Incidental Mutation 'R8922:Clasp2'
ID 679344
Institutional Source Beutler Lab
Gene Symbol Clasp2
Ensembl Gene ENSMUSG00000033392
Gene Name CLIP associating protein 2
Synonyms CLASP2alpha, 1500004F14Rik, CLASP2gamma, CLASP2, CLASP2beta, 8030404L10Rik
MMRRC Submission 068767-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8922 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 113570541-113748750 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 113725728 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 790 (K790*)
Ref Sequence ENSEMBL: ENSMUSP00000107469 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000111838] [ENSMUST00000163895] [ENSMUST00000166734] [ENSMUST00000213663] [ENSMUST00000214522] [ENSMUST00000215022]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000111838
AA Change: K790*
SMART Domains Protein: ENSMUSP00000107469
Gene: ENSMUSG00000033392
AA Change: K790*

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 562 572 N/A INTRINSIC
low complexity region 614 634 N/A INTRINSIC
TOG 640 877 2.03e-1 SMART
low complexity region 995 1009 N/A INTRINSIC
TOG 1043 1274 1.49e-24 SMART
Predicted Effect probably null
Transcript: ENSMUST00000163895
AA Change: K811*
SMART Domains Protein: ENSMUSP00000128460
Gene: ENSMUSG00000033392
AA Change: K811*

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 583 593 N/A INTRINSIC
low complexity region 635 655 N/A INTRINSIC
TOG 661 898 2.03e-1 SMART
low complexity region 1016 1030 N/A INTRINSIC
TOG 1064 1295 1.49e-24 SMART
Predicted Effect probably null
Transcript: ENSMUST00000166734
AA Change: K791*
SMART Domains Protein: ENSMUSP00000130201
Gene: ENSMUSG00000033392
AA Change: K791*

DomainStartEndE-ValueType
TOG 90 323 1.17e-8 SMART
low complexity region 382 395 N/A INTRINSIC
low complexity region 459 472 N/A INTRINSIC
low complexity region 473 484 N/A INTRINSIC
low complexity region 562 572 N/A INTRINSIC
low complexity region 614 634 N/A INTRINSIC
TOG 640 878 7.51e-1 SMART
low complexity region 996 1010 N/A INTRINSIC
TOG 1044 1275 1.49e-24 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000213663
Predicted Effect probably null
Transcript: ENSMUST00000214522
AA Change: K808*
Predicted Effect probably benign
Transcript: ENSMUST00000215022
Meta Mutation Damage Score 0.9756 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency 100% (78/78)
MGI Phenotype PHENOTYPE: Targeted deletion of this gene leads to impaired formation of stable microtubules in a wound healing assay, and results in a 2-fold reduction of directionally persistent migration in mutant embryonic fibroblasts. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933402J07Rik A G 8: 88,295,177 (GRCm39) D105G possibly damaging Het
Abhd14b T C 9: 106,328,835 (GRCm39) probably null Het
Acot1 C T 12: 84,064,085 (GRCm39) Q398* probably null Het
Adam26b A T 8: 43,973,216 (GRCm39) D595E probably damaging Het
Aldh1l1 T A 6: 90,536,256 (GRCm39) F54I probably damaging Het
Arhgap33 C T 7: 30,223,417 (GRCm39) E871K probably damaging Het
Aspg A T 12: 112,089,830 (GRCm39) D456V possibly damaging Het
Cacna1b A C 2: 24,622,340 (GRCm39) S215A possibly damaging Het
Car3 A T 3: 14,931,952 (GRCm39) T108S Het
Ccdc91 C T 6: 147,412,358 (GRCm39) Q23* probably null Het
Cd300lg A T 11: 101,945,028 (GRCm39) I413F probably damaging Het
Ces2h T A 8: 105,744,756 (GRCm39) M378K probably benign Het
Cfap44 C T 16: 44,272,030 (GRCm39) T1261I probably benign Het
Cir1 G A 2: 73,118,053 (GRCm39) S164L possibly damaging Het
Cpne8 A T 15: 90,456,213 (GRCm39) D183E probably damaging Het
Dhrs13 A G 11: 77,923,425 (GRCm39) I48V possibly damaging Het
Dpp8 G T 9: 64,981,793 (GRCm39) V692L probably benign Het
Exoc2 A T 13: 31,055,838 (GRCm39) I660N probably benign Het
Exosc5 T C 7: 25,363,673 (GRCm39) V88A probably benign Het
Extl3 G A 14: 65,292,255 (GRCm39) T856I probably damaging Het
Flnc T C 6: 29,456,835 (GRCm39) V2277A probably damaging Het
Frmd8 A G 19: 5,923,295 (GRCm39) I52T probably benign Het
Gm8947 C T 1: 151,068,655 (GRCm39) R163C probably benign Het
Golga7 A T 8: 23,740,288 (GRCm39) C81S probably damaging Het
Grik1 A C 16: 87,693,167 (GRCm39) S879A unknown Het
Helz A G 11: 107,539,985 (GRCm39) T1002A possibly damaging Het
Hes1 T A 16: 29,884,725 (GRCm39) L62* probably null Het
Hmgn2-ps A G 8: 73,058,953 (GRCm39) S25P probably benign Het
Hnrnpdl A T 5: 100,184,419 (GRCm39) Y371* probably null Het
Ifna11 T C 4: 88,738,431 (GRCm39) V79A probably benign Het
Itga4 A G 2: 79,085,938 (GRCm39) probably benign Het
Kap T C 6: 133,827,054 (GRCm39) I110V probably benign Het
Lmbrd2 A G 15: 9,172,231 (GRCm39) K342E probably damaging Het
Lrba A G 3: 86,263,973 (GRCm39) D1549G probably damaging Het
Luzp1 C T 4: 136,270,233 (GRCm39) H819Y probably damaging Het
Mmp21 T A 7: 133,276,000 (GRCm39) probably benign Het
Mto1 T C 9: 78,377,928 (GRCm39) V590A probably benign Het
Myom3 T C 4: 135,492,222 (GRCm39) L122P probably damaging Het
Nat10 T C 2: 103,582,938 (GRCm39) Y161C probably damaging Het
Ncor2 A G 5: 125,163,939 (GRCm39) V197A unknown Het
Opn4 A C 14: 34,314,955 (GRCm39) S439R probably benign Het
Or12j3 T A 7: 139,953,389 (GRCm39) I45F possibly damaging Het
Or4c3d C A 2: 89,882,695 (GRCm39) probably benign Het
Or56a41 C A 7: 104,740,469 (GRCm39) V126L probably benign Het
Or5b12b A G 19: 12,861,458 (GRCm39) Y71C probably damaging Het
Or5p75-ps1 T A 7: 108,107,957 (GRCm39) D231E unknown Het
Pik3c2a G T 7: 116,017,659 (GRCm39) Q33K probably damaging Het
Pm20d1 G T 1: 131,728,853 (GRCm39) S93I possibly damaging Het
Pou3f1 C T 4: 124,552,176 (GRCm39) A226V possibly damaging Het
Ppl T C 16: 4,923,815 (GRCm39) E191G probably benign Het
Prkag1 T C 15: 98,712,147 (GRCm39) T208A probably benign Het
Rb1cc1 T C 1: 6,319,194 (GRCm39) I871T probably benign Het
Rhd T C 4: 134,612,627 (GRCm39) S293P probably damaging Het
Rprd2 G T 3: 95,687,896 (GRCm39) T252K probably damaging Het
Scn5a C A 9: 119,363,766 (GRCm39) R458L probably benign Het
Scrib C T 15: 75,933,587 (GRCm39) probably null Het
Sec24d G A 3: 123,144,488 (GRCm39) G655E probably damaging Het
Serpine3 A G 14: 62,910,503 (GRCm39) R199G probably benign Het
Sh2b1 TGGGGACCAGCTCAGCCACGGGGACCAGCTC TGGGGACCAGCTCAGCCACGGGGACCAGCTCAGCCACGGGGACCAGCTC 7: 126,066,742 (GRCm39) probably benign Het
Slc44a1 A G 4: 53,544,545 (GRCm39) K419E probably damaging Het
Speer4a3 C T 5: 26,156,594 (GRCm39) M128I possibly damaging Het
Styxl1 T C 5: 135,776,634 (GRCm39) E318G probably benign Het
Tcstv2a A G 13: 120,725,666 (GRCm39) E110G probably benign Het
Tesmin A G 19: 3,454,163 (GRCm39) K346E probably damaging Het
Thpo A T 16: 20,547,680 (GRCm39) L6Q unknown Het
Tlr2 T A 3: 83,745,075 (GRCm39) E336V probably benign Het
Tmem167b A G 3: 108,467,541 (GRCm39) L35P probably benign Het
Topaz1 A T 9: 122,625,101 (GRCm39) E1395D possibly damaging Het
Trim29 G T 9: 43,233,636 (GRCm39) R434L possibly damaging Het
Trim68 T C 7: 102,327,550 (GRCm39) I468V probably benign Het
Ttn C A 2: 76,542,628 (GRCm39) V33453F probably benign Het
Ubac1 A T 2: 25,896,621 (GRCm39) V298D probably damaging Het
Vmn1r185 C A 7: 26,310,825 (GRCm39) V227F probably damaging Het
Vmn1r21 T A 6: 57,820,829 (GRCm39) H205L probably damaging Het
Zbtb16 A G 9: 48,743,857 (GRCm39) Y152H probably benign Het
Zbtb20 A T 16: 43,397,968 (GRCm39) N19I probably damaging Het
Zfp438 A G 18: 5,213,422 (GRCm39) M512T possibly damaging Het
Other mutations in Clasp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00772:Clasp2 APN 9 113,735,060 (GRCm39) splice site probably benign
IGL00885:Clasp2 APN 9 113,740,484 (GRCm39) missense probably damaging 1.00
IGL01314:Clasp2 APN 9 113,735,195 (GRCm39) missense possibly damaging 0.89
IGL01344:Clasp2 APN 9 113,642,360 (GRCm39) splice site probably null
IGL01567:Clasp2 APN 9 113,709,164 (GRCm39) missense probably damaging 1.00
IGL02238:Clasp2 APN 9 113,709,088 (GRCm39) missense probably damaging 1.00
IGL02299:Clasp2 APN 9 113,709,057 (GRCm39) missense probably damaging 1.00
IGL02323:Clasp2 APN 9 113,697,794 (GRCm39) splice site probably benign
IGL02635:Clasp2 APN 9 113,737,910 (GRCm39) missense probably damaging 0.98
IGL02645:Clasp2 APN 9 113,719,129 (GRCm39) missense probably damaging 1.00
IGL02976:Clasp2 APN 9 113,735,204 (GRCm39) missense probably damaging 1.00
IGL03190:Clasp2 APN 9 113,673,208 (GRCm39) nonsense probably null
IGL03219:Clasp2 APN 9 113,677,545 (GRCm39) splice site probably benign
PIT4810001:Clasp2 UTSW 9 113,735,135 (GRCm39) missense probably damaging 1.00
R0067:Clasp2 UTSW 9 113,689,209 (GRCm39) splice site probably benign
R0067:Clasp2 UTSW 9 113,689,209 (GRCm39) splice site probably benign
R0421:Clasp2 UTSW 9 113,683,370 (GRCm39) missense probably benign 0.02
R0432:Clasp2 UTSW 9 113,738,487 (GRCm39) missense probably benign 0.00
R0458:Clasp2 UTSW 9 113,735,292 (GRCm39) splice site probably null
R0865:Clasp2 UTSW 9 113,740,568 (GRCm39) missense possibly damaging 0.57
R0972:Clasp2 UTSW 9 113,676,773 (GRCm39) missense possibly damaging 0.58
R1037:Clasp2 UTSW 9 113,725,702 (GRCm39) splice site probably benign
R1925:Clasp2 UTSW 9 113,735,265 (GRCm39) missense possibly damaging 0.88
R2015:Clasp2 UTSW 9 113,740,568 (GRCm39) missense possibly damaging 0.57
R2066:Clasp2 UTSW 9 113,735,225 (GRCm39) missense possibly damaging 0.86
R2330:Clasp2 UTSW 9 113,705,372 (GRCm39) missense probably damaging 1.00
R2568:Clasp2 UTSW 9 113,707,832 (GRCm39) missense probably benign
R3011:Clasp2 UTSW 9 113,730,581 (GRCm39) missense probably damaging 1.00
R3879:Clasp2 UTSW 9 113,719,029 (GRCm39) missense probably damaging 0.98
R3915:Clasp2 UTSW 9 113,737,805 (GRCm39) missense probably damaging 0.99
R3928:Clasp2 UTSW 9 113,735,173 (GRCm39) missense probably benign 0.28
R4323:Clasp2 UTSW 9 113,719,027 (GRCm39) missense possibly damaging 0.91
R4571:Clasp2 UTSW 9 113,676,789 (GRCm39) missense probably damaging 1.00
R4975:Clasp2 UTSW 9 113,732,984 (GRCm39) missense probably damaging 1.00
R5445:Clasp2 UTSW 9 113,733,014 (GRCm39) missense probably damaging 1.00
R5564:Clasp2 UTSW 9 113,641,836 (GRCm39) critical splice donor site probably null
R5697:Clasp2 UTSW 9 113,689,190 (GRCm39) missense probably benign 0.01
R5780:Clasp2 UTSW 9 113,679,220 (GRCm39) missense probably damaging 0.99
R5787:Clasp2 UTSW 9 113,691,310 (GRCm39) missense probably damaging 1.00
R6011:Clasp2 UTSW 9 113,705,315 (GRCm39) missense probably benign 0.07
R6026:Clasp2 UTSW 9 113,740,646 (GRCm39) missense probably benign 0.13
R6090:Clasp2 UTSW 9 113,681,803 (GRCm39) missense probably benign 0.06
R6262:Clasp2 UTSW 9 113,705,420 (GRCm39) critical splice donor site probably null
R6427:Clasp2 UTSW 9 113,721,512 (GRCm39) missense probably damaging 1.00
R6464:Clasp2 UTSW 9 113,602,785 (GRCm39) missense probably damaging 1.00
R6586:Clasp2 UTSW 9 113,642,332 (GRCm39) missense probably damaging 1.00
R6628:Clasp2 UTSW 9 113,725,788 (GRCm39) missense probably damaging 1.00
R6745:Clasp2 UTSW 9 113,704,338 (GRCm39) nonsense probably null
R7032:Clasp2 UTSW 9 113,683,391 (GRCm39) missense probably benign 0.04
R7165:Clasp2 UTSW 9 113,615,467 (GRCm39) splice site probably null
R7221:Clasp2 UTSW 9 113,681,825 (GRCm39) missense probably damaging 0.99
R7336:Clasp2 UTSW 9 113,705,421 (GRCm39) splice site probably null
R7583:Clasp2 UTSW 9 113,737,755 (GRCm39) missense probably benign 0.02
R7774:Clasp2 UTSW 9 113,677,804 (GRCm39) splice site probably null
R7895:Clasp2 UTSW 9 113,733,016 (GRCm39) missense probably benign 0.03
R8084:Clasp2 UTSW 9 113,676,823 (GRCm39) missense probably benign 0.16
R8109:Clasp2 UTSW 9 113,740,588 (GRCm39) missense probably damaging 1.00
R8171:Clasp2 UTSW 9 113,732,974 (GRCm39) missense possibly damaging 0.88
R8230:Clasp2 UTSW 9 113,721,482 (GRCm39) missense possibly damaging 0.73
R8810:Clasp2 UTSW 9 113,728,649 (GRCm39) missense probably damaging 1.00
R8879:Clasp2 UTSW 9 113,602,773 (GRCm39) missense probably benign 0.39
R8888:Clasp2 UTSW 9 113,732,936 (GRCm39) missense possibly damaging 0.54
R8889:Clasp2 UTSW 9 113,709,251 (GRCm39) missense probably damaging 1.00
R8892:Clasp2 UTSW 9 113,709,251 (GRCm39) missense probably damaging 1.00
R9042:Clasp2 UTSW 9 113,735,065 (GRCm39) missense probably benign
R9195:Clasp2 UTSW 9 113,671,045 (GRCm39) missense probably benign 0.06
R9355:Clasp2 UTSW 9 113,664,309 (GRCm39) missense probably damaging 1.00
R9481:Clasp2 UTSW 9 113,670,669 (GRCm39) missense probably damaging 1.00
R9502:Clasp2 UTSW 9 113,737,866 (GRCm39) missense probably benign 0.01
R9523:Clasp2 UTSW 9 113,705,372 (GRCm39) missense probably damaging 0.98
R9525:Clasp2 UTSW 9 113,740,677 (GRCm39) missense probably damaging 1.00
R9653:Clasp2 UTSW 9 113,670,993 (GRCm39) missense probably benign 0.01
R9699:Clasp2 UTSW 9 113,738,614 (GRCm39) critical splice donor site probably null
R9738:Clasp2 UTSW 9 113,590,665 (GRCm39) nonsense probably null
R9775:Clasp2 UTSW 9 113,725,740 (GRCm39) missense probably benign
X0022:Clasp2 UTSW 9 113,681,740 (GRCm39) missense probably damaging 1.00
Z1177:Clasp2 UTSW 9 113,599,289 (GRCm39) missense probably damaging 1.00
Z1177:Clasp2 UTSW 9 113,737,863 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GCTCATACTCTGGAAATGGAGTAAG -3'
(R):5'- GGCTCGTAGCTAACAAAAGAGC -3'

Sequencing Primer
(F):5'- TGGAAACAGGGTCCTCACCTC -3'
(R):5'- CTCTGTCGTCCAAGTGAT -3'
Posted On 2021-08-02