Mutagenetix > Incidental Mutations

Incidental Mutation 'R8896:Zfp738'

678050

Institutional Source

Beutler Lab

Gene Symbol

Zfp738

Ensembl Gene

ENSMUSG00000048280

Gene Name

zinc finger protein 738

Synonyms

6720487G11Rik, 3830402I07Rik

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.077) question?

Stock #

R8896 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

67658685-67687071 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 67669791 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 694 (L694F)

Ref Sequence

ENSEMBL: ENSMUSP00000121275 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000110973] [ENSMUST00000125495] [ENSMUST00000137496] [ENSMUST00000175678] [ENSMUST00000175821]

AlphaFold

B8JJX8

Predicted Effect

probably benign
Transcript: ENSMUST00000110973

SMART Domains

Protein: ENSMUSP00000106600
Gene: ENSMUSG00000048280

Domain	Start	End	E-Value	Type
KRAB	2	62	1.97e-31	SMART
SCOP:d1fgja_	76	119	1e-7	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000125495

SMART Domains

Protein: ENSMUSP00000135683
Gene: ENSMUSG00000048280

Domain	Start	End	E-Value	Type
KRAB	5	65	1.97e-31	SMART

Predicted Effect

SMART Domains

Protein: ENSMUSP00000121275
Gene: ENSMUSG00000048280
AA Change: L694F

Domain	Start	End	E-Value	Type
KRAB	15	75	1.97e-31	SMART
ZnF_C2H2	91	111	3.13e1	SMART
ZnF_C2H2	119	141	9.56e1	SMART
ZnF_C2H2	147	169	3.58e-2	SMART
ZnF_C2H2	175	197	3.21e-4	SMART
ZnF_C2H2	203	225	6.78e-3	SMART
ZnF_C2H2	231	253	8.34e-3	SMART
ZnF_C2H2	259	281	6.67e-2	SMART
ZnF_C2H2	287	309	1.12e-3	SMART
ZnF_C2H2	315	337	3.83e-2	SMART
ZnF_C2H2	343	365	8.34e-3	SMART
ZnF_C2H2	371	393	4.87e-4	SMART
ZnF_C2H2	427	449	9.58e-3	SMART
ZnF_C2H2	455	477	1.38e-3	SMART
ZnF_C2H2	483	505	3.89e-3	SMART
ZnF_C2H2	511	533	7.49e-5	SMART
ZnF_C2H2	539	561	5.5e-3	SMART
ZnF_C2H2	567	589	5.42e-2	SMART
ZnF_C2H2	595	617	7.78e-3	SMART
ZnF_C2H2	623	645	2.05e-2	SMART
ZnF_C2H2	651	673	2.57e-3	SMART
ZnF_C2H2	679	701	7.26e-3	SMART
ZnF_C2H2	735	757	5.42e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000175678

SMART Domains

Protein: ENSMUSP00000134865
Gene: ENSMUSG00000048280

Domain	Start	End	E-Value	Type
KRAB	15	75	1.97e-31	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000175821

SMART Domains

Protein: ENSMUSP00000135050
Gene: ENSMUSG00000048280

Domain	Start	End	E-Value	Type
KRAB	5	65	1.97e-31	SMART
ZnF_C2H2	81	101	3.13e1	SMART
ZnF_C2H2	109	131	9.56e1	SMART
ZnF_C2H2	137	159	3.58e-2	SMART
ZnF_C2H2	165	187	3.21e-4	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (73/73)

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox4	T	G	1: 58,252,074	S784A	probably benign	Het
Ap3d1	T	A	10: 80,716,591	H581L	probably benign	Het
Atp11a	T	C	8: 12,849,781	Y915H	probably damaging	Het
Atp4b	T	C	8: 13,387,514	D213G	probably benign	Het
Bcl11a	A	G	11: 24,163,640	S328G	probably benign	Het
Bean1	CT	C	8: 104,182,032		probably null	Het
Cadps2	T	A	6: 23,410,877	Y685F	probably damaging	Het
Ccdc88b	C	T	19: 6,853,835	A580T	probably benign	Het
Cdc42bpa	GACAACA	GACA	1: 180,130,808		probably benign	Het
Cep152	A	T	2: 125,566,235	V1396D	possibly damaging	Het
Ces1c	T	C	8: 93,106,626	I404V	probably benign	Het
Cr2	A	T	1: 195,169,273	M137K	possibly damaging	Het
Cyp2d40	T	C	15: 82,760,253	Y257C	unknown	Het
Dennd1c	T	A	17: 57,074,512	D116V	probably damaging	Het
Dph2	G	A	4: 117,890,378	R270*	probably null	Het
Dpp8	A	C	9: 65,078,036	H792P	possibly damaging	Het
Dupd1	T	C	14: 21,686,695	D113G	probably benign	Het
Efs	T	C	14: 54,920,299	E185G	possibly damaging	Het
Eml3	A	G	19: 8,936,692	E480G	probably damaging	Het
Fam193a	A	G	5: 34,426,484	T336A	probably benign	Het
Fermt1	C	T	2: 132,941,932		probably benign	Het
Galnt4	T	A	10: 99,110,093	V560D	probably damaging	Het
Gbp2b	C	A	3: 142,603,566	T146K	probably damaging	Het
Gbp5	C	T	3: 142,505,547	T346I	probably damaging	Het
Glrx	G	T	13: 75,847,198	C79F	probably damaging	Het
Glt8d2	T	A	10: 82,654,782	T225S	probably damaging	Het
Grm3	A	G	5: 9,512,483	F456L	possibly damaging	Het
Gse1	T	G	8: 120,576,446	S1109A	unknown	Het
Gstp3	A	T	19: 4,058,573	L63Q	probably damaging	Het
Hapln3	G	A	7: 79,117,491	R267W	probably benign	Het
Herc4	T	A	10: 63,311,507	I801N	possibly damaging	Het
Ido1	G	T	8: 24,587,864	D153E	probably benign	Het
Itpr3	G	A	17: 27,118,677		probably benign	Het
Kcnj9	T	A	1: 172,325,793	S255C	probably damaging	Het
Kpna3	T	C	14: 61,391,845	N39D	probably benign	Het
Krt39	A	T	11: 99,518,269	S269T	probably damaging	Het
Lfng	G	A	5: 140,613,223	V296I	probably benign	Het
Lrit3	T	A	3: 129,791,483	I209F	probably damaging	Het
Map4k5	T	A	12: 69,823,501	D523V	possibly damaging	Het
Mdn1	C	T	4: 32,678,328	P652L	probably benign	Het
Med30	G	A	15: 52,721,120	V145I	possibly damaging	Het
Megf6	T	A	4: 154,242,403	D163E	probably damaging	Het
Meltf	T	A	16: 31,890,704		probably benign	Het
Mindy4	T	C	6: 55,278,238	L567P	probably benign	Het
Mppe1	T	C	18: 67,237,401	D75G	probably damaging	Het
Muc4	C	T	16: 32,754,673	P1516S	probably benign	Het
Myo3b	C	A	2: 70,238,816	F494L	probably damaging	Het
Nedd4l	A	G	18: 65,165,617	T226A	probably benign	Het
Nod1	A	G	6: 54,944,292	V347A	probably benign	Het
Nup210	A	T	6: 91,042,253		probably null	Het
Nup210l	A	G	3: 90,118,625	R185G	probably damaging	Het
Olfr202	A	T	16: 59,284,089	M136K	probably damaging	Het
Olfr62	A	T	4: 118,666,305	M263L	probably benign	Het
Olfr957	A	G	9: 39,511,474	L82P	probably damaging	Het
Oma1	T	C	4: 103,353,632	L445S	probably damaging	Het
Oxsm	A	T	14: 16,242,677	F31I	probably benign	Het
Pdcd5	A	T	7: 35,647,370	M1K	probably null	Het
Pkd1l2	T	C	8: 117,013,876	T2161A	possibly damaging	Het
Pla2g3	A	T	11: 3,492,151	S404C	probably null	Het
Plec	A	G	15: 76,194,360	V60A	unknown	Het
Prpsap2	A	G	11: 61,752,910	S66P	possibly damaging	Het
Rarb	A	G	14: 16,436,804	L239P	probably damaging	Het
Ryr3	A	T	2: 112,753,050	Y2845*	probably null	Het
Spta1	T	C	1: 174,217,982	C1569R	probably damaging	Het
Stard13	G	A	5: 151,062,650	S465L	probably damaging	Het
Tmub1	A	T	5: 24,446,682	S80T	probably benign	Het
Trpv5	A	G	6: 41,670,913	F322S	probably damaging	Het
Vmn2r5	G	A	3: 64,503,782	A455V	probably benign	Het
Washc4	T	A	10: 83,570,018	N459K	probably damaging	Het
Wdr11	C	T	7: 129,605,713	R300*	probably null	Het
Zer1	A	G	2: 30,103,418	F559L	probably damaging	Het
Zfat	A	T	15: 68,180,670	V425D	probably damaging	Het
Zfp839	C	T	12: 110,868,843	A844V	probably damaging	Het

Other mutations in Zfp738

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01511:Zfp738	APN	13	67683401	critical splice donor site	probably null
IGL01734:Zfp738	APN	13	67683444	utr 5 prime	probably benign
IGL01980:Zfp738	APN	13	67669977	missense	possibly damaging	0.80
IGL02052:Zfp738	APN	13	67671481	missense	possibly damaging	0.87
IGL02330:Zfp738	APN	13	67671431	missense	probably damaging	0.99
IGL02686:Zfp738	APN	13	67673652	missense	probably damaging	1.00
I2505:Zfp738	UTSW	13	67673067	missense	probably benign	0.36
R0219:Zfp738	UTSW	13	67683389	intron	probably benign
R0491:Zfp738	UTSW	13	67670021	missense	possibly damaging	0.87
R0722:Zfp738	UTSW	13	67671524	missense	probably benign	0.09
R1116:Zfp738	UTSW	13	67670243	splice site	probably null
R1425:Zfp738	UTSW	13	67670775	missense	possibly damaging	0.77
R1854:Zfp738	UTSW	13	67670357	missense	probably damaging	1.00
R2095:Zfp738	UTSW	13	67671303	missense	probably damaging	1.00
R2171:Zfp738	UTSW	13	67670977	nonsense	probably null
R2180:Zfp738	UTSW	13	67671194	missense	probably damaging	1.00
R2225:Zfp738	UTSW	13	67670312	missense	probably damaging	1.00
R2226:Zfp738	UTSW	13	67670312	missense	probably damaging	1.00
R2907:Zfp738	UTSW	13	67670112	missense	probably benign	0.33
R3605:Zfp738	UTSW	13	67671389	nonsense	probably null
R4731:Zfp738	UTSW	13	67669914	missense	probably damaging	1.00
R5037:Zfp738	UTSW	13	67670201	missense	probably damaging	1.00
R5223:Zfp738	UTSW	13	67673063	missense	probably damaging	0.99
R5259:Zfp738	UTSW	13	67669686	missense	probably benign
R5358:Zfp738	UTSW	13	67671012	missense	probably damaging	0.98
R6404:Zfp738	UTSW	13	67671060	missense	possibly damaging	0.89
R6874:Zfp738	UTSW	13	67670263	missense	possibly damaging	0.93
R7041:Zfp738	UTSW	13	67670301	missense	probably damaging	1.00
R7172:Zfp738	UTSW	13	67670408	missense	probably damaging	1.00
R7178:Zfp738	UTSW	13	67673028	missense	probably damaging	1.00
R7308:Zfp738	UTSW	13	67669553	missense	probably benign	0.00
R7386:Zfp738	UTSW	13	67670250	missense	probably damaging	1.00
R7453:Zfp738	UTSW	13	67670355	missense	probably benign	0.42
R7456:Zfp738	UTSW	13	67669500	missense	probably damaging	1.00
R7467:Zfp738	UTSW	13	67672961	missense	probably benign	0.03
R7615:Zfp738	UTSW	13	67670203	missense	probably damaging	0.96
R7663:Zfp738	UTSW	13	67683401	critical splice donor site	probably null
R7752:Zfp738	UTSW	13	67672991	nonsense	probably null
R7901:Zfp738	UTSW	13	67672991	nonsense	probably null
R8042:Zfp738	UTSW	13	67670891	missense	probably damaging	0.98
R8288:Zfp738	UTSW	13	67670789	missense	possibly damaging	0.88
R8340:Zfp738	UTSW	13	67671112	missense	probably damaging	0.98
R8735:Zfp738	UTSW	13	67671431	missense	probably damaging	0.99
R8846:Zfp738	UTSW	13	67670036	missense	probably benign	0.00
R9124:Zfp738	UTSW	13	67671338	missense	possibly damaging	0.94
R9233:Zfp738	UTSW	13	67670898	missense	possibly damaging	0.88

Predicted Primers

Posted On

2021-08-02