Mutagenetix > Incidental Mutation

Incidental Mutation 'R8900:Cdcp3'

679907

Institutional Source

Beutler Lab

Gene Symbol

Cdcp3

Ensembl Gene

ENSMUSG00000006204

Gene Name

CUB domain containing protein 3

Synonyms

5430419D17Rik

MMRRC Submission

068757-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8900 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

130776131-130908180 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to T at 130904197 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000130971 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000124096] [ENSMUST00000208921]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000124096

SMART Domains

Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
Pfam:Pkinase	1	118	4.8e-19	PFAM
Pfam:Pkinase_Tyr	1	118	1.7e-50	PFAM
low complexity region	146	160	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000208921
AA Change: D2305V

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.4%

Validation Efficiency

100% (63/63)

Allele List at MGI

Other mutations in this stock

Total: 64 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	T	C	11: 110,045,218 (GRCm39)	T372A	probably benign	Het
Adamts8	C	A	9: 30,865,930 (GRCm39)	R493S	probably benign	Het
Ankrd33b	G	A	15: 31,297,830 (GRCm39)	T309I	probably damaging	Het
Arhgap22	G	A	14: 32,993,880 (GRCm39)	W58*	probably null	Het
B4galt4	C	T	16: 38,572,404 (GRCm39)		probably benign	Het
Bcl2a1a	A	T	9: 88,839,311 (GRCm39)	I70L	probably benign	Het
Bst1	A	G	5: 43,977,942 (GRCm39)	D97G	possibly damaging	Het
Cand2	C	T	6: 115,757,894 (GRCm39)	T52M	probably benign	Het
Cd101	C	A	3: 100,926,062 (GRCm39)	R219L	probably benign	Het
Cd5l	T	A	3: 87,274,882 (GRCm39)	D140E	probably benign	Het
Cebpa	A	G	7: 34,819,906 (GRCm39)	M355V	possibly damaging	Het
Cfap74	G	A	4: 155,521,187 (GRCm39)	E620K		Het
Clec4a4	A	G	6: 123,000,875 (GRCm39)	E196G	probably damaging	Het
Cpxm1	T	A	2: 130,235,360 (GRCm39)	D544V	probably damaging	Het
Cwf19l2	T	A	9: 3,447,245 (GRCm39)	D535E	probably benign	Het
Daw1	T	G	1: 83,175,898 (GRCm39)	L212R	probably benign	Het
Dnm3	T	A	1: 162,135,445 (GRCm39)	T443S	probably benign	Het
Dock9	T	C	14: 121,817,940 (GRCm39)	D1627G	probably damaging	Het
Dohh	A	G	10: 81,223,735 (GRCm39)	I263V	probably benign	Het
Dsp	G	A	13: 38,365,155 (GRCm39)	V513M	probably damaging	Het
Dus4l	G	T	12: 31,690,692 (GRCm39)	L320I	possibly damaging	Het
Edc4	A	C	8: 106,617,857 (GRCm39)	Q1139P	probably damaging	Het
Fam220a	T	A	5: 143,549,228 (GRCm39)	C213*	probably null	Het
Fgf14	A	T	14: 124,221,326 (GRCm39)	Y159*	probably null	Het
Gm45861	A	T	8: 28,019,632 (GRCm39)	D749V	unknown	Het
Hip1	T	C	5: 135,459,144 (GRCm39)	T203A	probably benign	Het
Igfals	A	G	17: 25,099,014 (GRCm39)	D35G	possibly damaging	Het
Itga4	T	A	2: 79,145,332 (GRCm39)	I716K	probably damaging	Het
Ncaph2	T	A	15: 89,253,594 (GRCm39)	I282N	probably benign	Het
Ndufb3	T	C	1: 58,634,824 (GRCm39)	Y59H	probably damaging	Het
Nxpe3	T	C	16: 55,665,023 (GRCm39)	H399R	probably damaging	Het
Nxph1	T	C	6: 9,247,601 (GRCm39)	S191P	probably damaging	Het
Or13c7e-ps1	G	T	4: 43,781,432 (GRCm39)	S299R	probably benign	Het
Or1p1	T	C	11: 74,180,413 (GRCm39)	S314P	probably damaging	Het
Pcdha11	T	G	18: 37,145,799 (GRCm39)	I630S	probably damaging	Het
Pfkl	C	G	10: 77,836,615 (GRCm39)	G134A	probably damaging	Het
Phf19	A	T	2: 34,795,484 (GRCm39)	C196S	probably damaging	Het
Piezo2	T	C	18: 63,248,096 (GRCm39)	K468R	probably benign	Het
Plekhn1	T	C	4: 156,310,078 (GRCm39)	S79G	possibly damaging	Het
Pomk	A	G	8: 26,473,384 (GRCm39)	Y190H	possibly damaging	Het
Ppp1r13b	T	A	12: 111,838,778 (GRCm39)	E33D	probably damaging	Het
Raly	A	T	2: 154,705,493 (GRCm39)	I174F	probably damaging	Het
Rint1	T	C	5: 24,016,882 (GRCm39)	V549A	possibly damaging	Het
Rnf31	T	G	14: 55,833,689 (GRCm39)	C566G	probably damaging	Het
Scart1	G	A	7: 139,808,478 (GRCm39)	W796*	probably null	Het
Sdc1	C	T	12: 8,840,460 (GRCm39)	T79I	possibly damaging	Het
Sema6a	T	G	18: 47,424,182 (GRCm39)	E242A	probably damaging	Het
Slc22a30	A	C	19: 8,315,340 (GRCm39)	M430R	probably damaging	Het
Sp9	C	A	2: 73,103,863 (GRCm39)	T139K	probably benign	Het
Tbkbp1	T	C	11: 97,040,327 (GRCm39)	D29G	probably benign	Het
Tcf4	T	C	18: 69,697,761 (GRCm39)		probably benign	Het
Tenm3	A	T	8: 48,689,437 (GRCm39)	I2050N	probably damaging	Het
Tiparp	T	A	3: 65,460,603 (GRCm39)	F531I	probably damaging	Het
Tmem132b	A	T	5: 125,855,884 (GRCm39)	I539F	probably damaging	Het
Ttf2	T	C	3: 100,859,956 (GRCm39)	D666G	probably damaging	Het
Vmn1r51	T	C	6: 90,106,842 (GRCm39)	S253P	probably damaging	Het
Vmn2r104	A	G	17: 20,261,924 (GRCm39)	I402T	probably damaging	Het
Vmn2r16	T	C	5: 109,511,619 (GRCm39)	Y609H	probably benign	Het
Vmn2r17	A	T	5: 109,575,863 (GRCm39)	M245L	probably benign	Het
Vmn2r42	C	T	7: 8,197,792 (GRCm39)	E276K	probably benign	Het
Wdr75	C	A	1: 45,838,287 (GRCm39)	N65K	probably damaging	Het
Zbtb47	A	C	9: 121,596,705 (GRCm39)	K687T	probably damaging	Het
Zfhx4	T	C	3: 5,463,924 (GRCm39)	S1361P	probably damaging	Het
Zfp317	T	A	9: 19,558,708 (GRCm39)	C396*	probably null	Het

Other mutations in Cdcp3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00226:Cdcp3	APN	7	130,839,823 (GRCm39)	splice site	probably null
IGL00848:Cdcp3	APN	7	130,848,453 (GRCm39)	missense	probably damaging	1.00
IGL00966:Cdcp3	APN	7	130,844,836 (GRCm39)	nonsense	probably null
IGL01286:Cdcp3	APN	7	130,848,432 (GRCm39)	missense	probably damaging	1.00
IGL01303:Cdcp3	APN	7	130,796,060 (GRCm39)	missense	possibly damaging	0.53
IGL01585:Cdcp3	APN	7	130,846,487 (GRCm39)	missense	probably damaging	0.97
IGL01665:Cdcp3	APN	7	130,848,386 (GRCm39)	nonsense	probably null
IGL01953:Cdcp3	APN	7	130,826,709 (GRCm39)	missense	probably benign	0.04
IGL02427:Cdcp3	APN	7	130,846,517 (GRCm39)	missense	probably damaging	0.99
IGL02508:Cdcp3	APN	7	130,824,559 (GRCm39)	missense	probably damaging	1.00
IGL02678:Cdcp3	APN	7	130,830,646 (GRCm39)	missense	probably damaging	1.00
IGL03092:Cdcp3	APN	7	130,803,527 (GRCm39)	critical splice donor site	probably null
IGL03122:Cdcp3	APN	7	130,798,243 (GRCm39)	missense	possibly damaging	0.68
IGL03343:Cdcp3	APN	7	130,848,420 (GRCm39)	missense	probably damaging	1.00
R0011:Cdcp3	UTSW	7	130,831,722 (GRCm39)	missense	probably damaging	0.99
R0011:Cdcp3	UTSW	7	130,831,722 (GRCm39)	missense	probably damaging	0.99
R0234:Cdcp3	UTSW	7	130,796,032 (GRCm39)	splice site	probably null
R0234:Cdcp3	UTSW	7	130,796,032 (GRCm39)	splice site	probably null
R0268:Cdcp3	UTSW	7	130,839,905 (GRCm39)	missense	probably damaging	1.00
R0383:Cdcp3	UTSW	7	130,841,268 (GRCm39)	missense	probably benign	0.05
R0973:Cdcp3	UTSW	7	130,839,911 (GRCm39)	missense	probably damaging	1.00
R0973:Cdcp3	UTSW	7	130,839,911 (GRCm39)	missense	probably damaging	1.00
R0974:Cdcp3	UTSW	7	130,839,911 (GRCm39)	missense	probably damaging	1.00
R1572:Cdcp3	UTSW	7	130,846,560 (GRCm39)	nonsense	probably null
R1911:Cdcp3	UTSW	7	130,839,818 (GRCm39)	missense	probably damaging	1.00
R2032:Cdcp3	UTSW	7	130,844,781 (GRCm39)	missense	probably damaging	1.00
R2097:Cdcp3	UTSW	7	130,783,693 (GRCm39)	nonsense	probably null
R2221:Cdcp3	UTSW	7	130,849,186 (GRCm39)	critical splice acceptor site	probably null
R2223:Cdcp3	UTSW	7	130,849,186 (GRCm39)	critical splice acceptor site	probably null
R2254:Cdcp3	UTSW	7	130,824,634 (GRCm39)	missense	probably damaging	1.00
R2913:Cdcp3	UTSW	7	130,783,753 (GRCm39)	missense	possibly damaging	0.90
R2991:Cdcp3	UTSW	7	130,848,429 (GRCm39)	missense	probably damaging	1.00
R3439:Cdcp3	UTSW	7	130,790,508 (GRCm39)	critical splice donor site	probably null
R4418:Cdcp3	UTSW	7	130,849,194 (GRCm39)	missense	possibly damaging	0.86
R4916:Cdcp3	UTSW	7	130,776,206 (GRCm39)	splice site	probably null
R5488:Cdcp3	UTSW	7	130,848,324 (GRCm39)	missense	probably damaging	1.00
R5594:Cdcp3	UTSW	7	130,841,252 (GRCm39)	missense	probably benign	0.12
R5897:Cdcp3	UTSW	7	130,798,280 (GRCm39)	splice site	probably null
R5898:Cdcp3	UTSW	7	130,843,696 (GRCm39)	splice site	probably null
R5940:Cdcp3	UTSW	7	130,839,992 (GRCm39)	missense	probably damaging	1.00
R6170:Cdcp3	UTSW	7	130,776,216 (GRCm39)	splice site	probably null
R6187:Cdcp3	UTSW	7	130,872,328 (GRCm39)	intron	probably benign
R6321:Cdcp3	UTSW	7	130,858,735 (GRCm39)	critical splice donor site	probably null
R6409:Cdcp3	UTSW	7	130,863,800 (GRCm39)	intron	probably benign
R6432:Cdcp3	UTSW	7	130,846,601 (GRCm39)	critical splice donor site	probably null
R6481:Cdcp3	UTSW	7	130,858,530 (GRCm39)	missense	probably benign	0.05
R6750:Cdcp3	UTSW	7	130,889,974 (GRCm39)	intron	probably benign
R6783:Cdcp3	UTSW	7	130,828,493 (GRCm39)	missense	probably damaging	0.99
R6836:Cdcp3	UTSW	7	130,798,233 (GRCm39)	missense	possibly damaging	0.84
R6925:Cdcp3	UTSW	7	130,824,436 (GRCm39)	missense	possibly damaging	0.92
R6995:Cdcp3	UTSW	7	130,824,400 (GRCm39)	missense	probably damaging	1.00
R7199:Cdcp3	UTSW	7	130,837,641 (GRCm39)	nonsense	probably null
R7205:Cdcp3	UTSW	7	130,879,352 (GRCm39)	critical splice donor site	probably null
R7340:Cdcp3	UTSW	7	130,879,344 (GRCm39)	missense	unknown
R7354:Cdcp3	UTSW	7	130,873,762 (GRCm39)	missense	unknown
R7354:Cdcp3	UTSW	7	130,858,458 (GRCm39)	missense	possibly damaging	0.84
R7434:Cdcp3	UTSW	7	130,881,212 (GRCm39)	missense	unknown
R7485:Cdcp3	UTSW	7	130,830,562 (GRCm39)	missense	probably damaging	0.99
R7513:Cdcp3	UTSW	7	130,873,800 (GRCm39)	missense	unknown
R7562:Cdcp3	UTSW	7	130,904,426 (GRCm39)	missense	unknown
R7623:Cdcp3	UTSW	7	130,879,295 (GRCm39)	splice site	probably null
R7782:Cdcp3	UTSW	7	130,904,466 (GRCm39)	splice site	probably null
R7879:Cdcp3	UTSW	7	130,844,871 (GRCm39)	missense	probably damaging	0.98
R7935:Cdcp3	UTSW	7	130,852,205 (GRCm39)	missense	probably damaging	0.96
R7949:Cdcp3	UTSW	7	130,895,324 (GRCm39)	splice site	probably null
R7964:Cdcp3	UTSW	7	130,899,963 (GRCm39)	missense	unknown
R7980:Cdcp3	UTSW	7	130,836,506 (GRCm39)	missense	probably damaging	0.98
R8145:Cdcp3	UTSW	7	130,898,045 (GRCm39)	missense	unknown
R8673:Cdcp3	UTSW	7	130,844,846 (GRCm39)	missense	probably damaging	0.99
R8684:Cdcp3	UTSW	7	130,837,688 (GRCm39)	nonsense	probably null
R8721:Cdcp3	UTSW	7	130,879,335 (GRCm39)	missense	unknown
R8725:Cdcp3	UTSW	7	130,875,485 (GRCm39)	missense	unknown
R8727:Cdcp3	UTSW	7	130,875,485 (GRCm39)	missense	unknown
R8742:Cdcp3	UTSW	7	130,783,741 (GRCm39)	missense	unknown
R8807:Cdcp3	UTSW	7	130,846,507 (GRCm39)	missense	probably damaging	0.97
R8822:Cdcp3	UTSW	7	130,843,706 (GRCm39)	critical splice acceptor site	probably null
R8861:Cdcp3	UTSW	7	130,861,690 (GRCm39)	nonsense	probably null
R8897:Cdcp3	UTSW	7	130,867,566 (GRCm39)	missense	unknown
R9214:Cdcp3	UTSW	7	130,824,481 (GRCm39)	missense	possibly damaging	0.89
R9218:Cdcp3	UTSW	7	130,863,728 (GRCm39)	missense	unknown
R9311:Cdcp3	UTSW	7	130,859,490 (GRCm39)	missense	unknown
R9323:Cdcp3	UTSW	7	130,828,401 (GRCm39)	missense	probably damaging	0.96
R9384:Cdcp3	UTSW	7	130,904,404 (GRCm39)	missense	unknown
R9387:Cdcp3	UTSW	7	130,863,620 (GRCm39)	missense	unknown
R9417:Cdcp3	UTSW	7	130,852,218 (GRCm39)	missense	possibly damaging	0.60
R9502:Cdcp3	UTSW	7	130,836,815 (GRCm39)	missense	possibly damaging	0.61
R9603:Cdcp3	UTSW	7	130,830,643 (GRCm39)	missense	probably damaging	0.98
R9642:Cdcp3	UTSW	7	130,848,257 (GRCm39)	missense	probably benign	0.01
Z1088:Cdcp3	UTSW	7	130,848,362 (GRCm39)	missense	probably damaging	1.00
Z1177:Cdcp3	UTSW	7	130,867,595 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- ATGGAGCTAGTACCCAGCACAG -3'
(R):5'- GTGAAATCACTGGCGTCAGG -3'

Sequencing Primer
(F):5'- GGTGCACCATCAACCAACTGATTC -3'
(R):5'- GAGAAGCCACACAGGTGTCC -3'

Posted On

2021-08-31