Incidental Mutation 'R8913:Lcn2'
ID 678737
Institutional Source Beutler Lab
Gene Symbol Lcn2
Ensembl Gene ENSMUSG00000026822
Gene Name lipocalin 2
Synonyms 24p3, neu-related lipocalin, NGAL, NRL
MMRRC Submission 068702-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8913 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 32274649-32277751 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 32277158 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Phenylalanine at position 53 (V53F)
Ref Sequence ENSEMBL: ENSMUSP00000053962 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050785] [ENSMUST00000192241]
AlphaFold P11672
PDB Structure Crystal Structure of Murine Siderocalin (Lipocalin 2, 24p3) [X-RAY DIFFRACTION]
Crystal Structure of Murine Siderocalin in Complex with an Fab Fragment [X-RAY DIFFRACTION]
Predicted Effect possibly damaging
Transcript: ENSMUST00000050785
AA Change: V53F

PolyPhen 2 Score 0.884 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000053962
Gene: ENSMUSG00000026822
AA Change: V53F

DomainStartEndE-ValueType
Pfam:Lipocalin 48 195 2.2e-27 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000192241
AA Change: V139F

PolyPhen 2 Score 0.952 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000141430
Gene: ENSMUSG00000026822
AA Change: V139F

DomainStartEndE-ValueType
low complexity region 30 45 N/A INTRINSIC
Pfam:Lipocalin 134 271 5.3e-22 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 96% (65/68)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous mutants are more susceptible to infection with bacteria that utilize enterochelin-type siderophores to acquire iron and impaired thermogenesis. Mice homozygous for another knock-out allele exhibit apoptotic defects in hematopoietic cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A G 1: 71,303,972 (GRCm39) Y2102H probably damaging Het
Adam30 A T 3: 98,068,580 (GRCm39) I10F possibly damaging Het
Afap1l1 C T 18: 61,889,910 (GRCm39) probably null Het
Asz1 T C 6: 18,054,570 (GRCm39) D411G probably benign Het
Atp8b2 A G 3: 89,852,830 (GRCm39) L144P Het
Atxn7l3 G T 11: 102,185,787 (GRCm39) N13K probably damaging Het
Cap1 C A 4: 122,761,445 (GRCm39) probably null Het
Cd244a T A 1: 171,401,774 (GRCm39) Y167N probably damaging Het
Cd244a A T 1: 171,401,775 (GRCm39) Y167F probably damaging Het
Cd302 A G 2: 60,088,241 (GRCm39) F92S probably damaging Het
Cep128 C T 12: 91,331,221 (GRCm39) probably null Het
Csmd2 C A 4: 128,417,351 (GRCm39) P2770T Het
Cyp4f40 G T 17: 32,886,810 (GRCm39) D122Y probably benign Het
Dnah14 A G 1: 181,553,063 (GRCm39) E2583G probably benign Het
Dync1h1 T C 12: 110,624,602 (GRCm39) V3714A probably benign Het
Fam114a1 G T 5: 65,185,821 (GRCm39) A381S possibly damaging Het
Fzd8 A G 18: 9,213,869 (GRCm39) Y317C probably damaging Het
Igfn1 T C 1: 135,891,579 (GRCm39) K2312R possibly damaging Het
Il18rap C T 1: 40,582,177 (GRCm39) T366M probably benign Het
Klhl23 G A 2: 69,664,234 (GRCm39) E528K probably damaging Het
Lama4 T C 10: 38,982,039 (GRCm39) V1756A probably benign Het
Lrp4 T C 2: 91,331,785 (GRCm39) S1633P probably benign Het
Map3k19 A G 1: 127,750,363 (GRCm39) V996A probably benign Het
Mettl9 T G 7: 120,675,539 (GRCm39) F313C probably damaging Het
Mios T A 6: 8,215,924 (GRCm39) H373Q probably benign Het
Mroh2b A G 15: 4,947,010 (GRCm39) probably benign Het
Myo1a T C 10: 127,541,710 (GRCm39) V83A probably benign Het
Naxe T C 3: 87,965,665 (GRCm39) T45A probably benign Het
Nckap1 A G 2: 80,401,564 (GRCm39) V40A possibly damaging Het
Nherf2 G A 17: 24,863,839 (GRCm39) S12L probably benign Het
Nmt1 G T 11: 102,948,271 (GRCm39) R265L probably damaging Het
Nwd2 C A 5: 63,963,440 (GRCm39) A1008D possibly damaging Het
Obsl1 C T 1: 75,467,892 (GRCm39) A1334T probably benign Het
Oplah T C 15: 76,181,680 (GRCm39) M1114V Het
Or10a3n T C 7: 108,492,736 (GRCm39) R298G probably damaging Het
Or10a49 A T 7: 108,467,809 (GRCm39) V184E probably damaging Het
Or2n1d A T 17: 38,646,320 (GRCm39) T91S possibly damaging Het
Or2w6 A G 13: 21,843,274 (GRCm39) F73S probably damaging Het
Or4c29 A G 2: 88,739,991 (GRCm39) F249L probably benign Het
Pdlim5 A T 3: 141,950,666 (GRCm39) F582L probably damaging Het
Plcb2 A G 2: 118,544,365 (GRCm39) F671L probably damaging Het
Ppfibp1 T A 6: 146,923,947 (GRCm39) V725E probably damaging Het
Psmd11 C T 11: 80,362,338 (GRCm39) T396I probably damaging Het
Ptn C T 6: 36,718,276 (GRCm39) D130N probably benign Het
Rasgrf2 T C 13: 92,159,034 (GRCm39) D473G probably benign Het
Robo1 A C 16: 72,701,622 (GRCm39) I163L probably damaging Het
Ror1 A C 4: 100,265,027 (GRCm39) D167A possibly damaging Het
Rps6ka5 T C 12: 100,520,595 (GRCm39) D709G Het
Rsf1 GGCG GGCGACGGCCGCG 7: 97,229,113 (GRCm39) probably benign Het
Runx2 T C 17: 44,919,169 (GRCm39) T472A probably benign Het
Scn11a T C 9: 119,623,094 (GRCm39) T582A probably damaging Het
Serpina3m C T 12: 104,355,477 (GRCm39) A48V probably benign Het
Smim8 T A 4: 34,769,056 (GRCm39) D76V possibly damaging Het
Sqor A G 2: 122,641,806 (GRCm39) K260R probably benign Het
Syde2 A T 3: 145,708,148 (GRCm39) I963F probably damaging Het
Tasor A T 14: 27,188,145 (GRCm39) N864Y probably damaging Het
Tenm4 G A 7: 96,351,952 (GRCm39) probably benign Het
Tm7sf3 A T 6: 146,527,621 (GRCm39) Y68* probably null Het
Tmtc2 T A 10: 105,158,887 (GRCm39) I569F probably damaging Het
Upf3a G A 8: 13,845,728 (GRCm39) V276M possibly damaging Het
Vmn1r174 G A 7: 23,453,375 (GRCm39) V14M possibly damaging Het
Vmn2r104 A G 17: 20,249,968 (GRCm39) S768P probably damaging Het
Vmn2r60 A T 7: 41,785,778 (GRCm39) T194S probably benign Het
Zfhx2 A G 14: 55,309,543 (GRCm39) M852T probably benign Het
Zfp207 T A 11: 80,276,744 (GRCm39) D19E probably damaging Het
Zfp318 G A 17: 46,722,699 (GRCm39) M1567I probably benign Het
Zfp407 T A 18: 84,578,653 (GRCm39) E820V probably damaging Het
Zfp512b A T 2: 181,227,282 (GRCm39) C46S Het
Other mutations in Lcn2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00935:Lcn2 APN 2 32,277,590 (GRCm39) critical splice donor site probably null
IGL01327:Lcn2 APN 2 32,276,030 (GRCm39) missense possibly damaging 0.62
IGL01913:Lcn2 APN 2 32,277,157 (GRCm39) missense possibly damaging 0.46
IGL02108:Lcn2 APN 2 32,277,617 (GRCm39) missense probably damaging 0.99
IGL02215:Lcn2 APN 2 32,274,877 (GRCm39) makesense probably null
IGL02577:Lcn2 APN 2 32,277,101 (GRCm39) missense probably damaging 0.97
IGL03129:Lcn2 APN 2 32,277,716 (GRCm39) missense possibly damaging 0.70
R0302:Lcn2 UTSW 2 32,274,901 (GRCm39) unclassified probably benign
R1864:Lcn2 UTSW 2 32,275,434 (GRCm39) missense possibly damaging 0.77
R1865:Lcn2 UTSW 2 32,275,434 (GRCm39) missense possibly damaging 0.77
R4093:Lcn2 UTSW 2 32,277,728 (GRCm39) start codon destroyed probably null 1.00
R4621:Lcn2 UTSW 2 32,274,655 (GRCm39) unclassified probably benign
R5236:Lcn2 UTSW 2 32,275,973 (GRCm39) missense probably benign 0.06
R5716:Lcn2 UTSW 2 32,275,825 (GRCm39) missense possibly damaging 0.88
R6785:Lcn2 UTSW 2 32,277,039 (GRCm39) critical splice donor site probably null
R7059:Lcn2 UTSW 2 32,277,608 (GRCm39) missense possibly damaging 0.85
R7514:Lcn2 UTSW 2 32,277,861 (GRCm39) critical splice donor site probably null
R7596:Lcn2 UTSW 2 32,275,721 (GRCm39) missense probably damaging 1.00
R7694:Lcn2 UTSW 2 32,278,042 (GRCm39) missense unknown
R7778:Lcn2 UTSW 2 32,277,927 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GTCCTTCTCACTTTGACAGAAGTC -3'
(R):5'- TCTGACAGTAACCCCTTGCC -3'

Sequencing Primer
(F):5'- GACAGAAGTCAGGAATGGGAG -3'
(R):5'- ACTCAGGGTTAACTCCATCTAGG -3'
Posted On 2021-08-02