Incidental Mutation 'R8912:Or5h19'
ID 678720
Institutional Source Beutler Lab
Gene Symbol Or5h19
Ensembl Gene ENSMUSG00000043357
Gene Name olfactory receptor family 5 subfamily H member 19
Synonyms Olfr187, GA_x54KRFPKG5P-55265713-55264787, MOR183-8
MMRRC Submission 068765-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.060) question?
Stock # R8912 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 58856143-58860112 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 58856263 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 279 (V279A)
Ref Sequence ENSEMBL: ENSMUSP00000147035 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000206428] [ENSMUST00000207673]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000206428
AA Change: V279A

PolyPhen 2 Score 0.206 (Sensitivity: 0.92; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000207673
AA Change: V279A

PolyPhen 2 Score 0.206 (Sensitivity: 0.92; Specificity: 0.88)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 99% (68/69)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700069L16Rik C T 5: 113,861,767 (GRCm39) W34* probably null Het
Adck5 T C 15: 76,477,435 (GRCm39) S90P probably damaging Het
Adgra3 C A 5: 50,118,273 (GRCm39) A1092S possibly damaging Het
Arhgap33 A T 7: 30,232,467 (GRCm39) probably benign Het
Arih2 C G 9: 108,488,938 (GRCm39) R260P probably damaging Het
Atp6ap1l T A 13: 91,046,979 (GRCm39) probably null Het
Brd2 A T 17: 34,332,458 (GRCm39) probably benign Het
Cfap46 A T 7: 139,260,097 (GRCm39) probably benign Het
Ciao1 A G 2: 127,088,599 (GRCm39) V108A possibly damaging Het
Clba1 T C 12: 112,779,323 (GRCm39) V320A possibly damaging Het
Dnah3 T A 7: 119,689,869 (GRCm39) H22L probably benign Het
Dnajc6 A G 4: 101,468,513 (GRCm39) Y251C probably damaging Het
Dsg2 T A 18: 20,715,878 (GRCm39) N273K probably damaging Het
Egf A G 3: 129,531,164 (GRCm39) V137A possibly damaging Het
Ercc6 C T 14: 32,248,211 (GRCm39) P254L probably benign Het
Erh G T 12: 80,684,282 (GRCm39) A65E probably benign Het
Fbln2 A G 6: 91,240,420 (GRCm39) E789G possibly damaging Het
Fbxl13 T G 5: 21,727,184 (GRCm39) D571A probably damaging Het
Fbxw26 T A 9: 109,561,717 (GRCm39) E159V probably damaging Het
Fndc1 T C 17: 8,019,778 (GRCm39) I134V probably null Het
Fsip2 A G 2: 82,810,938 (GRCm39) D2419G probably benign Het
Gm3371 T C 14: 44,641,238 (GRCm39) K109E Het
Gm5414 A G 15: 101,536,620 (GRCm39) S2P possibly damaging Het
Igkv1-110 G T 6: 68,247,950 (GRCm39) D20Y probably damaging Het
Il18rap C T 1: 40,582,177 (GRCm39) T366M probably benign Het
Ippk A G 13: 49,603,513 (GRCm39) D422G probably damaging Het
Irs2 A T 8: 11,056,655 (GRCm39) D592E probably damaging Het
Klra9 A G 6: 130,159,368 (GRCm39) I215T probably damaging Het
Lrrc8b T A 5: 105,629,424 (GRCm39) L590Q probably damaging Het
Myh10 A G 11: 68,680,929 (GRCm39) probably null Het
Neto1 A G 18: 86,479,173 (GRCm39) D159G probably damaging Het
Nr1d2 T C 14: 18,220,030 (GRCm38) K104E probably damaging Het
Nrcam T C 12: 44,645,366 (GRCm39) V1256A probably damaging Het
Nufip2 T C 11: 77,632,554 (GRCm39) V690A unknown Het
Or13e8 T A 4: 43,697,017 (GRCm39) D52V probably benign Het
Or2n1d A T 17: 38,646,320 (GRCm39) T91S possibly damaging Het
Or9m1b C T 2: 87,836,661 (GRCm39) A145T possibly damaging Het
Patj A G 4: 98,385,565 (GRCm39) H444R Het
Pclo T C 5: 14,825,335 (GRCm39) L1356P Het
Pde4dip A G 3: 97,617,633 (GRCm39) S1732P probably damaging Het
Pi4ka A T 16: 17,207,230 (GRCm39) I25N Het
Pira13 A T 7: 3,825,818 (GRCm39) D350E unknown Het
Pou2f3 C A 9: 43,110,336 (GRCm39) V30L probably benign Het
Qrich2 GCTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTG GCTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTGCAACACACCAGGCTGAACTGCACCTGGTTG 11: 116,348,367 (GRCm39) probably benign Het
Reck T A 4: 43,938,802 (GRCm39) probably benign Het
Sdha A T 13: 74,475,323 (GRCm39) probably benign Het
Serinc1 A C 10: 57,400,075 (GRCm39) S191A probably benign Het
Sgo2a T C 1: 58,056,560 (GRCm39) S915P probably damaging Het
Sgsh T C 11: 119,243,486 (GRCm39) T79A probably damaging Het
Sik1 A G 17: 32,069,919 (GRCm39) V207A possibly damaging Het
Skap1 A T 11: 96,644,902 (GRCm39) I338F probably damaging Het
Skic3 T A 13: 76,305,361 (GRCm39) probably benign Het
Sowahc G T 10: 59,057,813 (GRCm39) probably benign Het
Spata31d1d T C 13: 59,875,136 (GRCm39) K800E possibly damaging Het
Spin1 T A 13: 51,298,433 (GRCm39) W151R probably damaging Het
Srfbp1 A G 18: 52,623,686 (GRCm39) T438A possibly damaging Het
Srrm2 A G 17: 24,038,575 (GRCm39) T1740A probably benign Het
Tacr1 A T 6: 82,534,014 (GRCm39) S347C probably damaging Het
Taf1b T C 12: 24,566,860 (GRCm39) S185P possibly damaging Het
Tanc2 C T 11: 105,758,153 (GRCm39) T638I probably benign Het
Tdrkh T C 3: 94,336,478 (GRCm39) Y472H probably damaging Het
Trav4-2 C G 14: 53,656,266 (GRCm39) Y89* probably null Het
Trpm1 G T 7: 63,918,628 (GRCm39) R1540L probably benign Het
Ttc21a T C 9: 119,770,367 (GRCm39) probably null Het
Tti1 A G 2: 157,851,188 (GRCm39) V17A probably benign Het
Vamp8 A G 6: 72,365,276 (GRCm39) L44P probably benign Het
Vmn1r63 G T 7: 5,806,131 (GRCm39) S167Y probably damaging Het
Xrn2 T C 2: 146,891,913 (GRCm39) V710A probably benign Het
Zfp518a A C 19: 40,901,870 (GRCm39) K600Q possibly damaging Het
Zfyve28 T C 5: 34,374,655 (GRCm39) D453G probably benign Het
Other mutations in Or5h19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01333:Or5h19 APN 16 58,856,269 (GRCm39) missense probably damaging 1.00
R0218:Or5h19 UTSW 16 58,856,456 (GRCm39) missense probably benign 0.00
R1023:Or5h19 UTSW 16 58,856,178 (GRCm39) missense probably benign 0.00
R1086:Or5h19 UTSW 16 58,856,626 (GRCm39) missense probably damaging 1.00
R1472:Or5h19 UTSW 16 58,856,920 (GRCm39) missense probably damaging 1.00
R4710:Or5h19 UTSW 16 58,856,638 (GRCm39) missense possibly damaging 0.94
R4738:Or5h19 UTSW 16 58,856,558 (GRCm39) missense probably benign 0.00
R5265:Or5h19 UTSW 16 58,856,506 (GRCm39) missense possibly damaging 0.94
R6053:Or5h19 UTSW 16 58,856,351 (GRCm39) missense probably damaging 1.00
R6704:Or5h19 UTSW 16 58,856,225 (GRCm39) missense probably damaging 1.00
R6854:Or5h19 UTSW 16 58,856,428 (GRCm39) missense possibly damaging 0.75
R7178:Or5h19 UTSW 16 58,856,296 (GRCm39) missense probably benign 0.06
R7198:Or5h19 UTSW 16 58,856,456 (GRCm39) missense probably benign 0.00
R7404:Or5h19 UTSW 16 58,856,603 (GRCm39) missense possibly damaging 0.81
R7462:Or5h19 UTSW 16 58,856,379 (GRCm39) nonsense probably null
R7938:Or5h19 UTSW 16 58,856,325 (GRCm39) nonsense probably null
R8785:Or5h19 UTSW 16 58,856,530 (GRCm39) missense probably damaging 1.00
R8790:Or5h19 UTSW 16 58,856,580 (GRCm39) missense possibly damaging 0.96
R9198:Or5h19 UTSW 16 58,856,263 (GRCm39) missense probably benign 0.21
R9234:Or5h19 UTSW 16 58,856,789 (GRCm39) missense probably benign 0.05
R9368:Or5h19 UTSW 16 58,856,678 (GRCm39) missense probably benign 0.04
R9568:Or5h19 UTSW 16 58,856,213 (GRCm39) missense probably damaging 1.00
R9679:Or5h19 UTSW 16 58,856,521 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- CATTTGTTAGGAAGCACTCATGTG -3'
(R):5'- GGCTCGATCCAGGTTTTCAC -3'

Sequencing Primer
(F):5'- ATGTTTTAAGGAGATTTGAGGCAC -3'
(R):5'- CGATCCAGGTTTTCACTATTTCAAC -3'
Posted On 2021-08-02