Incidental Mutation 'R8936:Tacc2'
| ID |
680644 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tacc2
|
| Ensembl Gene |
ENSMUSG00000030852 |
| Gene Name |
transforming, acidic coiled-coil containing protein 2 |
| Synonyms |
|
| MMRRC Submission |
068779-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8936 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
130179168-130366515 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 130228367 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 1684
(N1684S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000146419
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000059145]
[ENSMUST00000084513]
[ENSMUST00000124096]
[ENSMUST00000207789]
[ENSMUST00000207918]
[ENSMUST00000208722]
[ENSMUST00000215492]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000059145
|
| SMART Domains |
Protein: ENSMUSP00000061242
Gene: ENSMUSG00000030852
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
87 |
102 |
N/A |
INTRINSIC |
|
low complexity region
|
147 |
173 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
291 |
2.03e-5 |
PROSPERO |
|
low complexity region
|
345 |
356 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
483 |
566 |
2.03e-5 |
PROSPERO |
|
low complexity region
|
571 |
586 |
N/A |
INTRINSIC |
|
low complexity region
|
603 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
648 |
662 |
N/A |
INTRINSIC |
|
coiled coil region
|
873 |
900 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
939 |
1145 |
4e-85 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084513
AA Change: N1684S
PolyPhen 2
Score 0.099 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000081561
Gene: ENSMUSG00000030852
AA Change: N1684S
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
19 |
346 |
3.83e-6 |
PROSPERO |
|
low complexity region
|
398 |
410 |
N/A |
INTRINSIC |
|
low complexity region
|
413 |
431 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
778 |
1068 |
3.83e-6 |
PROSPERO |
|
low complexity region
|
1397 |
1415 |
N/A |
INTRINSIC |
|
low complexity region
|
1723 |
1739 |
N/A |
INTRINSIC |
|
low complexity region
|
1794 |
1809 |
N/A |
INTRINSIC |
|
low complexity region
|
1854 |
1880 |
N/A |
INTRINSIC |
|
low complexity region
|
2052 |
2063 |
N/A |
INTRINSIC |
|
low complexity region
|
2278 |
2293 |
N/A |
INTRINSIC |
|
low complexity region
|
2310 |
2321 |
N/A |
INTRINSIC |
|
low complexity region
|
2355 |
2369 |
N/A |
INTRINSIC |
|
coiled coil region
|
2606 |
2633 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
2673 |
2873 |
6.1e-87 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124096
|
| SMART Domains |
Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
1 |
118 |
4.8e-19 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1 |
118 |
1.7e-50 |
PFAM |
|
low complexity region
|
146 |
160 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207789
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000207918
AA Change: N1684S
PolyPhen 2
Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000208722
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000215492
AA Change: N1703S
PolyPhen 2
Score 0.853 (Sensitivity: 0.83; Specificity: 0.93)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are healthy and fertile and do not display any increase in tumorigenesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 85 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc2 |
A |
G |
19: 43,797,101 (GRCm39) |
K491E |
probably benign |
Het |
| Abcd3 |
T |
C |
3: 121,569,117 (GRCm39) |
I374V |
probably benign |
Het |
| Adam34 |
G |
A |
8: 44,104,439 (GRCm39) |
T402I |
probably benign |
Het |
| Angptl7 |
G |
T |
4: 148,581,790 (GRCm39) |
H199N |
probably benign |
Het |
| Ankrd11 |
A |
G |
8: 123,621,840 (GRCm39) |
C671R |
possibly damaging |
Het |
| Anxa7 |
G |
A |
14: 20,521,495 (GRCm39) |
P67L |
unknown |
Het |
| Ap3d1 |
T |
A |
10: 80,547,952 (GRCm39) |
Q913H |
probably benign |
Het |
| Arhgef37 |
A |
G |
18: 61,656,948 (GRCm39) |
I39T |
probably damaging |
Het |
| Armh4 |
G |
A |
14: 50,008,024 (GRCm39) |
T483I |
probably damaging |
Het |
| C3ar1 |
T |
A |
6: 122,828,044 (GRCm39) |
T58S |
probably damaging |
Het |
| Caap1 |
A |
T |
4: 94,389,332 (GRCm39) |
L334Q |
probably damaging |
Het |
| Ccr1 |
A |
T |
9: 123,763,882 (GRCm39) |
I216K |
probably damaging |
Het |
| Cdh9 |
T |
A |
15: 16,831,162 (GRCm39) |
|
probably null |
Het |
| Cept1 |
A |
G |
3: 106,411,921 (GRCm39) |
F351S |
possibly damaging |
Het |
| Cfap61 |
A |
G |
2: 145,791,879 (GRCm39) |
D112G |
possibly damaging |
Het |
| Cul9 |
T |
A |
17: 46,839,528 (GRCm39) |
S817C |
possibly damaging |
Het |
| Dido1 |
A |
G |
2: 180,303,195 (GRCm39) |
S1570P |
probably benign |
Het |
| Disc1 |
A |
G |
8: 125,814,754 (GRCm39) |
D206G |
probably damaging |
Het |
| Dock5 |
T |
A |
14: 68,083,439 (GRCm39) |
R157* |
probably null |
Het |
| Dpp6 |
A |
G |
5: 27,926,140 (GRCm39) |
D738G |
probably damaging |
Het |
| Enpep |
A |
G |
3: 129,125,884 (GRCm39) |
F83L |
possibly damaging |
Het |
| F10 |
G |
T |
8: 13,095,086 (GRCm39) |
W81L |
probably damaging |
Het |
| Fam217a |
T |
C |
13: 35,095,147 (GRCm39) |
D356G |
probably damaging |
Het |
| Fes |
T |
C |
7: 80,031,473 (GRCm39) |
E467G |
probably damaging |
Het |
| Fignl2 |
A |
T |
15: 100,951,339 (GRCm39) |
D314E |
unknown |
Het |
| Foxh1 |
T |
C |
15: 76,552,719 (GRCm39) |
|
probably benign |
Het |
| Gdpd5 |
T |
C |
7: 99,109,199 (GRCm39) |
L573P |
probably benign |
Het |
| Gigyf1 |
T |
A |
5: 137,523,469 (GRCm39) |
S934T |
probably damaging |
Het |
| Gm7356 |
C |
T |
17: 14,221,937 (GRCm39) |
V31I |
probably benign |
Het |
| Hoatz |
A |
G |
9: 51,011,298 (GRCm39) |
|
probably null |
Het |
| Hoxa2 |
C |
A |
6: 52,140,517 (GRCm39) |
K156N |
probably damaging |
Het |
| Ifi203 |
G |
A |
1: 173,756,857 (GRCm39) |
|
probably benign |
Het |
| Il5ra |
A |
T |
6: 106,692,604 (GRCm39) |
D380E |
possibly damaging |
Het |
| Ino80c |
C |
A |
18: 24,254,865 (GRCm39) |
|
probably benign |
Het |
| Kif18a |
T |
A |
2: 109,163,966 (GRCm39) |
W772R |
probably benign |
Het |
| Lipo3 |
G |
T |
19: 33,557,880 (GRCm39) |
Q171K |
probably damaging |
Het |
| Mga |
A |
T |
2: 119,794,709 (GRCm39) |
T2798S |
probably damaging |
Het |
| Msantd5l |
A |
G |
11: 51,145,249 (GRCm39) |
S113P |
probably damaging |
Het |
| Mybpc1 |
T |
A |
10: 88,394,437 (GRCm39) |
T297S |
probably benign |
Het |
| Myh7 |
T |
G |
14: 55,228,440 (GRCm39) |
Q222P |
probably benign |
Het |
| N4bp2l2 |
T |
C |
5: 150,585,362 (GRCm39) |
D206G |
probably benign |
Het |
| Nacc2 |
G |
C |
2: 25,952,216 (GRCm39) |
T380S |
probably benign |
Het |
| Niban3 |
T |
A |
8: 72,060,307 (GRCm39) |
|
probably benign |
Het |
| Nkpd1 |
T |
A |
7: 19,255,875 (GRCm39) |
D186E |
probably damaging |
Het |
| Nol10 |
A |
T |
12: 17,466,863 (GRCm39) |
E581V |
probably benign |
Het |
| Ntrk1 |
A |
T |
3: 87,693,366 (GRCm39) |
N255K |
possibly damaging |
Het |
| Nudt5 |
T |
G |
2: 5,869,228 (GRCm39) |
D151E |
probably benign |
Het |
| Obscn |
A |
T |
11: 58,892,858 (GRCm39) |
L6796Q |
probably benign |
Het |
| Or10p21 |
C |
T |
10: 128,847,802 (GRCm39) |
A216V |
probably benign |
Het |
| Or4k2 |
A |
G |
14: 50,423,999 (GRCm39) |
I225T |
possibly damaging |
Het |
| Oxct2b |
A |
G |
4: 123,010,838 (GRCm39) |
T253A |
probably benign |
Het |
| Patl1 |
G |
A |
19: 11,891,725 (GRCm39) |
C10Y |
probably damaging |
Het |
| Pikfyve |
A |
G |
1: 65,310,427 (GRCm39) |
R1905G |
possibly damaging |
Het |
| Pkhd1l1 |
A |
G |
15: 44,402,312 (GRCm39) |
E2228G |
possibly damaging |
Het |
| Plcg1 |
A |
G |
2: 160,589,986 (GRCm39) |
K135E |
probably benign |
Het |
| Proz |
A |
G |
8: 13,115,319 (GRCm39) |
T112A |
probably benign |
Het |
| Prune2 |
A |
G |
19: 17,099,199 (GRCm39) |
N1568D |
probably benign |
Het |
| Rbm4 |
A |
G |
19: 4,837,539 (GRCm39) |
V431A |
probably benign |
Het |
| Rgs19 |
G |
T |
2: 181,333,058 (GRCm39) |
C40* |
probably null |
Het |
| Rimbp3 |
T |
A |
16: 17,030,884 (GRCm39) |
I1436K |
probably benign |
Het |
| Rnps1 |
T |
A |
17: 24,641,176 (GRCm39) |
M192K |
probably damaging |
Het |
| Rrad |
C |
T |
8: 105,355,222 (GRCm39) |
R262Q |
possibly damaging |
Het |
| Slc17a9 |
G |
A |
2: 180,380,210 (GRCm39) |
V318I |
probably benign |
Het |
| Slc5a12 |
A |
G |
2: 110,467,455 (GRCm39) |
I412V |
probably damaging |
Het |
| Smc4 |
T |
A |
3: 68,925,491 (GRCm39) |
N329K |
probably benign |
Het |
| St3gal4 |
G |
A |
9: 34,964,723 (GRCm39) |
R165W |
probably damaging |
Het |
| Strbp |
G |
A |
2: 37,493,949 (GRCm39) |
R375* |
probably null |
Het |
| Tet1 |
A |
T |
10: 62,676,063 (GRCm39) |
L671* |
probably null |
Het |
| Tex2 |
C |
A |
11: 106,458,144 (GRCm39) |
E429* |
probably null |
Het |
| Tgm4 |
T |
C |
9: 122,869,541 (GRCm39) |
I40T |
possibly damaging |
Het |
| Tmem132d |
C |
T |
5: 127,869,676 (GRCm39) |
D553N |
probably damaging |
Het |
| Tnks |
A |
T |
8: 35,320,501 (GRCm39) |
Y723* |
probably null |
Het |
| Tnks1bp1 |
A |
T |
2: 84,894,320 (GRCm39) |
T1416S |
probably benign |
Het |
| Tnxb |
T |
A |
17: 34,904,646 (GRCm39) |
L1137Q |
probably damaging |
Het |
| Tor4a |
A |
C |
2: 25,085,202 (GRCm39) |
C68G |
probably damaging |
Het |
| Tubb2b |
A |
C |
13: 34,312,445 (GRCm39) |
V116G |
probably damaging |
Het |
| Upb1 |
T |
A |
10: 75,250,827 (GRCm39) |
S99T |
probably benign |
Het |
| Vmn1r31 |
T |
A |
6: 58,449,083 (GRCm39) |
I261F |
unknown |
Het |
| Vmn1r53 |
T |
C |
6: 90,200,571 (GRCm39) |
Y251C |
probably benign |
Het |
| Vmn2r58 |
T |
C |
7: 41,513,981 (GRCm39) |
R221G |
|
Het |
| Vmn2r88 |
A |
T |
14: 51,655,983 (GRCm39) |
I740F |
possibly damaging |
Het |
| Zfp644 |
C |
T |
5: 106,783,503 (GRCm39) |
G1015R |
probably damaging |
Het |
| Zfy1 |
T |
C |
Y: 738,726 (GRCm39) |
D160G |
unknown |
Het |
| Zscan25 |
T |
A |
5: 145,223,200 (GRCm39) |
V156E |
probably damaging |
Het |
| Zyg11b |
A |
T |
4: 108,109,356 (GRCm39) |
F443I |
|
Het |
|
| Other mutations in Tacc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00836:Tacc2
|
APN |
7 |
130,360,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01396:Tacc2
|
APN |
7 |
130,360,919 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01621:Tacc2
|
APN |
7 |
130,331,498 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02000:Tacc2
|
APN |
7 |
130,330,898 (GRCm39) |
splice site |
probably null |
|
|
IGL02075:Tacc2
|
APN |
7 |
130,330,582 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02201:Tacc2
|
APN |
7 |
130,227,942 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02205:Tacc2
|
APN |
7 |
130,228,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02399:Tacc2
|
APN |
7 |
130,225,129 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02456:Tacc2
|
APN |
7 |
130,227,991 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL02559:Tacc2
|
APN |
7 |
130,360,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02734:Tacc2
|
APN |
7 |
130,227,829 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02800:Tacc2
|
APN |
7 |
130,225,809 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02938:Tacc2
|
APN |
7 |
130,330,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03031:Tacc2
|
APN |
7 |
130,225,585 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03278:Tacc2
|
APN |
7 |
130,335,298 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03283:Tacc2
|
APN |
7 |
130,343,996 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL03371:Tacc2
|
APN |
7 |
130,227,791 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
aces
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Jacks
|
UTSW |
7 |
130,227,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
kings
|
UTSW |
7 |
130,225,213 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0002:Tacc2
|
UTSW |
7 |
130,223,515 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0119:Tacc2
|
UTSW |
7 |
130,223,605 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0244:Tacc2
|
UTSW |
7 |
130,353,555 (GRCm39) |
splice site |
probably benign |
|
|
R0619:Tacc2
|
UTSW |
7 |
130,318,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0624:Tacc2
|
UTSW |
7 |
130,179,239 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0632:Tacc2
|
UTSW |
7 |
130,227,325 (GRCm39) |
nonsense |
probably null |
|
|
R1015:Tacc2
|
UTSW |
7 |
130,225,795 (GRCm39) |
missense |
probably benign |
|
|
R1081:Tacc2
|
UTSW |
7 |
130,330,304 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1086:Tacc2
|
UTSW |
7 |
130,228,227 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1351:Tacc2
|
UTSW |
7 |
130,264,733 (GRCm39) |
intron |
probably benign |
|
|
R1538:Tacc2
|
UTSW |
7 |
130,227,149 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1743:Tacc2
|
UTSW |
7 |
130,228,328 (GRCm39) |
nonsense |
probably null |
|
|
R1771:Tacc2
|
UTSW |
7 |
130,343,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1876:Tacc2
|
UTSW |
7 |
130,225,475 (GRCm39) |
missense |
probably benign |
0.38 |
|
R1893:Tacc2
|
UTSW |
7 |
130,227,055 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1899:Tacc2
|
UTSW |
7 |
130,225,932 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2005:Tacc2
|
UTSW |
7 |
130,333,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Tacc2
|
UTSW |
7 |
130,223,587 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2338:Tacc2
|
UTSW |
7 |
130,335,299 (GRCm39) |
splice site |
probably null |
|
|
R2407:Tacc2
|
UTSW |
7 |
130,223,770 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R3051:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3052:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3053:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3116:Tacc2
|
UTSW |
7 |
130,360,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3412:Tacc2
|
UTSW |
7 |
130,336,724 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3683:Tacc2
|
UTSW |
7 |
130,226,800 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3685:Tacc2
|
UTSW |
7 |
130,226,800 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3872:Tacc2
|
UTSW |
7 |
130,224,152 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4063:Tacc2
|
UTSW |
7 |
130,330,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4410:Tacc2
|
UTSW |
7 |
130,343,941 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4434:Tacc2
|
UTSW |
7 |
130,225,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4438:Tacc2
|
UTSW |
7 |
130,225,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4618:Tacc2
|
UTSW |
7 |
130,227,946 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4674:Tacc2
|
UTSW |
7 |
130,226,591 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4742:Tacc2
|
UTSW |
7 |
130,227,697 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4934:Tacc2
|
UTSW |
7 |
130,330,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4947:Tacc2
|
UTSW |
7 |
130,227,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4964:Tacc2
|
UTSW |
7 |
130,330,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4966:Tacc2
|
UTSW |
7 |
130,330,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4967:Tacc2
|
UTSW |
7 |
130,225,678 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5052:Tacc2
|
UTSW |
7 |
130,336,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5276:Tacc2
|
UTSW |
7 |
130,331,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tacc2
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5331:Tacc2
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5372:Tacc2
|
UTSW |
7 |
130,224,990 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5556:Tacc2
|
UTSW |
7 |
130,276,336 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5645:Tacc2
|
UTSW |
7 |
130,225,781 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5886:Tacc2
|
UTSW |
7 |
130,330,850 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5996:Tacc2
|
UTSW |
7 |
130,225,213 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6074:Tacc2
|
UTSW |
7 |
130,227,165 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6127:Tacc2
|
UTSW |
7 |
130,227,845 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6156:Tacc2
|
UTSW |
7 |
130,227,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6298:Tacc2
|
UTSW |
7 |
130,228,255 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6444:Tacc2
|
UTSW |
7 |
130,225,142 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6533:Tacc2
|
UTSW |
7 |
130,224,567 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6724:Tacc2
|
UTSW |
7 |
130,330,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7111:Tacc2
|
UTSW |
7 |
130,330,618 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7150:Tacc2
|
UTSW |
7 |
130,330,807 (GRCm39) |
missense |
probably benign |
|
|
R7290:Tacc2
|
UTSW |
7 |
130,331,103 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7404:Tacc2
|
UTSW |
7 |
130,225,066 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7460:Tacc2
|
UTSW |
7 |
130,226,363 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7651:Tacc2
|
UTSW |
7 |
130,224,884 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7666:Tacc2
|
UTSW |
7 |
130,318,544 (GRCm39) |
start gained |
probably benign |
|
|
R7695:Tacc2
|
UTSW |
7 |
130,330,633 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7766:Tacc2
|
UTSW |
7 |
130,345,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7793:Tacc2
|
UTSW |
7 |
130,224,843 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7861:Tacc2
|
UTSW |
7 |
130,227,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8204:Tacc2
|
UTSW |
7 |
130,226,159 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8244:Tacc2
|
UTSW |
7 |
130,330,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tacc2
|
UTSW |
7 |
130,331,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Tacc2
|
UTSW |
7 |
130,227,034 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8348:Tacc2
|
UTSW |
7 |
130,225,019 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8369:Tacc2
|
UTSW |
7 |
130,223,888 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8381:Tacc2
|
UTSW |
7 |
130,225,972 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8804:Tacc2
|
UTSW |
7 |
130,294,693 (GRCm39) |
missense |
probably benign |
|
|
R8809:Tacc2
|
UTSW |
7 |
130,276,421 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8835:Tacc2
|
UTSW |
7 |
130,228,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8880:Tacc2
|
UTSW |
7 |
130,318,564 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8918:Tacc2
|
UTSW |
7 |
130,227,823 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8953:Tacc2
|
UTSW |
7 |
130,227,487 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9026:Tacc2
|
UTSW |
7 |
130,225,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9193:Tacc2
|
UTSW |
7 |
130,228,304 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9221:Tacc2
|
UTSW |
7 |
130,226,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9221:Tacc2
|
UTSW |
7 |
130,226,058 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9222:Tacc2
|
UTSW |
7 |
130,227,985 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9264:Tacc2
|
UTSW |
7 |
130,228,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9312:Tacc2
|
UTSW |
7 |
130,223,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9380:Tacc2
|
UTSW |
7 |
130,226,771 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9515:Tacc2
|
UTSW |
7 |
130,366,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9705:Tacc2
|
UTSW |
7 |
130,361,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0010:Tacc2
|
UTSW |
7 |
130,336,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,346,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,226,000 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,225,100 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,336,679 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,227,504 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,226,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTGGATCCCAGCAAAATGGC -3'
(R):5'- ATTGCACCCATGTACCTGTCAC -3'
Sequencing Primer
(F):5'- CCCAGCAAAATGGCAAGAGCTG -3'
(R):5'- CATGTACCTGTCACTGAGGAG -3'
|
| Posted On |
2021-08-31 |
Incidental Mutation