Mutagenetix > Incidental Mutation

Incidental Mutation 'R8899:Olfr918'

679846

Institutional Source

Beutler Lab

Gene Symbol

Olfr918

Ensembl Gene

ENSMUSG00000046150

Gene Name

olfactory receptor 918

Synonyms

GA_x6K02T2PVTD-32375756-32374818, MOR164-3

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.139) question?

Stock #

R8899 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

38669861-38674601 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 38672851 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 198 (V198I)

Ref Sequence

ENSEMBL: ENSMUSP00000150182 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055099] [ENSMUST00000215461]

AlphaFold

E9PVZ7

Predicted Effect

probably damaging
Transcript: ENSMUST00000055099
AA Change: V211I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000057210
Gene: ENSMUSG00000046150
AA Change: V211I

Domain	Start	End	E-Value	Type
transmembrane domain	9	31	N/A	INTRINSIC
Pfam:7tm_4	44	319	6.5e-48	PFAM
Pfam:7tm_1	54	301	3.9e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000215461
AA Change: V198I

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

Meta Mutation Damage Score

0.4709

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.4%

Validation Efficiency

100% (70/70)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4932438A13Rik	T	C	3: 36,988,280	I2805T	probably damaging	Het
Agxt2	A	T	15: 10,378,814	N167I	probably damaging	Het
Arel1	A	G	12: 84,934,243	I330T	probably benign	Het
Ate1	T	C	7: 130,394,659	K484E	possibly damaging	Het
Atl2	T	C	17: 79,876,040	D42G	probably benign	Het
Cd209e	C	T	8: 3,851,212	W147*	probably null	Het
Cdc40	G	A	10: 40,841,813	Q365*	probably null	Het
Cenpe	A	G	3: 135,239,883	T1053A	probably benign	Het
Colgalt1	T	C	8: 71,623,662	S586P	probably damaging	Het
Crem	A	G	18: 3,295,370	I91T	probably damaging	Het
Csrnp3	G	A	2: 66,022,643	V460I	possibly damaging	Het
Cul1	T	A	6: 47,497,312	I136N	possibly damaging	Het
Ddx19b	A	T	8: 111,011,297	I273N	probably damaging	Het
Fap	A	G	2: 62,518,473	I505T	probably damaging	Het
Fbxo44	A	T	4: 148,153,621	Y216*	probably null	Het
Fbxw10	T	A	11: 62,857,741	M398K	probably damaging	Het
Fut10	T	C	8: 31,236,486	V423A	possibly damaging	Het
Fyco1	A	C	9: 123,826,581	D1037E	probably benign	Het
Gabrg2	G	A	11: 41,976,550	R81*	probably null	Het
Gcn1l1	T	C	5: 115,579,161	V204A	probably benign	Het
Gm5615	A	T	9: 36,534,958	C53S	probably damaging	Het
Gnl1	T	C	17: 35,988,716	L593P	probably damaging	Het
Grm4	T	C	17: 27,434,780	Q732R	probably damaging	Het
Icam5	T	C	9: 21,037,119	V741A	possibly damaging	Het
Iqub	C	T	6: 24,505,769	E47K	probably benign	Het
Kcnk3	A	G	5: 30,622,236	K210R	probably benign	Het
Kdm2b	T	A	5: 122,987,788	R12*	probably null	Het
Kif1bp	T	C	10: 62,563,503		probably benign	Het
Kndc1	C	T	7: 139,927,795	S1222F	possibly damaging	Het
Lgi1	C	T	19: 38,306,090	H413Y	probably damaging	Het
Lhx8	A	G	3: 154,328,016	Y51H	probably damaging	Het
Lim2	T	C	7: 43,433,631	I80T	probably benign	Het
Macf1	A	G	4: 123,475,059	F405L	probably benign	Het
Mefv	G	A	16: 3,710,900	T559I	probably damaging	Het
Nin	A	G	12: 70,030,936	W1739R	probably damaging	Het
Olfr1101	A	G	2: 86,988,366	I270T	probably benign	Het
Olfr239	A	T	17: 33,199,744	K232M	probably damaging	Het
Olfr736	T	C	14: 50,392,812	F19L	probably damaging	Het
Otop3	T	C	11: 115,341,060		probably null	Het
Pip5kl1	A	G	2: 32,579,070	I247V	probably benign	Het
Polr2d	T	A	18: 31,789,173	M1K	probably null	Het
Prss53	T	C	7: 127,889,021	T141A	possibly damaging	Het
Rdh12	A	G	12: 79,222,028	N293S	probably benign	Het
Rnf146	G	A	10: 29,347,758	T44I	probably benign	Het
Rsbn1l	A	T	5: 20,896,867	C588S	probably damaging	Het
Sept8	G	A	11: 53,536,035	V208I	probably damaging	Het
Sgo2a	T	G	1: 58,019,663	S1134A	possibly damaging	Het
Sh3bp4	C	T	1: 89,145,575	T715I	probably benign	Het
Snrnp200	A	G	2: 127,236,597	T1758A	probably damaging	Het
Snx6	A	T	12: 54,765,638	D70E	probably benign	Het
Spag9	T	C	11: 94,092,869	S341P	probably damaging	Het
Sparcl1	T	C	5: 104,092,724	D278G	probably benign	Het
Srbd1	T	A	17: 85,985,457	S895C		Het
Stxbp5l	ATTTT	ATTTTT	16: 37,216,052		probably null	Het
Tas2r136	T	C	6: 132,777,360	D268G	probably benign	Het
Tas2r143	T	A	6: 42,400,954	Y239*	probably null	Het
Tbc1d17	C	T	7: 44,842,904	G419D	probably damaging	Het
Tff2	C	T	17: 31,143,139	W68*	probably null	Het
Thegl	T	A	5: 77,037,353		probably null	Het
Thop1	T	C	10: 81,080,606	C483R	probably damaging	Het
Tmem245	A	C	4: 56,903,916		probably null	Het
Tmem67	A	G	4: 12,055,038	F655S	probably damaging	Het
Trim36	T	G	18: 46,169,197	S583R	possibly damaging	Het
Ucp1	T	C	8: 83,290,587	V2A	probably benign	Het
Ugt1a6a	T	A	1: 88,139,081	M203K	probably damaging	Het
Usp1	A	G	4: 98,931,110	K270E	probably damaging	Het
Vps13c	T	C	9: 67,934,501	F1935S	probably damaging	Het
Zfp521	C	A	18: 13,846,080	L425F	probably damaging	Het
Zfp799	G	T	17: 32,820,374	P306Q	probably damaging	Het
Zfp831	A	T	2: 174,644,185	R218W	probably damaging	Het

Other mutations in Olfr918

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00958:Olfr918	APN	9	38673024	missense	probably benign	0.01
IGL01388:Olfr918	APN	9	38673083	nonsense	probably null
IGL01516:Olfr918	APN	9	38672863	missense	probably benign	0.09
IGL02121:Olfr918	APN	9	38673415	missense	probably damaging	0.98
IGL02209:Olfr918	APN	9	38673046	missense	possibly damaging	0.84
IGL02256:Olfr918	APN	9	38673480	start codon destroyed	probably null
IGL02517:Olfr918	APN	9	38672913	missense	probably damaging	1.00
IGL02648:Olfr918	APN	9	38673016	missense	probably benign
IGL02747:Olfr918	APN	9	38673084	missense	probably benign	0.11
IGL02971:Olfr918	APN	9	38673268	missense	probably damaging	0.96
E0370:Olfr918	UTSW	9	38672561	missense	probably damaging	0.99
R0616:Olfr918	UTSW	9	38673480	start codon destroyed	probably null
R2173:Olfr918	UTSW	9	38672944	missense	probably benign	0.03
R2989:Olfr918	UTSW	9	38672535	missense	probably benign
R3430:Olfr918	UTSW	9	38673139	missense	probably damaging	1.00
R3809:Olfr918	UTSW	9	38672863	missense	probably benign	0.09
R4688:Olfr918	UTSW	9	38673363	missense	probably damaging	1.00
R4702:Olfr918	UTSW	9	38673480	start codon destroyed	probably null
R5548:Olfr918	UTSW	9	38673304	missense	probably benign	0.00
R5590:Olfr918	UTSW	9	38672965	missense	probably damaging	1.00
R6082:Olfr918	UTSW	9	38672570	missense	probably damaging	1.00
R6214:Olfr918	UTSW	9	38673214	missense	probably benign	0.13
R6215:Olfr918	UTSW	9	38673214	missense	probably benign	0.13
R6893:Olfr918	UTSW	9	38673059	missense	possibly damaging	0.95
R7215:Olfr918	UTSW	9	38673447	missense	probably benign	0.05
R7624:Olfr918	UTSW	9	38672623	missense	probably benign	0.18
R7862:Olfr918	UTSW	9	38673328	missense	probably benign	0.01
R8116:Olfr918	UTSW	9	38673168	missense	possibly damaging	0.93
R8897:Olfr918	UTSW	9	38672851	missense	probably damaging	1.00
R9114:Olfr918	UTSW	9	38672596	missense	probably benign
R9293:Olfr918	UTSW	9	38673118	missense	probably damaging	1.00
R9311:Olfr918	UTSW	9	38672629	missense	probably damaging	1.00
R9690:Olfr918	UTSW	9	38673181	nonsense	probably null
R9734:Olfr918	UTSW	9	38672943	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TACATGAATGCCCCTGACCC -3'
(R):5'- TAGCCATCTGTAATCCACTGC -3'

Sequencing Primer
(F):5'- AATGTGAGAGCTGCAGGT -3'
(R):5'- CACTGCTGTATAAGGTCACCATG -3'

Posted On

2021-08-31