Mutagenetix > Incidental Mutation

Incidental Mutation 'R8917:Or9m1'

678977

Institutional Source

Beutler Lab

Gene Symbol

Or9m1

Ensembl Gene

ENSMUSG00000075146

Gene Name

olfactory receptor family 9 subfamily M member 1

Synonyms

Olfr1154, MOR173-2, GA_x6K02T2Q125-49403456-49402524

MMRRC Submission

068704-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.106) question?

Stock #

R8917 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

87733086-87734018 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 87733307 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Threonine at position 238 (S238T)

Ref Sequence

ENSEMBL: ENSMUSP00000148909 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099844] [ENSMUST00000215017] [ENSMUST00000215862] [ENSMUST00000217436]

AlphaFold

L7MU57

Predicted Effect

possibly damaging
Transcript: ENSMUST00000099844
AA Change: S238T

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000097432
Gene: ENSMUSG00000075146
AA Change: S238T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	8.1e-47	PFAM
Pfam:7tm_1	41	289	3.6e-18	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000215017
AA Change: S238T

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000215862
AA Change: S238T

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)

Predicted Effect

probably benign
Transcript: ENSMUST00000217436

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

100% (57/57)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610528J11Rik	A	G	4: 118,386,490 (GRCm39)	M1V	probably null	Het
Acss3	T	C	10: 106,773,124 (GRCm39)	S621G	probably benign	Het
Adam1a	C	T	5: 121,657,145 (GRCm39)	R716Q	probably benign	Het
Ankrd26	G	T	6: 118,535,902 (GRCm39)	N177K	probably damaging	Het
Ankrd31	G	A	13: 96,969,212 (GRCm39)	V950I	probably damaging	Het
Ano4	A	G	10: 88,788,160 (GRCm39)	Y922H	probably damaging	Het
Axin2	A	T	11: 108,822,341 (GRCm39)	N298Y	probably damaging	Het
Celsr2	A	T	3: 108,303,882 (GRCm39)	M2392K	probably benign	Het
Coasy	A	G	11: 100,974,202 (GRCm39)	S123G	probably benign	Het
Cracdl	A	G	1: 37,676,993 (GRCm39)	V63A	probably damaging	Het
Ctla2a	A	T	13: 61,083,854 (GRCm39)	M26K	probably benign	Het
Cts8	A	T	13: 61,396,882 (GRCm39)		probably benign	Het
Cyp4a30b	C	A	4: 115,311,662 (GRCm39)	S110*	probably null	Het
Eif2ak4	A	G	2: 118,287,617 (GRCm39)	Y1195C	probably damaging	Het
Erh	G	T	12: 80,684,282 (GRCm39)	A65E	probably benign	Het
Exoc6	A	G	19: 37,578,360 (GRCm39)	D401G	probably benign	Het
Fmo1	A	G	1: 162,663,773 (GRCm39)	V252A	probably benign	Het
Furin	T	C	7: 80,048,437 (GRCm39)	K28E	probably benign	Het
Gmip	T	A	8: 70,270,428 (GRCm39)	F713I	probably damaging	Het
Hyal6	T	C	6: 24,734,103 (GRCm39)	L12P	possibly damaging	Het
Ido1	T	C	8: 25,081,523 (GRCm39)	N144D	probably benign	Het
Igsf10	T	A	3: 59,226,888 (GRCm39)	T2262S	possibly damaging	Het
Insrr	T	C	3: 87,718,276 (GRCm39)	F923S	probably benign	Het
Kank1	G	T	19: 25,386,928 (GRCm39)	M200I	probably damaging	Het
Kctd15	A	G	7: 34,341,508 (GRCm39)	Y140H	probably damaging	Het
Kif3c	T	A	12: 3,416,690 (GRCm39)	I237N	probably damaging	Het
Klhl26	T	C	8: 70,905,455 (GRCm39)	S152G	possibly damaging	Het
Lce1k	C	A	3: 92,714,097 (GRCm39)	C29F	unknown	Het
Map1a	A	G	2: 121,131,791 (GRCm39)	E869G	possibly damaging	Het
Mcmbp	T	C	7: 128,300,281 (GRCm39)	E576G	probably benign	Het
Mrps22	A	G	9: 98,476,163 (GRCm39)	V231A	probably benign	Het
Myo1a	C	T	10: 127,551,534 (GRCm39)	L697F	possibly damaging	Het
Ncapd3	T	C	9: 26,999,297 (GRCm39)	V1291A	probably benign	Het
Nherf4	T	A	9: 44,160,141 (GRCm39)		probably benign	Het
Pcdhb6	A	G	18: 37,468,431 (GRCm39)	T451A	possibly damaging	Het
Pi4ka	C	A	16: 17,130,310 (GRCm39)	W1032L		Het
Pkhd1l1	T	A	15: 44,396,403 (GRCm39)	I1975N	probably benign	Het
Pnpla6	T	C	8: 3,567,637 (GRCm39)	M115T	possibly damaging	Het
Poldip2	G	A	11: 78,412,667 (GRCm39)	R347Q	probably damaging	Het
Pramel18	G	A	4: 101,768,935 (GRCm39)	V429M	probably benign	Het
Rapgef6	C	T	11: 54,582,392 (GRCm39)	Q1440*	probably null	Het
Rtn3	A	T	19: 7,434,105 (GRCm39)	I629K	possibly damaging	Het
Selenov	A	G	7: 27,987,728 (GRCm39)	F278L	probably damaging	Het
Skor2	G	A	18: 76,948,504 (GRCm39)	G742D	probably damaging	Het
Spata31d1c	C	T	13: 65,183,429 (GRCm39)	P324S	probably benign	Het
Tbc1d14	A	T	5: 36,676,682 (GRCm39)	I403N	probably damaging	Het
Tekt3	A	T	11: 62,978,052 (GRCm39)	Q374L	probably damaging	Het
Tg	T	C	15: 66,645,332 (GRCm39)		probably null	Het
Thnsl2	T	C	6: 71,116,927 (GRCm39)	D75G	probably benign	Het
Tnr	A	T	1: 159,701,692 (GRCm39)	K598*	probably null	Het
Tshr	T	A	12: 91,468,829 (GRCm39)		probably benign	Het
Uggt1	A	G	1: 36,185,735 (GRCm39)	S1483P		Het
Usp42	T	C	5: 143,701,695 (GRCm39)	E776G		Het
Vmn2r118	T	C	17: 55,917,216 (GRCm39)	E432G	possibly damaging	Het
Vmn2r-ps158	T	C	7: 42,697,433 (GRCm39)	I830T	probably damaging	Het
Zfhx4	A	G	3: 5,464,159 (GRCm39)	E1464G	probably damaging	Het
Zfp518a	A	C	19: 40,901,870 (GRCm39)	K600Q	possibly damaging	Het
Zxdc	A	G	6: 90,359,305 (GRCm39)	T646A	probably benign	Het

Other mutations in Or9m1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01360:Or9m1	APN	2	87,733,871 (GRCm39)	missense	probably benign	0.00
IGL01878:Or9m1	APN	2	87,733,675 (GRCm39)	nonsense	probably null
IGL02683:Or9m1	APN	2	87,733,448 (GRCm39)	missense	possibly damaging	0.80
IGL02836:Or9m1	APN	2	87,733,724 (GRCm39)	missense	possibly damaging	0.81
R0432:Or9m1	UTSW	2	87,733,304 (GRCm39)	missense	probably damaging	1.00
R1123:Or9m1	UTSW	2	87,733,248 (GRCm39)	missense	probably damaging	0.99
R1223:Or9m1	UTSW	2	87,733,163 (GRCm39)	missense	probably damaging	0.99
R1561:Or9m1	UTSW	2	87,733,505 (GRCm39)	missense	probably benign	0.00
R1964:Or9m1	UTSW	2	87,734,011 (GRCm39)	missense	probably benign	0.00
R2041:Or9m1	UTSW	2	87,733,141 (GRCm39)	missense	probably damaging	1.00
R2219:Or9m1	UTSW	2	87,733,269 (GRCm39)	nonsense	probably null
R2233:Or9m1	UTSW	2	87,733,819 (GRCm39)	missense	probably damaging	1.00
R3719:Or9m1	UTSW	2	87,733,447 (GRCm39)	missense	probably benign	0.05
R4826:Or9m1	UTSW	2	87,733,693 (GRCm39)	missense	probably damaging	1.00
R4908:Or9m1	UTSW	2	87,733,533 (GRCm39)	missense	probably damaging	1.00
R5056:Or9m1	UTSW	2	87,733,915 (GRCm39)	missense	probably damaging	1.00
R5589:Or9m1	UTSW	2	87,733,691 (GRCm39)	missense	probably benign	0.26
R6477:Or9m1	UTSW	2	87,733,334 (GRCm39)	missense	probably damaging	1.00
R6532:Or9m1	UTSW	2	87,733,546 (GRCm39)	missense	probably damaging	1.00
R6666:Or9m1	UTSW	2	87,733,852 (GRCm39)	missense	probably damaging	1.00
R6693:Or9m1	UTSW	2	87,733,652 (GRCm39)	missense	probably damaging	1.00
R6724:Or9m1	UTSW	2	87,733,946 (GRCm39)	missense	probably benign	0.00
R7784:Or9m1	UTSW	2	87,733,537 (GRCm39)	missense	probably benign	0.01
R8099:Or9m1	UTSW	2	87,733,852 (GRCm39)	missense	probably damaging	1.00
R8168:Or9m1	UTSW	2	87,733,543 (GRCm39)	missense	probably damaging	0.97
R8998:Or9m1	UTSW	2	87,733,189 (GRCm39)	missense	probably damaging	1.00
R9039:Or9m1	UTSW	2	87,733,907 (GRCm39)	missense	probably damaging	0.98
R9093:Or9m1	UTSW	2	87,733,480 (GRCm39)	missense	probably benign	0.44
R9139:Or9m1	UTSW	2	87,733,108 (GRCm39)	missense	probably benign	0.04
R9780:Or9m1	UTSW	2	87,733,426 (GRCm39)	missense	probably damaging	1.00
Z1088:Or9m1	UTSW	2	87,733,928 (GRCm39)	missense	possibly damaging	0.87

Predicted Primers

PCR Primer
(F):5'- AATTTGACGTCTTTGTTCCTGAGAC -3'
(R):5'- TCCAATTGTCATTCTGCTCCAAAG -3'

Sequencing Primer
(F):5'- GAATGGCCTGTACTAGGA -3'
(R):5'- GTCATTCTGCTCCAAAGTAATTAACC -3'

Posted On

2021-08-02