Incidental Mutation 'R8925:Fmo2'
ID 680161
Institutional Source Beutler Lab
Gene Symbol Fmo2
Ensembl Gene ENSMUSG00000040170
Gene Name flavin containing monooxygenase 2
Synonyms 2310042I22Rik, 2310008D08Rik
MMRRC Submission 068708-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # R8925 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 162701886-162726295 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 162704398 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 503 (T503A)
Ref Sequence ENSEMBL: ENSMUSP00000044405 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045902] [ENSMUST00000111510]
AlphaFold Q8K2I3
Predicted Effect probably benign
Transcript: ENSMUST00000045902
AA Change: T503A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000044405
Gene: ENSMUSG00000040170
AA Change: T503A

DomainStartEndE-ValueType
Pfam:FMO-like 2 533 8.7e-296 PFAM
Pfam:Pyr_redox_2 3 230 6.4e-12 PFAM
Pfam:Pyr_redox_3 6 220 4.4e-10 PFAM
Pfam:K_oxygenase 69 233 2.2e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111510
AA Change: T503A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000107135
Gene: ENSMUSG00000040170
AA Change: T503A

DomainStartEndE-ValueType
Pfam:FMO-like 2 533 8.7e-296 PFAM
Pfam:Pyr_redox_2 4 446 1.3e-6 PFAM
Pfam:Pyr_redox_3 6 220 8e-17 PFAM
Pfam:NAD_binding_8 7 72 4.3e-6 PFAM
Pfam:K_oxygenase 78 333 1.3e-12 PFAM
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 95% (54/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik G A 9: 57,165,805 (GRCm39) R190* probably null Het
Aldh7a1 A T 18: 56,660,060 (GRCm39) S529T probably benign Het
Carmil2 T G 8: 106,415,130 (GRCm39) Y214* probably null Het
Ccdc136 A G 6: 29,406,109 (GRCm39) I152V probably damaging Het
Ccdc88c T C 12: 100,932,676 (GRCm39) D285G possibly damaging Het
Clec4a3 T A 6: 122,946,328 (GRCm39) F191I probably damaging Het
Dlg5 A T 14: 24,206,547 (GRCm39) S1222T Het
Dnaaf9 T A 2: 130,579,300 (GRCm39) R777* probably null Het
Dnah14 T G 1: 181,508,321 (GRCm39) L1833W probably damaging Het
Dsg2 T C 18: 20,725,535 (GRCm39) W549R probably damaging Het
Ezh2 A T 6: 47,510,713 (GRCm39) V632E possibly damaging Het
Fam83a G A 15: 57,873,313 (GRCm39) V381M probably benign Het
Flacc1 A T 1: 58,706,882 (GRCm39) probably null Het
Foxo1 T C 3: 52,252,703 (GRCm39) F289L probably damaging Het
Gckr A G 5: 31,456,903 (GRCm39) E96G probably damaging Het
Gm18596 G A 10: 77,578,162 (GRCm39) A104V unknown Het
Gm21680 A T 5: 26,176,347 (GRCm39) N83K probably damaging Het
Gnb5 T C 9: 75,252,236 (GRCm39) V393A possibly damaging Het
Grin2b T G 6: 135,749,339 (GRCm39) Q621P probably damaging Het
Gtsf2 T C 15: 103,352,783 (GRCm39) I79V probably benign Het
Itga1 T C 13: 115,105,055 (GRCm39) I1040V probably benign Het
Kif2b C T 11: 91,468,023 (GRCm39) E87K probably benign Het
Klk1b8 G A 7: 43,604,206 (GRCm39) G225S probably damaging Het
L3mbtl3 A T 10: 26,220,084 (GRCm39) C94S unknown Het
Man2c1 T G 9: 57,048,456 (GRCm39) Y872* probably null Het
Mical3 T A 6: 120,984,325 (GRCm39) M832L probably benign Het
Mrc2 A G 11: 105,216,334 (GRCm39) D41G probably benign Het
Nedd1 T A 10: 92,558,258 (GRCm39) probably benign Het
Nefh TTTGGCCTCAGCTGGTGACTTGGGCTCAGCTGGAGACTTGGCCTCACCTGGTGACTTG TTTGGCCTCACCTGGTGACTTG 11: 4,890,530 (GRCm39) probably benign Het
Nicn1 C T 9: 108,171,708 (GRCm39) R163C possibly damaging Het
Notch3 C T 17: 32,372,792 (GRCm39) R593Q probably benign Het
Nxpe3 T G 16: 55,669,997 (GRCm39) E369D possibly damaging Het
Obscn T A 11: 58,977,695 (GRCm39) T1802S possibly damaging Het
Or1e33 A T 11: 73,738,406 (GRCm39) F182I probably benign Het
Or2a7 T C 6: 43,151,669 (GRCm39) F250L probably benign Het
Or4k51 A T 2: 111,585,107 (GRCm39) H171L probably benign Het
Or9s14 A G 1: 92,536,438 (GRCm39) N293S probably damaging Het
Oscar A C 7: 3,614,747 (GRCm39) V75G probably benign Het
Pcdhb17 G A 18: 37,620,372 (GRCm39) A721T probably benign Het
Pcnx2 T C 8: 126,614,659 (GRCm39) Y264C probably benign Het
Pear1 G T 3: 87,661,890 (GRCm39) A495D probably damaging Het
Peg10 GC GCTCC 6: 4,756,452 (GRCm39) probably benign Het
Plekhf1 C A 7: 37,920,998 (GRCm39) R190L probably damaging Het
Plppr5 T C 3: 117,369,532 (GRCm39) V63A probably benign Het
Pyroxd1 T A 6: 142,300,437 (GRCm39) F189Y probably damaging Het
Rab13 C T 3: 90,128,120 (GRCm39) probably benign Het
Rptor C T 11: 119,782,036 (GRCm39) T1121I probably benign Het
Scgb2b7 T C 7: 31,404,602 (GRCm39) S33G probably benign Het
Slc25a36 A G 9: 96,982,126 (GRCm39) probably null Het
Smc1b A T 15: 84,991,273 (GRCm39) probably null Het
Smtn T A 11: 3,479,477 (GRCm39) H530L possibly damaging Het
Srrt C T 5: 137,297,070 (GRCm39) C411Y probably benign Het
Stag1 C A 9: 100,587,298 (GRCm39) P7Q possibly damaging Het
Tarm1 G A 7: 3,537,719 (GRCm39) T248I possibly damaging Het
Tektl1 T C 10: 78,588,258 (GRCm39) Y184C probably damaging Het
Trim6 C T 7: 103,881,655 (GRCm39) A328V probably benign Het
Vmn1r189 T C 13: 22,286,811 (GRCm39) I9V probably benign Het
Vmn2r93 A G 17: 18,546,500 (GRCm39) T791A probably damaging Het
Vsig10l A G 7: 43,116,020 (GRCm39) T454A probably benign Het
Other mutations in Fmo2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00715:Fmo2 APN 1 162,716,282 (GRCm39) nonsense probably null
IGL01299:Fmo2 APN 1 162,705,599 (GRCm39) missense probably benign
IGL02617:Fmo2 APN 1 162,704,490 (GRCm39) missense probably damaging 1.00
IGL02994:Fmo2 APN 1 162,708,189 (GRCm39) missense probably damaging 1.00
IGL03270:Fmo2 APN 1 162,709,595 (GRCm39) missense probably damaging 1.00
F5493:Fmo2 UTSW 1 162,708,101 (GRCm39) missense probably benign 0.41
R0058:Fmo2 UTSW 1 162,713,893 (GRCm39) missense probably benign 0.38
R0058:Fmo2 UTSW 1 162,713,893 (GRCm39) missense probably benign 0.38
R0501:Fmo2 UTSW 1 162,704,497 (GRCm39) missense probably benign 0.00
R0658:Fmo2 UTSW 1 162,704,343 (GRCm39) missense possibly damaging 0.57
R0800:Fmo2 UTSW 1 162,704,383 (GRCm39) missense probably benign 0.00
R2223:Fmo2 UTSW 1 162,725,813 (GRCm39) missense probably damaging 1.00
R4360:Fmo2 UTSW 1 162,709,583 (GRCm39) missense probably damaging 0.99
R4523:Fmo2 UTSW 1 162,715,277 (GRCm39) missense probably benign 0.44
R4755:Fmo2 UTSW 1 162,716,374 (GRCm39) missense probably damaging 1.00
R6087:Fmo2 UTSW 1 162,708,002 (GRCm39) missense probably benign 0.45
R6219:Fmo2 UTSW 1 162,708,085 (GRCm39) missense probably damaging 0.97
R6668:Fmo2 UTSW 1 162,704,617 (GRCm39) missense probably benign 0.15
R7042:Fmo2 UTSW 1 162,708,226 (GRCm39) missense probably damaging 1.00
R7291:Fmo2 UTSW 1 162,715,271 (GRCm39) missense probably benign 0.06
R7560:Fmo2 UTSW 1 162,716,318 (GRCm39) missense probably damaging 1.00
R7580:Fmo2 UTSW 1 162,704,613 (GRCm39) missense possibly damaging 0.46
R7657:Fmo2 UTSW 1 162,716,413 (GRCm39) missense probably damaging 1.00
R8757:Fmo2 UTSW 1 162,708,005 (GRCm39) missense probably benign 0.09
R8759:Fmo2 UTSW 1 162,708,005 (GRCm39) missense probably benign 0.09
R8765:Fmo2 UTSW 1 162,707,966 (GRCm39) missense probably benign 0.36
R8927:Fmo2 UTSW 1 162,704,398 (GRCm39) missense probably benign 0.00
R9002:Fmo2 UTSW 1 162,705,647 (GRCm39) nonsense probably null
R9141:Fmo2 UTSW 1 162,709,623 (GRCm39) missense probably null 0.01
R9486:Fmo2 UTSW 1 162,708,292 (GRCm39) missense probably damaging 1.00
Z1176:Fmo2 UTSW 1 162,725,843 (GRCm39) missense probably damaging 1.00
Z1176:Fmo2 UTSW 1 162,715,167 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- CTCAAAACCTGCCATGGCTG -3'
(R):5'- AGGTGCAAAGCCAGATTTCG -3'

Sequencing Primer
(F):5'- ACCTGCCATGGCTGATAGTAC -3'
(R):5'- GTGCAAAGCCAGATTTCGTCTCTC -3'
Posted On 2021-08-31