Incidental Mutation 'R8895:Lrrc37'
ID 677973
Institutional Source Beutler Lab
Gene Symbol Lrrc37
Ensembl Gene ENSMUSG00000034239
Gene Name leucine rich repeat containing 37
Synonyms LOC380730, Gm884
MMRRC Submission 068754-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.257) question?
Stock # R8895 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 103425403-103511966 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 103509656 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 771 (T771S)
Ref Sequence ENSEMBL: ENSMUSP00000058511 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059279] [ENSMUST00000167262]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000059279
AA Change: T771S
SMART Domains Protein: ENSMUSP00000058511
Gene: ENSMUSG00000034239
AA Change: T771S

DomainStartEndE-ValueType
Pfam:LRRC37 149 223 5.4e-10 PFAM
low complexity region 244 264 N/A INTRINSIC
low complexity region 298 308 N/A INTRINSIC
Pfam:LRRC37 335 403 1.9e-14 PFAM
Pfam:LRRC37 419 514 1.2e-8 PFAM
Pfam:LRRC37 565 620 2e-10 PFAM
Pfam:LRRC37 669 739 7.6e-18 PFAM
Pfam:LRRC37 741 792 1.6e-9 PFAM
Pfam:LRRC37 789 860 1.4e-23 PFAM
Pfam:LRRC37 861 914 2.8e-9 PFAM
Pfam:LRRC37 911 983 1.9e-23 PFAM
Pfam:LRRC37 979 1038 1e-8 PFAM
Pfam:LRRC37 1034 1105 2.7e-24 PFAM
Pfam:LRRC37 1105 1158 2.3e-9 PFAM
Pfam:LRRC37 1155 1219 2.4e-17 PFAM
Pfam:LRRC37 1222 1265 9.2e-7 PFAM
Pfam:LRRC37 1263 1330 4.9e-24 PFAM
Pfam:LRRC37 1331 1384 1.4e-10 PFAM
Pfam:LRRC37 1380 1451 4.3e-15 PFAM
Pfam:LRRC37 1487 1558 1.9e-15 PFAM
Pfam:LRRC37 1594 1665 2.9e-18 PFAM
Pfam:LRRC37 1701 1772 5.6e-23 PFAM
Pfam:LRRC37 1808 1910 2.8e-18 PFAM
Pfam:LRRC37 1915 1986 7.2e-17 PFAM
Pfam:LRRC37 2022 2093 4.9e-22 PFAM
Pfam:LRRC37 2129 2200 4.4e-22 PFAM
Pfam:LRRC37 2236 2307 2.1e-21 PFAM
Pfam:LRRC37 2343 2414 3.8e-17 PFAM
Pfam:LRRC37 2449 2519 1.6e-19 PFAM
LRR 2777 2796 3.09e1 SMART
LRR_TYP 2797 2820 2.09e-3 SMART
LRR 2821 2844 4.44e0 SMART
LRR 2848 2872 8.26e1 SMART
low complexity region 2991 3002 N/A INTRINSIC
low complexity region 3220 3230 N/A INTRINSIC
low complexity region 3382 3393 N/A INTRINSIC
Pfam:LRRC37AB_C 3424 3570 7.7e-76 PFAM
low complexity region 3571 3589 N/A INTRINSIC
low complexity region 3622 3640 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000167262
SMART Domains Protein: ENSMUSP00000129662
Gene: ENSMUSG00000034239

DomainStartEndE-ValueType
internal_repeat_1 1 70 1.46e-11 PROSPERO
internal_repeat_1 108 290 1.46e-11 PROSPERO
LRR 601 620 3.09e1 SMART
LRR_TYP 621 644 2.09e-3 SMART
LRR 645 668 4.44e0 SMART
LRR 672 696 8.26e1 SMART
low complexity region 815 826 N/A INTRINSIC
low complexity region 1044 1054 N/A INTRINSIC
low complexity region 1206 1217 N/A INTRINSIC
Pfam:LRRC37AB_C 1243 1396 1.2e-92 PFAM
low complexity region 1446 1464 N/A INTRINSIC
Meta Mutation Damage Score 0.0852 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (74/74)
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930567H17Rik G A X: 69,437,994 (GRCm39) R100W possibly damaging Het
Adamts10 G A 17: 33,768,270 (GRCm39) R814H probably damaging Het
Akr1a1 A G 4: 116,498,260 (GRCm39) L95P probably damaging Het
Amigo2 G T 15: 97,143,389 (GRCm39) N344K probably damaging Het
Ankrd11 T C 8: 123,621,014 (GRCm39) D946G possibly damaging Het
Arb2a T A 13: 78,147,773 (GRCm39) N280K probably damaging Het
Btnl6 T G 17: 34,734,391 (GRCm39) I124L probably benign Het
Bzw2 A T 12: 36,173,982 (GRCm39) C97* probably null Het
Celsr2 G A 3: 108,320,880 (GRCm39) T644I possibly damaging Het
Cep85l A T 10: 53,224,911 (GRCm39) L226Q possibly damaging Het
Ces1g T C 8: 94,046,512 (GRCm39) K338E possibly damaging Het
Cldn10 G A 14: 119,092,507 (GRCm39) D36N probably damaging Het
Cntnap4 T A 8: 113,479,598 (GRCm39) I261N probably benign Het
Csnk1g1 T C 9: 65,915,109 (GRCm39) probably null Het
Cyp2c69 T C 19: 39,869,910 (GRCm39) D104G possibly damaging Het
Cyp3a11 T C 5: 145,797,330 (GRCm39) T350A probably benign Het
Daw1 T A 1: 83,187,011 (GRCm39) C274S probably damaging Het
Dmtn T C 14: 70,850,144 (GRCm39) T267A probably benign Het
Dock5 A G 14: 68,055,112 (GRCm39) Y585H possibly damaging Het
Dsg2 T G 18: 20,723,126 (GRCm39) V384G probably damaging Het
Elmo1 C T 13: 20,748,630 (GRCm39) L492F probably damaging Het
Fmo1 T C 1: 162,657,827 (GRCm39) D438G probably benign Het
Folr2 C T 7: 101,489,408 (GRCm39) V244M unknown Het
Galnt18 T C 7: 111,378,709 (GRCm39) I16V possibly damaging Het
Gm10036 C A 18: 15,966,207 (GRCm39) Y119* probably null Het
Gria4 A G 9: 4,664,951 (GRCm39) S102P probably damaging Het
Hc A T 2: 34,890,861 (GRCm39) N1318K probably benign Het
Ifitm1 T C 7: 140,549,499 (GRCm39) L94P probably damaging Het
Iqca1l T C 5: 24,755,628 (GRCm39) D298G probably benign Het
Itga9 G A 9: 118,510,835 (GRCm39) V455M probably damaging Het
Kank4 C T 4: 98,653,747 (GRCm39) V894I possibly damaging Het
Kcnip2 T A 19: 45,785,100 (GRCm39) probably benign Het
Lamb1 A G 12: 31,352,953 (GRCm39) T885A possibly damaging Het
Lamp5 A G 2: 135,902,874 (GRCm39) T198A probably benign Het
Ldc1 T C 4: 130,105,223 (GRCm39) K316E probably benign Het
Lipi A T 16: 75,352,710 (GRCm39) L376I probably benign Het
Luc7l T C 17: 26,472,978 (GRCm39) I31T possibly damaging Het
Malrd1 A T 2: 15,850,038 (GRCm39) N1219I unknown Het
Mcf2l C T 8: 13,034,330 (GRCm39) probably benign Het
Mrc1 A C 2: 14,312,760 (GRCm39) N894T probably damaging Het
Mrpl35 C T 6: 71,793,271 (GRCm39) A127T possibly damaging Het
Myom2 T A 8: 15,152,589 (GRCm39) Y645* probably null Het
Naip2 T C 13: 100,325,644 (GRCm39) H88R probably benign Het
Noc3l T A 19: 38,798,751 (GRCm39) K282N probably damaging Het
Nwd2 T C 5: 63,963,241 (GRCm39) Y942H probably damaging Het
Or10ag2 T C 2: 87,248,659 (GRCm39) V87A probably benign Het
Or52d1 T A 7: 103,756,302 (GRCm39) I272N probably damaging Het
Osbpl9 C A 4: 108,930,333 (GRCm39) A221S probably benign Het
Paip1 T C 13: 119,566,801 (GRCm39) L45S probably benign Het
Peak1 T C 9: 56,113,938 (GRCm39) T1668A probably benign Het
Pgap3 A G 11: 98,281,602 (GRCm39) F199L possibly damaging Het
Ppip5k2 T C 1: 97,639,544 (GRCm39) M1061V probably benign Het
Ppp6r3 A T 19: 3,544,017 (GRCm39) W333R probably damaging Het
Ptk2b T A 14: 66,412,242 (GRCm39) N383I probably benign Het
Rab21 G C 10: 115,151,080 (GRCm39) R58G probably benign Het
Rabif C T 1: 134,433,935 (GRCm39) T83I probably damaging Het
Rdh7 A T 10: 127,724,430 (GRCm39) F18Y probably benign Het
Scart2 C T 7: 139,841,532 (GRCm39) P279S possibly damaging Het
Septin5 A G 16: 18,441,861 (GRCm39) M315T possibly damaging Het
Slc27a6 A G 18: 58,715,306 (GRCm39) Y303C probably damaging Het
Slc7a7 T A 14: 54,607,293 (GRCm39) M495L probably benign Het
Sntg1 T A 1: 8,748,074 (GRCm39) probably null Het
Spred2 T A 11: 19,951,019 (GRCm39) I72N probably benign Het
St3gal1 A T 15: 66,980,086 (GRCm39) I271N possibly damaging Het
Stox1 A T 10: 62,495,386 (GRCm39) H962Q probably benign Het
Supt6 A T 11: 78,103,664 (GRCm39) M1347K probably damaging Het
Susd2 G T 10: 75,475,452 (GRCm39) A484D possibly damaging Het
Tmem260 A G 14: 48,737,845 (GRCm39) probably benign Het
Tpbg C A 9: 85,726,520 (GRCm39) A163E possibly damaging Het
Tpx2 T C 2: 152,724,255 (GRCm39) Y344H probably damaging Het
Ttf2 A T 3: 100,870,028 (GRCm39) F348L probably benign Het
Ttn A T 2: 76,663,650 (GRCm39) V11675E unknown Het
Txnl4b T A 8: 110,299,467 (GRCm39) Y142* probably null Het
Vmn2r18 G A 5: 151,485,140 (GRCm39) R785C possibly damaging Het
Zbtb18 T A 1: 177,276,044 (GRCm39) V459E probably damaging Het
Other mutations in Lrrc37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00572:Lrrc37 APN 11 103,506,236 (GRCm39) missense probably benign 0.01
IGL00576:Lrrc37 APN 11 103,508,212 (GRCm39) unclassified probably benign
IGL00813:Lrrc37 APN 11 103,505,324 (GRCm39) missense probably benign 0.05
IGL01311:Lrrc37 APN 11 103,425,502 (GRCm39) missense unknown
IGL01946:Lrrc37 APN 11 103,503,759 (GRCm39) missense probably benign 0.28
IGL02217:Lrrc37 APN 11 103,503,697 (GRCm39) splice site probably benign
IGL02556:Lrrc37 APN 11 103,504,109 (GRCm39) missense probably benign 0.01
IGL02825:Lrrc37 APN 11 103,507,894 (GRCm39) unclassified probably benign
IGL02868:Lrrc37 APN 11 103,505,965 (GRCm39) missense probably benign 0.10
IGL02904:Lrrc37 APN 11 103,507,187 (GRCm39) unclassified probably benign
IGL03008:Lrrc37 APN 11 103,511,293 (GRCm39) missense unknown
IGL03120:Lrrc37 APN 11 103,507,801 (GRCm39) unclassified probably benign
IGL03159:Lrrc37 APN 11 103,495,328 (GRCm39) splice site probably benign
IGL03181:Lrrc37 APN 11 103,507,242 (GRCm39) unclassified probably benign
IGL03202:Lrrc37 APN 11 103,506,199 (GRCm39) missense probably benign 0.03
IGL03263:Lrrc37 APN 11 103,504,525 (GRCm39) missense possibly damaging 0.86
esteemed UTSW 11 103,509,656 (GRCm39) missense unknown
lauded UTSW 11 103,503,929 (GRCm39) missense possibly damaging 0.62
PIT4486001:Lrrc37 UTSW 11 103,509,027 (GRCm39) missense unknown
R0040:Lrrc37 UTSW 11 103,433,816 (GRCm39) missense probably damaging 0.99
R0135:Lrrc37 UTSW 11 103,508,873 (GRCm39) unclassified probably benign
R0141:Lrrc37 UTSW 11 103,504,512 (GRCm39) missense probably damaging 1.00
R0226:Lrrc37 UTSW 11 103,494,067 (GRCm39) missense probably benign 0.08
R0547:Lrrc37 UTSW 11 103,510,990 (GRCm39) missense unknown
R0646:Lrrc37 UTSW 11 103,503,986 (GRCm39) nonsense probably null
R0685:Lrrc37 UTSW 11 103,507,714 (GRCm39) unclassified probably benign
R0732:Lrrc37 UTSW 11 103,510,664 (GRCm39) missense unknown
R1015:Lrrc37 UTSW 11 103,436,622 (GRCm39) missense probably benign 0.01
R1166:Lrrc37 UTSW 11 103,506,209 (GRCm39) missense probably benign 0.21
R1168:Lrrc37 UTSW 11 103,509,776 (GRCm39) unclassified probably benign
R1257:Lrrc37 UTSW 11 103,425,467 (GRCm39) missense unknown
R1545:Lrrc37 UTSW 11 103,499,745 (GRCm39) missense probably benign 0.16
R1570:Lrrc37 UTSW 11 103,500,764 (GRCm39) missense possibly damaging 0.76
R1677:Lrrc37 UTSW 11 103,505,768 (GRCm39) missense probably benign 0.19
R1703:Lrrc37 UTSW 11 103,431,700 (GRCm39) missense probably benign 0.39
R1719:Lrrc37 UTSW 11 103,507,897 (GRCm39) unclassified probably benign
R1752:Lrrc37 UTSW 11 103,505,381 (GRCm39) missense possibly damaging 0.67
R1870:Lrrc37 UTSW 11 103,511,431 (GRCm39) missense unknown
R2155:Lrrc37 UTSW 11 103,511,285 (GRCm39) missense unknown
R2191:Lrrc37 UTSW 11 103,509,793 (GRCm39) unclassified probably benign
R2271:Lrrc37 UTSW 11 103,505,033 (GRCm39) missense possibly damaging 0.53
R2378:Lrrc37 UTSW 11 103,510,537 (GRCm39) unclassified probably benign
R2405:Lrrc37 UTSW 11 103,511,810 (GRCm39) missense unknown
R2864:Lrrc37 UTSW 11 103,431,744 (GRCm39) missense probably benign 0.34
R3011:Lrrc37 UTSW 11 103,503,929 (GRCm39) missense possibly damaging 0.62
R3415:Lrrc37 UTSW 11 103,505,435 (GRCm39) missense possibly damaging 0.82
R3417:Lrrc37 UTSW 11 103,505,435 (GRCm39) missense possibly damaging 0.82
R3835:Lrrc37 UTSW 11 103,510,836 (GRCm39) missense unknown
R3974:Lrrc37 UTSW 11 103,509,927 (GRCm39) unclassified probably benign
R4019:Lrrc37 UTSW 11 103,506,119 (GRCm39) missense probably benign 0.19
R4020:Lrrc37 UTSW 11 103,506,119 (GRCm39) missense probably benign 0.19
R4176:Lrrc37 UTSW 11 103,427,426 (GRCm39) missense unknown
R4361:Lrrc37 UTSW 11 103,508,327 (GRCm39) frame shift probably null
R4418:Lrrc37 UTSW 11 103,509,140 (GRCm39) unclassified probably benign
R4633:Lrrc37 UTSW 11 103,509,957 (GRCm39) unclassified probably benign
R4693:Lrrc37 UTSW 11 103,510,686 (GRCm39) missense unknown
R4758:Lrrc37 UTSW 11 103,505,290 (GRCm39) missense possibly damaging 0.48
R4878:Lrrc37 UTSW 11 103,508,717 (GRCm39) unclassified probably benign
R4887:Lrrc37 UTSW 11 103,505,698 (GRCm39) missense probably benign 0.03
R4944:Lrrc37 UTSW 11 103,504,286 (GRCm39) missense possibly damaging 0.68
R4952:Lrrc37 UTSW 11 103,505,033 (GRCm39) missense possibly damaging 0.53
R5030:Lrrc37 UTSW 11 103,425,675 (GRCm39) missense unknown
R5183:Lrrc37 UTSW 11 103,433,947 (GRCm39) missense probably damaging 0.99
R5294:Lrrc37 UTSW 11 103,507,057 (GRCm39) unclassified probably benign
R5317:Lrrc37 UTSW 11 103,504,971 (GRCm39) missense possibly damaging 0.73
R5334:Lrrc37 UTSW 11 103,504,699 (GRCm39) missense probably benign 0.18
R5426:Lrrc37 UTSW 11 103,511,586 (GRCm39) missense unknown
R5467:Lrrc37 UTSW 11 103,494,091 (GRCm39) nonsense probably null
R5518:Lrrc37 UTSW 11 103,506,079 (GRCm39) missense probably benign 0.03
R5634:Lrrc37 UTSW 11 103,432,840 (GRCm39) missense possibly damaging 0.95
R5647:Lrrc37 UTSW 11 103,508,300 (GRCm39) unclassified probably benign
R5663:Lrrc37 UTSW 11 103,503,949 (GRCm39) missense probably benign 0.01
R5668:Lrrc37 UTSW 11 103,507,880 (GRCm39) unclassified probably benign
R5763:Lrrc37 UTSW 11 103,504,469 (GRCm39) missense probably damaging 0.97
R5829:Lrrc37 UTSW 11 103,432,712 (GRCm39) missense possibly damaging 0.95
R5871:Lrrc37 UTSW 11 103,507,280 (GRCm39) unclassified probably benign
R5905:Lrrc37 UTSW 11 103,505,081 (GRCm39) missense probably damaging 0.98
R5940:Lrrc37 UTSW 11 103,504,712 (GRCm39) missense probably benign 0.18
R5964:Lrrc37 UTSW 11 103,432,946 (GRCm39) missense possibly damaging 0.92
R5988:Lrrc37 UTSW 11 103,506,722 (GRCm39) unclassified probably benign
R5992:Lrrc37 UTSW 11 103,504,618 (GRCm39) missense possibly damaging 0.81
R6114:Lrrc37 UTSW 11 103,508,617 (GRCm39) unclassified probably benign
R6154:Lrrc37 UTSW 11 103,504,969 (GRCm39) missense probably benign 0.33
R6233:Lrrc37 UTSW 11 103,504,214 (GRCm39) missense probably damaging 0.98
R6301:Lrrc37 UTSW 11 103,509,756 (GRCm39) unclassified probably benign
R6362:Lrrc37 UTSW 11 103,511,478 (GRCm39) missense unknown
R6471:Lrrc37 UTSW 11 103,510,448 (GRCm39) unclassified probably benign
R6806:Lrrc37 UTSW 11 103,511,950 (GRCm39) missense unknown
R6962:Lrrc37 UTSW 11 103,505,126 (GRCm39) missense possibly damaging 0.67
R6996:Lrrc37 UTSW 11 103,509,583 (GRCm39) nonsense probably null
R7028:Lrrc37 UTSW 11 103,505,363 (GRCm39) missense probably benign 0.28
R7034:Lrrc37 UTSW 11 103,506,638 (GRCm39) unclassified probably benign
R7036:Lrrc37 UTSW 11 103,506,638 (GRCm39) unclassified probably benign
R7113:Lrrc37 UTSW 11 103,509,625 (GRCm39) missense unknown
R7405:Lrrc37 UTSW 11 103,505,987 (GRCm39) missense probably benign 0.02
R7420:Lrrc37 UTSW 11 103,504,451 (GRCm39) missense probably benign 0.11
R7461:Lrrc37 UTSW 11 103,507,116 (GRCm39) missense unknown
R7544:Lrrc37 UTSW 11 103,506,274 (GRCm39) missense probably benign 0.01
R7613:Lrrc37 UTSW 11 103,507,116 (GRCm39) missense unknown
R7711:Lrrc37 UTSW 11 103,505,738 (GRCm39) missense probably benign 0.02
R7714:Lrrc37 UTSW 11 103,507,719 (GRCm39) missense unknown
R7747:Lrrc37 UTSW 11 103,505,081 (GRCm39) missense probably damaging 0.98
R7814:Lrrc37 UTSW 11 103,504,999 (GRCm39) missense possibly damaging 0.53
R8053:Lrrc37 UTSW 11 103,495,392 (GRCm39) missense unknown
R8063:Lrrc37 UTSW 11 103,433,087 (GRCm39) missense unknown
R8116:Lrrc37 UTSW 11 103,434,115 (GRCm39) missense unknown
R8124:Lrrc37 UTSW 11 103,511,257 (GRCm39) missense unknown
R8141:Lrrc37 UTSW 11 103,511,855 (GRCm39) missense unknown
R8163:Lrrc37 UTSW 11 103,506,688 (GRCm39) missense unknown
R8270:Lrrc37 UTSW 11 103,434,141 (GRCm39) missense unknown
R8348:Lrrc37 UTSW 11 103,511,726 (GRCm39) missense unknown
R8362:Lrrc37 UTSW 11 103,506,163 (GRCm39) missense probably benign 0.34
R8448:Lrrc37 UTSW 11 103,511,726 (GRCm39) missense unknown
R8465:Lrrc37 UTSW 11 103,506,947 (GRCm39) unclassified probably benign
R8473:Lrrc37 UTSW 11 103,434,266 (GRCm39) missense unknown
R8781:Lrrc37 UTSW 11 103,508,958 (GRCm39) missense unknown
R8821:Lrrc37 UTSW 11 103,510,470 (GRCm39) missense unknown
R8859:Lrrc37 UTSW 11 103,506,370 (GRCm39) missense unknown
R8888:Lrrc37 UTSW 11 103,509,656 (GRCm39) missense unknown
R9083:Lrrc37 UTSW 11 103,509,830 (GRCm39) missense unknown
R9085:Lrrc37 UTSW 11 103,507,565 (GRCm39) missense unknown
R9088:Lrrc37 UTSW 11 103,511,762 (GRCm39) missense unknown
R9124:Lrrc37 UTSW 11 103,509,721 (GRCm39) missense unknown
R9177:Lrrc37 UTSW 11 103,508,263 (GRCm39) missense unknown
R9238:Lrrc37 UTSW 11 103,509,859 (GRCm39) missense unknown
R9267:Lrrc37 UTSW 11 103,495,406 (GRCm39) missense unknown
R9444:Lrrc37 UTSW 11 103,508,846 (GRCm39) nonsense probably null
R9517:Lrrc37 UTSW 11 103,433,416 (GRCm39) missense unknown
R9564:Lrrc37 UTSW 11 103,503,822 (GRCm39) missense unknown
R9632:Lrrc37 UTSW 11 103,433,252 (GRCm39) missense unknown
R9741:Lrrc37 UTSW 11 103,504,255 (GRCm39) missense possibly damaging 0.68
Z1176:Lrrc37 UTSW 11 103,504,507 (GRCm39) missense probably benign 0.45
Predicted Primers PCR Primer
(F):5'- ATGGTGGGTTCCAGATCTAAGG -3'
(R):5'- ACAGTTCCAAGACCAGATCAGG -3'

Sequencing Primer
(F):5'- GGTTCCAGATCTAAGGATTGAAATG -3'
(R):5'- GTTCCAAGACCAGATCAGGATCAAG -3'
Posted On 2021-08-02