Incidental Mutation 'R8909:Prokr2'
ID 678491
Institutional Source Beutler Lab
Gene Symbol Prokr2
Ensembl Gene ENSMUSG00000050558
Gene Name prokineticin receptor 2
Synonyms Gpcr73l1, EG-VEGRF2, B830005M06Rik, PKR2, Gpr73l1
MMRRC Submission 068700-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.169) question?
Stock # R8909 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 132211625-132227413 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 132215723 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 246 (E246G)
Ref Sequence ENSEMBL: ENSMUSP00000056659 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049997] [ENSMUST00000110156] [ENSMUST00000110157] [ENSMUST00000142766]
AlphaFold Q8K458
Predicted Effect probably damaging
Transcript: ENSMUST00000049997
AA Change: E246G

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000056659
Gene: ENSMUSG00000050558
AA Change: E246G

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 61 349 3.3e-7 PFAM
Pfam:7tm_1 67 330 8.2e-48 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000110156
AA Change: E246G

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000105784
Gene: ENSMUSG00000050558
AA Change: E246G

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 61 349 3.3e-7 PFAM
Pfam:7tm_1 67 330 1.7e-48 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000110157
SMART Domains Protein: ENSMUSP00000105785
Gene: ENSMUSG00000050558

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 61 153 5.2e-7 PFAM
Pfam:7tm_1 67 155 1.7e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000142766
AA Change: E85G

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000124526
Gene: ENSMUSG00000050558
AA Change: E85G

DomainStartEndE-ValueType
Pfam:7tm_1 1 169 4.9e-19 PFAM
Meta Mutation Damage Score 0.7270 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 96% (47/49)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73, another G protein-coupled receptor for prokineticins. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a null allele show 50% neonatal lethality, olfactory bulb malformation, and reproductive system atrophy related to a lack of hypothalamic gonadotropin-releasing hormone synthesizing neurons. Homozygotes for another null allele show impaired circadian behavior and thermoregulation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aopep G T 13: 63,388,111 (GRCm39) R698L possibly damaging Het
Btnl10 T C 11: 58,813,198 (GRCm39) C276R probably benign Het
Calcoco2 GGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC GGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC 11: 95,990,808 (GRCm39) probably benign Het
Cavin4 G A 4: 48,672,421 (GRCm39) G289R probably benign Het
Cdh9 T C 15: 16,848,610 (GRCm39) F430S probably damaging Het
Cfh A G 1: 140,014,086 (GRCm39) I1246T possibly damaging Het
Chd8 C T 14: 52,450,389 (GRCm39) V1490M possibly damaging Het
Clec2g A G 6: 128,958,195 (GRCm39) N137S probably benign Het
Cntn6 T A 6: 104,825,093 (GRCm39) S878T probably benign Het
Cryga G T 1: 65,142,173 (GRCm39) S73R probably benign Het
Dach1 T C 14: 98,406,120 (GRCm39) D209G probably damaging Het
Dnai4 T G 4: 102,944,607 (GRCm39) E248A possibly damaging Het
Duox2 A G 2: 122,126,862 (GRCm39) S218P probably benign Het
Fbn2 T A 18: 58,192,508 (GRCm39) Q1491L possibly damaging Het
Foxg1 CCAGCAGCAGCAGCAGCAGC CCAGCAGCAGCAGCAGC 12: 49,431,475 (GRCm39) probably benign Het
Glra3 A T 8: 56,444,159 (GRCm39) probably null Het
Helz A G 11: 107,556,834 (GRCm39) D1284G possibly damaging Het
Iqsec3 G A 6: 121,390,118 (GRCm39) A451V unknown Het
Kat6b A G 14: 21,719,214 (GRCm39) T1189A probably benign Het
Lama1 T A 17: 68,079,736 (GRCm39) F1203Y Het
Lingo2 A G 4: 35,708,349 (GRCm39) S544P probably damaging Het
Llcfc1 T C 6: 41,661,525 (GRCm39) V25A probably benign Het
Map1a A C 2: 121,129,391 (GRCm39) H143P probably damaging Het
Mbd5 T C 2: 49,169,233 (GRCm39) V1468A probably benign Het
Meis3 T A 7: 15,919,385 (GRCm39) M367K possibly damaging Het
Myo3b G A 2: 70,083,440 (GRCm39) A698T probably damaging Het
Nbn A T 4: 15,970,833 (GRCm39) D272V probably damaging Het
Or51a43 A G 7: 103,718,032 (GRCm39) S69P probably damaging Het
Or56a5 C T 7: 104,793,249 (GRCm39) V84I probably benign Het
Or7g20 G T 9: 18,946,888 (GRCm39) M156I probably benign Het
Or8k27 C T 2: 86,276,082 (GRCm39) M81I possibly damaging Het
Os9 C A 10: 126,956,825 (GRCm39) probably null Het
Pard3b A G 1: 62,383,294 (GRCm39) D796G probably benign Het
Peg10 T TCCG 6: 4,756,451 (GRCm39) probably benign Het
Pkp4 A G 2: 59,184,758 (GRCm39) E1180G possibly damaging Het
Plod1 T A 4: 148,011,563 (GRCm39) K221* probably null Het
Ppp6r3 T C 19: 3,509,461 (GRCm39) T795A probably benign Het
Pramel15 T C 4: 144,103,553 (GRCm39) Q191R probably benign Het
Psmb7 A G 2: 38,503,481 (GRCm39) M178T probably damaging Het
Rbm39 C T 2: 156,019,697 (GRCm39) probably benign Het
Saa1 T C 7: 46,390,773 (GRCm39) N46S probably benign Het
Samd12 A G 15: 53,521,853 (GRCm39) L119P probably damaging Het
Sdc3 A G 4: 130,546,094 (GRCm39) E151G unknown Het
Serpina1a T C 12: 103,820,938 (GRCm39) K370E probably damaging Het
Slc49a3 C T 5: 108,592,432 (GRCm39) V253I probably benign Het
Tnrc18 C A 5: 142,762,131 (GRCm39) S681I Het
Ulk2 C T 11: 61,690,380 (GRCm39) G636R probably benign Het
V1ra8 T C 6: 90,179,938 (GRCm39) L47P possibly damaging Het
Wasf3 T C 5: 146,392,410 (GRCm39) L160P Het
Zbtb34 A C 2: 33,301,701 (GRCm39) V280G possibly damaging Het
Zfp646 T C 7: 127,478,515 (GRCm39) Y231H probably damaging Het
Other mutations in Prokr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00592:Prokr2 APN 2 132,223,424 (GRCm39) missense probably benign 0.28
IGL01948:Prokr2 APN 2 132,215,603 (GRCm39) missense probably damaging 0.97
IGL02930:Prokr2 APN 2 132,215,394 (GRCm39) missense probably benign 0.00
R0092:Prokr2 UTSW 2 132,215,517 (GRCm39) missense probably damaging 1.00
R0717:Prokr2 UTSW 2 132,223,254 (GRCm39) missense probably damaging 1.00
R1547:Prokr2 UTSW 2 132,215,522 (GRCm39) missense probably damaging 1.00
R1573:Prokr2 UTSW 2 132,215,684 (GRCm39) missense probably damaging 0.99
R2302:Prokr2 UTSW 2 132,223,104 (GRCm39) missense probably damaging 1.00
R2336:Prokr2 UTSW 2 132,223,359 (GRCm39) missense probably damaging 0.99
R2483:Prokr2 UTSW 2 132,223,095 (GRCm39) missense probably damaging 1.00
R4049:Prokr2 UTSW 2 132,223,414 (GRCm39) missense probably benign 0.16
R4518:Prokr2 UTSW 2 132,216,012 (GRCm39) critical splice acceptor site probably null
R4947:Prokr2 UTSW 2 132,215,573 (GRCm39) missense probably damaging 1.00
R5961:Prokr2 UTSW 2 132,215,595 (GRCm39) missense possibly damaging 0.95
R5997:Prokr2 UTSW 2 132,223,362 (GRCm39) missense probably damaging 0.99
R6333:Prokr2 UTSW 2 132,215,898 (GRCm39) missense probably damaging 0.98
R6543:Prokr2 UTSW 2 132,215,819 (GRCm39) missense probably benign 0.13
R6599:Prokr2 UTSW 2 132,215,469 (GRCm39) missense possibly damaging 0.92
R6623:Prokr2 UTSW 2 132,215,494 (GRCm39) missense probably damaging 1.00
R7092:Prokr2 UTSW 2 132,223,236 (GRCm39) missense possibly damaging 0.88
R7252:Prokr2 UTSW 2 132,223,360 (GRCm39) missense probably benign 0.03
R7736:Prokr2 UTSW 2 132,223,500 (GRCm39) nonsense probably null
R7767:Prokr2 UTSW 2 132,215,996 (GRCm39) missense probably damaging 1.00
R8209:Prokr2 UTSW 2 132,215,961 (GRCm39) missense probably damaging 0.98
R8226:Prokr2 UTSW 2 132,215,961 (GRCm39) missense probably damaging 0.98
R8511:Prokr2 UTSW 2 132,223,422 (GRCm39) missense probably benign 0.00
R8931:Prokr2 UTSW 2 132,215,996 (GRCm39) missense possibly damaging 0.66
R9240:Prokr2 UTSW 2 132,223,377 (GRCm39) missense possibly damaging 0.77
R9342:Prokr2 UTSW 2 132,182,790 (GRCm39) missense possibly damaging 0.56
Z1177:Prokr2 UTSW 2 132,215,585 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- ACTACCGTGGGGAAGAAGTC -3'
(R):5'- CACCCTTTGAAACCACGGATG -3'

Sequencing Primer
(F):5'- GTCTCGCACTATGGTAAAGCC -3'
(R):5'- CGGATGAATTATCAGACCGCTTC -3'
Posted On 2021-08-02