Incidental Mutation 'R8893:Vmn2r45'
| ID |
677831 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r45
|
| Ensembl Gene |
ENSMUSG00000090662 |
| Gene Name |
vomeronasal 2, receptor 45 |
| Synonyms |
|
| MMRRC Submission |
068696-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R8893 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
8474468-8491958 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 8488619 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Tyrosine
at position 137
(C137Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129466
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164845]
|
| AlphaFold |
L7N2B5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000164845
AA Change: C137Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000129466
Gene: ENSMUSG00000090662
AA Change: C137Y
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
154 |
469 |
4.5e-26 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
6.4e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
2.1e-54 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
98% (57/58) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 60 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adprhl1 |
T |
C |
8: 13,274,511 (GRCm39) |
D749G |
probably benign |
Het |
| Ank1 |
T |
A |
8: 23,598,241 (GRCm39) |
I782N |
probably damaging |
Het |
| Arap2 |
T |
A |
5: 62,888,037 (GRCm39) |
Q436H |
probably damaging |
Het |
| Baz2b |
A |
C |
2: 59,755,149 (GRCm39) |
F269L |
probably damaging |
Het |
| Bivm |
C |
T |
1: 44,158,439 (GRCm39) |
|
probably benign |
Het |
| Brsk1 |
A |
T |
7: 4,711,089 (GRCm39) |
D603V |
probably damaging |
Het |
| C2cd3 |
C |
T |
7: 100,104,004 (GRCm39) |
P2006S |
probably benign |
Het |
| Cacna1a |
T |
C |
8: 85,313,764 (GRCm39) |
F1513L |
probably benign |
Het |
| Cdin1 |
T |
A |
2: 115,505,265 (GRCm39) |
S179T |
probably benign |
Het |
| Cep128 |
C |
T |
12: 91,263,006 (GRCm39) |
E298K |
probably damaging |
Het |
| Cfap74 |
A |
G |
4: 155,531,152 (GRCm39) |
T802A |
unknown |
Het |
| Cnbd2 |
G |
A |
2: 156,154,460 (GRCm39) |
R3Q |
unknown |
Het |
| Cul9 |
TTCCTCCTCCTCCTCCTCCTCCTC |
TTCCTCCTCCTCCTCCTCCTC |
17: 46,811,775 (GRCm39) |
|
probably benign |
Het |
| Defa28 |
C |
T |
8: 22,073,840 (GRCm39) |
T81I |
|
Het |
| Dync1h1 |
A |
G |
12: 110,608,477 (GRCm39) |
D2735G |
probably damaging |
Het |
| Eif5b |
A |
T |
1: 38,090,300 (GRCm39) |
I1160F |
possibly damaging |
Het |
| Fzd9 |
T |
C |
5: 135,279,178 (GRCm39) |
M236V |
possibly damaging |
Het |
| H2ac7 |
A |
G |
13: 23,758,664 (GRCm39) |
Q7R |
unknown |
Het |
| Haus6 |
A |
G |
4: 86,501,364 (GRCm39) |
S836P |
possibly damaging |
Het |
| Hdac5 |
T |
A |
11: 102,097,512 (GRCm39) |
K167I |
possibly damaging |
Het |
| Heatr5b |
C |
G |
17: 79,069,424 (GRCm39) |
|
probably benign |
Het |
| Impdh1 |
G |
A |
6: 29,216,248 (GRCm39) |
|
probably benign |
Het |
| Iqgap3 |
T |
C |
3: 87,997,193 (GRCm39) |
I192T |
probably damaging |
Het |
| Lama1 |
C |
T |
17: 68,112,367 (GRCm39) |
A2269V |
|
Het |
| Lamb3 |
A |
G |
1: 193,014,644 (GRCm39) |
N601S |
probably damaging |
Het |
| Ltbp2 |
G |
T |
12: 84,875,316 (GRCm39) |
N569K |
probably damaging |
Het |
| Macf1 |
T |
C |
4: 123,304,323 (GRCm39) |
S60G |
probably benign |
Het |
| Marchf6 |
A |
T |
15: 31,498,850 (GRCm39) |
V149E |
probably damaging |
Het |
| Mcu |
A |
G |
10: 59,287,078 (GRCm39) |
S160P |
probably benign |
Het |
| Miga1 |
A |
G |
3: 151,982,294 (GRCm39) |
L594P |
probably damaging |
Het |
| Mindy4 |
T |
C |
6: 55,255,223 (GRCm39) |
L567P |
probably benign |
Het |
| Ndst2 |
A |
G |
14: 20,774,830 (GRCm39) |
I791T |
probably benign |
Het |
| Nebl |
A |
T |
2: 17,735,671 (GRCm39) |
M1K |
probably null |
Het |
| Or2bd2 |
T |
C |
7: 6,443,285 (GRCm39) |
C129R |
probably damaging |
Het |
| Or5c1 |
A |
G |
2: 37,222,388 (GRCm39) |
I210V |
probably damaging |
Het |
| Ormdl1 |
A |
T |
1: 53,344,708 (GRCm39) |
D90V |
probably damaging |
Het |
| Pank1 |
A |
T |
19: 34,804,903 (GRCm39) |
|
probably benign |
Het |
| Pcdhac2 |
T |
A |
18: 37,277,071 (GRCm39) |
L17Q |
probably benign |
Het |
| Pde3a |
A |
T |
6: 141,405,522 (GRCm39) |
D458V |
probably damaging |
Het |
| Pgm1 |
T |
G |
4: 99,824,297 (GRCm39) |
N323K |
probably damaging |
Het |
| Pigt |
CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT |
CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT |
2: 164,341,589 (GRCm39) |
|
probably null |
Het |
| Pigw |
A |
T |
11: 84,767,961 (GRCm39) |
I456K |
possibly damaging |
Het |
| Pkd1l3 |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
8: 110,350,827 (GRCm39) |
|
probably benign |
Het |
| Plxnc1 |
T |
A |
10: 94,685,709 (GRCm39) |
I761L |
probably benign |
Het |
| Pramel22 |
A |
T |
4: 143,382,060 (GRCm39) |
M212K |
probably damaging |
Het |
| Prkaca |
A |
G |
8: 84,717,151 (GRCm39) |
N172D |
probably damaging |
Het |
| Rab3b |
A |
C |
4: 108,797,925 (GRCm39) |
D192A |
probably benign |
Het |
| Rims2 |
T |
C |
15: 39,398,350 (GRCm39) |
L1105P |
probably benign |
Het |
| Rinl |
T |
A |
7: 28,491,747 (GRCm39) |
I100N |
probably damaging |
Het |
| Rnf13 |
T |
G |
3: 57,714,520 (GRCm39) |
I193S |
probably damaging |
Het |
| Rnf213 |
A |
G |
11: 119,333,868 (GRCm39) |
I3027V |
|
Het |
| Sik2 |
A |
T |
9: 50,810,026 (GRCm39) |
S512R |
probably damaging |
Het |
| Snx17 |
A |
G |
5: 31,353,887 (GRCm39) |
Y225C |
probably damaging |
Het |
| Spata13 |
A |
T |
14: 60,987,524 (GRCm39) |
D894V |
probably damaging |
Het |
| Spx |
A |
G |
6: 142,360,543 (GRCm39) |
D65G |
probably damaging |
Het |
| Syne1 |
G |
T |
10: 5,299,020 (GRCm39) |
S1022* |
probably null |
Het |
| Tchh |
C |
T |
3: 93,354,957 (GRCm39) |
Q1466* |
probably null |
Het |
| Tmem120b |
T |
C |
5: 123,254,302 (GRCm39) |
L292P |
probably damaging |
Het |
| Vmn2r10 |
T |
C |
5: 109,143,677 (GRCm39) |
T758A |
probably benign |
Het |
| Zfp994 |
A |
G |
17: 22,424,306 (GRCm39) |
S4P |
probably damaging |
Het |
|
| Other mutations in Vmn2r45 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01287:Vmn2r45
|
APN |
7 |
8,488,622 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01322:Vmn2r45
|
APN |
7 |
8,484,332 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01402:Vmn2r45
|
APN |
7 |
8,484,467 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01404:Vmn2r45
|
APN |
7 |
8,484,467 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01529:Vmn2r45
|
APN |
7 |
8,486,493 (GRCm39) |
missense |
probably benign |
|
|
IGL01596:Vmn2r45
|
APN |
7 |
8,486,272 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01646:Vmn2r45
|
APN |
7 |
8,486,337 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01819:Vmn2r45
|
APN |
7 |
8,488,556 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02096:Vmn2r45
|
APN |
7 |
8,484,443 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02130:Vmn2r45
|
APN |
7 |
8,486,556 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
IGL02409:Vmn2r45
|
APN |
7 |
8,488,727 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02517:Vmn2r45
|
APN |
7 |
8,486,185 (GRCm39) |
nonsense |
probably null |
|
|
IGL02633:Vmn2r45
|
APN |
7 |
8,488,728 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02940:Vmn2r45
|
APN |
7 |
8,475,369 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03281:Vmn2r45
|
APN |
7 |
8,486,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03358:Vmn2r45
|
APN |
7 |
8,474,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB004:Vmn2r45
|
UTSW |
7 |
8,486,513 (GRCm39) |
missense |
probably benign |
|
|
BB014:Vmn2r45
|
UTSW |
7 |
8,486,513 (GRCm39) |
missense |
probably benign |
|
|
R0382:Vmn2r45
|
UTSW |
7 |
8,486,098 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0532:Vmn2r45
|
UTSW |
7 |
8,474,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0932:Vmn2r45
|
UTSW |
7 |
8,478,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1125:Vmn2r45
|
UTSW |
7 |
8,488,542 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1580:Vmn2r45
|
UTSW |
7 |
8,474,746 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1817:Vmn2r45
|
UTSW |
7 |
8,475,372 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1996:Vmn2r45
|
UTSW |
7 |
8,475,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Vmn2r45
|
UTSW |
7 |
8,475,021 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2284:Vmn2r45
|
UTSW |
7 |
8,488,765 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4019:Vmn2r45
|
UTSW |
7 |
8,474,580 (GRCm39) |
nonsense |
probably null |
|
|
R4227:Vmn2r45
|
UTSW |
7 |
8,486,277 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4381:Vmn2r45
|
UTSW |
7 |
8,474,912 (GRCm39) |
nonsense |
probably null |
|
|
R4618:Vmn2r45
|
UTSW |
7 |
8,486,436 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4624:Vmn2r45
|
UTSW |
7 |
8,484,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Vmn2r45
|
UTSW |
7 |
8,486,535 (GRCm39) |
nonsense |
probably null |
|
|
R4735:Vmn2r45
|
UTSW |
7 |
8,486,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4868:Vmn2r45
|
UTSW |
7 |
8,484,480 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4983:Vmn2r45
|
UTSW |
7 |
8,486,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5246:Vmn2r45
|
UTSW |
7 |
8,486,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5430:Vmn2r45
|
UTSW |
7 |
8,486,333 (GRCm39) |
nonsense |
probably null |
|
|
R5504:Vmn2r45
|
UTSW |
7 |
8,486,176 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5511:Vmn2r45
|
UTSW |
7 |
8,474,832 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5745:Vmn2r45
|
UTSW |
7 |
8,486,074 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5814:Vmn2r45
|
UTSW |
7 |
8,474,475 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6223:Vmn2r45
|
UTSW |
7 |
8,486,301 (GRCm39) |
missense |
probably benign |
|
|
R6267:Vmn2r45
|
UTSW |
7 |
8,475,207 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6623:Vmn2r45
|
UTSW |
7 |
8,474,500 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6999:Vmn2r45
|
UTSW |
7 |
8,486,219 (GRCm39) |
missense |
probably benign |
|
|
R7242:Vmn2r45
|
UTSW |
7 |
8,488,612 (GRCm39) |
nonsense |
probably null |
|
|
R7491:Vmn2r45
|
UTSW |
7 |
8,484,342 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7620:Vmn2r45
|
UTSW |
7 |
8,486,222 (GRCm39) |
nonsense |
probably null |
|
|
R7719:Vmn2r45
|
UTSW |
7 |
8,486,460 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7720:Vmn2r45
|
UTSW |
7 |
8,486,460 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7853:Vmn2r45
|
UTSW |
7 |
8,485,987 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7873:Vmn2r45
|
UTSW |
7 |
8,486,074 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7882:Vmn2r45
|
UTSW |
7 |
8,486,409 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7927:Vmn2r45
|
UTSW |
7 |
8,486,513 (GRCm39) |
missense |
probably benign |
|
|
R8684:Vmn2r45
|
UTSW |
7 |
8,486,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8780:Vmn2r45
|
UTSW |
7 |
8,484,371 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8811:Vmn2r45
|
UTSW |
7 |
8,474,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9043:Vmn2r45
|
UTSW |
7 |
8,474,904 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9208:Vmn2r45
|
UTSW |
7 |
8,486,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9327:Vmn2r45
|
UTSW |
7 |
8,474,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9586:Vmn2r45
|
UTSW |
7 |
8,486,050 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9599:Vmn2r45
|
UTSW |
7 |
8,478,457 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
U24488:Vmn2r45
|
UTSW |
7 |
8,475,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r45
|
UTSW |
7 |
8,474,484 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCAGAAGGCCTAACATGTTTC -3'
(R):5'- GGTGTTTGCAATGGATGAAATCAAC -3'
Sequencing Primer
(F):5'- ACTAAGTGTCCTGGGACTACCTAG -3'
(R):5'- GGATGAAATCAACAGAAATCCTGATC -3'
|
| Posted On |
2021-08-02 |
Incidental Mutation