Incidental Mutation 'R8894:Nudt21'
ID 677889
Institutional Source Beutler Lab
Gene Symbol Nudt21
Ensembl Gene ENSMUSG00000031754
Gene Name nudix hydrolase 21
Synonyms Cpsf5, 3110048P04Rik, nudix (nucleoside diphosphate linked moiety X)-type motif 21, 5730530J16Rik, 25kDa
MMRRC Submission 068697-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8894 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 94746031-94763667 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 94755498 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Tryptophan at position 146 (G146W)
Ref Sequence ENSEMBL: ENSMUSP00000034204 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034204] [ENSMUST00000212622] [ENSMUST00000212911] [ENSMUST00000212981]
AlphaFold Q9CQF3
Predicted Effect probably damaging
Transcript: ENSMUST00000034204
AA Change: G146W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000034204
Gene: ENSMUSG00000031754
AA Change: G146W

DomainStartEndE-ValueType
Pfam:NUDIX_2 35 222 9.9e-85 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000212622
AA Change: G85W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000212911
AA Change: G20W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000212981
AA Change: G137W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (63/64)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931429L15Rik C T 9: 46,216,397 (GRCm39) V291M probably benign Het
Abca14 A C 7: 119,847,368 (GRCm39) Y744S probably damaging Het
Acly T C 11: 100,407,639 (GRCm39) E237G probably benign Het
Adcy1 T A 11: 7,087,375 (GRCm39) D416E probably damaging Het
Arid1b T A 17: 5,377,668 (GRCm39) M1217K probably damaging Het
Atad2b T C 12: 5,064,001 (GRCm39) probably null Het
Ccdc177 A G 12: 80,806,077 (GRCm39) S66P probably damaging Het
Clpsl2 T C 17: 28,769,645 (GRCm39) C36R possibly damaging Het
Cramp1 C T 17: 25,202,114 (GRCm39) G456D probably damaging Het
Crb1 T A 1: 139,175,750 (GRCm39) L744F possibly damaging Het
Crybg3 T A 16: 59,342,552 (GRCm39) E980D probably damaging Het
Cyp2d11 A T 15: 82,274,671 (GRCm39) V302E probably benign Het
Cyp3a25 A C 5: 145,931,670 (GRCm39) probably benign Het
Dhx35 G C 2: 158,676,795 (GRCm39) A410P possibly damaging Het
Dlg2 A T 7: 91,614,946 (GRCm39) H295L probably benign Het
Dnah2 T A 11: 69,383,048 (GRCm39) M1172L probably benign Het
Dock9 T C 14: 121,860,373 (GRCm39) S850G probably benign Het
Dst A T 1: 34,213,214 (GRCm39) M1369L possibly damaging Het
Fcrl6 T C 1: 172,426,856 (GRCm39) N30S probably benign Het
Fibp A T 19: 5,513,309 (GRCm39) Q208L probably benign Het
Foxc1 T G 13: 31,992,205 (GRCm39) S339A unknown Het
Fras1 T C 5: 96,907,402 (GRCm39) C3196R probably damaging Het
Galnt7 C T 8: 57,979,176 (GRCm39) W649* probably null Het
H2-M10.2 T C 17: 36,595,555 (GRCm39) N245S possibly damaging Het
Hapln3 G A 7: 78,767,239 (GRCm39) R267W probably benign Het
Hkdc1 T C 10: 62,244,400 (GRCm39) I229V probably damaging Het
Kank1 G A 19: 25,408,378 (GRCm39) G1286R probably damaging Het
Krba1 A G 6: 48,388,629 (GRCm39) I543V probably damaging Het
Lipn A T 19: 34,062,248 (GRCm39) *401L probably null Het
Lrrc37a T C 11: 103,347,449 (GRCm39) N3082S unknown Het
Magi1 A T 6: 93,663,586 (GRCm39) F1117Y probably benign Het
Man2a1 A G 17: 65,020,596 (GRCm39) K791E probably benign Het
Mindy4 T C 6: 55,255,223 (GRCm39) L567P probably benign Het
Mpp4 A G 1: 59,197,743 (GRCm39) probably null Het
Muc2 T G 7: 141,280,758 (GRCm39) C371W probably damaging Het
Nebl A T 2: 17,380,036 (GRCm39) N779K probably benign Het
Nf1 T C 11: 79,336,619 (GRCm39) L1066P probably damaging Het
Npat T C 9: 53,467,951 (GRCm39) L302P probably damaging Het
Or10al6 T A 17: 38,082,940 (GRCm39) I132K probably damaging Het
Or10g1 A T 14: 52,647,465 (GRCm39) L288Q probably damaging Het
Or4c11c T G 2: 88,661,809 (GRCm39) M116R probably benign Het
Or8c13 A T 9: 38,091,370 (GRCm39) F250I probably damaging Het
Pkd2l2 T C 18: 34,571,273 (GRCm39) probably benign Het
Plcd3 T A 11: 102,962,592 (GRCm39) N620Y probably damaging Het
Ppl T C 16: 4,925,206 (GRCm39) probably benign Het
Pramel41 T G 5: 94,596,399 (GRCm39) C479G probably damaging Het
Prep T C 10: 45,034,620 (GRCm39) *711Q probably null Het
Psap T A 10: 60,135,736 (GRCm39) V394E possibly damaging Het
Ptprr T A 10: 115,884,250 (GRCm39) D102E probably benign Het
Rgsl1 T A 1: 153,698,119 (GRCm39) probably null Het
Rimbp2 T A 5: 128,850,454 (GRCm39) D943V possibly damaging Het
Rsrc2 G T 5: 123,878,793 (GRCm39) R113S unknown Het
Sim1 T A 10: 50,786,626 (GRCm39) V286E possibly damaging Het
Slc35d1 A T 4: 103,068,529 (GRCm39) F124L Het
Sort1 T C 3: 108,246,228 (GRCm39) F402L probably damaging Het
Spata31f1a A G 4: 42,853,688 (GRCm39) C47R possibly damaging Het
Tlr2 T A 3: 83,744,091 (GRCm39) E664V probably damaging Het
Tmppe A T 9: 114,230,260 (GRCm39) probably benign Het
Tnfrsf8 T C 4: 145,001,038 (GRCm39) D356G possibly damaging Het
Tnrc18 T C 5: 142,725,212 (GRCm39) E1839G unknown Het
Trgv4 T C 13: 19,369,627 (GRCm39) S124P probably damaging Het
Trim17 T A 11: 58,859,536 (GRCm39) M250K probably benign Het
Trim33 C T 3: 103,218,807 (GRCm39) L315F probably damaging Het
Vmn1r43 A G 6: 89,846,746 (GRCm39) S247P probably benign Het
Vmn2r33 T A 7: 7,566,809 (GRCm39) Y101F probably benign Het
Vmn2r40 T C 7: 8,923,197 (GRCm39) D388G Het
Wdr36 C T 18: 32,970,340 (GRCm39) probably benign Het
Zfp2 T A 11: 50,791,843 (GRCm39) I67F possibly damaging Het
Other mutations in Nudt21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02226:Nudt21 APN 8 94,746,329 (GRCm39) nonsense probably null
PIT4544001:Nudt21 UTSW 8 94,746,225 (GRCm39) missense unknown
R1172:Nudt21 UTSW 8 94,757,757 (GRCm39) splice site probably benign
R1576:Nudt21 UTSW 8 94,755,461 (GRCm39) critical splice donor site probably null
R6293:Nudt21 UTSW 8 94,755,506 (GRCm39) missense probably damaging 1.00
R6474:Nudt21 UTSW 8 94,746,282 (GRCm39) missense probably benign 0.02
R6961:Nudt21 UTSW 8 94,755,508 (GRCm39) missense probably benign
R7312:Nudt21 UTSW 8 94,746,227 (GRCm39) missense probably benign 0.00
R7737:Nudt21 UTSW 8 94,749,461 (GRCm39) missense probably damaging 1.00
R7755:Nudt21 UTSW 8 94,749,493 (GRCm39) missense probably benign 0.33
R8539:Nudt21 UTSW 8 94,763,601 (GRCm39) start gained probably benign
R9103:Nudt21 UTSW 8 94,746,321 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GGAAGCTAAGGTCTACTCTGATT -3'
(R):5'- CCTAATATTCTACGGCAGTTGGAAA -3'

Sequencing Primer
(F):5'- TCAGCAGTTAGAGTCACTCACTGG -3'
(R):5'- GAACCCAGAAGGGAATTC -3'
Posted On 2021-08-02