Incidental Mutation 'R8905:Vmn2r3'
| ID |
680011 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r3
|
| Ensembl Gene |
ENSMUSG00000091572 |
| Gene Name |
vomeronasal 2, receptor 3 |
| Synonyms |
EG637004 |
| MMRRC Submission |
068762-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8905 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
64166225-64197130 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 64166695 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Phenylalanine
at position 812
(Y812F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134891
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170244]
[ENSMUST00000176328]
|
| AlphaFold |
H3BJ88 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000170244
AA Change: Y784F
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000126165
Gene: ENSMUSG00000091572
AA Change: Y784F
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
64 |
479 |
4e-64 |
PFAM |
|
Pfam:NCD3G
|
521 |
574 |
1.1e-17 |
PFAM |
|
Pfam:7tm_3
|
605 |
842 |
2.9e-75 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176328
AA Change: Y812F
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000134891
Gene: ENSMUSG00000091572
AA Change: Y812F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
92 |
507 |
9.5e-66 |
PFAM |
|
Pfam:NCD3G
|
549 |
602 |
8.8e-17 |
PFAM |
|
Pfam:7tm_3
|
635 |
869 |
8.5e-48 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.5%
- 20x: 98.3%
|
| Validation Efficiency |
100% (77/77) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700013G24Rik |
T |
C |
4: 137,182,553 (GRCm39) |
V236A |
probably benign |
Het |
| Abca15 |
A |
T |
7: 119,960,771 (GRCm39) |
R744S |
probably benign |
Het |
| Adgra1 |
T |
C |
7: 139,455,763 (GRCm39) |
S464P |
probably damaging |
Het |
| Arhgap45 |
T |
C |
10: 79,855,570 (GRCm39) |
V3A |
probably benign |
Het |
| AW554918 |
T |
A |
18: 25,473,206 (GRCm39) |
S134T |
probably damaging |
Het |
| Bmper |
A |
G |
9: 23,318,082 (GRCm39) |
E567G |
probably benign |
Het |
| C2cd3 |
T |
C |
7: 100,074,132 (GRCm39) |
|
probably null |
Het |
| Cars1 |
A |
G |
7: 143,140,196 (GRCm39) |
Y170H |
probably damaging |
Het |
| Celsr1 |
A |
T |
15: 85,788,269 (GRCm39) |
|
probably benign |
Het |
| Celsr3 |
C |
T |
9: 108,718,501 (GRCm39) |
H2351Y |
probably damaging |
Het |
| Cfap210 |
A |
G |
2: 69,612,104 (GRCm39) |
S175P |
probably benign |
Het |
| Clxn |
A |
G |
16: 14,738,275 (GRCm39) |
I147V |
possibly damaging |
Het |
| Cyp2d11 |
T |
C |
15: 82,275,102 (GRCm39) |
I282V |
probably benign |
Het |
| Dhfr |
A |
G |
13: 92,494,467 (GRCm39) |
T57A |
probably damaging |
Het |
| Dhrs7l |
T |
A |
12: 72,666,431 (GRCm39) |
D80V |
probably damaging |
Het |
| Dnah7b |
A |
C |
1: 46,292,534 (GRCm39) |
Q2973P |
probably damaging |
Het |
| Dnajc5b |
T |
C |
3: 19,633,184 (GRCm39) |
C136R |
probably benign |
Het |
| Ercc3 |
T |
G |
18: 32,398,771 (GRCm39) |
D683E |
possibly damaging |
Het |
| Faxc |
A |
G |
4: 21,982,398 (GRCm39) |
Y279C |
probably damaging |
Het |
| Fbxw7 |
T |
C |
3: 84,872,634 (GRCm39) |
M191T |
possibly damaging |
Het |
| Fcgbp |
T |
A |
7: 27,785,934 (GRCm39) |
V457E |
probably damaging |
Het |
| Fip1l1 |
A |
T |
5: 74,756,624 (GRCm39) |
T539S |
probably damaging |
Het |
| Gabra1 |
T |
C |
11: 42,038,052 (GRCm39) |
T189A |
possibly damaging |
Het |
| Glg1 |
T |
C |
8: 111,884,668 (GRCm39) |
D1118G |
probably damaging |
Het |
| Gli3 |
A |
G |
13: 15,901,116 (GRCm39) |
D1501G |
probably benign |
Het |
| Hacd1 |
A |
G |
2: 14,049,761 (GRCm39) |
I91T |
possibly damaging |
Het |
| Ift22 |
T |
C |
5: 136,941,745 (GRCm39) |
V159A |
probably benign |
Het |
| Igkv1-110 |
T |
A |
6: 68,248,070 (GRCm39) |
Y60N |
probably damaging |
Het |
| Inpp5d |
A |
G |
1: 87,637,348 (GRCm39) |
K502E |
probably damaging |
Het |
| Kcnt2 |
A |
T |
1: 140,435,467 (GRCm39) |
Q478L |
possibly damaging |
Het |
| Mettl13 |
A |
G |
1: 162,364,847 (GRCm39) |
F511L |
probably damaging |
Het |
| Mis18bp1 |
T |
C |
12: 65,180,401 (GRCm39) |
|
probably null |
Het |
| Mrps30 |
A |
T |
13: 118,523,479 (GRCm39) |
S98T |
probably benign |
Het |
| Muc2 |
C |
T |
7: 141,279,643 (GRCm39) |
A209V |
probably benign |
Het |
| Nfs1 |
A |
T |
2: 155,970,503 (GRCm39) |
I270N |
probably damaging |
Het |
| Nlgn3 |
T |
C |
X: 100,352,390 (GRCm39) |
V179A |
probably damaging |
Het |
| Nsmaf |
A |
G |
4: 6,424,951 (GRCm39) |
S266P |
probably benign |
Het |
| Obscn |
A |
G |
11: 58,960,784 (GRCm39) |
S3176P |
probably damaging |
Het |
| Or4c123 |
A |
T |
2: 89,126,801 (GRCm39) |
L271Q |
possibly damaging |
Het |
| Or7g12 |
A |
G |
9: 18,899,494 (GRCm39) |
D70G |
possibly damaging |
Het |
| P2ry12 |
T |
A |
3: 59,124,997 (GRCm39) |
Y226F |
probably damaging |
Het |
| Pabpc2 |
C |
A |
18: 39,907,704 (GRCm39) |
T323K |
probably benign |
Het |
| Pank2 |
A |
G |
2: 131,124,646 (GRCm39) |
D71G |
possibly damaging |
Het |
| Patj |
A |
T |
4: 98,385,412 (GRCm39) |
H393L |
probably damaging |
Het |
| Pde8b |
A |
G |
13: 95,182,993 (GRCm39) |
V255A |
probably damaging |
Het |
| Plekhs1 |
T |
C |
19: 56,471,028 (GRCm39) |
W374R |
probably damaging |
Het |
| Ppm1g |
T |
C |
5: 31,361,437 (GRCm39) |
D313G |
probably damaging |
Het |
| Rnf114 |
A |
G |
2: 167,353,134 (GRCm39) |
N135S |
probably benign |
Het |
| Rnf43 |
T |
G |
11: 87,621,951 (GRCm39) |
Y351D |
probably damaging |
Het |
| Robo1 |
A |
T |
16: 72,539,173 (GRCm39) |
D90V |
probably damaging |
Het |
| Sbds |
A |
G |
5: 130,277,125 (GRCm39) |
V172A |
possibly damaging |
Het |
| Scamp5 |
T |
A |
9: 57,352,669 (GRCm39) |
I167F |
probably benign |
Het |
| Sec14l5 |
A |
G |
16: 4,994,364 (GRCm39) |
E386G |
probably damaging |
Het |
| Sfxn1 |
T |
A |
13: 54,246,433 (GRCm39) |
V159E |
probably damaging |
Het |
| Sgsm1 |
C |
T |
5: 113,421,495 (GRCm39) |
G531R |
probably benign |
Het |
| Slc22a26 |
T |
A |
19: 7,760,331 (GRCm39) |
I471F |
probably damaging |
Het |
| Slc41a3 |
T |
A |
6: 90,589,123 (GRCm39) |
M78K |
probably benign |
Het |
| Slc8a1 |
A |
T |
17: 81,749,084 (GRCm39) |
Y653N |
probably benign |
Het |
| Slco6c1 |
A |
T |
1: 97,053,391 (GRCm39) |
M170K |
possibly damaging |
Het |
| Smarca5 |
A |
T |
8: 81,440,577 (GRCm39) |
I629K |
probably benign |
Het |
| Smg7 |
T |
A |
1: 152,715,817 (GRCm39) |
D1099V |
probably damaging |
Het |
| Spata31e2 |
A |
G |
1: 26,721,895 (GRCm39) |
V1095A |
probably damaging |
Het |
| Srbd1 |
T |
C |
17: 86,308,890 (GRCm39) |
I763V |
probably benign |
Het |
| Stk25 |
A |
G |
1: 93,556,929 (GRCm39) |
S30P |
probably damaging |
Het |
| Sv2b |
C |
T |
7: 74,767,459 (GRCm39) |
A646T |
probably benign |
Het |
| Tardbp |
T |
C |
4: 148,705,093 (GRCm39) |
M167V |
probably benign |
Het |
| Tmem132a |
T |
C |
19: 10,842,647 (GRCm39) |
N276S |
probably damaging |
Het |
| Ttpa |
T |
A |
4: 20,028,435 (GRCm39) |
S162T |
probably benign |
Het |
| Usp13 |
T |
C |
3: 32,935,572 (GRCm39) |
Y333H |
probably damaging |
Het |
| Yeats2 |
A |
G |
16: 20,009,144 (GRCm39) |
T463A |
probably benign |
Het |
| Zbtb26 |
T |
A |
2: 37,326,927 (GRCm39) |
K36N |
probably benign |
Het |
| Zfc3h1 |
A |
T |
10: 115,259,383 (GRCm39) |
T1652S |
probably benign |
Het |
| Zfp472 |
G |
A |
17: 33,197,455 (GRCm39) |
C510Y |
possibly damaging |
Het |
| Zfp518a |
C |
A |
19: 40,902,780 (GRCm39) |
T903K |
probably damaging |
Het |
| Zfp668 |
T |
C |
7: 127,465,598 (GRCm39) |
T529A |
probably benign |
Het |
| Zfp930 |
A |
G |
8: 69,681,351 (GRCm39) |
T349A |
possibly damaging |
Het |
| Zmiz2 |
T |
G |
11: 6,346,840 (GRCm39) |
Y182D |
probably damaging |
Het |
|
| Other mutations in Vmn2r3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01019:Vmn2r3
|
APN |
3 |
64,167,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01468:Vmn2r3
|
APN |
3 |
64,182,382 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
IGL02032:Vmn2r3
|
APN |
3 |
64,182,476 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02405:Vmn2r3
|
APN |
3 |
64,178,620 (GRCm39) |
splice site |
probably benign |
|
|
IGL02640:Vmn2r3
|
APN |
3 |
64,194,816 (GRCm39) |
missense |
probably benign |
|
|
IGL02719:Vmn2r3
|
APN |
3 |
64,183,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02746:Vmn2r3
|
APN |
3 |
64,167,239 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL02952:Vmn2r3
|
APN |
3 |
64,186,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03390:Vmn2r3
|
APN |
3 |
64,182,767 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
G1citation:Vmn2r3
|
UTSW |
3 |
64,194,876 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0023:Vmn2r3
|
UTSW |
3 |
64,182,787 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0433:Vmn2r3
|
UTSW |
3 |
64,183,054 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R0647:Vmn2r3
|
UTSW |
3 |
64,183,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1071:Vmn2r3
|
UTSW |
3 |
64,182,697 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1536:Vmn2r3
|
UTSW |
3 |
64,182,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1806:Vmn2r3
|
UTSW |
3 |
64,194,810 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1806:Vmn2r3
|
UTSW |
3 |
64,182,893 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1852:Vmn2r3
|
UTSW |
3 |
64,166,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1868:Vmn2r3
|
UTSW |
3 |
64,166,537 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2072:Vmn2r3
|
UTSW |
3 |
64,182,493 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2240:Vmn2r3
|
UTSW |
3 |
64,166,483 (GRCm39) |
missense |
probably benign |
0.44 |
|
R2446:Vmn2r3
|
UTSW |
3 |
64,182,733 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4133:Vmn2r3
|
UTSW |
3 |
64,183,138 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4159:Vmn2r3
|
UTSW |
3 |
64,194,850 (GRCm39) |
nonsense |
probably null |
|
|
R4494:Vmn2r3
|
UTSW |
3 |
64,182,692 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4860:Vmn2r3
|
UTSW |
3 |
64,183,022 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4895:Vmn2r3
|
UTSW |
3 |
64,167,182 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4912:Vmn2r3
|
UTSW |
3 |
64,166,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5018:Vmn2r3
|
UTSW |
3 |
64,178,774 (GRCm39) |
missense |
probably benign |
|
|
R5033:Vmn2r3
|
UTSW |
3 |
64,167,220 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5126:Vmn2r3
|
UTSW |
3 |
64,166,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5148:Vmn2r3
|
UTSW |
3 |
64,186,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5414:Vmn2r3
|
UTSW |
3 |
64,166,978 (GRCm39) |
nonsense |
probably null |
|
|
R5785:Vmn2r3
|
UTSW |
3 |
64,166,444 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5905:Vmn2r3
|
UTSW |
3 |
64,182,698 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5992:Vmn2r3
|
UTSW |
3 |
64,167,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6028:Vmn2r3
|
UTSW |
3 |
64,182,698 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6331:Vmn2r3
|
UTSW |
3 |
64,186,182 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Vmn2r3
|
UTSW |
3 |
64,182,517 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6775:Vmn2r3
|
UTSW |
3 |
64,183,039 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6822:Vmn2r3
|
UTSW |
3 |
64,194,876 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6826:Vmn2r3
|
UTSW |
3 |
64,182,327 (GRCm39) |
nonsense |
probably null |
|
|
R6886:Vmn2r3
|
UTSW |
3 |
64,166,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6971:Vmn2r3
|
UTSW |
3 |
64,166,668 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7154:Vmn2r3
|
UTSW |
3 |
64,194,732 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7192:Vmn2r3
|
UTSW |
3 |
64,167,364 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7282:Vmn2r3
|
UTSW |
3 |
64,168,825 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7472:Vmn2r3
|
UTSW |
3 |
64,182,953 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7563:Vmn2r3
|
UTSW |
3 |
64,182,770 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R7726:Vmn2r3
|
UTSW |
3 |
64,182,939 (GRCm39) |
nonsense |
probably null |
|
|
R7966:Vmn2r3
|
UTSW |
3 |
64,186,235 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8025:Vmn2r3
|
UTSW |
3 |
64,182,871 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8050:Vmn2r3
|
UTSW |
3 |
64,178,714 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8300:Vmn2r3
|
UTSW |
3 |
64,182,347 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8402:Vmn2r3
|
UTSW |
3 |
64,178,617 (GRCm39) |
splice site |
probably benign |
|
|
R8486:Vmn2r3
|
UTSW |
3 |
64,186,370 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8523:Vmn2r3
|
UTSW |
3 |
64,182,311 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8678:Vmn2r3
|
UTSW |
3 |
64,166,896 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R8885:Vmn2r3
|
UTSW |
3 |
64,182,383 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8886:Vmn2r3
|
UTSW |
3 |
64,194,892 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8937:Vmn2r3
|
UTSW |
3 |
64,166,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8955:Vmn2r3
|
UTSW |
3 |
64,168,803 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R9172:Vmn2r3
|
UTSW |
3 |
64,186,403 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9485:Vmn2r3
|
UTSW |
3 |
64,183,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9575:Vmn2r3
|
UTSW |
3 |
64,178,735 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9618:Vmn2r3
|
UTSW |
3 |
64,178,724 (GRCm39) |
missense |
probably damaging |
0.98 |
|
X0022:Vmn2r3
|
UTSW |
3 |
64,182,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0022:Vmn2r3
|
UTSW |
3 |
64,178,669 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACCAACAGTTTCATCAGTGTTCC -3'
(R):5'- TCTTACTTGGTGTTGAAGCCAC -3'
Sequencing Primer
(F):5'- CTTTGGCCTCAGCAAGATAATGAAGC -3'
(R):5'- GTTGAAGCCACCCAGCATGTTC -3'
|
| Posted On |
2021-08-31 |
Incidental Mutation