Incidental Mutation 'R8931:Ifna2'
ID 680295
Institutional Source Beutler Lab
Gene Symbol Ifna2
Ensembl Gene ENSMUSG00000078354
Gene Name interferon alpha 2
Synonyms Ifa2
MMRRC Submission 068775-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R8931 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 88601444-88602016 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 88601712 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 102 (T102I)
Ref Sequence ENSEMBL: ENSMUSP00000100778 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105147]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000105147
AA Change: T102I

PolyPhen 2 Score 0.304 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000100778
Gene: ENSMUSG00000078354
AA Change: T102I

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 1.24e-70 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acat3 G C 17: 13,147,405 (GRCm39) P204R probably damaging Het
Aldh3b1 A G 19: 3,968,803 (GRCm39) I250T possibly damaging Het
Ankrd11 C T 8: 123,622,718 (GRCm39) R378K probably damaging Het
Arap1 G A 7: 101,057,324 (GRCm39) R1355Q possibly damaging Het
Arhgef19 T C 4: 140,976,603 (GRCm39) V455A probably damaging Het
BC051019 T C 7: 109,315,286 (GRCm39) E323G probably damaging Het
Bzw2 T C 12: 36,184,943 (GRCm39) N2S possibly damaging Het
Calm3 G C 7: 16,651,398 (GRCm39) F66L probably damaging Het
Carmil1 T A 13: 24,338,704 (GRCm39) T191S probably benign Het
Cemip2 T A 19: 21,770,323 (GRCm39) S104T probably benign Het
Cep170 A T 1: 176,597,377 (GRCm39) C389S probably benign Het
Clhc1 C T 11: 29,510,533 (GRCm39) Q195* probably null Het
Cttnbp2 A G 6: 18,434,808 (GRCm39) L350P probably benign Het
Cyp7a1 T C 4: 6,271,238 (GRCm39) E306G possibly damaging Het
Ddx25 T C 9: 35,465,864 (GRCm39) N119S possibly damaging Het
Ephx2 G T 14: 66,322,441 (GRCm39) probably benign Het
Ern2 C T 7: 121,769,363 (GRCm39) A888T probably benign Het
Fbln2 A T 6: 91,246,072 (GRCm39) I973F probably damaging Het
Fbn1 T C 2: 125,202,095 (GRCm39) I1259M probably damaging Het
Glis1 A G 4: 107,421,060 (GRCm39) H92R probably benign Het
Gm13283 A C 4: 88,679,516 (GRCm39) D169A probably benign Het
Gpr61 A G 3: 108,057,470 (GRCm39) L397P probably benign Het
H4c11 T A 13: 21,919,369 (GRCm39) I35N probably damaging Het
Hip1 A T 5: 135,460,297 (GRCm39) probably benign Het
Hmgcs2 C T 3: 98,203,557 (GRCm39) A222V probably damaging Het
Kat6b T C 14: 21,674,995 (GRCm39) S387P probably damaging Het
Ldlr G A 9: 21,643,108 (GRCm39) V45M probably damaging Het
Mc3r A T 2: 172,091,515 (GRCm39) I246F possibly damaging Het
Mug1 G C 6: 121,861,296 (GRCm39) A1306P probably benign Het
Myo15a A G 11: 60,368,020 (GRCm39) E260G probably benign Het
Naa16 A G 14: 79,582,395 (GRCm39) Y565H probably damaging Het
Ndufaf7 A G 17: 79,244,950 (GRCm39) Y23C possibly damaging Het
Nop58 G A 1: 59,731,549 (GRCm39) probably null Het
Or6c33 A T 10: 129,853,769 (GRCm39) T180S possibly damaging Het
Or6c88 A T 10: 129,406,550 (GRCm39) T9S probably benign Het
Or7g19 T A 9: 18,855,920 (GRCm39) probably benign Het
Pcdh8 G A 14: 80,006,971 (GRCm39) Q531* probably null Het
Pik3c2g A G 6: 139,821,093 (GRCm39) T297A probably benign Het
Poc1b T C 10: 99,028,861 (GRCm39) probably null Het
Prb1c G A 6: 132,338,897 (GRCm39) P107L Het
Prokr2 A G 2: 132,215,996 (GRCm39) V155A possibly damaging Het
Rce1 C T 19: 4,674,094 (GRCm39) probably benign Het
Rnf148 A T 6: 23,654,704 (GRCm39) N97K possibly damaging Het
Setbp1 A G 18: 78,899,723 (GRCm39) S1315P probably benign Het
Sgcz A G 8: 38,107,140 (GRCm39) V124A probably damaging Het
Slc25a2 C A 18: 37,771,089 (GRCm39) G147C probably damaging Het
Slc28a2b C A 2: 122,348,983 (GRCm39) P303Q Het
Sod2 T C 17: 13,227,193 (GRCm39) L49P probably damaging Het
Tbc1d12 T C 19: 38,854,098 (GRCm39) V260A probably benign Het
Tcte2 C A 17: 13,933,410 (GRCm39) probably benign Het
Tenm3 T C 8: 48,688,637 (GRCm39) T2317A probably damaging Het
Tfcp2 T C 15: 100,402,298 (GRCm39) I500V possibly damaging Het
Trav14-3 C A 14: 54,001,112 (GRCm39) Q108K probably damaging Het
Trbv14 T C 6: 41,112,364 (GRCm39) Y54H probably damaging Het
Trpm3 T A 19: 22,744,034 (GRCm39) V337E probably damaging Het
Tsbp1 T C 17: 34,659,328 (GRCm39) probably benign Het
Uox A T 3: 146,318,047 (GRCm39) I14F probably damaging Het
Wdfy3 A G 5: 102,065,421 (GRCm39) V1249A probably benign Het
Zfp511 T C 7: 139,617,194 (GRCm39) Y97H probably damaging Het
Zfp536 G T 7: 37,268,721 (GRCm39) Q232K probably benign Het
Zng1 T G 19: 24,932,780 (GRCm39) K84N probably damaging Het
Other mutations in Ifna2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01882:Ifna2 APN 4 88,601,979 (GRCm39) missense possibly damaging 0.87
IGL03247:Ifna2 APN 4 88,601,614 (GRCm39) missense probably benign 0.00
PIT4687001:Ifna2 UTSW 4 88,601,542 (GRCm39) missense possibly damaging 0.92
R0691:Ifna2 UTSW 4 88,601,895 (GRCm39) missense probably damaging 1.00
R1305:Ifna2 UTSW 4 88,601,614 (GRCm39) missense probably benign 0.00
R6470:Ifna2 UTSW 4 88,601,751 (GRCm39) missense probably benign 0.01
R7886:Ifna2 UTSW 4 88,601,506 (GRCm39) missense probably damaging 1.00
R8560:Ifna2 UTSW 4 88,601,502 (GRCm39) missense possibly damaging 0.93
R9037:Ifna2 UTSW 4 88,601,664 (GRCm39) missense probably benign 0.11
X0013:Ifna2 UTSW 4 88,601,771 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AGACTTCTGCTCTGACCACC -3'
(R):5'- TCTCTAGGATGCGATCTGCCTC -3'

Sequencing Primer
(F):5'- ACAGGGGCTGTGTTTCTTCTCTC -3'
(R):5'- GATGCGATCTGCCTCACACTTATAAC -3'
Posted On 2021-08-31