|Institutional Source||Beutler Lab|
|Gene Name||aurora kinase C|
|Synonyms||IAK3, AIK3, Stk13, AIE1|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8933 (G1)|
|Chromosomal Location||6995300-7003091 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to C at 7002797 bp (GRCm38)|
|Amino Acid Change||Aspartic acid to Alanine at position 136 (D136A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000147055 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000086248] [ENSMUST00000207660] [ENSMUST00000207711] [ENSMUST00000208049] [ENSMUST00000208518]|
AA Change: D267A
PolyPhen 2 Score 0.055 (Sensitivity: 0.94; Specificity: 0.84)
AA Change: D267A
AA Change: D136A
PolyPhen 2 Score 0.916 (Sensitivity: 0.81; Specificity: 0.94)
AA Change: D228A
PolyPhen 2 Score 0.907 (Sensitivity: 0.81; Specificity: 0.94)
|Coding Region Coverage||
|Validation Efficiency||100% (86/86)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Male mice homozygous for a knock-out allele are viable but subfertile, as shown by reduced litter sizes or failure to produce a litter. Observed sperm abnormalities include heterogeneous chromatin condensation, loose acrosomes, and blunted heads. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Aurkc||
(F):5'- TTCACCAGGAAGCCAGACAG -3'
(R):5'- AAACAGAGCCTGGAGACCTTCC -3'
(F):5'- AAGCCAGACAGTGATGGCTCC -3'
(R):5'- TGGAGACCTTCCTGAAGAAATAC -3'