Incidental Mutation 'R8928:Mtcl1'
| ID |
679713 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mtcl1
|
| Ensembl Gene |
ENSMUSG00000052105 |
| Gene Name |
microtubule crosslinking factor 1 |
| Synonyms |
1110012J17Rik, Soga2, t8219b25 |
| MMRRC Submission |
068772-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.154)
|
| Stock # |
R8928 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
66643977-66756745 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 66755628 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Lysine
at position 238
(I238K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000083899
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000086693]
[ENSMUST00000097291]
|
| AlphaFold |
Q3UHU5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000086693
AA Change: I238K
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000083899
Gene: ENSMUSG00000052105
AA Change: I238K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
166 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
SCOP:d1fxkc_
|
332 |
466 |
3e-7 |
SMART |
|
Blast:BRLZ
|
339 |
362 |
1e-5 |
BLAST |
|
Pfam:DUF3166
|
493 |
587 |
1.8e-34 |
PFAM |
|
Pfam:DUF3166
|
622 |
714 |
3.8e-39 |
PFAM |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1120 |
1159 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
1220 |
1344 |
3e-40 |
PFAM |
|
low complexity region
|
1464 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1672 |
1681 |
N/A |
INTRINSIC |
|
low complexity region
|
1912 |
1924 |
N/A |
INTRINSIC |
|
low complexity region
|
1931 |
1943 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000097291
AA Change: I238K
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000094894
Gene: ENSMUSG00000052105
AA Change: I238K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
42 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
98 |
N/A |
INTRINSIC |
|
low complexity region
|
99 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
127 |
132 |
N/A |
INTRINSIC |
|
low complexity region
|
166 |
183 |
N/A |
INTRINSIC |
|
low complexity region
|
240 |
259 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
290 |
N/A |
INTRINSIC |
|
SCOP:d1fxkc_
|
332 |
466 |
3e-7 |
SMART |
|
Blast:BRLZ
|
339 |
362 |
1e-5 |
BLAST |
|
Pfam:DUF3166
|
492 |
588 |
1.8e-43 |
PFAM |
|
Pfam:DUF3166
|
621 |
716 |
5e-19 |
PFAM |
|
low complexity region
|
843 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
910 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1049 |
1062 |
N/A |
INTRINSIC |
|
coiled coil region
|
1120 |
1159 |
N/A |
INTRINSIC |
|
Pfam:DUF4482
|
1220 |
1392 |
3.9e-49 |
PFAM |
|
low complexity region
|
1464 |
1476 |
N/A |
INTRINSIC |
|
low complexity region
|
1672 |
1681 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Global or Purkinje cell-specific homozygous knockout affects Purkinje cell axon and dendrite morphology, resulting in abnormal motor function. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A630089N07Rik |
A |
T |
16: 97,867,367 (GRCm39) |
H198Q |
probably damaging |
Het |
| Abcb9 |
T |
C |
5: 124,221,706 (GRCm39) |
T223A |
probably benign |
Het |
| Actc1 |
T |
A |
2: 113,880,881 (GRCm39) |
K115* |
probably null |
Het |
| Angptl2 |
G |
A |
2: 33,132,316 (GRCm39) |
D308N |
probably benign |
Het |
| Arl4d |
A |
C |
11: 101,557,892 (GRCm39) |
Q139H |
possibly damaging |
Het |
| Aspm |
T |
A |
1: 139,418,125 (GRCm39) |
C2951* |
probably null |
Het |
| Atp23 |
A |
T |
10: 126,723,362 (GRCm39) |
*247R |
probably null |
Het |
| B3gnt7 |
T |
A |
1: 86,232,839 (GRCm39) |
S28R |
probably benign |
Het |
| Blm |
GCCTCCTCCTCCTCCTCCTCCTCCTCCTCC |
GCCTCCTCCTCCTCCTCCTCCTCCTCC |
7: 80,162,652 (GRCm39) |
|
probably benign |
Het |
| Bmp7 |
C |
T |
2: 172,721,211 (GRCm39) |
R288H |
probably damaging |
Het |
| Bsdc1 |
G |
T |
4: 129,355,439 (GRCm39) |
|
probably benign |
Het |
| Ccdc146 |
T |
C |
5: 21,538,060 (GRCm39) |
E88G |
probably damaging |
Het |
| Ccdc73 |
C |
A |
2: 104,822,542 (GRCm39) |
D2E |
|
Het |
| Cdc5l |
C |
A |
17: 45,721,839 (GRCm39) |
R477L |
|
Het |
| Cdh22 |
T |
A |
2: 164,965,504 (GRCm39) |
H529L |
possibly damaging |
Het |
| Chchd3 |
T |
A |
6: 32,780,951 (GRCm39) |
E178D |
probably benign |
Het |
| Ciz1 |
A |
T |
2: 32,257,512 (GRCm39) |
R186* |
probably null |
Het |
| Copa |
T |
A |
1: 171,931,737 (GRCm39) |
H329Q |
probably null |
Het |
| Dcaf7 |
A |
G |
11: 105,942,752 (GRCm39) |
D233G |
probably damaging |
Het |
| Dclk2 |
G |
T |
3: 86,739,048 (GRCm39) |
P317Q |
probably damaging |
Het |
| Dsc3 |
A |
T |
18: 20,107,234 (GRCm39) |
H462Q |
probably benign |
Het |
| Fn1 |
T |
C |
1: 71,638,535 (GRCm39) |
N1998S |
probably benign |
Het |
| Fpr2 |
T |
C |
17: 18,113,724 (GRCm39) |
L240S |
possibly damaging |
Het |
| Fzd9 |
A |
T |
5: 135,278,589 (GRCm39) |
M432K |
probably damaging |
Het |
| Gm5862 |
T |
A |
5: 26,226,678 (GRCm39) |
I75F |
probably damaging |
Het |
| Gpr45 |
T |
A |
1: 43,072,314 (GRCm39) |
V319D |
probably damaging |
Het |
| H4c11 |
T |
C |
13: 21,919,525 (GRCm39) |
V87A |
possibly damaging |
Het |
| Igfn1 |
T |
A |
1: 135,905,984 (GRCm39) |
R275W |
probably damaging |
Het |
| Inafm1 |
G |
A |
7: 16,006,980 (GRCm39) |
A79V |
unknown |
Het |
| Itfg1 |
C |
T |
8: 86,567,420 (GRCm39) |
|
probably benign |
Het |
| Klhl35 |
T |
G |
7: 99,120,221 (GRCm39) |
I366S |
probably damaging |
Het |
| Lysmd1 |
A |
T |
3: 95,045,831 (GRCm39) |
I223F |
probably damaging |
Het |
| Mrps30 |
A |
G |
13: 118,523,205 (GRCm39) |
L189P |
probably damaging |
Het |
| Ms4a4d |
A |
C |
19: 11,533,574 (GRCm39) |
T152P |
probably benign |
Het |
| Musk |
T |
C |
4: 58,301,638 (GRCm39) |
I132T |
probably damaging |
Het |
| Myh2 |
A |
T |
11: 67,079,509 (GRCm39) |
M989L |
probably benign |
Het |
| Myh8 |
G |
A |
11: 67,174,081 (GRCm39) |
R172H |
probably benign |
Het |
| Nt5c1a |
C |
T |
4: 123,102,281 (GRCm39) |
T69M |
possibly damaging |
Het |
| Nuak2 |
T |
A |
1: 132,255,916 (GRCm39) |
D196E |
probably damaging |
Het |
| Or52h7 |
A |
T |
7: 104,214,229 (GRCm39) |
H267L |
probably damaging |
Het |
| Or5ap2 |
A |
T |
2: 85,679,918 (GRCm39) |
I41F |
possibly damaging |
Het |
| Or5t7 |
T |
C |
2: 86,507,630 (GRCm39) |
T16A |
probably benign |
Het |
| Or8k53 |
T |
C |
2: 86,178,090 (GRCm39) |
T7A |
possibly damaging |
Het |
| Palb2 |
A |
T |
7: 121,723,821 (GRCm39) |
C643S |
probably damaging |
Het |
| Pde5a |
T |
A |
3: 122,633,249 (GRCm39) |
I706N |
probably damaging |
Het |
| Pdlim4 |
T |
C |
11: 53,950,790 (GRCm39) |
R100G |
probably benign |
Het |
| Pip5k1c |
T |
A |
10: 81,128,906 (GRCm39) |
V5E |
possibly damaging |
Het |
| Pira1 |
A |
C |
7: 3,742,358 (GRCm39) |
N56K |
probably benign |
Het |
| Plekhm1 |
A |
G |
11: 103,268,039 (GRCm39) |
V644A |
probably benign |
Het |
| Plk2 |
T |
G |
13: 110,535,750 (GRCm39) |
V524G |
probably damaging |
Het |
| Ppl |
T |
A |
16: 4,905,474 (GRCm39) |
N1607I |
probably benign |
Het |
| Prag1 |
T |
G |
8: 36,614,360 (GRCm39) |
V1304G |
probably damaging |
Het |
| Prex1 |
C |
T |
2: 166,426,995 (GRCm39) |
V1077M |
probably damaging |
Het |
| Prmt6 |
T |
C |
3: 110,158,248 (GRCm39) |
S14G |
probably benign |
Het |
| Psrc1 |
T |
G |
3: 108,293,973 (GRCm39) |
S263R |
probably damaging |
Het |
| Qrfprl |
C |
A |
6: 65,358,597 (GRCm39) |
S107* |
probably null |
Het |
| Rbp7 |
A |
T |
4: 149,537,958 (GRCm39) |
L36* |
probably null |
Het |
| Rgs12 |
G |
T |
5: 35,123,633 (GRCm39) |
W472L |
possibly damaging |
Het |
| Rrp8 |
C |
A |
7: 105,384,073 (GRCm39) |
C143F |
possibly damaging |
Het |
| Sart1 |
T |
C |
19: 5,438,529 (GRCm39) |
S43G |
probably benign |
Het |
| Setx |
A |
G |
2: 29,016,971 (GRCm39) |
T25A |
possibly damaging |
Het |
| Skint5 |
G |
A |
4: 113,341,099 (GRCm39) |
T1414I |
probably benign |
Het |
| Sorbs2 |
T |
A |
8: 46,248,952 (GRCm39) |
S734R |
probably damaging |
Het |
| Spata31g1 |
A |
T |
4: 42,972,251 (GRCm39) |
Y528F |
probably benign |
Het |
| Spon1 |
T |
C |
7: 113,629,592 (GRCm39) |
|
probably null |
Het |
| Sptbn1 |
C |
T |
11: 30,088,962 (GRCm39) |
V767I |
probably damaging |
Het |
| Srf |
T |
C |
17: 46,860,095 (GRCm39) |
I477V |
probably damaging |
Het |
| Tanc2 |
A |
G |
11: 105,701,331 (GRCm39) |
Y282C |
probably damaging |
Het |
| Tbc1d23 |
A |
G |
16: 56,992,152 (GRCm39) |
Y603H |
probably damaging |
Het |
| Tdpoz6 |
T |
A |
3: 93,599,950 (GRCm39) |
T140S |
probably benign |
Het |
| Tfap4 |
T |
C |
16: 4,369,218 (GRCm39) |
D134G |
probably damaging |
Het |
| Tmem200c |
A |
G |
17: 69,148,733 (GRCm39) |
T439A |
probably benign |
Het |
| Tmem63b |
A |
T |
17: 45,975,908 (GRCm39) |
M515K |
probably damaging |
Het |
| Tnc |
A |
T |
4: 63,925,595 (GRCm39) |
N980K |
probably damaging |
Het |
| Ttc23l |
T |
A |
15: 10,530,720 (GRCm39) |
L297F |
probably damaging |
Het |
| Vinac1 |
A |
G |
2: 128,882,789 (GRCm39) |
S76P |
|
Het |
| Vmn1r170 |
A |
G |
7: 23,305,814 (GRCm39) |
N72S |
possibly damaging |
Het |
| Vmn2r8 |
T |
C |
5: 108,950,131 (GRCm39) |
M239V |
|
Het |
| Vopp1 |
A |
G |
6: 57,731,578 (GRCm39) |
F138L |
probably damaging |
Het |
| Vps41 |
T |
A |
13: 18,929,501 (GRCm39) |
F79I |
probably benign |
Het |
| Zfp317 |
T |
C |
9: 19,552,521 (GRCm39) |
M1T |
probably null |
Het |
|
| Other mutations in Mtcl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Mtcl1
|
APN |
17 |
66,651,314 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01774:Mtcl1
|
APN |
17 |
66,692,880 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01918:Mtcl1
|
APN |
17 |
66,675,263 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL02000:Mtcl1
|
APN |
17 |
66,661,185 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02074:Mtcl1
|
APN |
17 |
66,673,463 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02338:Mtcl1
|
APN |
17 |
66,686,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02597:Mtcl1
|
APN |
17 |
66,645,016 (GRCm39) |
missense |
probably benign |
|
|
IGL03034:Mtcl1
|
APN |
17 |
66,651,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Mtcl1
|
APN |
17 |
66,686,378 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03184:Mtcl1
|
APN |
17 |
66,661,209 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03240:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03294:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03332:Mtcl1
|
APN |
17 |
66,645,014 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Mtcl1
|
UTSW |
17 |
66,745,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4520001:Mtcl1
|
UTSW |
17 |
66,692,907 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R0110:Mtcl1
|
UTSW |
17 |
66,665,109 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R0113:Mtcl1
|
UTSW |
17 |
66,661,237 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0321:Mtcl1
|
UTSW |
17 |
66,686,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0366:Mtcl1
|
UTSW |
17 |
66,645,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0629:Mtcl1
|
UTSW |
17 |
66,645,137 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1466:Mtcl1
|
UTSW |
17 |
66,687,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Mtcl1
|
UTSW |
17 |
66,687,430 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Mtcl1
|
UTSW |
17 |
66,755,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Mtcl1
|
UTSW |
17 |
66,755,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1471:Mtcl1
|
UTSW |
17 |
66,686,143 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1650:Mtcl1
|
UTSW |
17 |
66,692,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1754:Mtcl1
|
UTSW |
17 |
66,687,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Mtcl1
|
UTSW |
17 |
66,686,509 (GRCm39) |
missense |
probably benign |
|
|
R1882:Mtcl1
|
UTSW |
17 |
66,686,315 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1935:Mtcl1
|
UTSW |
17 |
66,686,409 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2063:Mtcl1
|
UTSW |
17 |
66,653,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Mtcl1
|
UTSW |
17 |
66,650,618 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2197:Mtcl1
|
UTSW |
17 |
66,673,427 (GRCm39) |
missense |
probably benign |
|
|
R3196:Mtcl1
|
UTSW |
17 |
66,650,829 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3877:Mtcl1
|
UTSW |
17 |
66,649,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4116:Mtcl1
|
UTSW |
17 |
66,673,476 (GRCm39) |
missense |
probably benign |
|
|
R4204:Mtcl1
|
UTSW |
17 |
66,745,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4373:Mtcl1
|
UTSW |
17 |
66,687,074 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4396:Mtcl1
|
UTSW |
17 |
66,651,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4591:Mtcl1
|
UTSW |
17 |
66,655,506 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4610:Mtcl1
|
UTSW |
17 |
66,684,882 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4681:Mtcl1
|
UTSW |
17 |
66,756,139 (GRCm39) |
missense |
unknown |
|
|
R4922:Mtcl1
|
UTSW |
17 |
66,655,474 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4992:Mtcl1
|
UTSW |
17 |
66,649,834 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5169:Mtcl1
|
UTSW |
17 |
66,650,818 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5542:Mtcl1
|
UTSW |
17 |
66,691,354 (GRCm39) |
intron |
probably benign |
|
|
R5804:Mtcl1
|
UTSW |
17 |
66,650,132 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5998:Mtcl1
|
UTSW |
17 |
66,675,275 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6163:Mtcl1
|
UTSW |
17 |
66,686,326 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6191:Mtcl1
|
UTSW |
17 |
66,650,521 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6254:Mtcl1
|
UTSW |
17 |
66,665,129 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6260:Mtcl1
|
UTSW |
17 |
66,650,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6524:Mtcl1
|
UTSW |
17 |
66,655,280 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6884:Mtcl1
|
UTSW |
17 |
66,745,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7199:Mtcl1
|
UTSW |
17 |
66,647,534 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7431:Mtcl1
|
UTSW |
17 |
66,649,901 (GRCm39) |
nonsense |
probably null |
|
|
R7479:Mtcl1
|
UTSW |
17 |
66,686,485 (GRCm39) |
missense |
probably benign |
|
|
R7564:Mtcl1
|
UTSW |
17 |
66,678,322 (GRCm39) |
missense |
probably benign |
|
|
R7608:Mtcl1
|
UTSW |
17 |
66,650,300 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7691:Mtcl1
|
UTSW |
17 |
66,687,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7847:Mtcl1
|
UTSW |
17 |
66,651,328 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7908:Mtcl1
|
UTSW |
17 |
66,678,325 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8262:Mtcl1
|
UTSW |
17 |
66,650,653 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8324:Mtcl1
|
UTSW |
17 |
66,743,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8477:Mtcl1
|
UTSW |
17 |
66,684,942 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8927:Mtcl1
|
UTSW |
17 |
66,755,628 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9016:Mtcl1
|
UTSW |
17 |
66,651,062 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9048:Mtcl1
|
UTSW |
17 |
66,678,331 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9059:Mtcl1
|
UTSW |
17 |
66,650,606 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9221:Mtcl1
|
UTSW |
17 |
66,650,879 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9327:Mtcl1
|
UTSW |
17 |
66,645,130 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9398:Mtcl1
|
UTSW |
17 |
66,755,462 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9762:Mtcl1
|
UTSW |
17 |
66,673,347 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0065:Mtcl1
|
UTSW |
17 |
66,686,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Mtcl1
|
UTSW |
17 |
66,650,723 (GRCm39) |
missense |
probably benign |
0.20 |
|
Z1176:Mtcl1
|
UTSW |
17 |
66,686,455 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Mtcl1
|
UTSW |
17 |
66,651,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AACATCCTCCTGAGAACCGG -3'
(R):5'- TTCCTCAAGGACCTGCACAC -3'
Sequencing Primer
(F):5'- TCCTGAGAACCGGGTCCC -3'
(R):5'- TAGCCTTGCCGGGAAGG -3'
|
| Posted On |
2021-08-02 |
Incidental Mutation