Mutagenetix > Incidental Mutation

Incidental Mutation 'R8930:Vmn1r238'

680279

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r238

Ensembl Gene

ENSMUSG00000091539

Gene Name

vomeronasal 1 receptor, 238

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R8930 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

3122492-3123412 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 3123127 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 96 (V96M)

Ref Sequence

ENSEMBL: ENSMUSP00000129804 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165255]

AlphaFold

E9Q373

Predicted Effect

probably benign
Transcript: ENSMUST00000165255
AA Change: V96M

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000129804
Gene: ENSMUSG00000091539
AA Change: V96M

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	302	5.3e-8	PFAM
Pfam:7tm_1	27	292	8.8e-7	PFAM
Pfam:V1R	34	298	1.9e-33	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.5%

Validation Efficiency

100% (64/64)

Allele List at MGI

Other mutations in this stock

Total: 66 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700014D04Rik	C	T	13: 59,742,201	E184K	possibly damaging	Het
4921524L21Rik	T	C	18: 6,629,693		probably null	Het
Abl2	A	G	1: 156,633,832	T435A	probably damaging	Het
Adamtsl3	C	T	7: 82,611,861	P29S		Het
Ankrd11	C	T	8: 122,895,979	R378K	probably damaging	Het
Arap1	G	A	7: 101,408,117	R1355Q	possibly damaging	Het
Ass1	T	A	2: 31,492,375	M186K	probably damaging	Het
Bckdk	A	G	7: 127,908,010	D312G	probably benign	Het
Btg3	T	A	16: 78,373,410	N3I	probably benign	Het
C87414	T	G	5: 93,638,085	D112A	probably benign	Het
Cd163	T	C	6: 124,317,923	F649L	probably damaging	Het
Cdh1	ACTCGAAATGATGTGGCTC	ACTC	8: 106,666,238		probably benign	Het
Cnksr3	A	T	10: 7,160,780	V27E	probably damaging	Het
Col12a1	A	T	9: 79,673,383	S1512T	probably benign	Het
Cstf1	A	G	2: 172,375,703	T79A	probably benign	Het
Defa24	T	C	8: 21,735,357	Y88H	probably benign	Het
Dgkz	C	T	2: 91,939,570	R389Q	probably damaging	Het
Dsg3	T	A	18: 20,539,661	D796E	probably damaging	Het
Dyrk3	G	T	1: 131,129,556	D293E	probably damaging	Het
Epb42	T	C	2: 121,024,286	D606G	probably benign	Het
Erich5	G	A	15: 34,453,698	G18S	probably benign	Het
Fam196a	A	G	7: 134,899,152	I408T	probably damaging	Het
Fam196b	T	C	11: 34,402,707	S250P	probably benign	Het
Fam8a1	C	T	13: 46,674,392	T352M	probably benign	Het
Fastkd3	T	A	13: 68,583,716	L52Q	probably benign	Het
Fat3	G	A	9: 15,999,523	H1728Y	probably benign	Het
Fgl1	A	G	8: 41,209,831	V39A	probably benign	Het
Gm7298	T	C	6: 121,765,071	V484A	probably benign	Het
Gpr75	A	G	11: 30,892,571	Q492R	possibly damaging	Het
Hoxc8	A	G	15: 102,990,886	H36R	possibly damaging	Het
Isy1	T	C	6: 87,821,531	I214V	probably damaging	Het
Kdm5b	C	T	1: 134,616,272	P853L	probably damaging	Het
Man2b1	A	G	8: 85,095,393	T746A	probably damaging	Het
Mast3	A	T	8: 70,781,733		probably benign	Het
Mki67	A	G	7: 135,698,899	S1469P	possibly damaging	Het
Mrps30	C	T	13: 118,387,159	A26T	probably benign	Het
Mup10	T	A	4: 60,580,709	T92S	possibly damaging	Het
Otud7a	A	G	7: 63,757,491	D514G	possibly damaging	Het
Pacs1	T	A	19: 5,135,002	S932C	probably damaging	Het
Pbx2	C	T	17: 34,594,589	R188C	probably damaging	Het
Pclo	C	T	5: 14,712,975	P536S	possibly damaging	Het
Pdxdc1	A	T	16: 13,854,405	I377N	probably damaging	Het
Peg10	GAT	GATCAT	6: 4,756,449		probably benign	Het
Phip	T	C	9: 82,906,988	K758E	possibly damaging	Het
Ptprm	C	T	17: 66,956,851	R467H	probably benign	Het
Scnn1b	C	T	7: 121,902,844	R242C	probably damaging	Het
Seh1l	T	C	18: 67,775,064	S19P	possibly damaging	Het
Slc28a1	T	A	7: 81,167,967	V528D	probably benign	Het
Slc6a17	G	T	3: 107,472,191	Q554K	probably benign	Het
Spag16	G	A	1: 70,299,769		probably null	Het
Srfbp1	T	A	18: 52,490,045	N377K	possibly damaging	Het
Stap2	A	G	17: 55,997,895	S296P	probably benign	Het
Tnr	A	T	1: 159,912,789	I1178F	probably damaging	Het
Tomt	C	T	7: 101,901,143	A139T	probably damaging	Het
Trak2	T	C	1: 58,935,808	Q75R	probably benign	Het
Tulp1	T	C	17: 28,364,494	K58E	probably benign	Het
Utp6	A	G	11: 79,943,229		probably null	Het
Vmn1r21	T	C	6: 57,844,013	T149A	probably benign	Het
Vmn1r9	T	A	6: 57,071,681	I247N	probably damaging	Het
Vps33b	T	C	7: 80,282,493	C138R	possibly damaging	Het
Wnk1	A	T	6: 119,963,265	V837E	probably damaging	Het
Xirp2	C	T	2: 67,482,363	H59Y	possibly damaging	Het
Zbtb38	G	T	9: 96,686,381	D883E	probably benign	Het
Zbtb7a	C	A	10: 81,144,534	D187E	probably benign	Het
Zfp511	T	C	7: 140,037,529	V148A	probably damaging	Het
Zfp52	A	G	17: 21,560,430	D180G	possibly damaging	Het

Other mutations in Vmn1r238

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn1r238	APN	18	3123243	missense	probably benign	0.01
IGL01385:Vmn1r238	APN	18	3122770	missense	possibly damaging	0.83
IGL02716:Vmn1r238	APN	18	3123124	missense	probably damaging	1.00
R1219:Vmn1r238	UTSW	18	3123135	missense	possibly damaging	0.81
R1568:Vmn1r238	UTSW	18	3123358	missense	probably benign	0.00
R1864:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R3024:Vmn1r238	UTSW	18	3123305	missense	probably benign	0.13
R4291:Vmn1r238	UTSW	18	3123214	nonsense	probably null
R4304:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R4586:Vmn1r238	UTSW	18	3123294	missense	probably damaging	1.00
R4664:Vmn1r238	UTSW	18	3123300	missense	probably damaging	0.99
R5123:Vmn1r238	UTSW	18	3123243	missense	probably benign
R5430:Vmn1r238	UTSW	18	3122521	missense	possibly damaging	0.63
R5834:Vmn1r238	UTSW	18	3123168	missense	probably benign
R7186:Vmn1r238	UTSW	18	3122661	missense	probably damaging	0.99
R7206:Vmn1r238	UTSW	18	3122623	missense	possibly damaging	0.94
R7308:Vmn1r238	UTSW	18	3122875	missense	probably benign	0.09
R7346:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R7467:Vmn1r238	UTSW	18	3123393	missense	probably benign	0.10
R7571:Vmn1r238	UTSW	18	3122721	missense	probably damaging	1.00
R7808:Vmn1r238	UTSW	18	3123033	missense	probably benign	0.03
R8085:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R8086:Vmn1r238	UTSW	18	3123250	missense	probably damaging	1.00
R8325:Vmn1r238	UTSW	18	3122529	missense	probably benign	0.00
R8423:Vmn1r238	UTSW	18	3123365	nonsense	probably null
R8747:Vmn1r238	UTSW	18	3123232	missense	possibly damaging	0.87
R8932:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R9279:Vmn1r238	UTSW	18	3122994	missense	probably damaging	0.99
R9382:Vmn1r238	UTSW	18	3122676	missense	probably damaging	0.99
R9644:Vmn1r238	UTSW	18	3122635	missense	probably benign	0.10
R9725:Vmn1r238	UTSW	18	3122577	missense	probably benign	0.00
Z1177:Vmn1r238	UTSW	18	3122505	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- GCCTGATTCTCTTAGTGGAGTC -3'
(R):5'- CAGTGGGAATGTTTGGCAATTC -3'

Sequencing Primer
(F):5'- TCAAGATGTTTAGAAGCAGGTGCAC -3'
(R):5'- GGGAATGTTTGGCAATTCCTCAATC -3'

Posted On

2021-08-31