Incidental Mutation 'R8895:Mcf2l'
| ID |
677954 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mcf2l
|
| Ensembl Gene |
ENSMUSG00000031442 |
| Gene Name |
mcf.2 transforming sequence-like |
| Synonyms |
Dbs, C130040G20Rik |
| MMRRC Submission |
068754-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8895 (G1)
|
| Quality Score |
81.0075 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
12923806-13070502 bp(+) (GRCm39) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
C to T
at 13034330 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133776
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000095456]
[ENSMUST00000098927]
[ENSMUST00000110866]
[ENSMUST00000110867]
[ENSMUST00000110871]
[ENSMUST00000110873]
[ENSMUST00000110876]
[ENSMUST00000110879]
[ENSMUST00000145067]
[ENSMUST00000173006]
[ENSMUST00000173099]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000095456
|
| SMART Domains |
Protein: ENSMUSP00000093108
Gene: ENSMUSG00000031442
| Domain | Start | End | E-Value | Type |
|---|
|
SEC14
|
75 |
221 |
1.77e-24 |
SMART |
|
SPEC
|
354 |
455 |
4.41e-15 |
SMART |
|
coiled coil region
|
507 |
529 |
N/A |
INTRINSIC |
|
low complexity region
|
578 |
594 |
N/A |
INTRINSIC |
|
RhoGEF
|
636 |
811 |
2.83e-63 |
SMART |
|
PH
|
831 |
948 |
8.13e-14 |
SMART |
|
low complexity region
|
966 |
978 |
N/A |
INTRINSIC |
|
SH3
|
1058 |
1115 |
3.33e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098927
|
| SMART Domains |
Protein: ENSMUSP00000096528
Gene: ENSMUSG00000031442
| Domain | Start | End | E-Value | Type |
|---|
|
SEC14
|
49 |
195 |
1.77e-24 |
SMART |
|
SPEC
|
328 |
429 |
4.41e-15 |
SMART |
|
coiled coil region
|
481 |
503 |
N/A |
INTRINSIC |
|
low complexity region
|
552 |
568 |
N/A |
INTRINSIC |
|
RhoGEF
|
610 |
785 |
2.83e-63 |
SMART |
|
PH
|
805 |
922 |
8.13e-14 |
SMART |
|
low complexity region
|
940 |
952 |
N/A |
INTRINSIC |
|
low complexity region
|
1022 |
1033 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110866
|
| SMART Domains |
Protein: ENSMUSP00000106490
Gene: ENSMUSG00000031442
| Domain | Start | End | E-Value | Type |
|---|
|
SEC14
|
23 |
169 |
1.77e-24 |
SMART |
|
SPEC
|
302 |
403 |
4.41e-15 |
SMART |
|
coiled coil region
|
455 |
477 |
N/A |
INTRINSIC |
|
low complexity region
|
526 |
542 |
N/A |
INTRINSIC |
|
RhoGEF
|
584 |
759 |
2.83e-63 |
SMART |
|
PH
|
779 |
896 |
8.13e-14 |
SMART |
|
low complexity region
|
914 |
926 |
N/A |
INTRINSIC |
|
SH3
|
1006 |
1063 |
3.33e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110867
|
| SMART Domains |
Protein: ENSMUSP00000106491
Gene: ENSMUSG00000031442
| Domain | Start | End | E-Value | Type |
|---|
|
SEC14
|
23 |
169 |
1.77e-24 |
SMART |
|
SPEC
|
302 |
403 |
4.41e-15 |
SMART |
|
coiled coil region
|
455 |
477 |
N/A |
INTRINSIC |
|
low complexity region
|
526 |
542 |
N/A |
INTRINSIC |
|
RhoGEF
|
584 |
759 |
2.83e-63 |
SMART |
|
PH
|
779 |
896 |
8.13e-14 |
SMART |
|
low complexity region
|
914 |
926 |
N/A |
INTRINSIC |
|
SH3
|
1006 |
1063 |
3.33e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110871
|
| SMART Domains |
Protein: ENSMUSP00000106495
Gene: ENSMUSG00000031442
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
SEC14
|
43 |
189 |
1.77e-24 |
SMART |
|
SPEC
|
322 |
423 |
4.41e-15 |
SMART |
|
coiled coil region
|
475 |
497 |
N/A |
INTRINSIC |
|
low complexity region
|
546 |
562 |
N/A |
INTRINSIC |
|
RhoGEF
|
604 |
779 |
2.83e-63 |
SMART |
|
PH
|
799 |
916 |
8.13e-14 |
SMART |
|
low complexity region
|
934 |
946 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110873
|
| SMART Domains |
Protein: ENSMUSP00000106497
Gene: ENSMUSG00000031442
| Domain | Start | End | E-Value | Type |
|---|
|
SPEC
|
165 |
266 |
4.41e-15 |
SMART |
|
coiled coil region
|
318 |
340 |
N/A |
INTRINSIC |
|
low complexity region
|
389 |
405 |
N/A |
INTRINSIC |
|
RhoGEF
|
447 |
622 |
2.83e-63 |
SMART |
|
PH
|
642 |
759 |
8.13e-14 |
SMART |
|
low complexity region
|
777 |
789 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110876
|
| SMART Domains |
Protein: ENSMUSP00000106500
Gene: ENSMUSG00000031442
| Domain | Start | End | E-Value | Type |
|---|
|
SEC14
|
45 |
191 |
1.77e-24 |
SMART |
|
SPEC
|
324 |
425 |
4.41e-15 |
SMART |
|
coiled coil region
|
477 |
499 |
N/A |
INTRINSIC |
|
low complexity region
|
548 |
564 |
N/A |
INTRINSIC |
|
RhoGEF
|
606 |
781 |
2.83e-63 |
SMART |
|
PH
|
801 |
918 |
8.13e-14 |
SMART |
|
low complexity region
|
936 |
948 |
N/A |
INTRINSIC |
|
SH3
|
1084 |
1141 |
3.33e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110879
|
| SMART Domains |
Protein: ENSMUSP00000106503
Gene: ENSMUSG00000031442
| Domain | Start | End | E-Value | Type |
|---|
|
SEC14
|
45 |
191 |
1.77e-24 |
SMART |
|
SPEC
|
324 |
425 |
4.41e-15 |
SMART |
|
coiled coil region
|
477 |
499 |
N/A |
INTRINSIC |
|
low complexity region
|
548 |
564 |
N/A |
INTRINSIC |
|
RhoGEF
|
606 |
781 |
2.83e-63 |
SMART |
|
PH
|
801 |
918 |
8.13e-14 |
SMART |
|
low complexity region
|
936 |
948 |
N/A |
INTRINSIC |
|
SH3
|
1028 |
1085 |
3.33e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145067
|
| SMART Domains |
Protein: ENSMUSP00000133577
Gene: ENSMUSG00000031442
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:CRAL_TRIO_2
|
16 |
132 |
2.4e-12 |
PFAM |
|
SPEC
|
261 |
362 |
4.41e-15 |
SMART |
|
coiled coil region
|
414 |
436 |
N/A |
INTRINSIC |
|
low complexity region
|
485 |
501 |
N/A |
INTRINSIC |
|
RhoGEF
|
543 |
718 |
2.83e-63 |
SMART |
|
PH
|
738 |
855 |
8.13e-14 |
SMART |
|
low complexity region
|
873 |
885 |
N/A |
INTRINSIC |
|
SH3
|
1021 |
1078 |
3.33e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173006
|
| SMART Domains |
Protein: ENSMUSP00000134147
Gene: ENSMUSG00000031442
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:CRAL_TRIO_2
|
1 |
104 |
1.3e-12 |
PFAM |
|
SPEC
|
233 |
334 |
4.41e-15 |
SMART |
|
coiled coil region
|
386 |
408 |
N/A |
INTRINSIC |
|
low complexity region
|
457 |
473 |
N/A |
INTRINSIC |
|
RhoGEF
|
515 |
690 |
2.83e-63 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173099
|
| SMART Domains |
Protein: ENSMUSP00000133776
Gene: ENSMUSG00000031442
| Domain | Start | End | E-Value | Type |
|---|
|
SEC14
|
41 |
187 |
1.77e-24 |
SMART |
|
SPEC
|
320 |
421 |
4.41e-15 |
SMART |
|
coiled coil region
|
473 |
495 |
N/A |
INTRINSIC |
|
low complexity region
|
544 |
560 |
N/A |
INTRINSIC |
|
RhoGEF
|
602 |
777 |
2.83e-63 |
SMART |
|
PH
|
797 |
914 |
8.13e-14 |
SMART |
|
low complexity region
|
932 |
944 |
N/A |
INTRINSIC |
|
low complexity region
|
1014 |
1025 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (74/74) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930567H17Rik |
G |
A |
X: 69,437,994 (GRCm39) |
R100W |
possibly damaging |
Het |
| Adamts10 |
G |
A |
17: 33,768,270 (GRCm39) |
R814H |
probably damaging |
Het |
| Akr1a1 |
A |
G |
4: 116,498,260 (GRCm39) |
L95P |
probably damaging |
Het |
| Amigo2 |
G |
T |
15: 97,143,389 (GRCm39) |
N344K |
probably damaging |
Het |
| Ankrd11 |
T |
C |
8: 123,621,014 (GRCm39) |
D946G |
possibly damaging |
Het |
| Arb2a |
T |
A |
13: 78,147,773 (GRCm39) |
N280K |
probably damaging |
Het |
| Btnl6 |
T |
G |
17: 34,734,391 (GRCm39) |
I124L |
probably benign |
Het |
| Bzw2 |
A |
T |
12: 36,173,982 (GRCm39) |
C97* |
probably null |
Het |
| Celsr2 |
G |
A |
3: 108,320,880 (GRCm39) |
T644I |
possibly damaging |
Het |
| Cep85l |
A |
T |
10: 53,224,911 (GRCm39) |
L226Q |
possibly damaging |
Het |
| Ces1g |
T |
C |
8: 94,046,512 (GRCm39) |
K338E |
possibly damaging |
Het |
| Cldn10 |
G |
A |
14: 119,092,507 (GRCm39) |
D36N |
probably damaging |
Het |
| Cntnap4 |
T |
A |
8: 113,479,598 (GRCm39) |
I261N |
probably benign |
Het |
| Csnk1g1 |
T |
C |
9: 65,915,109 (GRCm39) |
|
probably null |
Het |
| Cyp2c69 |
T |
C |
19: 39,869,910 (GRCm39) |
D104G |
possibly damaging |
Het |
| Cyp3a11 |
T |
C |
5: 145,797,330 (GRCm39) |
T350A |
probably benign |
Het |
| Daw1 |
T |
A |
1: 83,187,011 (GRCm39) |
C274S |
probably damaging |
Het |
| Dmtn |
T |
C |
14: 70,850,144 (GRCm39) |
T267A |
probably benign |
Het |
| Dock5 |
A |
G |
14: 68,055,112 (GRCm39) |
Y585H |
possibly damaging |
Het |
| Dsg2 |
T |
G |
18: 20,723,126 (GRCm39) |
V384G |
probably damaging |
Het |
| Elmo1 |
C |
T |
13: 20,748,630 (GRCm39) |
L492F |
probably damaging |
Het |
| Fmo1 |
T |
C |
1: 162,657,827 (GRCm39) |
D438G |
probably benign |
Het |
| Folr2 |
C |
T |
7: 101,489,408 (GRCm39) |
V244M |
unknown |
Het |
| Galnt18 |
T |
C |
7: 111,378,709 (GRCm39) |
I16V |
possibly damaging |
Het |
| Gm10036 |
C |
A |
18: 15,966,207 (GRCm39) |
Y119* |
probably null |
Het |
| Gria4 |
A |
G |
9: 4,664,951 (GRCm39) |
S102P |
probably damaging |
Het |
| Hc |
A |
T |
2: 34,890,861 (GRCm39) |
N1318K |
probably benign |
Het |
| Ifitm1 |
T |
C |
7: 140,549,499 (GRCm39) |
L94P |
probably damaging |
Het |
| Iqca1l |
T |
C |
5: 24,755,628 (GRCm39) |
D298G |
probably benign |
Het |
| Itga9 |
G |
A |
9: 118,510,835 (GRCm39) |
V455M |
probably damaging |
Het |
| Kank4 |
C |
T |
4: 98,653,747 (GRCm39) |
V894I |
possibly damaging |
Het |
| Kcnip2 |
T |
A |
19: 45,785,100 (GRCm39) |
|
probably benign |
Het |
| Lamb1 |
A |
G |
12: 31,352,953 (GRCm39) |
T885A |
possibly damaging |
Het |
| Lamp5 |
A |
G |
2: 135,902,874 (GRCm39) |
T198A |
probably benign |
Het |
| Ldc1 |
T |
C |
4: 130,105,223 (GRCm39) |
K316E |
probably benign |
Het |
| Lipi |
A |
T |
16: 75,352,710 (GRCm39) |
L376I |
probably benign |
Het |
| Lrrc37 |
T |
A |
11: 103,509,656 (GRCm39) |
T771S |
unknown |
Het |
| Luc7l |
T |
C |
17: 26,472,978 (GRCm39) |
I31T |
possibly damaging |
Het |
| Malrd1 |
A |
T |
2: 15,850,038 (GRCm39) |
N1219I |
unknown |
Het |
| Mrc1 |
A |
C |
2: 14,312,760 (GRCm39) |
N894T |
probably damaging |
Het |
| Mrpl35 |
C |
T |
6: 71,793,271 (GRCm39) |
A127T |
possibly damaging |
Het |
| Myom2 |
T |
A |
8: 15,152,589 (GRCm39) |
Y645* |
probably null |
Het |
| Naip2 |
T |
C |
13: 100,325,644 (GRCm39) |
H88R |
probably benign |
Het |
| Noc3l |
T |
A |
19: 38,798,751 (GRCm39) |
K282N |
probably damaging |
Het |
| Nwd2 |
T |
C |
5: 63,963,241 (GRCm39) |
Y942H |
probably damaging |
Het |
| Or10ag2 |
T |
C |
2: 87,248,659 (GRCm39) |
V87A |
probably benign |
Het |
| Or52d1 |
T |
A |
7: 103,756,302 (GRCm39) |
I272N |
probably damaging |
Het |
| Osbpl9 |
C |
A |
4: 108,930,333 (GRCm39) |
A221S |
probably benign |
Het |
| Paip1 |
T |
C |
13: 119,566,801 (GRCm39) |
L45S |
probably benign |
Het |
| Peak1 |
T |
C |
9: 56,113,938 (GRCm39) |
T1668A |
probably benign |
Het |
| Pgap3 |
A |
G |
11: 98,281,602 (GRCm39) |
F199L |
possibly damaging |
Het |
| Ppip5k2 |
T |
C |
1: 97,639,544 (GRCm39) |
M1061V |
probably benign |
Het |
| Ppp6r3 |
A |
T |
19: 3,544,017 (GRCm39) |
W333R |
probably damaging |
Het |
| Ptk2b |
T |
A |
14: 66,412,242 (GRCm39) |
N383I |
probably benign |
Het |
| Rab21 |
G |
C |
10: 115,151,080 (GRCm39) |
R58G |
probably benign |
Het |
| Rabif |
C |
T |
1: 134,433,935 (GRCm39) |
T83I |
probably damaging |
Het |
| Rdh7 |
A |
T |
10: 127,724,430 (GRCm39) |
F18Y |
probably benign |
Het |
| Scart2 |
C |
T |
7: 139,841,532 (GRCm39) |
P279S |
possibly damaging |
Het |
| Septin5 |
A |
G |
16: 18,441,861 (GRCm39) |
M315T |
possibly damaging |
Het |
| Slc27a6 |
A |
G |
18: 58,715,306 (GRCm39) |
Y303C |
probably damaging |
Het |
| Slc7a7 |
T |
A |
14: 54,607,293 (GRCm39) |
M495L |
probably benign |
Het |
| Sntg1 |
T |
A |
1: 8,748,074 (GRCm39) |
|
probably null |
Het |
| Spred2 |
T |
A |
11: 19,951,019 (GRCm39) |
I72N |
probably benign |
Het |
| St3gal1 |
A |
T |
15: 66,980,086 (GRCm39) |
I271N |
possibly damaging |
Het |
| Stox1 |
A |
T |
10: 62,495,386 (GRCm39) |
H962Q |
probably benign |
Het |
| Supt6 |
A |
T |
11: 78,103,664 (GRCm39) |
M1347K |
probably damaging |
Het |
| Susd2 |
G |
T |
10: 75,475,452 (GRCm39) |
A484D |
possibly damaging |
Het |
| Tmem260 |
A |
G |
14: 48,737,845 (GRCm39) |
|
probably benign |
Het |
| Tpbg |
C |
A |
9: 85,726,520 (GRCm39) |
A163E |
possibly damaging |
Het |
| Tpx2 |
T |
C |
2: 152,724,255 (GRCm39) |
Y344H |
probably damaging |
Het |
| Ttf2 |
A |
T |
3: 100,870,028 (GRCm39) |
F348L |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,663,650 (GRCm39) |
V11675E |
unknown |
Het |
| Txnl4b |
T |
A |
8: 110,299,467 (GRCm39) |
Y142* |
probably null |
Het |
| Vmn2r18 |
G |
A |
5: 151,485,140 (GRCm39) |
R785C |
possibly damaging |
Het |
| Zbtb18 |
T |
A |
1: 177,276,044 (GRCm39) |
V459E |
probably damaging |
Het |
|
| Other mutations in Mcf2l |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00402:Mcf2l
|
APN |
8 |
13,050,857 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00426:Mcf2l
|
APN |
8 |
13,034,910 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01391:Mcf2l
|
APN |
8 |
13,064,010 (GRCm39) |
splice site |
probably null |
|
|
IGL01795:Mcf2l
|
APN |
8 |
13,050,749 (GRCm39) |
splice site |
probably null |
|
|
IGL02314:Mcf2l
|
APN |
8 |
13,051,851 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02716:Mcf2l
|
APN |
8 |
13,047,277 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02985:Mcf2l
|
APN |
8 |
13,013,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03073:Mcf2l
|
APN |
8 |
13,050,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03308:Mcf2l
|
APN |
8 |
13,059,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03371:Mcf2l
|
APN |
8 |
13,051,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0022:Mcf2l
|
UTSW |
8 |
13,068,897 (GRCm39) |
nonsense |
probably null |
|
|
R0062:Mcf2l
|
UTSW |
8 |
13,056,766 (GRCm39) |
unclassified |
probably benign |
|
|
R0067:Mcf2l
|
UTSW |
8 |
13,063,060 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0110:Mcf2l
|
UTSW |
8 |
13,047,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0450:Mcf2l
|
UTSW |
8 |
13,047,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0469:Mcf2l
|
UTSW |
8 |
13,047,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0510:Mcf2l
|
UTSW |
8 |
13,047,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0543:Mcf2l
|
UTSW |
8 |
13,046,728 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0591:Mcf2l
|
UTSW |
8 |
13,068,751 (GRCm39) |
missense |
probably benign |
0.11 |
|
R0801:Mcf2l
|
UTSW |
8 |
13,064,020 (GRCm39) |
intron |
probably benign |
|
|
R0962:Mcf2l
|
UTSW |
8 |
13,051,964 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1084:Mcf2l
|
UTSW |
8 |
13,052,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1794:Mcf2l
|
UTSW |
8 |
12,965,982 (GRCm39) |
missense |
probably benign |
0.33 |
|
R2111:Mcf2l
|
UTSW |
8 |
13,051,867 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2112:Mcf2l
|
UTSW |
8 |
13,051,867 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3785:Mcf2l
|
UTSW |
8 |
12,930,099 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4777:Mcf2l
|
UTSW |
8 |
13,068,051 (GRCm39) |
splice site |
probably null |
|
|
R4858:Mcf2l
|
UTSW |
8 |
13,063,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4980:Mcf2l
|
UTSW |
8 |
13,034,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5021:Mcf2l
|
UTSW |
8 |
13,061,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5067:Mcf2l
|
UTSW |
8 |
12,965,959 (GRCm39) |
intron |
probably benign |
|
|
R5158:Mcf2l
|
UTSW |
8 |
13,059,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5439:Mcf2l
|
UTSW |
8 |
12,976,646 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5569:Mcf2l
|
UTSW |
8 |
13,055,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5655:Mcf2l
|
UTSW |
8 |
13,060,444 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5668:Mcf2l
|
UTSW |
8 |
13,063,812 (GRCm39) |
nonsense |
probably null |
|
|
R5753:Mcf2l
|
UTSW |
8 |
13,049,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5808:Mcf2l
|
UTSW |
8 |
13,043,937 (GRCm39) |
start codon destroyed |
probably null |
0.92 |
|
R5946:Mcf2l
|
UTSW |
8 |
13,063,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6168:Mcf2l
|
UTSW |
8 |
13,051,823 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6174:Mcf2l
|
UTSW |
8 |
13,063,849 (GRCm39) |
nonsense |
probably null |
|
|
R6212:Mcf2l
|
UTSW |
8 |
13,067,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6270:Mcf2l
|
UTSW |
8 |
13,068,701 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6383:Mcf2l
|
UTSW |
8 |
12,929,912 (GRCm39) |
start gained |
probably benign |
|
|
R6850:Mcf2l
|
UTSW |
8 |
13,059,476 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6908:Mcf2l
|
UTSW |
8 |
13,068,919 (GRCm39) |
missense |
probably benign |
|
|
R7101:Mcf2l
|
UTSW |
8 |
13,063,579 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7163:Mcf2l
|
UTSW |
8 |
12,965,439 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7203:Mcf2l
|
UTSW |
8 |
13,060,456 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7414:Mcf2l
|
UTSW |
8 |
13,069,022 (GRCm39) |
makesense |
probably null |
|
|
R7553:Mcf2l
|
UTSW |
8 |
13,047,268 (GRCm39) |
missense |
probably benign |
|
|
R7556:Mcf2l
|
UTSW |
8 |
13,023,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7688:Mcf2l
|
UTSW |
8 |
12,998,130 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7776:Mcf2l
|
UTSW |
8 |
12,930,127 (GRCm39) |
missense |
probably benign |
|
|
R7947:Mcf2l
|
UTSW |
8 |
13,053,529 (GRCm39) |
splice site |
probably null |
|
|
R8077:Mcf2l
|
UTSW |
8 |
13,048,494 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8083:Mcf2l
|
UTSW |
8 |
13,057,875 (GRCm39) |
splice site |
probably null |
|
|
R8133:Mcf2l
|
UTSW |
8 |
13,061,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8189:Mcf2l
|
UTSW |
8 |
13,013,164 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8453:Mcf2l
|
UTSW |
8 |
13,034,956 (GRCm39) |
splice site |
probably null |
|
|
R8520:Mcf2l
|
UTSW |
8 |
12,930,089 (GRCm39) |
missense |
probably benign |
|
|
R8865:Mcf2l
|
UTSW |
8 |
12,930,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9081:Mcf2l
|
UTSW |
8 |
13,068,697 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9143:Mcf2l
|
UTSW |
8 |
13,062,883 (GRCm39) |
splice site |
probably benign |
|
|
R9219:Mcf2l
|
UTSW |
8 |
13,061,383 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9229:Mcf2l
|
UTSW |
8 |
13,063,584 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9335:Mcf2l
|
UTSW |
8 |
13,050,812 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9351:Mcf2l
|
UTSW |
8 |
13,050,757 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9406:Mcf2l
|
UTSW |
8 |
13,059,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9442:Mcf2l
|
UTSW |
8 |
13,023,048 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9618:Mcf2l
|
UTSW |
8 |
13,034,320 (GRCm39) |
intron |
probably benign |
|
|
X0052:Mcf2l
|
UTSW |
8 |
13,068,713 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
Z1177:Mcf2l
|
UTSW |
8 |
13,059,654 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CGTTCATGGATTCAGAAACCAGG -3'
(R):5'- CCACGTCATGTCAGTCCTAG -3'
Sequencing Primer
(F):5'- TGGATTCAGAAACCAGGCATTC -3'
(R):5'- CATGTCAGTCCTAGCATCTGAGG -3'
|
| Posted On |
2021-08-02 |
Incidental Mutation