Mutagenetix > Incidental Mutation

Incidental Mutation 'R8914:Vmn2r26'

678813

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r26

Ensembl Gene

ENSMUSG00000096630

Gene Name

vomeronasal 2, receptor 26

Synonyms

V2r1b

MMRRC Submission

068766-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.117) question?

Stock #

R8914 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

124024758-124062035 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 124062024 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 853 (F853L)

Ref Sequence

ENSEMBL: ENSMUSP00000032238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032238]

AlphaFold

Q6TAC4

Predicted Effect

probably benign
Transcript: ENSMUST00000032238
AA Change: F853L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: F853L

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	471	1.5e-31	PFAM
Pfam:NCD3G	519	572	4.6e-25	PFAM
Pfam:7tm_3	603	840	1.5e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

100% (62/62)

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5330417H12Rik	C	T	7: 107,624,715	E51K	unknown	Het
Akr1c20	T	C	13: 4,511,216	D146G	probably benign	Het
Anapc4	T	A	5: 52,843,501	C205*	probably null	Het
Ap3s2	A	G	7: 79,915,163	I86T	probably benign	Het
Arih2	C	G	9: 108,611,739	R260P	probably damaging	Het
Atp9a	C	T	2: 168,637,500		probably null	Het
Bcl11b	C	A	12: 107,916,904	R384L	probably damaging	Het
Brca2	T	A	5: 150,541,743	D1657E	probably damaging	Het
Cabyr	C	A	18: 12,751,020	T188N	probably damaging	Het
Capn5	C	A	7: 98,135,790	W159L	probably damaging	Het
Ccnl1	A	T	3: 65,946,659	S514T	unknown	Het
Cdk14	G	T	5: 5,036,515	H286Q	possibly damaging	Het
Cpsf3	T	A	12: 21,295,111	H141Q	probably damaging	Het
Ddx24	A	G	12: 103,424,406	S109P	possibly damaging	Het
Dnmt3a	A	T	12: 3,866,192	R126*	probably null	Het
Dpys	C	A	15: 39,857,223	R47L	probably benign	Het
Dync1li2	A	G	8: 104,425,458	V361A	probably benign	Het
Epha7	T	G	4: 28,963,892	D962E	probably damaging	Het
Erh	G	T	12: 80,637,508	A65E	probably benign	Het
Fyb2	T	C	4: 105,000,503	S626P	probably benign	Het
Gm6583	A	T	5: 112,355,221	Y206N	probably damaging	Het
Gtpbp1	T	A	15: 79,716,192	V442D	probably damaging	Het
Hecw1	T	A	13: 14,247,603	I973F	probably damaging	Het
Igkv1-99	A	C	6: 68,542,356	K99T		Het
Igkv6-14	C	T	6: 70,435,196	V35I	probably benign	Het
Il18rap	C	T	1: 40,543,017	T366M	probably benign	Het
Klk1b9	C	T	7: 43,979,501	T143I	possibly damaging	Het
Krt1	AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC	AAGCTGCCACCCCCAAAGCCACCACCGCCGTAGCTGCCACCCCCAAAGCCACCAC	15: 101,850,378		probably benign	Het
Mettl15	A	C	2: 109,137,280		probably benign	Het
Mki67	A	G	7: 135,697,866	V1813A		Het
Mrps30	A	G	13: 118,387,219	Y6H	possibly damaging	Het
Mthfd1	T	A	12: 76,282,936	I176K	probably benign	Het
Nckap5l	C	T	15: 99,425,880	G914D	probably damaging	Het
Nemf	C	A	12: 69,316,315	E930*	probably null	Het
Nuggc	G	A	14: 65,641,905	V705I	probably benign	Het
Olfr1290	C	A	2: 111,489,659	L166F	probably damaging	Het
Olfr136	A	T	17: 38,335,429	T91S	possibly damaging	Het
Olfr493	A	G	7: 108,346,552	V143A	probably benign	Het
Olfr519	T	C	7: 108,893,529	R298G	probably damaging	Het
Olfr606	T	A	7: 103,451,883	L182Q	probably damaging	Het
Olfr764-ps1	C	A	10: 129,035,503	M2I	probably benign	Het
Olfr996	A	G	2: 85,579,712	T158A	possibly damaging	Het
Omd	A	T	13: 49,592,242	K376M	probably damaging	Het
Pi15	A	G	1: 17,621,738	Y217C	probably damaging	Het
Pou5f1	T	C	17: 35,510,474	S328P	probably benign	Het
Pparg	T	A	6: 115,463,172	S236T	probably benign	Het
Prss23	T	C	7: 89,510,646	T72A	probably benign	Het
Ptprb	C	A	10: 116,322,662	S546*	probably null	Het
Ranbp9	A	G	13: 43,425,084	I171T	probably benign	Het
Rap1gap2	A	T	11: 74,435,761	L160*	probably null	Het
Rfxap	T	C	3: 54,807,621	T19A	probably benign	Het
Sctr	T	A	1: 120,031,656	F95I	probably benign	Het
Sf3b3	T	A	8: 110,813,807	Q994L	probably benign	Het
Slfn9	A	T	11: 82,981,306	I868N	probably damaging	Het
Top3a	A	T	11: 60,740,579	C986S	probably damaging	Het
Trak1	T	A	9: 121,443,781	L245Q	unknown	Het
Trim27	A	G	13: 21,180,823	D110G	possibly damaging	Het
Ubxn2a	T	C	12: 4,880,754	D202G	probably benign	Het
Uhrf1bp1	T	G	17: 27,886,913	D804E	possibly damaging	Het
Urb1	T	C	16: 90,810,234	K36R	probably damaging	Het
Usp34	A	G	11: 23,343,604	T252A		Het
Vmn1r73	C	A	7: 11,756,401	H49N	probably damaging	Het
Vmn2r117	C	T	17: 23,460,169	V694I	probably benign	Het
Vmn2r55	A	T	7: 12,671,097	H126Q	probably benign	Het

Other mutations in Vmn2r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01070:Vmn2r26	APN	6	124061607	missense	probably benign	0.00
IGL01370:Vmn2r26	APN	6	124061756	missense	probably benign	0.08
IGL01603:Vmn2r26	APN	6	124053874	missense	probably damaging	1.00
IGL01651:Vmn2r26	APN	6	124050673	missense	probably benign	0.01
IGL02282:Vmn2r26	APN	6	124061625	missense	probably damaging	1.00
IGL02425:Vmn2r26	APN	6	124061818	missense	probably damaging	1.00
IGL02551:Vmn2r26	APN	6	124026141	missense	probably benign	0.11
IGL02690:Vmn2r26	APN	6	124026132	missense	probably benign	0.14
IGL03002:Vmn2r26	APN	6	124039795	missense	possibly damaging	0.78
IGL03270:Vmn2r26	APN	6	124050819	missense	probably benign	0.16
R0032:Vmn2r26	UTSW	6	124039899	missense	possibly damaging	0.72
R0052:Vmn2r26	UTSW	6	124062033	makesense	probably null
R0083:Vmn2r26	UTSW	6	124053981	splice site	probably null
R0682:Vmn2r26	UTSW	6	124061170	missense	probably damaging	0.97
R1061:Vmn2r26	UTSW	6	124061644	missense	probably benign	0.12
R1077:Vmn2r26	UTSW	6	124053913	missense	probably benign	0.00
R1263:Vmn2r26	UTSW	6	124050708	missense	probably benign
R1579:Vmn2r26	UTSW	6	124039747	missense	probably benign	0.00
R1741:Vmn2r26	UTSW	6	124061472	missense	probably damaging	1.00
R1834:Vmn2r26	UTSW	6	124061410	missense	possibly damaging	0.54
R1838:Vmn2r26	UTSW	6	124024771	missense	probably benign
R1956:Vmn2r26	UTSW	6	124053887	missense	probably damaging	1.00
R1996:Vmn2r26	UTSW	6	124061185	missense	probably damaging	1.00
R2140:Vmn2r26	UTSW	6	124061237	missense	probably benign	0.01
R2327:Vmn2r26	UTSW	6	124039749	missense	probably benign	0.07
R2417:Vmn2r26	UTSW	6	124061350	missense	probably damaging	1.00
R3930:Vmn2r26	UTSW	6	124025979	missense	probably benign
R4490:Vmn2r26	UTSW	6	124050738	missense	possibly damaging	0.47
R4629:Vmn2r26	UTSW	6	124061191	missense	possibly damaging	0.50
R4655:Vmn2r26	UTSW	6	124061416	missense	probably damaging	1.00
R4709:Vmn2r26	UTSW	6	124053965	missense	probably damaging	1.00
R4992:Vmn2r26	UTSW	6	124026111	missense	probably benign	0.00
R5297:Vmn2r26	UTSW	6	124061873	missense	probably damaging	1.00
R5482:Vmn2r26	UTSW	6	124061326	missense	possibly damaging	0.88
R5517:Vmn2r26	UTSW	6	124050717	missense	probably damaging	1.00
R5737:Vmn2r26	UTSW	6	124039449	missense	probably benign	0.00
R5739:Vmn2r26	UTSW	6	124025966	missense	probably benign	0.00
R5873:Vmn2r26	UTSW	6	124061674	missense	probably benign	0.01
R5907:Vmn2r26	UTSW	6	124039871	missense	probably benign	0.00
R6086:Vmn2r26	UTSW	6	124039560	missense	possibly damaging	0.48
R6134:Vmn2r26	UTSW	6	124061485	missense	probably damaging	0.97
R6391:Vmn2r26	UTSW	6	124061389	missense	probably damaging	1.00
R6428:Vmn2r26	UTSW	6	124026080	missense	probably benign	0.17
R6637:Vmn2r26	UTSW	6	124061691	missense	probably damaging	1.00
R6927:Vmn2r26	UTSW	6	124039098	missense	possibly damaging	0.93
R6953:Vmn2r26	UTSW	6	124039782	missense	probably benign	0.00
R7173:Vmn2r26	UTSW	6	124061296	missense	probably benign	0.16
R7206:Vmn2r26	UTSW	6	124039768	missense	probably benign	0.17
R7208:Vmn2r26	UTSW	6	124061989	missense	probably damaging	1.00
R7283:Vmn2r26	UTSW	6	124025955	missense	probably damaging	0.97
R7506:Vmn2r26	UTSW	6	124039741	missense	probably benign	0.00
R7672:Vmn2r26	UTSW	6	124039647	missense	probably benign	0.25
R7674:Vmn2r26	UTSW	6	124039362	missense	probably benign
R7696:Vmn2r26	UTSW	6	124061535	missense	possibly damaging	0.94
R7716:Vmn2r26	UTSW	6	124061745	missense	probably damaging	1.00
R7831:Vmn2r26	UTSW	6	124039799	nonsense	probably null
R8063:Vmn2r26	UTSW	6	124024955	missense	probably benign	0.00
R8331:Vmn2r26	UTSW	6	124061928	missense	probably benign	0.22
R8352:Vmn2r26	UTSW	6	124039618	missense	probably benign	0.09
R8445:Vmn2r26	UTSW	6	124026036	missense	probably damaging	0.97
R8452:Vmn2r26	UTSW	6	124039618	missense	probably benign	0.09
R8681:Vmn2r26	UTSW	6	124024918	missense	probably benign	0.00
R9333:Vmn2r26	UTSW	6	124026050	missense	probably benign	0.13
R9351:Vmn2r26	UTSW	6	124039374	missense	probably benign
R9436:Vmn2r26	UTSW	6	124025867	missense	probably damaging	1.00
R9515:Vmn2r26	UTSW	6	124061178	missense	probably damaging	1.00
RF010:Vmn2r26	UTSW	6	124039489	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- AGAAGGCTACCTGACAGCTTC -3'
(R):5'- TCACTGTGTCTAGTTGGCTCTAAG -3'

Sequencing Primer
(F):5'- GCTACCTGACAGCTTCAATGAGG -3'
(R):5'- TCTAGTTGGCTCTAAGGATAACAGG -3'

Posted On

2021-08-02