Incidental Mutation 'R8898:Or4n4'
ID 678198
Institutional Source Beutler Lab
Gene Symbol Or4n4
Ensembl Gene ENSMUSG00000091873
Gene Name olfactory receptor family 4 subfamily N member 4
Synonyms GA_x6K02T2PMLR-5975274-5974348, Olfr732, MOR241-1
MMRRC Submission 068755-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R8898 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 50518685-50519728 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 50518952 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 253 (P253S)
Ref Sequence ENSEMBL: ENSMUSP00000148984 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071208] [ENSMUST00000213701]
AlphaFold Q8VFT5
Predicted Effect probably damaging
Transcript: ENSMUST00000071208
AA Change: P253S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000071195
Gene: ENSMUSG00000091873
AA Change: P253S

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 7.4e-45 PFAM
Pfam:7tm_1 41 288 4.5e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213701
AA Change: P253S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.5834 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency 100% (64/64)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A T 14: 32,383,001 (GRCm39) L988* probably null Het
4930546C10Rik A G 18: 69,083,106 (GRCm39) F36S unknown Het
Acan C A 7: 78,750,101 (GRCm39) T1624K possibly damaging Het
Ambn T C 5: 88,613,051 (GRCm39) probably null Het
Ankrd24 T C 10: 81,478,352 (GRCm39) I437T unknown Het
Arl4d C T 11: 101,557,827 (GRCm39) R118W probably damaging Het
Atg2a A G 19: 6,306,721 (GRCm39) probably benign Het
Bcan T C 3: 87,895,695 (GRCm39) T814A probably benign Het
Brca2 T A 5: 150,492,498 (GRCm39) M3171K possibly damaging Het
Cd209a T A 8: 3,798,739 (GRCm39) S23C probably damaging Het
Chek2 A T 5: 111,011,175 (GRCm39) K324N probably benign Het
Col12a1 C T 9: 79,599,577 (GRCm39) V859I probably benign Het
Cyp7b1 C T 3: 18,150,788 (GRCm39) R317H probably benign Het
Dmxl2 A G 9: 54,308,941 (GRCm39) S1937P probably benign Het
Epb41l1 T G 2: 156,335,869 (GRCm39) V11G probably damaging Het
Ephb6 C T 6: 41,590,293 (GRCm39) A15V probably benign Het
Fat3 G A 9: 15,858,822 (GRCm39) P3798L probably benign Het
Foxd1 T A 13: 98,491,596 (GRCm39) C157S probably damaging Het
Gja10 T C 4: 32,601,058 (GRCm39) Q442R probably benign Het
Gm17019 A C 5: 15,081,798 (GRCm39) M47R possibly damaging Het
Gpr179 C A 11: 97,242,329 (GRCm39) E172* probably null Het
Grhl1 G A 12: 24,634,945 (GRCm39) probably null Het
Gtf2ird2 A T 5: 134,226,106 (GRCm39) E184V probably benign Het
Hace1 A G 10: 45,576,766 (GRCm39) I813V probably benign Het
Hk2 A T 6: 82,715,379 (GRCm39) L385Q probably damaging Het
Htt C T 5: 34,976,376 (GRCm39) T726I probably benign Het
Itga8 T C 2: 12,145,206 (GRCm39) S916G probably benign Het
Jag1 A T 2: 136,935,175 (GRCm39) F396I probably damaging Het
Kif16b A G 2: 142,554,899 (GRCm39) M633T possibly damaging Het
Klf5 T A 14: 99,538,922 (GRCm39) F112I probably damaging Het
Lama1 A T 17: 68,128,610 (GRCm39) Q2989L Het
Lrrc28 C A 7: 67,278,042 (GRCm39) probably null Het
Map4k5 T C 12: 69,859,931 (GRCm39) T739A possibly damaging Het
Mbd3l2 A T 9: 18,355,914 (GRCm39) R80* probably null Het
Mctp2 T C 7: 71,752,904 (GRCm39) E783G probably damaging Het
Mill2 A T 7: 18,590,489 (GRCm39) M190L probably benign Het
N4bp3 T C 11: 51,535,256 (GRCm39) N311S probably benign Het
Nanos2 A T 7: 18,721,549 (GRCm39) D7V probably damaging Het
Ndufs7 T A 10: 80,089,619 (GRCm39) probably null Het
Nexn T C 3: 151,948,306 (GRCm39) N483S probably benign Het
Nlrp1b T G 11: 71,073,288 (GRCm39) E185A probably damaging Het
Nop2 C A 6: 125,114,118 (GRCm39) Q195K probably benign Het
Or4a15 A G 2: 89,192,957 (GRCm39) V272A possibly damaging Het
Pde12 G A 14: 26,390,577 (GRCm39) S44L probably benign Het
Pde1c A T 6: 56,114,371 (GRCm39) V514E probably damaging Het
Pdzph1 A T 17: 59,281,334 (GRCm39) V316D probably benign Het
Prl3c1 A T 13: 27,387,578 (GRCm39) I208F possibly damaging Het
Raver2 G A 4: 100,964,399 (GRCm39) probably null Het
Rpl13a-ps1 T A 19: 50,018,747 (GRCm39) H143L probably benign Het
Septin14 A T 5: 129,760,642 (GRCm39) I402K possibly damaging Het
Sla2 T A 2: 156,717,885 (GRCm39) Y129F possibly damaging Het
Smarca2 TGCAGCAGCAGCAGCAGCA TGCAGCAGCAGCAGCA 19: 26,608,358 (GRCm39) probably benign Het
Sorl1 A G 9: 41,911,567 (GRCm39) S1448P probably damaging Het
Spast G A 17: 74,695,273 (GRCm39) R604H probably damaging Het
Speg G A 1: 75,365,517 (GRCm39) G633S probably damaging Het
Stxbp5l ATTTT ATTTTT 16: 37,036,414 (GRCm39) probably null Het
Syt11 T C 3: 88,669,335 (GRCm39) M186V probably benign Het
Tex26 C A 5: 149,380,369 (GRCm39) N133K probably benign Het
Tnfrsf17 T C 16: 11,131,910 (GRCm39) C32R probably damaging Het
Trem1 T A 17: 48,544,374 (GRCm39) V133E probably damaging Het
Trpm7 A T 2: 126,664,661 (GRCm39) M906K possibly damaging Het
Ugt2b35 T A 5: 87,159,189 (GRCm39) I461K possibly damaging Het
Vmn2r77 T A 7: 86,444,430 (GRCm39) C28S probably damaging Het
Zfp521 C A 18: 13,979,137 (GRCm39) L425F probably damaging Het
Zfp790 C T 7: 29,522,525 (GRCm39) probably benign Het
Other mutations in Or4n4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01370:Or4n4 APN 14 50,519,689 (GRCm39) missense probably damaging 0.99
IGL01801:Or4n4 APN 14 50,519,665 (GRCm39) missense probably benign
IGL01992:Or4n4 APN 14 50,518,798 (GRCm39) missense probably benign 0.09
IGL02137:Or4n4 APN 14 50,519,135 (GRCm39) missense probably benign 0.16
IGL02494:Or4n4 APN 14 50,519,683 (GRCm39) missense probably damaging 1.00
IGL02606:Or4n4 APN 14 50,519,530 (GRCm39) missense probably damaging 1.00
IGL02799:Or4n4 UTSW 14 50,518,801 (GRCm39) missense probably benign
PIT4142001:Or4n4 UTSW 14 50,518,784 (GRCm39) makesense probably null
R0570:Or4n4 UTSW 14 50,519,370 (GRCm39) missense probably benign 0.00
R1570:Or4n4 UTSW 14 50,518,981 (GRCm39) missense probably damaging 1.00
R1860:Or4n4 UTSW 14 50,518,848 (GRCm39) nonsense probably null
R2313:Or4n4 UTSW 14 50,519,431 (GRCm39) missense probably damaging 1.00
R4594:Or4n4 UTSW 14 50,519,140 (GRCm39) missense probably benign 0.02
R6442:Or4n4 UTSW 14 50,518,826 (GRCm39) missense probably damaging 0.98
R6783:Or4n4 UTSW 14 50,519,644 (GRCm39) missense probably benign
R7334:Or4n4 UTSW 14 50,519,036 (GRCm39) missense probably benign 0.08
R7763:Or4n4 UTSW 14 50,518,945 (GRCm39) missense probably damaging 1.00
R8207:Or4n4 UTSW 14 50,519,036 (GRCm39) missense probably benign 0.02
R8228:Or4n4 UTSW 14 50,518,997 (GRCm39) missense probably damaging 1.00
R8806:Or4n4 UTSW 14 50,519,236 (GRCm39) missense probably benign 0.04
R8809:Or4n4 UTSW 14 50,519,236 (GRCm39) missense probably benign 0.04
R8962:Or4n4 UTSW 14 50,518,816 (GRCm39) missense possibly damaging 0.95
R9800:Or4n4 UTSW 14 50,519,701 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GCCATGCAAAATTATCACATTGATTGC -3'
(R):5'- TGTACAGACACCTTTGCAGTTG -3'

Sequencing Primer
(F):5'- TCACATTGATTGCTAATTTAAAACCC -3'
(R):5'- AGACACCTTTGCAGTTGAGCTC -3'
Posted On 2021-08-02