Incidental Mutation 'R8890:Tmem109'
ID 677659
Institutional Source Beutler Lab
Gene Symbol Tmem109
Ensembl Gene ENSMUSG00000034659
Gene Name transmembrane protein 109
Synonyms MG23, 1110006I15Rik, mitsugumin23
MMRRC Submission 068694-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8890 (G1)
Quality Score 225.009
Status Validated
Chromosome 19
Chromosomal Location 10848021-10859107 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 10849235 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 207 (S207G)
Ref Sequence ENSEMBL: ENSMUSP00000039529 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025645] [ENSMUST00000038128] [ENSMUST00000120524] [ENSMUST00000128835] [ENSMUST00000133303] [ENSMUST00000144681] [ENSMUST00000147699]
AlphaFold Q3UBX0
Predicted Effect probably benign
Transcript: ENSMUST00000025645
SMART Domains Protein: ENSMUSP00000025645
Gene: ENSMUSG00000024736

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
Pfam:TMEM132D_N 44 167 1.6e-35 PFAM
low complexity region 206 223 N/A INTRINSIC
Pfam:TMEM132 403 745 4.1e-108 PFAM
low complexity region 759 776 N/A INTRINSIC
Pfam:TMEM132D_C 809 897 1.5e-31 PFAM
low complexity region 906 923 N/A INTRINSIC
low complexity region 932 944 N/A INTRINSIC
low complexity region 960 976 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000038128
AA Change: S207G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000039529
Gene: ENSMUSG00000034659
AA Change: S207G

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:BRI3BP 57 231 9.9e-57 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000120524
SMART Domains Protein: ENSMUSP00000113696
Gene: ENSMUSG00000024736

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
low complexity region 206 223 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000128835
SMART Domains Protein: ENSMUSP00000122130
Gene: ENSMUSG00000034659

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000133303
AA Change: S207G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000120261
Gene: ENSMUSG00000034659
AA Change: S207G

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:BRI3BP 54 213 8.1e-65 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000144681
SMART Domains Protein: ENSMUSP00000116750
Gene: ENSMUSG00000034659

DomainStartEndE-ValueType
signal peptide 1 47 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000147699
SMART Domains Protein: ENSMUSP00000120662
Gene: ENSMUSG00000034659

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:BRI3BP 54 115 1.7e-23 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 100% (59/59)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele are viable, overtly normal and exhibit normal thymocyte maturation; however, mutant thymocytes are less sensitive to DNA damage caused by gamma-irradiation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930567H17Rik G A X: 69,437,994 (GRCm39) R100W possibly damaging Het
Acrv1 A T 9: 36,604,608 (GRCm39) M1L probably benign Het
Adam23 G A 1: 63,624,524 (GRCm39) G784D possibly damaging Het
Astl A T 2: 127,198,479 (GRCm39) M365L probably benign Het
C1ql3 T A 2: 13,015,184 (GRCm39) T159S Het
Ccser2 T G 14: 36,601,352 (GRCm39) D344A probably damaging Het
Cox11 A C 11: 90,534,599 (GRCm39) I214L probably damaging Het
Cramp1 C T 17: 25,202,114 (GRCm39) G456D probably damaging Het
Ctsq T A 13: 61,185,502 (GRCm39) Y213F probably damaging Het
Cyp2j5 T A 4: 96,522,555 (GRCm39) I340F probably damaging Het
Efcab6 A G 15: 83,829,349 (GRCm39) F664L probably damaging Het
Eif3j2 A G 18: 43,610,276 (GRCm39) L179P probably benign Het
Fhad1 A T 4: 141,656,902 (GRCm39) M84K probably benign Het
Gabbr1 T C 17: 37,358,436 (GRCm39) V58A probably benign Het
Gabra1 T A 11: 42,024,553 (GRCm39) Y374F probably benign Het
Glt28d2 A T 3: 85,779,359 (GRCm39) V38D possibly damaging Het
Grid2 A T 6: 63,233,923 (GRCm39) H28L probably benign Het
Hat1 G A 2: 71,269,137 (GRCm39) R355K probably damaging Het
Hivep3 T C 4: 119,953,657 (GRCm39) Y658H possibly damaging Het
Hsh2d T C 8: 72,951,690 (GRCm39) F108S probably damaging Het
Il17rc G T 6: 113,456,031 (GRCm39) C292F probably damaging Het
Il31ra T C 13: 112,660,861 (GRCm39) D576G possibly damaging Het
Iqsec3 T C 6: 121,389,515 (GRCm39) D652G probably damaging Het
Kdm5a T A 6: 120,366,624 (GRCm39) S420R probably damaging Het
Klhdc7b A G 15: 89,272,888 (GRCm39) T599A probably benign Het
Lrrc8c A T 5: 105,754,954 (GRCm39) E243V probably damaging Het
Mecom A G 3: 30,006,882 (GRCm39) S714P probably damaging Het
Mindy4 T C 6: 55,255,223 (GRCm39) L567P probably benign Het
Mipep G T 14: 61,109,506 (GRCm39) A628S probably damaging Het
Mmp1a TG TGG 9: 7,465,083 (GRCm38) probably null Het
Mterf3 C T 13: 67,064,676 (GRCm39) probably null Het
Myh15 C A 16: 48,959,130 (GRCm39) L1001I probably damaging Het
Myom3 G A 4: 135,541,565 (GRCm39) M1385I probably benign Het
Nbea T C 3: 55,926,784 (GRCm39) probably benign Het
Nphs1 C T 7: 30,162,080 (GRCm39) R270W probably damaging Het
Nwd1 T A 8: 73,438,484 (GRCm39) S1552T probably benign Het
Or10ag60 A T 2: 87,438,412 (GRCm39) I227F probably damaging Het
Or10j5 G A 1: 172,785,045 (GRCm39) V228M probably benign Het
Or52ae9 G T 7: 103,389,675 (GRCm39) F257L probably damaging Het
Or52r1 A T 7: 102,536,699 (GRCm39) Y220* probably null Het
Pcdh7 A T 5: 57,876,717 (GRCm39) I91F probably damaging Het
Pheta2 G T 15: 82,227,618 (GRCm39) V46F probably damaging Het
Piezo1 T C 8: 123,216,330 (GRCm39) R1394G Het
Pramel28 G T 4: 143,691,494 (GRCm39) Q410K probably benign Het
Psmd1 G A 1: 86,012,914 (GRCm39) R361Q probably damaging Het
Ralb G A 1: 119,411,246 (GRCm39) T31M probably damaging Het
Rassf4 T A 6: 116,617,305 (GRCm39) K233N probably damaging Het
Rif1 T C 2: 51,988,875 (GRCm39) F756S probably damaging Het
Rpgrip1 G A 14: 52,382,501 (GRCm39) D556N possibly damaging Het
Scai T C 2: 39,040,400 (GRCm39) probably benign Het
Scfd1 A G 12: 51,474,678 (GRCm39) T478A probably benign Het
Spag17 T A 3: 99,911,994 (GRCm39) I288N possibly damaging Het
Sult1e1 C T 5: 87,727,719 (GRCm39) V188I probably benign Het
Tmco1 A G 1: 167,143,814 (GRCm39) R82G Het
Vmn2r115 A G 17: 23,578,497 (GRCm39) T657A probably damaging Het
Whamm A G 7: 81,243,640 (GRCm39) T621A probably benign Het
Zbtb40 A G 4: 136,725,897 (GRCm39) L554P probably damaging Het
Zfp131 A T 13: 120,244,338 (GRCm39) M114K probably damaging Het
Zfp532 C T 18: 65,757,404 (GRCm39) P446S probably damaging Het
Other mutations in Tmem109
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03003:Tmem109 APN 19 10,851,695 (GRCm39) missense probably benign 0.27
R0882:Tmem109 UTSW 19 10,849,205 (GRCm39) missense possibly damaging 0.91
R1221:Tmem109 UTSW 19 10,851,733 (GRCm39) missense possibly damaging 0.88
R1571:Tmem109 UTSW 19 10,849,993 (GRCm39) missense probably damaging 1.00
R5437:Tmem109 UTSW 19 10,849,378 (GRCm39) missense probably damaging 1.00
R6367:Tmem109 UTSW 19 10,851,727 (GRCm39) missense possibly damaging 0.66
R6708:Tmem109 UTSW 19 10,849,395 (GRCm39) missense probably damaging 1.00
R7422:Tmem109 UTSW 19 10,849,124 (GRCm39) makesense probably null
R7867:Tmem109 UTSW 19 10,855,466 (GRCm39) missense unknown
R8545:Tmem109 UTSW 19 10,851,734 (GRCm39) nonsense probably null
R8796:Tmem109 UTSW 19 10,849,995 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGAAGCAGCTCAGCTCTTTG -3'
(R):5'- TCCAGACCCTTCTACTGTGG -3'

Sequencing Primer
(F):5'- AGCAGCTCAGCTCTTTGGTACG -3'
(R):5'- AGCAGCACTGGTCATCTACTG -3'
Posted On 2021-08-02