Incidental Mutation 'R8894:Or4c11c'
ID 677865
Institutional Source Beutler Lab
Gene Symbol Or4c11c
Ensembl Gene ENSMUSG00000057447
Gene Name olfactory receptor family 4 subfamily C member 11C
Synonyms GA_x6K02T2Q125-50336588-50337313, MOR230-1, MOR230-3, Olfr1205, GA_x6K02T2Q125-50304328-50305251, Olfr1203
MMRRC Submission 068697-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R8894 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88660101-88662386 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 88661809 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 116 (M116R)
Ref Sequence ENSEMBL: ENSMUSP00000150206 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076438] [ENSMUST00000215929]
AlphaFold A2ATJ7
Predicted Effect probably benign
Transcript: ENSMUST00000076438
AA Change: M116R

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000075769
Gene: ENSMUSG00000057447
AA Change: M116R

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 5e-45 PFAM
Pfam:7tm_1 39 285 9.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215929
AA Change: M116R

PolyPhen 2 Score 0.117 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (63/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931429L15Rik C T 9: 46,216,397 (GRCm39) V291M probably benign Het
Abca14 A C 7: 119,847,368 (GRCm39) Y744S probably damaging Het
Acly T C 11: 100,407,639 (GRCm39) E237G probably benign Het
Adcy1 T A 11: 7,087,375 (GRCm39) D416E probably damaging Het
Arid1b T A 17: 5,377,668 (GRCm39) M1217K probably damaging Het
Atad2b T C 12: 5,064,001 (GRCm39) probably null Het
Ccdc177 A G 12: 80,806,077 (GRCm39) S66P probably damaging Het
Clpsl2 T C 17: 28,769,645 (GRCm39) C36R possibly damaging Het
Cramp1 C T 17: 25,202,114 (GRCm39) G456D probably damaging Het
Crb1 T A 1: 139,175,750 (GRCm39) L744F possibly damaging Het
Crybg3 T A 16: 59,342,552 (GRCm39) E980D probably damaging Het
Cyp2d11 A T 15: 82,274,671 (GRCm39) V302E probably benign Het
Cyp3a25 A C 5: 145,931,670 (GRCm39) probably benign Het
Dhx35 G C 2: 158,676,795 (GRCm39) A410P possibly damaging Het
Dlg2 A T 7: 91,614,946 (GRCm39) H295L probably benign Het
Dnah2 T A 11: 69,383,048 (GRCm39) M1172L probably benign Het
Dock9 T C 14: 121,860,373 (GRCm39) S850G probably benign Het
Dst A T 1: 34,213,214 (GRCm39) M1369L possibly damaging Het
Fcrl6 T C 1: 172,426,856 (GRCm39) N30S probably benign Het
Fibp A T 19: 5,513,309 (GRCm39) Q208L probably benign Het
Foxc1 T G 13: 31,992,205 (GRCm39) S339A unknown Het
Fras1 T C 5: 96,907,402 (GRCm39) C3196R probably damaging Het
Galnt7 C T 8: 57,979,176 (GRCm39) W649* probably null Het
H2-M10.2 T C 17: 36,595,555 (GRCm39) N245S possibly damaging Het
Hapln3 G A 7: 78,767,239 (GRCm39) R267W probably benign Het
Hkdc1 T C 10: 62,244,400 (GRCm39) I229V probably damaging Het
Kank1 G A 19: 25,408,378 (GRCm39) G1286R probably damaging Het
Krba1 A G 6: 48,388,629 (GRCm39) I543V probably damaging Het
Lipn A T 19: 34,062,248 (GRCm39) *401L probably null Het
Lrrc37a T C 11: 103,347,449 (GRCm39) N3082S unknown Het
Magi1 A T 6: 93,663,586 (GRCm39) F1117Y probably benign Het
Man2a1 A G 17: 65,020,596 (GRCm39) K791E probably benign Het
Mindy4 T C 6: 55,255,223 (GRCm39) L567P probably benign Het
Mpp4 A G 1: 59,197,743 (GRCm39) probably null Het
Muc2 T G 7: 141,280,758 (GRCm39) C371W probably damaging Het
Nebl A T 2: 17,380,036 (GRCm39) N779K probably benign Het
Nf1 T C 11: 79,336,619 (GRCm39) L1066P probably damaging Het
Npat T C 9: 53,467,951 (GRCm39) L302P probably damaging Het
Nudt21 C A 8: 94,755,498 (GRCm39) G146W probably damaging Het
Or10al6 T A 17: 38,082,940 (GRCm39) I132K probably damaging Het
Or10g1 A T 14: 52,647,465 (GRCm39) L288Q probably damaging Het
Or8c13 A T 9: 38,091,370 (GRCm39) F250I probably damaging Het
Pkd2l2 T C 18: 34,571,273 (GRCm39) probably benign Het
Plcd3 T A 11: 102,962,592 (GRCm39) N620Y probably damaging Het
Ppl T C 16: 4,925,206 (GRCm39) probably benign Het
Pramel41 T G 5: 94,596,399 (GRCm39) C479G probably damaging Het
Prep T C 10: 45,034,620 (GRCm39) *711Q probably null Het
Psap T A 10: 60,135,736 (GRCm39) V394E possibly damaging Het
Ptprr T A 10: 115,884,250 (GRCm39) D102E probably benign Het
Rgsl1 T A 1: 153,698,119 (GRCm39) probably null Het
Rimbp2 T A 5: 128,850,454 (GRCm39) D943V possibly damaging Het
Rsrc2 G T 5: 123,878,793 (GRCm39) R113S unknown Het
Sim1 T A 10: 50,786,626 (GRCm39) V286E possibly damaging Het
Slc35d1 A T 4: 103,068,529 (GRCm39) F124L Het
Sort1 T C 3: 108,246,228 (GRCm39) F402L probably damaging Het
Spata31f1a A G 4: 42,853,688 (GRCm39) C47R possibly damaging Het
Tlr2 T A 3: 83,744,091 (GRCm39) E664V probably damaging Het
Tmppe A T 9: 114,230,260 (GRCm39) probably benign Het
Tnfrsf8 T C 4: 145,001,038 (GRCm39) D356G possibly damaging Het
Tnrc18 T C 5: 142,725,212 (GRCm39) E1839G unknown Het
Trgv4 T C 13: 19,369,627 (GRCm39) S124P probably damaging Het
Trim17 T A 11: 58,859,536 (GRCm39) M250K probably benign Het
Trim33 C T 3: 103,218,807 (GRCm39) L315F probably damaging Het
Vmn1r43 A G 6: 89,846,746 (GRCm39) S247P probably benign Het
Vmn2r33 T A 7: 7,566,809 (GRCm39) Y101F probably benign Het
Vmn2r40 T C 7: 8,923,197 (GRCm39) D388G Het
Wdr36 C T 18: 32,970,340 (GRCm39) probably benign Het
Zfp2 T A 11: 50,791,843 (GRCm39) I67F possibly damaging Het
Other mutations in Or4c11c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Or4c11c APN 2 88,661,456 (GRCm39) splice site probably null
IGL02079:Or4c11c APN 2 88,661,991 (GRCm39) missense probably damaging 1.00
IGL02183:Or4c11c APN 2 88,662,372 (GRCm39) missense probably benign
IGL02813:Or4c11c APN 2 88,661,495 (GRCm39) missense probably benign 0.34
IGL02839:Or4c11c APN 2 88,661,992 (GRCm39) missense probably damaging 1.00
IGL02895:Or4c11c APN 2 88,661,986 (GRCm39) missense probably damaging 1.00
R0680:Or4c11c UTSW 2 88,662,124 (GRCm39) missense probably benign
R2029:Or4c11c UTSW 2 88,661,749 (GRCm39) missense possibly damaging 0.88
R2095:Or4c11c UTSW 2 88,661,634 (GRCm39) missense probably damaging 1.00
R6158:Or4c11c UTSW 2 88,661,490 (GRCm39) missense probably damaging 1.00
R6216:Or4c11c UTSW 2 88,661,655 (GRCm39) missense probably damaging 1.00
R6240:Or4c11c UTSW 2 88,661,707 (GRCm39) missense probably benign 0.22
R6377:Or4c11c UTSW 2 88,661,613 (GRCm39) nonsense probably null
R6429:Or4c11c UTSW 2 88,661,869 (GRCm39) missense probably benign 0.01
R6521:Or4c11c UTSW 2 88,661,700 (GRCm39) missense probably benign 0.03
R7065:Or4c11c UTSW 2 88,661,730 (GRCm39) missense probably damaging 1.00
R7343:Or4c11c UTSW 2 88,662,190 (GRCm39) missense probably damaging 1.00
R7476:Or4c11c UTSW 2 88,661,932 (GRCm39) missense probably benign 0.07
R7570:Or4c11c UTSW 2 88,661,472 (GRCm39) missense possibly damaging 0.82
R8303:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8306:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8307:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8308:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8344:Or4c11c UTSW 2 88,661,727 (GRCm39) missense probably benign 0.00
R8386:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8387:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8809:Or4c11c UTSW 2 88,662,256 (GRCm39) missense probably benign 0.01
Z1176:Or4c11c UTSW 2 88,661,922 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGGGTCCCATGTACTTCTTC -3'
(R):5'- GCAGGCAAGCTCCAATAAGG -3'

Sequencing Primer
(F):5'- CCATGTACTTCTTCCTGTTTTATTTG -3'
(R):5'- GCTCCAATAAGGGCTGTAAGTCAC -3'
Posted On 2021-08-02