Mutagenetix > Incidental Mutation

Incidental Mutation 'R8919:Vmn1r209'

679150

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r209

Ensembl Gene

ENSMUSG00000071491

Gene Name

vomeronasal 1 receptor 209

Synonyms

Gm11315

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.091) question?

Stock #

R8919 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

22800629-22809682 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 22806053 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 156 (M156V)

Ref Sequence

ENSEMBL: ENSMUSP00000093657 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095961] [ENSMUST00000227038] [ENSMUST00000227265]

AlphaFold

Q5NC97

Predicted Effect

probably benign
Transcript: ENSMUST00000095961
AA Change: M156V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000093657
Gene: ENSMUSG00000071491
AA Change: M156V

Domain	Start	End	E-Value	Type
Pfam:TAS2R	2	294	9.8e-9	PFAM
Pfam:V1R	34	297	3e-36	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000227038
AA Change: M156V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

probably benign
Transcript: ENSMUST00000227265
AA Change: M156V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.9%

Validation Efficiency

99% (81/82)

Allele List at MGI

Other mutations in this stock

Total: 82 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700061G19Rik	A	C	17: 56,882,218	I209L	probably benign	Het
Aadat	C	T	8: 60,540,124	T373I	possibly damaging	Het
Abca13	T	C	11: 9,291,653	L1172P	possibly damaging	Het
Abcg2	A	G	6: 58,684,341	Y459C	probably benign	Het
AC125199.3	T	C	16: 88,812,173	N4D	possibly damaging	Het
Acad8	A	G	9: 26,999,489	M3T	probably benign	Het
Adcyap1r1	C	T	6: 55,497,095	T472I	probably damaging	Het
Ank3	A	T	10: 70,004,841	K1890N	possibly damaging	Het
Asic1	G	A	15: 99,671,945	C49Y	probably benign	Het
Atp1a1	T	C	3: 101,591,231	N215S	probably damaging	Het
C87436	A	G	6: 86,445,792	Y116C	probably damaging	Het
Car5a	T	C	8: 121,944,780	D5G	probably benign	Het
Ccdc169	T	C	3: 55,150,947		probably null	Het
Ccdc93	A	G	1: 121,499,241	R586G	probably damaging	Het
Cep295	A	G	9: 15,326,711	V131A	probably damaging	Het
Cox5a	A	G	9: 57,529,046	D60G	possibly damaging	Het
Cpne6	A	T	14: 55,512,647	E78D	probably benign	Het
Cyp2u1	T	C	3: 131,295,465	E390G	probably damaging	Het
Dab2	C	A	15: 6,435,790	N707K		Het
Dock10	A	T	1: 80,505,430	D2101E	probably benign	Het
Duoxa2	G	A	2: 122,301,876		probably null	Het
Eif4a3	T	C	11: 119,299,932	D22G	probably benign	Het
Fam160a2	T	C	7: 105,388,270	T369A	possibly damaging	Het
Fubp3	A	G	2: 31,592,464		probably null	Het
Gm10330	A	G	12: 23,779,886	L98P	probably benign	Het
Gm5108	A	G	5: 67,976,956	*102W	probably null	Het
Gpr149	A	C	3: 62,531,057	S560A	probably damaging	Het
Haspin	T	C	11: 73,136,604	D553G	probably benign	Het
Hsf1	C	T	15: 76,497,851	H104Y	probably benign	Het
Ifi203	T	C	1: 173,928,928	T430A	unknown	Het
Itih2	G	A	2: 10,098,011	Q771*	probably null	Het
Kazald1	T	A	19: 45,076,956	L92Q	probably damaging	Het
Krt19	T	C	11: 100,141,154	E324G	probably damaging	Het
Lrrc28	A	T	7: 67,619,085	V79E	possibly damaging	Het
Ltn1	T	A	16: 87,381,493	Q1616L	probably damaging	Het
Mdc1	A	G	17: 35,847,951	K408E	probably benign	Het
Nalcn	A	T	14: 123,323,872	M738K	probably benign	Het
Ncoa4	T	C	14: 32,172,891	L125P	probably damaging	Het
Ncor2	G	T	5: 125,029,189	R810S		Het
Neb	C	T	2: 52,237,129	G348D		Het
Nfat5	T	A	8: 107,368,596	F1156L	probably damaging	Het
Oit3	G	A	10: 59,441,646	T13I	unknown	Het
Olfr1135	A	C	2: 87,672,223	L48W	probably damaging	Het
Olfr1404	T	C	1: 173,216,497	I282T	probably damaging	Het
Olfr490	A	G	7: 108,287,082	F15L	probably damaging	Het
Olfr552	T	A	7: 102,604,504	I50N	probably damaging	Het
Olfr785	G	T	10: 129,410,213	M282I	probably benign	Het
Opa1	A	C	16: 29,605,522	Q230P	probably damaging	Het
Papd7	G	T	13: 69,503,709	T531N	possibly damaging	Het
Parpbp	T	C	10: 88,110,327	H410R	probably null	Het
Pex5l	A	G	3: 32,953,184	V481A	probably damaging	Het
Plekhh3	C	A	11: 101,166,399	R344L	probably benign	Het
Prrc2b	T	C	2: 32,214,941	V1477A	probably benign	Het
Ptp4a2	G	A	4: 129,845,152	G94S	possibly damaging	Het
Ptprk	T	A	10: 28,483,207	Y598*	probably null	Het
Rfx5	C	A	3: 94,957,164	T207N	probably damaging	Het
Rnase2b	A	G	14: 51,162,890	T143A	possibly damaging	Het
Scn1a	A	G	2: 66,337,986	V92A	probably benign	Het
Shank2	C	A	7: 144,411,528	P958T	probably damaging	Het
Slc13a1	A	G	6: 24,108,195	I294T	probably damaging	Het
Slc4a8	A	T	15: 100,814,540	E1084D	probably benign	Het
Smurf1	T	A	5: 144,883,612	R549*	probably null	Het
Sprr2b	T	C	3: 92,317,725	C93R	unknown	Het
Tcn2	G	T	11: 3,923,569	S259Y	probably damaging	Het
Tex43	T	C	18: 56,592,465	F66L	probably damaging	Het
Tle1	A	G	4: 72,158,288	S168P	possibly damaging	Het
Tnfrsf1b	C	T	4: 145,223,580	G264D	probably damaging	Het
Tnks2	T	A	19: 36,845,688	N118K	probably damaging	Het
Topaz1	G	T	9: 122,797,865		probably benign	Het
Traf3ip1	A	G	1: 91,516,074		probably benign	Het
Ttk	A	G	9: 83,839,269	E69G	probably damaging	Het
Tulp3	T	C	6: 128,334,003	D87G	probably benign	Het
Usp38	C	T	8: 80,981,850	G1033D	probably damaging	Het
Usp44	T	A	10: 93,857,913	N707K	probably benign	Het
Vipas39	T	A	12: 87,259,084	R112*	probably null	Het
Vmn1r185	A	C	7: 26,611,781	S100A	probably damaging	Het
Vmn1r3	G	A	4: 3,184,863	T148I	probably benign	Het
Wdr41	G	A	13: 95,015,112	R260H	probably benign	Het
Wdr90	G	A	17: 25,857,172	R104C		Het
Wnk2	A	T	13: 49,068,235	H1183Q	possibly damaging	Het
Zfp667	A	T	7: 6,305,257	H308L	possibly damaging	Het
Zfp952	A	G	17: 33,001,654	N18D	possibly damaging	Het

Other mutations in Vmn1r209

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01773:Vmn1r209	APN	13	22806280	missense	probably damaging	1.00
IGL01788:Vmn1r209	APN	13	22805662	missense	probably damaging	0.97
IGL02738:Vmn1r209	APN	13	22806120	nonsense	probably null
IGL03177:Vmn1r209	APN	13	22805854	missense	possibly damaging	0.46
IGL03199:Vmn1r209	APN	13	22806050	missense	possibly damaging	0.89
R0437:Vmn1r209	UTSW	13	22806356	missense	probably benign	0.01
R0497:Vmn1r209	UTSW	13	22805948	missense	probably damaging	1.00
R0506:Vmn1r209	UTSW	13	22805944	missense	probably damaging	0.98
R1496:Vmn1r209	UTSW	13	22805764	missense	probably damaging	1.00
R1644:Vmn1r209	UTSW	13	22806482	missense	possibly damaging	0.52
R1829:Vmn1r209	UTSW	13	22806239	missense	possibly damaging	0.95
R2360:Vmn1r209	UTSW	13	22805666	missense	probably damaging	1.00
R3434:Vmn1r209	UTSW	13	22806097	missense	probably benign	0.04
R3435:Vmn1r209	UTSW	13	22806097	missense	probably benign	0.04
R4082:Vmn1r209	UTSW	13	22805615	missense	probably null	0.15
R4451:Vmn1r209	UTSW	13	22806498	missense	probably benign	0.02
R4616:Vmn1r209	UTSW	13	22805965	missense	probably damaging	1.00
R4618:Vmn1r209	UTSW	13	22806449	missense	possibly damaging	0.87
R4801:Vmn1r209	UTSW	13	22805656	missense	probably damaging	1.00
R4802:Vmn1r209	UTSW	13	22805656	missense	probably damaging	1.00
R6035:Vmn1r209	UTSW	13	22806032	missense	probably benign	0.02
R6035:Vmn1r209	UTSW	13	22806032	missense	probably benign	0.02
R6908:Vmn1r209	UTSW	13	22806230	missense	possibly damaging	0.60
R7162:Vmn1r209	UTSW	13	22805958	missense	probably damaging	1.00
R7772:Vmn1r209	UTSW	13	22806494	missense	possibly damaging	0.77
R8328:Vmn1r209	UTSW	13	22806473	missense	probably benign	0.00
R8335:Vmn1r209	UTSW	13	22805807	missense	probably damaging	1.00
R8903:Vmn1r209	UTSW	13	22806514	missense	probably benign	0.00
R8932:Vmn1r209	UTSW	13	22806173	missense	probably damaging	1.00
R9307:Vmn1r209	UTSW	13	22805902	missense	probably damaging	0.98
R9343:Vmn1r209	UTSW	13	22806376	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGGAGGACACTTTGAGCAGC -3'
(R):5'- TTGCCAAAGACAGTAGCAGC -3'

Sequencing Primer
(F):5'- TCTCAGCTCAGGGGGAGTTC -3'
(R):5'- GGTTTGAGAAACTTCCTAGATGCC -3'

Posted On

2021-08-02