Incidental Mutation 'R8905:Slco6c1'
ID 679997
Institutional Source Beutler Lab
Gene Symbol Slco6c1
Ensembl Gene ENSMUSG00000026331
Gene Name solute carrier organic anion transporter family, member 6c1
Synonyms 4933404A18Rik
MMRRC Submission 068762-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8905 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 96986763-97056026 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 97053391 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 170 (M170K)
Ref Sequence ENSEMBL: ENSMUSP00000140791 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027569] [ENSMUST00000189547]
AlphaFold Q8C0X7
Predicted Effect possibly damaging
Transcript: ENSMUST00000027569
AA Change: M170K

PolyPhen 2 Score 0.682 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000027569
Gene: ENSMUSG00000026331
AA Change: M170K

DomainStartEndE-ValueType
low complexity region 44 55 N/A INTRINSIC
Pfam:OATP 95 654 3e-101 PFAM
Pfam:MFS_1 207 474 6.5e-14 PFAM
Pfam:Kazal_2 497 538 7.4e-10 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000189547
AA Change: M170K

PolyPhen 2 Score 0.682 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000140791
Gene: ENSMUSG00000026331
AA Change: M170K

DomainStartEndE-ValueType
low complexity region 44 55 N/A INTRINSIC
Pfam:OATP 93 197 7.4e-12 PFAM
Pfam:MFS_1 99 457 2.2e-15 PFAM
Pfam:OATP 192 638 2.5e-64 PFAM
Pfam:Kazal_2 480 521 2.1e-8 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.3%
Validation Efficiency 100% (77/77)
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700013G24Rik T C 4: 137,182,553 (GRCm39) V236A probably benign Het
Abca15 A T 7: 119,960,771 (GRCm39) R744S probably benign Het
Adgra1 T C 7: 139,455,763 (GRCm39) S464P probably damaging Het
Arhgap45 T C 10: 79,855,570 (GRCm39) V3A probably benign Het
AW554918 T A 18: 25,473,206 (GRCm39) S134T probably damaging Het
Bmper A G 9: 23,318,082 (GRCm39) E567G probably benign Het
C2cd3 T C 7: 100,074,132 (GRCm39) probably null Het
Cars1 A G 7: 143,140,196 (GRCm39) Y170H probably damaging Het
Celsr1 A T 15: 85,788,269 (GRCm39) probably benign Het
Celsr3 C T 9: 108,718,501 (GRCm39) H2351Y probably damaging Het
Cfap210 A G 2: 69,612,104 (GRCm39) S175P probably benign Het
Clxn A G 16: 14,738,275 (GRCm39) I147V possibly damaging Het
Cyp2d11 T C 15: 82,275,102 (GRCm39) I282V probably benign Het
Dhfr A G 13: 92,494,467 (GRCm39) T57A probably damaging Het
Dhrs7l T A 12: 72,666,431 (GRCm39) D80V probably damaging Het
Dnah7b A C 1: 46,292,534 (GRCm39) Q2973P probably damaging Het
Dnajc5b T C 3: 19,633,184 (GRCm39) C136R probably benign Het
Ercc3 T G 18: 32,398,771 (GRCm39) D683E possibly damaging Het
Faxc A G 4: 21,982,398 (GRCm39) Y279C probably damaging Het
Fbxw7 T C 3: 84,872,634 (GRCm39) M191T possibly damaging Het
Fcgbp T A 7: 27,785,934 (GRCm39) V457E probably damaging Het
Fip1l1 A T 5: 74,756,624 (GRCm39) T539S probably damaging Het
Gabra1 T C 11: 42,038,052 (GRCm39) T189A possibly damaging Het
Glg1 T C 8: 111,884,668 (GRCm39) D1118G probably damaging Het
Gli3 A G 13: 15,901,116 (GRCm39) D1501G probably benign Het
Hacd1 A G 2: 14,049,761 (GRCm39) I91T possibly damaging Het
Ift22 T C 5: 136,941,745 (GRCm39) V159A probably benign Het
Igkv1-110 T A 6: 68,248,070 (GRCm39) Y60N probably damaging Het
Inpp5d A G 1: 87,637,348 (GRCm39) K502E probably damaging Het
Kcnt2 A T 1: 140,435,467 (GRCm39) Q478L possibly damaging Het
Mettl13 A G 1: 162,364,847 (GRCm39) F511L probably damaging Het
Mis18bp1 T C 12: 65,180,401 (GRCm39) probably null Het
Mrps30 A T 13: 118,523,479 (GRCm39) S98T probably benign Het
Muc2 C T 7: 141,279,643 (GRCm39) A209V probably benign Het
Nfs1 A T 2: 155,970,503 (GRCm39) I270N probably damaging Het
Nlgn3 T C X: 100,352,390 (GRCm39) V179A probably damaging Het
Nsmaf A G 4: 6,424,951 (GRCm39) S266P probably benign Het
Obscn A G 11: 58,960,784 (GRCm39) S3176P probably damaging Het
Or4c123 A T 2: 89,126,801 (GRCm39) L271Q possibly damaging Het
Or7g12 A G 9: 18,899,494 (GRCm39) D70G possibly damaging Het
P2ry12 T A 3: 59,124,997 (GRCm39) Y226F probably damaging Het
Pabpc2 C A 18: 39,907,704 (GRCm39) T323K probably benign Het
Pank2 A G 2: 131,124,646 (GRCm39) D71G possibly damaging Het
Patj A T 4: 98,385,412 (GRCm39) H393L probably damaging Het
Pde8b A G 13: 95,182,993 (GRCm39) V255A probably damaging Het
Plekhs1 T C 19: 56,471,028 (GRCm39) W374R probably damaging Het
Ppm1g T C 5: 31,361,437 (GRCm39) D313G probably damaging Het
Rnf114 A G 2: 167,353,134 (GRCm39) N135S probably benign Het
Rnf43 T G 11: 87,621,951 (GRCm39) Y351D probably damaging Het
Robo1 A T 16: 72,539,173 (GRCm39) D90V probably damaging Het
Sbds A G 5: 130,277,125 (GRCm39) V172A possibly damaging Het
Scamp5 T A 9: 57,352,669 (GRCm39) I167F probably benign Het
Sec14l5 A G 16: 4,994,364 (GRCm39) E386G probably damaging Het
Sfxn1 T A 13: 54,246,433 (GRCm39) V159E probably damaging Het
Sgsm1 C T 5: 113,421,495 (GRCm39) G531R probably benign Het
Slc22a26 T A 19: 7,760,331 (GRCm39) I471F probably damaging Het
Slc41a3 T A 6: 90,589,123 (GRCm39) M78K probably benign Het
Slc8a1 A T 17: 81,749,084 (GRCm39) Y653N probably benign Het
Smarca5 A T 8: 81,440,577 (GRCm39) I629K probably benign Het
Smg7 T A 1: 152,715,817 (GRCm39) D1099V probably damaging Het
Spata31e2 A G 1: 26,721,895 (GRCm39) V1095A probably damaging Het
Srbd1 T C 17: 86,308,890 (GRCm39) I763V probably benign Het
Stk25 A G 1: 93,556,929 (GRCm39) S30P probably damaging Het
Sv2b C T 7: 74,767,459 (GRCm39) A646T probably benign Het
Tardbp T C 4: 148,705,093 (GRCm39) M167V probably benign Het
Tmem132a T C 19: 10,842,647 (GRCm39) N276S probably damaging Het
Ttpa T A 4: 20,028,435 (GRCm39) S162T probably benign Het
Usp13 T C 3: 32,935,572 (GRCm39) Y333H probably damaging Het
Vmn2r3 T A 3: 64,166,695 (GRCm39) Y812F probably damaging Het
Yeats2 A G 16: 20,009,144 (GRCm39) T463A probably benign Het
Zbtb26 T A 2: 37,326,927 (GRCm39) K36N probably benign Het
Zfc3h1 A T 10: 115,259,383 (GRCm39) T1652S probably benign Het
Zfp472 G A 17: 33,197,455 (GRCm39) C510Y possibly damaging Het
Zfp518a C A 19: 40,902,780 (GRCm39) T903K probably damaging Het
Zfp668 T C 7: 127,465,598 (GRCm39) T529A probably benign Het
Zfp930 A G 8: 69,681,351 (GRCm39) T349A possibly damaging Het
Zmiz2 T G 11: 6,346,840 (GRCm39) Y182D probably damaging Het
Other mutations in Slco6c1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00547:Slco6c1 APN 1 97,015,674 (GRCm39) missense probably benign 0.00
IGL00571:Slco6c1 APN 1 97,015,676 (GRCm39) missense probably benign 0.04
IGL01483:Slco6c1 APN 1 97,055,832 (GRCm39) missense probably benign
IGL01543:Slco6c1 APN 1 97,053,553 (GRCm39) missense possibly damaging 0.95
IGL01860:Slco6c1 APN 1 97,003,548 (GRCm39) splice site probably benign
IGL03106:Slco6c1 APN 1 96,993,748 (GRCm39) splice site probably benign
R0087:Slco6c1 UTSW 1 97,046,303 (GRCm39) missense probably benign 0.00
R0543:Slco6c1 UTSW 1 97,055,623 (GRCm39) missense probably damaging 0.99
R0674:Slco6c1 UTSW 1 97,032,498 (GRCm39) splice site probably benign
R0826:Slco6c1 UTSW 1 97,055,826 (GRCm39) missense probably benign 0.00
R0928:Slco6c1 UTSW 1 97,032,573 (GRCm39) missense possibly damaging 0.88
R0969:Slco6c1 UTSW 1 97,047,685 (GRCm39) missense probably benign 0.05
R1366:Slco6c1 UTSW 1 97,055,928 (GRCm39) start gained probably null
R1559:Slco6c1 UTSW 1 97,026,223 (GRCm39) missense probably damaging 1.00
R1594:Slco6c1 UTSW 1 96,990,163 (GRCm39) missense probably benign 0.36
R1901:Slco6c1 UTSW 1 97,000,707 (GRCm39) missense probably damaging 0.98
R2005:Slco6c1 UTSW 1 97,009,214 (GRCm39) missense probably damaging 0.99
R2101:Slco6c1 UTSW 1 97,000,595 (GRCm39) nonsense probably null
R2102:Slco6c1 UTSW 1 97,055,656 (GRCm39) missense probably benign 0.02
R2120:Slco6c1 UTSW 1 96,993,808 (GRCm39) missense possibly damaging 0.57
R2135:Slco6c1 UTSW 1 97,032,542 (GRCm39) missense probably benign 0.01
R2295:Slco6c1 UTSW 1 97,053,473 (GRCm39) missense probably damaging 1.00
R2437:Slco6c1 UTSW 1 96,990,201 (GRCm39) missense probably benign 0.22
R4004:Slco6c1 UTSW 1 97,003,610 (GRCm39) missense probably damaging 1.00
R4133:Slco6c1 UTSW 1 97,009,218 (GRCm39) missense probably benign 0.02
R4643:Slco6c1 UTSW 1 96,990,149 (GRCm39) missense probably benign 0.00
R4786:Slco6c1 UTSW 1 97,015,720 (GRCm39) missense probably benign 0.04
R4942:Slco6c1 UTSW 1 97,009,049 (GRCm39) missense probably damaging 1.00
R5485:Slco6c1 UTSW 1 97,053,481 (GRCm39) missense probably damaging 1.00
R5573:Slco6c1 UTSW 1 97,055,656 (GRCm39) missense probably benign 0.00
R5810:Slco6c1 UTSW 1 97,003,598 (GRCm39) missense probably damaging 1.00
R6033:Slco6c1 UTSW 1 97,009,041 (GRCm39) splice site probably null
R6033:Slco6c1 UTSW 1 97,009,041 (GRCm39) splice site probably null
R6191:Slco6c1 UTSW 1 96,993,808 (GRCm39) missense possibly damaging 0.57
R6197:Slco6c1 UTSW 1 97,000,518 (GRCm39) critical splice donor site probably null
R6286:Slco6c1 UTSW 1 97,053,445 (GRCm39) missense possibly damaging 0.90
R6404:Slco6c1 UTSW 1 97,046,330 (GRCm39) missense probably damaging 1.00
R6430:Slco6c1 UTSW 1 97,003,699 (GRCm39) missense probably benign 0.43
R6492:Slco6c1 UTSW 1 97,053,538 (GRCm39) missense probably damaging 0.99
R6649:Slco6c1 UTSW 1 97,053,436 (GRCm39) missense probably benign 0.44
R6940:Slco6c1 UTSW 1 97,000,626 (GRCm39) missense possibly damaging 0.80
R7138:Slco6c1 UTSW 1 97,047,706 (GRCm39) missense possibly damaging 0.95
R7213:Slco6c1 UTSW 1 97,055,671 (GRCm39) missense probably benign
R7234:Slco6c1 UTSW 1 97,053,466 (GRCm39) missense probably benign 0.06
R7320:Slco6c1 UTSW 1 97,055,887 (GRCm39) missense possibly damaging 0.83
R7375:Slco6c1 UTSW 1 97,009,146 (GRCm39) missense possibly damaging 0.58
R7383:Slco6c1 UTSW 1 97,003,608 (GRCm39) nonsense probably null
R7422:Slco6c1 UTSW 1 97,009,207 (GRCm39) missense probably benign 0.17
R7491:Slco6c1 UTSW 1 97,055,579 (GRCm39) missense probably benign 0.32
R7561:Slco6c1 UTSW 1 97,000,691 (GRCm39) missense probably damaging 1.00
R7890:Slco6c1 UTSW 1 96,990,192 (GRCm39) missense possibly damaging 0.59
R8115:Slco6c1 UTSW 1 97,000,686 (GRCm39) missense probably damaging 1.00
R8409:Slco6c1 UTSW 1 97,003,663 (GRCm39) missense probably damaging 0.99
R8422:Slco6c1 UTSW 1 97,053,508 (GRCm39) missense probably damaging 1.00
R8824:Slco6c1 UTSW 1 97,055,884 (GRCm39) missense possibly damaging 0.84
R9183:Slco6c1 UTSW 1 96,996,775 (GRCm39) critical splice acceptor site probably null
R9300:Slco6c1 UTSW 1 96,993,809 (GRCm39) missense probably benign 0.37
R9359:Slco6c1 UTSW 1 96,990,248 (GRCm39) missense possibly damaging 0.94
R9374:Slco6c1 UTSW 1 97,055,827 (GRCm39) missense probably benign 0.00
R9403:Slco6c1 UTSW 1 96,990,248 (GRCm39) missense possibly damaging 0.94
R9499:Slco6c1 UTSW 1 97,055,827 (GRCm39) missense probably benign 0.00
R9551:Slco6c1 UTSW 1 97,055,827 (GRCm39) missense probably benign 0.00
R9674:Slco6c1 UTSW 1 97,047,565 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAGCTACAGGTAGTTACTAAGTGTTG -3'
(R):5'- GAGGGTTCAAATGTAGTTGATCTC -3'

Sequencing Primer
(F):5'- GAAGAAAGGATACACAGATATACCCC -3'
(R):5'- ATCTTCCTAGGTGCTTTATTTGCTG -3'
Posted On 2021-08-31