Incidental Mutation 'R8916:Nop9'
ID 678958
Institutional Source Beutler Lab
Gene Symbol Nop9
Ensembl Gene ENSMUSG00000019297
Gene Name NOP9 nucleolar protein
Synonyms 2610027L16Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.946) question?
Stock # R8916 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 55983150-55992957 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 55991101 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 586 (E586G)
Ref Sequence ENSEMBL: ENSMUSP00000019441 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001497] [ENSMUST00000019441]
AlphaFold Q8BMC4
Predicted Effect probably benign
Transcript: ENSMUST00000001497
SMART Domains Protein: ENSMUSP00000001497
Gene: ENSMUSG00000022219

DomainStartEndE-ValueType
CAD 36 108 2.16e-41 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000019441
AA Change: E586G

PolyPhen 2 Score 0.172 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000019441
Gene: ENSMUSG00000019297
AA Change: E586G

DomainStartEndE-ValueType
low complexity region 11 55 N/A INTRINSIC
Blast:Pumilio 92 127 3e-15 BLAST
Pumilio 189 220 2.74e2 SMART
Blast:Pumilio 263 298 3e-14 BLAST
Pumilio 314 349 4.38e1 SMART
Pumilio 351 387 1.03e1 SMART
Pumilio 509 546 1.72e1 SMART
Pumilio 547 582 9.17e0 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts16 A G 13: 70,941,307 (GRCm39) L360S probably damaging Het
AW554918 T C 18: 25,423,049 (GRCm39) Y167H probably damaging Het
Cdh18 A T 15: 23,410,813 (GRCm39) I433F probably damaging Het
Cenpj A T 14: 56,790,352 (GRCm39) F566I probably damaging Het
Cntn4 T A 6: 106,652,915 (GRCm39) Y795N probably damaging Het
Col4a4 C T 1: 82,501,667 (GRCm39) G362E unknown Het
Crebrf A G 17: 26,958,583 (GRCm39) T18A probably damaging Het
D130043K22Rik G A 13: 25,056,254 (GRCm39) V529I probably benign Het
Dars2 T C 1: 160,881,552 (GRCm39) T326A probably benign Het
Eif4e T C 3: 138,256,043 (GRCm39) probably benign Het
Enpp2 T C 15: 54,733,722 (GRCm39) M413V possibly damaging Het
Fbn1 T C 2: 125,245,149 (GRCm39) D246G possibly damaging Het
Foxred2 A G 15: 77,837,514 (GRCm39) S241P probably damaging Het
Fras1 T C 5: 96,900,774 (GRCm39) F2998L probably damaging Het
Garin4 A G 1: 190,895,857 (GRCm39) I262T probably benign Het
Grb10 T C 11: 11,901,599 (GRCm39) T192A probably benign Het
Grid1 G A 14: 35,043,664 (GRCm39) D340N probably damaging Het
Heatr5a AGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGTGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGAGCACACTGCAGGAAGCTCA AGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGAGCACACTGCAGGAAGCTCA 12: 51,934,702 (GRCm39) probably benign Het
Hinfp A T 9: 44,209,673 (GRCm39) F234I probably damaging Het
Hmcn1 A T 1: 150,649,530 (GRCm39) I652N probably damaging Het
Kif24 T C 4: 41,394,963 (GRCm39) K771E probably benign Het
Lhcgr A G 17: 89,061,170 (GRCm39) probably null Het
Lnpk A T 2: 74,358,486 (GRCm39) S358T probably benign Het
Lpcat2 A T 8: 93,596,316 (GRCm39) M118L probably benign Het
Lypd1 T A 1: 125,801,120 (GRCm39) T127S unknown Het
Mettl23 C T 11: 116,740,111 (GRCm39) T194I probably damaging Het
Mga T C 2: 119,788,819 (GRCm39) V2227A possibly damaging Het
Mus81 A T 19: 5,534,214 (GRCm39) V368E probably damaging Het
Myo3a T A 2: 22,457,704 (GRCm39) F1046I probably damaging Het
Nfia G A 4: 97,888,667 (GRCm39) V222I probably benign Het
Niban2 T A 2: 32,811,106 (GRCm39) M372K possibly damaging Het
Nr2e1 G A 10: 42,443,864 (GRCm39) A286V possibly damaging Het
Nup153 G A 13: 46,863,462 (GRCm39) Q300* probably null Het
Plaat1 A G 16: 29,039,259 (GRCm39) D113G possibly damaging Het
Pnp2 T C 14: 51,201,234 (GRCm39) L202P probably damaging Het
Prss3b T A 6: 41,010,103 (GRCm39) H77L probably damaging Het
Psen2 A G 1: 180,063,495 (GRCm39) F183L probably benign Het
Rint1 G T 5: 23,992,826 (GRCm39) probably benign Het
Rsf1 GGC GGCGGCGGCCGC 7: 97,229,140 (GRCm39) probably benign Het
Ryr3 C A 2: 112,608,635 (GRCm39) R2335L probably damaging Het
Scn1a T C 2: 66,108,127 (GRCm39) D1544G probably damaging Het
Sec31b A C 19: 44,520,783 (GRCm39) S175A Het
Sgcg A G 14: 61,474,341 (GRCm39) S101P probably damaging Het
Shb A T 4: 45,489,154 (GRCm39) S241T probably damaging Het
Slc47a2 A T 11: 61,193,118 (GRCm39) L545Q probably damaging Het
Spata31g1 C A 4: 42,973,034 (GRCm39) P789H probably damaging Het
Spef2 C A 15: 9,725,266 (GRCm39) E164* probably null Het
Sphkap A T 1: 83,255,108 (GRCm39) N880K possibly damaging Het
Taf2 A G 15: 54,899,931 (GRCm39) V894A probably benign Het
Tgfa T G 6: 86,248,436 (GRCm39) L146R probably damaging Het
Tlr3 C T 8: 45,856,076 (GRCm39) V35I probably benign Het
Tlr4 G A 4: 66,847,268 (GRCm39) V132I probably benign Het
Tsen34 C T 7: 3,697,340 (GRCm39) probably benign Het
Ttc13 T G 8: 125,409,976 (GRCm39) K412T probably damaging Het
Unc45b A G 11: 82,804,038 (GRCm39) I72V probably benign Het
Vmn1r195 A G 13: 22,463,139 (GRCm39) Y203C probably damaging Het
Vmn2r65 T A 7: 84,595,665 (GRCm39) T340S probably benign Het
Vmn2r88 T A 14: 51,648,593 (GRCm39) C46S Het
Ythdf2 A T 4: 131,931,830 (GRCm39) D443E probably damaging Het
Zeb2 T C 2: 44,886,796 (GRCm39) R754G probably damaging Het
Zfp236 T A 18: 82,664,351 (GRCm39) E478V probably damaging Het
Zfp287 A T 11: 62,605,136 (GRCm39) Y590* probably null Het
Zfp9 A T 6: 118,442,223 (GRCm39) C146* probably null Het
Other mutations in Nop9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02156:Nop9 APN 14 55,990,740 (GRCm39) nonsense probably null
IGL02803:Nop9 APN 14 55,987,533 (GRCm39) missense probably benign
R0443:Nop9 UTSW 14 55,991,205 (GRCm39) missense probably benign 0.00
R1766:Nop9 UTSW 14 55,989,591 (GRCm39) missense possibly damaging 0.94
R1785:Nop9 UTSW 14 55,988,599 (GRCm39) missense probably damaging 1.00
R1786:Nop9 UTSW 14 55,988,599 (GRCm39) missense probably damaging 1.00
R3015:Nop9 UTSW 14 55,988,631 (GRCm39) missense probably benign 0.00
R4784:Nop9 UTSW 14 55,983,859 (GRCm39) small deletion probably benign
R5046:Nop9 UTSW 14 55,983,397 (GRCm39) missense possibly damaging 0.90
R5787:Nop9 UTSW 14 55,983,791 (GRCm39) missense possibly damaging 0.93
R6271:Nop9 UTSW 14 55,991,198 (GRCm39) missense probably damaging 1.00
R6379:Nop9 UTSW 14 55,983,249 (GRCm39) missense possibly damaging 0.83
R6943:Nop9 UTSW 14 55,990,270 (GRCm39) missense probably benign 0.25
R7562:Nop9 UTSW 14 55,986,809 (GRCm39) missense probably benign 0.01
R8992:Nop9 UTSW 14 55,983,438 (GRCm39) missense possibly damaging 0.86
R9070:Nop9 UTSW 14 55,990,757 (GRCm39) missense probably damaging 1.00
R9206:Nop9 UTSW 14 55,987,592 (GRCm39) critical splice donor site probably null
R9385:Nop9 UTSW 14 55,988,584 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GTACCCGGTAGCTGATTGGTTC -3'
(R):5'- TCCCGTTGCAAGTCTCAGTC -3'

Sequencing Primer
(F):5'- CAGCAGATTTCAAAAGTGCAGTCTG -3'
(R):5'- GTCTTCAAGTATAGAGCTCAATGCCC -3'
Posted On 2021-08-02