Incidental Mutation 'R8906:Iars1'
ID 680135
Institutional Source Beutler Lab
Gene Symbol Iars1
Ensembl Gene ENSMUSG00000037851
Gene Name isoleucyl-tRNA synthetase 1
Synonyms Iars, 2510016L12Rik, E430001P04Rik
MMRRC Submission 068699-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8906 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 49835606-49887743 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 49882177 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 1074 (C1074S)
Ref Sequence ENSEMBL: ENSMUSP00000132082 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047363] [ENSMUST00000164260] [ENSMUST00000165316]
AlphaFold Q8BU30
Predicted Effect probably benign
Transcript: ENSMUST00000047363
AA Change: C1074S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000048096
Gene: ENSMUSG00000037851
AA Change: C1074S

DomainStartEndE-ValueType
Pfam:tRNA-synt_1 17 639 9.2e-242 PFAM
Pfam:tRNA-synt_1g 46 197 3.7e-6 PFAM
Pfam:Anticodon_1 693 852 1.1e-23 PFAM
low complexity region 1159 1167 N/A INTRINSIC
low complexity region 1169 1180 N/A INTRINSIC
low complexity region 1220 1229 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000164260
AA Change: C1074S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000126806
Gene: ENSMUSG00000037851
AA Change: C1074S

DomainStartEndE-ValueType
Pfam:tRNA-synt_1 17 639 5.5e-238 PFAM
Pfam:tRNA-synt_1g 46 205 5.2e-8 PFAM
Pfam:tRNA-synt_1g 521 659 2.1e-5 PFAM
Pfam:Anticodon_1 693 852 7.1e-24 PFAM
low complexity region 1159 1167 N/A INTRINSIC
low complexity region 1169 1180 N/A INTRINSIC
low complexity region 1220 1229 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165316
AA Change: C1074S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000132082
Gene: ENSMUSG00000037851
AA Change: C1074S

DomainStartEndE-ValueType
Pfam:tRNA-synt_1 17 639 5.5e-238 PFAM
Pfam:tRNA-synt_1g 46 205 5.2e-8 PFAM
Pfam:tRNA-synt_1g 521 659 2.1e-5 PFAM
Pfam:Anticodon_1 693 852 7.1e-24 PFAM
low complexity region 1159 1167 N/A INTRINSIC
low complexity region 1169 1180 N/A INTRINSIC
low complexity region 1220 1229 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.4%
Validation Efficiency 100% (88/88)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]
Allele List at MGI
Other mutations in this stock
Total: 90 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810055G02Rik A C 19: 3,766,686 (GRCm39) N91T possibly damaging Het
2510009E07Rik CCGGAAGGGGAGGAGCAGTGACCCAGTTTCGGA CCGGA 16: 21,472,148 (GRCm39) probably null Het
4932414N04Rik A G 2: 68,562,498 (GRCm39) D375G possibly damaging Het
Adad2 C A 8: 120,339,725 (GRCm39) P69Q probably benign Het
Adamts3 G A 5: 89,825,575 (GRCm39) T1088I probably damaging Het
Ank2 A G 3: 126,726,720 (GRCm39) V858A probably benign Het
Ankrd13a A G 5: 114,939,798 (GRCm39) N475S probably benign Het
Barhl2 G A 5: 106,603,352 (GRCm39) T269I probably benign Het
Boc G A 16: 44,323,931 (GRCm39) R157W Het
Bsn G T 9: 107,984,752 (GRCm39) P3101T unknown Het
Catsperb C A 12: 101,486,904 (GRCm39) A477E possibly damaging Het
Ccser1 T A 6: 61,787,842 (GRCm39) I220K probably benign Het
Cd200r3 A T 16: 44,778,102 (GRCm39) I242F possibly damaging Het
Cdc34b A C 11: 94,632,911 (GRCm39) D37A probably damaging Het
Chek2 A G 5: 111,013,458 (GRCm39) probably benign Het
Cngb1 A T 8: 95,989,736 (GRCm39) V792D probably damaging Het
Cops7a T C 6: 124,939,371 (GRCm39) K93E possibly damaging Het
Crispld1 T C 1: 17,820,995 (GRCm39) I345T possibly damaging Het
Dgkd A G 1: 87,869,157 (GRCm39) D1170G probably damaging Het
Dhx35 A G 2: 158,648,918 (GRCm39) T115A possibly damaging Het
Dnai1 G A 4: 41,625,125 (GRCm39) R363H probably benign Het
Dnmbp T A 19: 43,878,681 (GRCm39) Q130L probably benign Het
Egfr A G 11: 16,861,635 (GRCm39) Y1138C probably damaging Het
Elf3 A T 1: 135,182,678 (GRCm39) L329Q probably damaging Het
Enkur A G 2: 21,201,568 (GRCm39) M39T probably benign Het
Epha7 T C 4: 28,821,615 (GRCm39) I260T probably damaging Het
Fbxo28 A T 1: 182,144,634 (GRCm39) I310K probably damaging Het
Fga C A 3: 82,939,111 (GRCm39) N495K probably benign Het
Galnt6 T C 15: 100,601,247 (GRCm39) D344G probably damaging Het
Gm572 A G 4: 148,751,290 (GRCm39) Q221R probably benign Het
Gpa33 G A 1: 165,974,216 (GRCm39) A18T probably benign Het
Gpatch11 C T 17: 79,145,289 (GRCm39) T6I probably benign Het
Gpr84 T A 15: 103,217,625 (GRCm39) S151C probably damaging Het
H2-M11 T A 17: 36,859,851 (GRCm39) Y281* probably null Het
Hadh T C 3: 131,038,891 (GRCm39) N155S probably benign Het
Hoxd13 A G 2: 74,500,266 (GRCm39) Y269C Het
Ibtk G T 9: 85,625,457 (GRCm39) H98N possibly damaging Het
Igsf10 C T 3: 59,233,739 (GRCm39) G1665R probably benign Het
Inpp5d A G 1: 87,625,337 (GRCm39) probably benign Het
Ipo9 A C 1: 135,321,951 (GRCm39) V593G probably damaging Het
Irx3 T C 8: 92,526,915 (GRCm39) D263G possibly damaging Het
Kif13a A G 13: 46,927,154 (GRCm39) V1179A probably benign Het
Lrrc4c T C 2: 97,460,393 (GRCm39) Y340H probably benign Het
Lysmd1 A G 3: 95,045,219 (GRCm39) D155G probably damaging Het
Mical2 T A 7: 111,980,671 (GRCm39) I105N probably damaging Het
Mob2 A T 7: 141,563,261 (GRCm39) L66Q probably damaging Het
Myh1 A G 11: 67,096,739 (GRCm39) S337G probably benign Het
Neb T C 2: 52,096,259 (GRCm39) D1002G probably benign Het
Nebl A T 2: 17,382,928 (GRCm39) N116K probably benign Het
Nkx2-6 T C 14: 69,412,623 (GRCm39) S264P probably benign Het
Nlgn3 T C X: 100,352,390 (GRCm39) V179A probably damaging Het
Nlrp4e A G 7: 23,020,556 (GRCm39) T348A possibly damaging Het
Nomo1 A T 7: 45,722,004 (GRCm39) I982F probably benign Het
Or10j5 A G 1: 172,784,186 (GRCm39) probably benign Het
Or11g24 T G 14: 50,662,291 (GRCm39) F105C probably damaging Het
Or1j19 A T 2: 36,676,621 (GRCm39) Y28F probably benign Het
Or8g22 A G 9: 38,958,077 (GRCm39) F213L possibly damaging Het
Palld A G 8: 62,003,198 (GRCm39) probably null Het
Pcdh7 A G 5: 57,879,154 (GRCm39) Y903C probably damaging Het
Pknox2 G A 9: 36,804,167 (GRCm39) T460M possibly damaging Het
Ppm1h C T 10: 122,714,451 (GRCm39) T330I probably damaging Het
Ppp2r2b C T 18: 42,821,399 (GRCm39) R253H probably damaging Het
Pramel58 G T 5: 94,831,413 (GRCm39) R140L possibly damaging Het
Prr18 G A 17: 8,560,476 (GRCm39) A211T probably benign Het
Ptgs2 A G 1: 149,979,859 (GRCm39) I321M Het
Rara G T 11: 98,860,989 (GRCm39) R159L probably damaging Het
Rasa4 T A 5: 136,133,446 (GRCm39) I635N probably benign Het
Rxfp2 A T 5: 149,989,888 (GRCm39) H423L possibly damaging Het
Scn4b A G 9: 45,059,169 (GRCm39) I147V possibly damaging Het
Scrn3 G A 2: 73,161,352 (GRCm39) V313I probably benign Het
Scrn3 C A 2: 73,161,355 (GRCm39) P314T possibly damaging Het
Sh2b1 A G 7: 126,070,292 (GRCm39) probably null Het
Slc26a10 T C 10: 127,016,459 (GRCm39) Q3R probably benign Het
Slitrk1 A G 14: 109,149,139 (GRCm39) I524T probably damaging Het
Smcp T A 3: 92,491,530 (GRCm39) N106Y unknown Het
Spata31h1 T C 10: 82,122,379 (GRCm39) T3544A probably benign Het
St8sia5 G A 18: 77,336,172 (GRCm39) V202M probably damaging Het
Stxbp5l A T 16: 37,028,526 (GRCm39) D512E probably damaging Het
Tas1r2 A G 4: 139,397,046 (GRCm39) E795G probably damaging Het
Tdrd1 T A 19: 56,831,145 (GRCm39) V320D probably damaging Het
Tmem71 T A 15: 66,404,606 (GRCm39) I261L probably benign Het
Tns2 T C 15: 102,020,039 (GRCm39) L643P probably damaging Het
Upf1 G A 8: 70,786,815 (GRCm39) Q890* probably null Het
Usp43 A T 11: 67,782,307 (GRCm39) H370Q possibly damaging Het
Vmn1r236 T A 17: 21,507,356 (GRCm39) I158N possibly damaging Het
Vmn2r98 T A 17: 19,286,532 (GRCm39) N343K probably benign Het
Vwa8 T C 14: 79,329,815 (GRCm39) S1216P probably benign Het
Yars1 A C 4: 129,090,747 (GRCm39) D97A probably damaging Het
Zer1 G A 2: 30,001,035 (GRCm39) H129Y probably benign Het
Zfat C T 15: 67,956,404 (GRCm39) D1143N possibly damaging Het
Other mutations in Iars1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00697:Iars1 APN 13 49,863,204 (GRCm39) missense probably damaging 1.00
IGL00764:Iars1 APN 13 49,865,303 (GRCm39) missense probably benign 0.34
IGL01153:Iars1 APN 13 49,865,281 (GRCm39) missense probably damaging 1.00
IGL01481:Iars1 APN 13 49,882,174 (GRCm39) missense probably benign 0.00
IGL01596:Iars1 APN 13 49,856,652 (GRCm39) missense probably benign
IGL01682:Iars1 APN 13 49,863,134 (GRCm39) missense probably damaging 1.00
IGL01885:Iars1 APN 13 49,844,975 (GRCm39) missense probably benign 0.25
IGL01907:Iars1 APN 13 49,863,131 (GRCm39) missense probably damaging 1.00
IGL02023:Iars1 APN 13 49,841,725 (GRCm39) missense probably damaging 1.00
IGL02121:Iars1 APN 13 49,878,172 (GRCm39) missense probably benign 0.00
IGL02365:Iars1 APN 13 49,844,975 (GRCm39) missense probably benign 0.25
IGL02704:Iars1 APN 13 49,874,576 (GRCm39) missense probably damaging 1.00
IGL02838:Iars1 APN 13 49,843,965 (GRCm39) missense possibly damaging 0.87
IGL02975:Iars1 APN 13 49,858,325 (GRCm39) missense probably damaging 1.00
IGL02982:Iars1 APN 13 49,863,185 (GRCm39) missense probably benign 0.00
IGL03034:Iars1 APN 13 49,843,965 (GRCm39) missense possibly damaging 0.87
IGL03060:Iars1 APN 13 49,843,923 (GRCm39) critical splice acceptor site probably null
IGL03156:Iars1 APN 13 49,856,655 (GRCm39) missense possibly damaging 0.87
IGL03206:Iars1 APN 13 49,846,546 (GRCm39) missense possibly damaging 0.81
IGL03343:Iars1 APN 13 49,878,223 (GRCm39) missense probably benign 0.12
gannett_peak UTSW 13 49,861,897 (GRCm39) missense probably damaging 1.00
missouri UTSW 13 49,841,752 (GRCm39) missense possibly damaging 0.82
spacex UTSW 13 49,876,478 (GRCm39) missense possibly damaging 0.85
wind_river UTSW 13 49,855,371 (GRCm39) missense probably damaging 1.00
R0054:Iars1 UTSW 13 49,846,611 (GRCm39) missense probably damaging 1.00
R0054:Iars1 UTSW 13 49,846,611 (GRCm39) missense probably damaging 1.00
R0184:Iars1 UTSW 13 49,875,688 (GRCm39) missense probably benign 0.00
R0200:Iars1 UTSW 13 49,879,678 (GRCm39) missense possibly damaging 0.62
R0356:Iars1 UTSW 13 49,856,709 (GRCm39) missense probably benign 0.03
R0383:Iars1 UTSW 13 49,885,818 (GRCm39) missense probably damaging 0.99
R0657:Iars1 UTSW 13 49,855,995 (GRCm39) missense probably damaging 1.00
R1005:Iars1 UTSW 13 49,840,921 (GRCm39) missense possibly damaging 0.94
R1427:Iars1 UTSW 13 49,857,745 (GRCm39) critical splice acceptor site probably null
R1449:Iars1 UTSW 13 49,887,186 (GRCm39) missense probably damaging 0.99
R1647:Iars1 UTSW 13 49,876,478 (GRCm39) missense possibly damaging 0.85
R1648:Iars1 UTSW 13 49,876,478 (GRCm39) missense possibly damaging 0.85
R1664:Iars1 UTSW 13 49,865,251 (GRCm39) missense probably damaging 0.98
R1763:Iars1 UTSW 13 49,876,553 (GRCm39) critical splice donor site probably null
R2192:Iars1 UTSW 13 49,841,605 (GRCm39) splice site probably null
R2203:Iars1 UTSW 13 49,876,151 (GRCm39) missense probably benign 0.00
R2357:Iars1 UTSW 13 49,841,679 (GRCm39) missense probably damaging 1.00
R3724:Iars1 UTSW 13 49,840,860 (GRCm39) critical splice acceptor site probably null
R4785:Iars1 UTSW 13 49,878,139 (GRCm39) missense probably damaging 0.99
R4934:Iars1 UTSW 13 49,871,460 (GRCm39) missense probably benign 0.17
R4999:Iars1 UTSW 13 49,863,137 (GRCm39) missense probably damaging 1.00
R5048:Iars1 UTSW 13 49,841,713 (GRCm39) missense probably damaging 0.99
R5268:Iars1 UTSW 13 49,843,967 (GRCm39) missense probably damaging 1.00
R5394:Iars1 UTSW 13 49,875,641 (GRCm39) missense probably damaging 1.00
R5486:Iars1 UTSW 13 49,863,049 (GRCm39) splice site probably null
R5960:Iars1 UTSW 13 49,878,113 (GRCm39) missense possibly damaging 0.68
R5972:Iars1 UTSW 13 49,863,108 (GRCm39) missense possibly damaging 0.91
R5978:Iars1 UTSW 13 49,876,469 (GRCm39) missense probably damaging 0.99
R6031:Iars1 UTSW 13 49,859,307 (GRCm39) missense probably damaging 0.98
R6031:Iars1 UTSW 13 49,859,307 (GRCm39) missense probably damaging 0.98
R6092:Iars1 UTSW 13 49,861,897 (GRCm39) missense probably damaging 1.00
R6167:Iars1 UTSW 13 49,876,190 (GRCm39) missense probably damaging 1.00
R6313:Iars1 UTSW 13 49,861,921 (GRCm39) missense probably damaging 0.99
R6358:Iars1 UTSW 13 49,880,619 (GRCm39) missense possibly damaging 0.67
R6385:Iars1 UTSW 13 49,855,371 (GRCm39) missense probably damaging 1.00
R6403:Iars1 UTSW 13 49,840,971 (GRCm39) missense probably damaging 1.00
R6575:Iars1 UTSW 13 49,878,745 (GRCm39) missense probably damaging 1.00
R6675:Iars1 UTSW 13 49,873,054 (GRCm39) missense probably damaging 0.99
R6957:Iars1 UTSW 13 49,875,637 (GRCm39) missense probably damaging 1.00
R7207:Iars1 UTSW 13 49,841,791 (GRCm39) critical splice donor site probably null
R7254:Iars1 UTSW 13 49,876,554 (GRCm39) critical splice donor site probably null
R7354:Iars1 UTSW 13 49,857,796 (GRCm39) missense probably benign
R7397:Iars1 UTSW 13 49,882,153 (GRCm39) missense probably benign 0.00
R7696:Iars1 UTSW 13 49,860,214 (GRCm39) missense probably damaging 1.00
R7799:Iars1 UTSW 13 49,876,494 (GRCm39) missense probably damaging 1.00
R7828:Iars1 UTSW 13 49,878,748 (GRCm39) missense probably benign
R8679:Iars1 UTSW 13 49,856,675 (GRCm39) unclassified probably benign
R8768:Iars1 UTSW 13 49,878,102 (GRCm39) missense probably damaging 0.99
R8797:Iars1 UTSW 13 49,841,738 (GRCm39) missense probably benign 0.12
R8990:Iars1 UTSW 13 49,841,752 (GRCm39) missense possibly damaging 0.82
R9134:Iars1 UTSW 13 49,855,323 (GRCm39) missense probably benign 0.00
R9137:Iars1 UTSW 13 49,855,350 (GRCm39) missense probably benign
R9394:Iars1 UTSW 13 49,883,536 (GRCm39) missense probably benign
R9668:Iars1 UTSW 13 49,840,885 (GRCm39) missense probably damaging 0.98
R9741:Iars1 UTSW 13 49,844,978 (GRCm39) missense probably damaging 0.99
Z1088:Iars1 UTSW 13 49,874,564 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGCAGTATATGAGAGAGCTGGC -3'
(R):5'- GTAAAGGACTCACTCGGGTGAC -3'

Sequencing Primer
(F):5'- CGAGGAGGTTGAGTTTGTACC -3'
(R):5'- CTCACTCGGGTGACAAGAG -3'
Posted On 2021-08-31