4 141,632,442 (GRCm39) missense probably benign 0.44
R5692:Fhad1 UTSW 4 141,690,768 (GRCm39) missense probably benign 0.00
R5706:Fhad1 UTSW 4 141,681,427 (GRCm39) missense probably damaging 1.00
R5773:Fhad1 UTSW 4 141,656,881 (GRCm39) missense probably damaging 0.99
R5823:Fhad1 UTSW 4 141,682,617 (GRCm39) missense possibly damaging 0.84
R5833:Fhad1 UTSW 4 141,729,838 (GRCm39) missense probably damaging 1.00
R6170:Fhad1 UTSW 4 141,618,263 (GRCm39) nonsense probably null
R6286:Fhad1 UTSW 4 141,648,209 (GRCm39) missense probably damaging 1.00
R6610:Fhad1 UTSW 4 141,643,707 (GRCm39) missense possibly damaging 0.94
R6755:Fhad1 UTSW 4 141,691,915 (GRCm39) missense probably damaging 1.00
R7006:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7008:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7012:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7014:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7058:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7059:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7060:Fhad1 UTSW 4 141,645,602 (GRCm39) frame shift probably null
R7159:Fhad1 UTSW 4 141,678,927 (GRCm39) missense probably benign 0.01
R7472:Fhad1 UTSW 4 141,691,937 (GRCm39) missense probably benign
R7670:Fhad1 UTSW 4 141,678,802 (GRCm39) missense probably benign 0.01
R7694:Fhad1 UTSW 4 141,632,375 (GRCm39) missense probably benign 0.41
R7745:Fhad1 UTSW 4 141,618,250 (GRCm39) missense probably benign 0.00
R7848:Fhad1 UTSW 4 141,632,913 (GRCm39) missense probably benign 0.29
R7853:Fhad1 UTSW 4 141,637,134 (GRCm39) missense probably damaging 0.99
R7867:Fhad1 UTSW 4 141,632,902 (GRCm39) missense probably benign 0.00
R7925:Fhad1 UTSW 4 141,681,498 (GRCm39) missense probably damaging 0.97
R8089:Fhad1 UTSW 4 141,684,971 (GRCm39) missense probably damaging 1.00
R8123:Fhad1 UTSW 4 141,712,836 (GRCm39) missense probably benign 0.02
R8711:Fhad1 UTSW 4 141,684,924 (GRCm39) missense probably benign 0.25
R8751:Fhad1 UTSW 4 141,646,134 (GRCm39) missense probably benign 0.04
R8783:Fhad1 UTSW 4 141,636,403 (GRCm39) missense probably benign 0.02
R8858:Fhad1 UTSW 4 141,666,339 (GRCm39) missense possibly damaging 0.87
R8867:Fhad1 UTSW 4 141,656,885 (GRCm39) missense probably damaging 0.97
R8982:Fhad1 UTSW 4 141,729,895 (GRCm39) missense probably damaging 1.00
R9004:Fhad1 UTSW 4 141,649,735 (GRCm39) splice site probably benign
R9021:Fhad1 UTSW 4 141,709,620 (GRCm39) missense probably damaging 0.97
R9190:Fhad1 UTSW 4 141,646,058 (GRCm39) critical splice donor site probably null
R9237:Fhad1 UTSW 4 141,632,483 (GRCm39) missense probably benign 0.11
R9614:Fhad1 UTSW 4 141,678,882 (GRCm39) missense possibly damaging 0.69
R9744:Fhad1 UTSW 4 141,637,124 (GRCm39) missense probably damaging 1.00
X0018:Fhad1 UTSW 4 141,678,927 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AGTGTTGGCTACTTCCAGCAG -3'
(R):5'- TTCCTCTTAACAGGTGCCG -3'

Sequencing Primer
(F):5'- AGCGGCGGTGGGTAGTG -3'
(R):5'- GGCTCCTGGTTTCCTGATCTATAAC -3'
Posted On 2021-08-02