Incidental Mutation 'R8927:Or2a7'
ID 679592
Institutional Source Beutler Lab
Gene Symbol Or2a7
Ensembl Gene ENSMUSG00000043605
Gene Name olfactory receptor family 2 subfamily A member 7
Synonyms MOR261-6, GA_x6K02T2P3E9-4384160-4383228, Olfr13
MMRRC Submission 068771-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.437) question?
Stock # R8927 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 43150922-43151854 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 43151669 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 250 (F250L)
Ref Sequence ENSEMBL: ENSMUSP00000149893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059512] [ENSMUST00000205175] [ENSMUST00000216179]
AlphaFold P34984
Predicted Effect probably benign
Transcript: ENSMUST00000059512
AA Change: F250L

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000053813
Gene: ENSMUSG00000043605
AA Change: F250L

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 4.8e-60 PFAM
Pfam:7TM_GPCR_Srsx 34 218 1.3e-6 PFAM
Pfam:7tm_1 40 289 6e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205175
SMART Domains Protein: ENSMUSP00000145490
Gene: ENSMUSG00000071481

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 7.5e-60 PFAM
Pfam:7tm_1 40 289 3e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216179
AA Change: F250L

PolyPhen 2 Score 0.440 (Sensitivity: 0.89; Specificity: 0.90)
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik G A 9: 57,165,805 (GRCm39) R190* probably null Het
Aldh7a1 A T 18: 56,660,060 (GRCm39) S529T probably benign Het
Carmil2 T G 8: 106,415,130 (GRCm39) Y214* probably null Het
Ccdc136 A G 6: 29,406,109 (GRCm39) I152V probably damaging Het
Ccdc88c T C 12: 100,932,676 (GRCm39) D285G possibly damaging Het
Clec4a3 T A 6: 122,946,328 (GRCm39) F191I probably damaging Het
Dennd6b AGCTGGGGTCCCGC AGC 15: 89,069,780 (GRCm39) probably null Het
Dlg5 A T 14: 24,206,547 (GRCm39) S1222T Het
Dnaaf9 T A 2: 130,579,300 (GRCm39) R777* probably null Het
Dnah14 T G 1: 181,508,321 (GRCm39) L1833W probably damaging Het
Dsg2 T C 18: 20,725,535 (GRCm39) W549R probably damaging Het
Ezh2 A T 6: 47,510,713 (GRCm39) V632E possibly damaging Het
Fam83a G A 15: 57,873,313 (GRCm39) V381M probably benign Het
Fmo2 T C 1: 162,704,398 (GRCm39) T503A probably benign Het
Foxo1 T C 3: 52,252,703 (GRCm39) F289L probably damaging Het
Gckr A G 5: 31,456,903 (GRCm39) E96G probably damaging Het
Gm18596 G A 10: 77,578,162 (GRCm39) A104V unknown Het
Gm21680 A T 5: 26,176,347 (GRCm39) N83K probably damaging Het
Gnb5 T C 9: 75,252,236 (GRCm39) V393A possibly damaging Het
Grin2b T G 6: 135,749,339 (GRCm39) Q621P probably damaging Het
Gtsf2 T C 15: 103,352,783 (GRCm39) I79V probably benign Het
Itga1 T C 13: 115,105,055 (GRCm39) I1040V probably benign Het
Kif2b C T 11: 91,468,023 (GRCm39) E87K probably benign Het
Klk1b8 G A 7: 43,604,206 (GRCm39) G225S probably damaging Het
L3mbtl3 A T 10: 26,220,084 (GRCm39) C94S unknown Het
Man2c1 T G 9: 57,048,456 (GRCm39) Y872* probably null Het
Mical3 T A 6: 120,984,325 (GRCm39) M832L probably benign Het
Mrc2 A G 11: 105,216,334 (GRCm39) D41G probably benign Het
Nedd1 T A 10: 92,558,258 (GRCm39) probably benign Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Notch3 C T 17: 32,372,792 (GRCm39) R593Q probably benign Het
Nxpe3 T G 16: 55,669,997 (GRCm39) E369D possibly damaging Het
Obscn T A 11: 58,977,695 (GRCm39) T1802S possibly damaging Het
Or1e33 A T 11: 73,738,406 (GRCm39) F182I probably benign Het
Or4k51 A T 2: 111,585,107 (GRCm39) H171L probably benign Het
Or9s14 A G 1: 92,536,438 (GRCm39) N293S probably damaging Het
Oscar A C 7: 3,614,747 (GRCm39) V75G probably benign Het
Pcdhb17 G A 18: 37,620,372 (GRCm39) A721T probably benign Het
Pcnx2 T C 8: 126,614,659 (GRCm39) Y264C probably benign Het
Pear1 G T 3: 87,661,890 (GRCm39) A495D probably damaging Het
Plekhf1 C A 7: 37,920,998 (GRCm39) R190L probably damaging Het
Plppr5 T C 3: 117,369,532 (GRCm39) V63A probably benign Het
Pyroxd1 T A 6: 142,300,437 (GRCm39) F189Y probably damaging Het
Rab13 C T 3: 90,128,120 (GRCm39) probably benign Het
Rptor C T 11: 119,782,036 (GRCm39) T1121I probably benign Het
Scgb2b7 T C 7: 31,404,602 (GRCm39) S33G probably benign Het
Slc25a36 A G 9: 96,982,126 (GRCm39) probably null Het
Smtn T A 11: 3,479,477 (GRCm39) H530L possibly damaging Het
Srrt C T 5: 137,297,070 (GRCm39) C411Y probably benign Het
Stag1 C A 9: 100,587,298 (GRCm39) P7Q possibly damaging Het
Tarm1 G A 7: 3,537,719 (GRCm39) T248I possibly damaging Het
Tektl1 T C 10: 78,588,258 (GRCm39) Y184C probably damaging Het
Trim6 C T 7: 103,881,655 (GRCm39) A328V probably benign Het
Vmn1r189 T C 13: 22,286,811 (GRCm39) I9V probably benign Het
Vmn2r93 A G 17: 18,546,500 (GRCm39) T791A probably damaging Het
Vsig10l A G 7: 43,116,020 (GRCm39) T454A probably benign Het
Other mutations in Or2a7
AlleleSourceChrCoordTypePredicted EffectPPH Score
N/A - 293:Or2a7 UTSW 6 43,151,493 (GRCm39) missense probably benign 0.45
R0279:Or2a7 UTSW 6 43,151,692 (GRCm39) missense probably benign 0.03
R0594:Or2a7 UTSW 6 43,151,541 (GRCm39) missense possibly damaging 0.64
R0669:Or2a7 UTSW 6 43,150,938 (GRCm39) missense probably benign 0.36
R1339:Or2a7 UTSW 6 43,151,544 (GRCm39) missense probably benign 0.39
R1371:Or2a7 UTSW 6 43,151,234 (GRCm39) missense probably benign 0.01
R1669:Or2a7 UTSW 6 43,151,755 (GRCm39) missense probably damaging 1.00
R1832:Or2a7 UTSW 6 43,151,834 (GRCm39) missense probably benign
R2136:Or2a7 UTSW 6 43,151,435 (GRCm39) missense probably benign
R4358:Or2a7 UTSW 6 43,151,160 (GRCm39) missense probably damaging 0.97
R4755:Or2a7 UTSW 6 43,150,977 (GRCm39) missense probably benign 0.00
R4933:Or2a7 UTSW 6 43,151,255 (GRCm39) missense probably benign 0.22
R5504:Or2a7 UTSW 6 43,151,572 (GRCm39) nonsense probably null
R5677:Or2a7 UTSW 6 43,151,265 (GRCm39) missense probably benign 0.35
R5917:Or2a7 UTSW 6 43,151,646 (GRCm39) missense probably damaging 1.00
R6287:Or2a7 UTSW 6 43,151,369 (GRCm39) missense probably benign 0.00
R6480:Or2a7 UTSW 6 43,151,000 (GRCm39) missense probably benign 0.05
R7020:Or2a7 UTSW 6 43,151,096 (GRCm39) missense possibly damaging 0.91
R7240:Or2a7 UTSW 6 43,151,435 (GRCm39) missense probably benign
R8925:Or2a7 UTSW 6 43,151,669 (GRCm39) missense probably benign 0.44
R9652:Or2a7 UTSW 6 43,150,991 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TCAATGAGACGATGGTCCTGG -3'
(R):5'- GGGTAGCATTCTCTGTCACAGTG -3'

Sequencing Primer
(F):5'- ACGATGGTCCTGGCTGGG -3'
(R):5'- CTCTGTCACAGTGAAAACATGATGC -3'
Posted On 2021-08-02