Incidental Mutation 'R8937:Shprh'
| ID |
680733 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Shprh
|
| Ensembl Gene |
ENSMUSG00000090112 |
| Gene Name |
SNF2 histone linker PHD RING helicase |
| Synonyms |
2610103K11Rik, D230017O13Rik |
| MMRRC Submission |
068710-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8937 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
11149427-11217595 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 11185437 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 1165
(T1165A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132870
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044053]
[ENSMUST00000054814]
[ENSMUST00000159541]
[ENSMUST00000159810]
|
| AlphaFold |
Q7TPQ3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044053
AA Change: T1165A
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000039422
Gene: ENSMUSG00000090112
AA Change: T1165A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
Pfam:Helicase_C
|
1500 |
1613 |
1.6e-8 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000054814
AA Change: T1165A
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000125849
Gene: ENSMUSG00000090112
AA Change: T1165A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1616 |
6e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
4e-46 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159541
AA Change: T1165A
PolyPhen 2
Score 0.597 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000132870
Gene: ENSMUSG00000090112
AA Change: T1165A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1619 |
4e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
6e-46 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159810
|
| SMART Domains |
Protein: ENSMUSP00000125457
Gene: ENSMUSG00000090112
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
2e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
Blast:DEXDc
|
948 |
1026 |
2e-9 |
BLAST |
|
| Meta Mutation Damage Score |
0.0591 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
95% (71/75) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
PHENOTYPE: The gene product is an E3 ligase involved in poly-ubiquitination of Pcna. Neither homozygous truncation nor KO affect B cell somatic hypermutation or class switching. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700074P13Rik |
A |
T |
6: 40,926,065 (GRCm38) |
Y124* |
probably null |
Het |
| 4930455H04Rik |
C |
A |
3: 116,968,471 (GRCm38) |
|
probably benign |
Het |
| Actn3 |
C |
T |
19: 4,871,770 (GRCm38) |
|
probably null |
Het |
| Akap13 |
T |
A |
7: 75,534,853 (GRCm38) |
|
probably null |
Het |
| Akap9 |
A |
T |
5: 4,044,048 (GRCm38) |
Q2190L |
possibly damaging |
Het |
| Ankrd6 |
A |
T |
4: 32,823,452 (GRCm38) |
V190D |
possibly damaging |
Het |
| Atrn |
T |
A |
2: 130,999,237 (GRCm38) |
D1186E |
probably benign |
Het |
| Bank1 |
A |
T |
3: 136,284,173 (GRCm38) |
V52E |
probably damaging |
Het |
| Blmh |
A |
G |
11: 76,967,057 (GRCm38) |
N342D |
probably benign |
Het |
| Card6 |
TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG |
TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG |
15: 5,098,691 (GRCm38) |
|
probably benign |
Het |
| Ces2f |
A |
G |
8: 104,951,037 (GRCm38) |
T225A |
probably damaging |
Het |
| Clic6 |
G |
T |
16: 92,499,357 (GRCm38) |
D302Y |
probably damaging |
Het |
| Clmn |
T |
A |
12: 104,797,082 (GRCm38) |
N95I |
probably damaging |
Het |
| Cmya5 |
A |
T |
13: 93,096,332 (GRCm38) |
F749L |
probably benign |
Het |
| Cramp1l |
A |
G |
17: 24,983,982 (GRCm38) |
F358L |
probably damaging |
Het |
| Dhx38 |
T |
C |
8: 109,556,466 (GRCm38) |
D573G |
probably damaging |
Het |
| Dync1h1 |
T |
C |
12: 110,618,037 (GRCm38) |
Y625H |
probably damaging |
Het |
| Enpep |
A |
G |
3: 129,321,358 (GRCm38) |
|
probably null |
Het |
| Fat1 |
T |
C |
8: 45,030,313 (GRCm38) |
L3146P |
probably damaging |
Het |
| Gal3st2b |
G |
A |
1: 93,940,848 (GRCm38) |
S265N |
probably benign |
Het |
| Glis3 |
G |
A |
19: 28,665,866 (GRCm38) |
A92V |
possibly damaging |
Het |
| Gm13089 |
T |
C |
4: 143,696,992 (GRCm38) |
Y409C |
probably damaging |
Het |
| Gm266 |
T |
C |
12: 111,485,739 (GRCm38) |
D11G |
probably benign |
Het |
| Hmcn2 |
A |
T |
2: 31,314,415 (GRCm38) |
M1L |
probably benign |
Het |
| Kcnj15 |
G |
A |
16: 95,296,689 (GRCm38) |
|
probably benign |
Het |
| Krt27 |
A |
G |
11: 99,348,725 (GRCm38) |
S310P |
probably damaging |
Het |
| Lama2 |
A |
T |
10: 26,986,820 (GRCm38) |
D2982E |
probably damaging |
Het |
| Lrfn3 |
A |
G |
7: 30,360,026 (GRCm38) |
V258A |
probably benign |
Het |
| Lrit3 |
A |
T |
3: 129,800,544 (GRCm38) |
M128K |
probably damaging |
Het |
| Ltbp3 |
A |
G |
19: 5,747,484 (GRCm38) |
T417A |
probably benign |
Het |
| Mettl25 |
T |
C |
10: 105,765,261 (GRCm38) |
T554A |
probably benign |
Het |
| Micall1 |
A |
G |
15: 79,126,998 (GRCm38) |
S523G |
probably damaging |
Het |
| Mmp21 |
G |
A |
7: 133,678,971 (GRCm38) |
A90V |
probably benign |
Het |
| Mon2 |
T |
C |
10: 123,059,205 (GRCm38) |
N53S |
probably benign |
Het |
| Mpp5 |
T |
A |
12: 78,819,341 (GRCm38) |
D313E |
probably benign |
Het |
| Muc15 |
T |
C |
2: 110,731,907 (GRCm38) |
|
probably null |
Het |
| Myo15b |
A |
T |
11: 115,882,301 (GRCm38) |
M431L |
probably benign |
Het |
| Nicn1 |
C |
T |
9: 108,294,509 (GRCm38) |
R163C |
possibly damaging |
Het |
| Nt5c3 |
T |
C |
6: 56,884,716 (GRCm38) |
D195G |
probably damaging |
Het |
| Olfr401 |
T |
A |
11: 74,122,048 (GRCm38) |
M253K |
probably benign |
Het |
| Olfr648 |
A |
G |
7: 104,179,742 (GRCm38) |
L222P |
possibly damaging |
Het |
| Pgrmc2 |
A |
G |
3: 41,082,690 (GRCm38) |
L102P |
probably damaging |
Het |
| Plekha1 |
T |
G |
7: 130,900,511 (GRCm38) |
|
probably benign |
Het |
| Ralgapa1 |
T |
G |
12: 55,702,560 (GRCm38) |
I1233L |
probably damaging |
Het |
| Rb1cc1 |
T |
A |
1: 6,263,217 (GRCm38) |
D68E |
probably benign |
Het |
| Rere |
C |
A |
4: 150,614,874 (GRCm38) |
|
probably benign |
Het |
| Rnf213 |
A |
T |
11: 119,430,274 (GRCm38) |
H1185L |
possibly damaging |
Het |
| Robo2 |
G |
T |
16: 73,973,262 (GRCm38) |
P529T |
probably damaging |
Het |
| Robo2 |
G |
A |
16: 73,973,261 (GRCm38) |
P529L |
probably damaging |
Het |
| Slc22a26 |
C |
T |
19: 7,791,025 (GRCm38) |
|
probably benign |
Het |
| Slc43a1 |
T |
C |
2: 84,860,106 (GRCm38) |
L456P |
probably damaging |
Het |
| Slc5a8 |
T |
C |
10: 88,905,023 (GRCm38) |
Y267H |
probably damaging |
Het |
| Snrnp200 |
T |
C |
2: 127,226,982 (GRCm38) |
I927T |
probably benign |
Het |
| Sorbs1 |
T |
C |
19: 40,373,562 (GRCm38) |
D156G |
probably benign |
Het |
| Sox5 |
A |
T |
6: 143,907,443 (GRCm38) |
S370T |
probably benign |
Het |
| Spen |
T |
C |
4: 141,474,063 (GRCm38) |
T2418A |
probably damaging |
Het |
| St8sia6 |
A |
T |
2: 13,696,894 (GRCm38) |
L104H |
probably damaging |
Het |
| Stox1 |
T |
A |
10: 62,664,651 (GRCm38) |
N710I |
probably damaging |
Het |
| Syncrip |
T |
C |
9: 88,462,847 (GRCm38) |
|
probably benign |
Het |
| Syt11 |
G |
A |
3: 88,747,744 (GRCm38) |
P417S |
probably damaging |
Het |
| Taf2 |
A |
T |
15: 55,047,453 (GRCm38) |
N608K |
probably benign |
Het |
| Tfcp2l1 |
G |
A |
1: 118,668,717 (GRCm38) |
G394E |
possibly damaging |
Het |
| Tial1 |
A |
G |
7: 128,454,991 (GRCm38) |
I13T |
probably damaging |
Het |
| Tmem108 |
T |
C |
9: 103,484,782 (GRCm38) |
D535G |
probably benign |
Het |
| Tpp1 |
T |
C |
7: 105,747,419 (GRCm38) |
M464V |
probably benign |
Het |
| Trrap |
C |
A |
5: 144,820,253 (GRCm38) |
N2108K |
probably damaging |
Het |
| Tspan3 |
T |
C |
9: 56,146,599 (GRCm38) |
D156G |
probably benign |
Het |
| Ttn |
C |
T |
2: 76,762,263 (GRCm38) |
V20842I |
probably benign |
Het |
| Ubr4 |
T |
A |
4: 139,463,575 (GRCm38) |
W4078R |
probably damaging |
Het |
| Uts2r |
G |
A |
11: 121,160,969 (GRCm38) |
V220M |
possibly damaging |
Het |
| Vmn2r19 |
G |
A |
6: 123,316,324 (GRCm38) |
|
probably null |
Het |
| Vmn2r3 |
A |
T |
3: 64,259,252 (GRCm38) |
F819L |
probably damaging |
Het |
| Wdtc1 |
T |
C |
4: 133,304,159 (GRCm38) |
Y250C |
probably damaging |
Het |
| Zan |
T |
C |
5: 137,395,626 (GRCm38) |
H4521R |
unknown |
Het |
| Zfp219 |
A |
T |
14: 52,006,767 (GRCm38) |
C652S |
probably damaging |
Het |
|
| Other mutations in Shprh |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Shprh
|
APN |
10 |
11,188,158 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00583:Shprh
|
APN |
10 |
11,188,020 (GRCm38) |
missense |
probably benign |
0.37 |
|
IGL00684:Shprh
|
APN |
10 |
11,163,037 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL01295:Shprh
|
APN |
10 |
11,183,868 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL01387:Shprh
|
APN |
10 |
11,170,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01635:Shprh
|
APN |
10 |
11,170,019 (GRCm38) |
nonsense |
probably null |
|
|
IGL01833:Shprh
|
APN |
10 |
11,191,062 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02013:Shprh
|
APN |
10 |
11,181,502 (GRCm38) |
splice site |
probably benign |
|
|
IGL02502:Shprh
|
APN |
10 |
11,194,357 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
IGL02819:Shprh
|
APN |
10 |
11,154,765 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
PIT4581001:Shprh
|
UTSW |
10 |
11,192,494 (GRCm38) |
frame shift |
probably null |
|
|
R0010:Shprh
|
UTSW |
10 |
11,151,931 (GRCm38) |
missense |
probably benign |
|
|
R0010:Shprh
|
UTSW |
10 |
11,151,931 (GRCm38) |
missense |
probably benign |
|
|
R0053:Shprh
|
UTSW |
10 |
11,194,372 (GRCm38) |
splice site |
probably null |
|
|
R0053:Shprh
|
UTSW |
10 |
11,194,372 (GRCm38) |
splice site |
probably null |
|
|
R0255:Shprh
|
UTSW |
10 |
11,186,391 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R0325:Shprh
|
UTSW |
10 |
11,170,109 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0331:Shprh
|
UTSW |
10 |
11,194,170 (GRCm38) |
splice site |
probably benign |
|
|
R0494:Shprh
|
UTSW |
10 |
11,157,191 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0532:Shprh
|
UTSW |
10 |
11,162,812 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R0546:Shprh
|
UTSW |
10 |
11,183,887 (GRCm38) |
splice site |
probably benign |
|
|
R0574:Shprh
|
UTSW |
10 |
11,163,077 (GRCm38) |
unclassified |
probably benign |
|
|
R0605:Shprh
|
UTSW |
10 |
11,207,112 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0662:Shprh
|
UTSW |
10 |
11,186,847 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1148:Shprh
|
UTSW |
10 |
11,213,482 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1148:Shprh
|
UTSW |
10 |
11,213,482 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1263:Shprh
|
UTSW |
10 |
11,159,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1588:Shprh
|
UTSW |
10 |
11,164,744 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1638:Shprh
|
UTSW |
10 |
11,157,078 (GRCm38) |
missense |
probably benign |
|
|
R1830:Shprh
|
UTSW |
10 |
11,186,911 (GRCm38) |
splice site |
probably null |
|
|
R1898:Shprh
|
UTSW |
10 |
11,186,869 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1903:Shprh
|
UTSW |
10 |
11,183,797 (GRCm38) |
nonsense |
probably null |
|
|
R2060:Shprh
|
UTSW |
10 |
11,152,120 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2225:Shprh
|
UTSW |
10 |
11,162,235 (GRCm38) |
unclassified |
probably benign |
|
|
R2363:Shprh
|
UTSW |
10 |
11,171,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2509:Shprh
|
UTSW |
10 |
11,166,724 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2891:Shprh
|
UTSW |
10 |
11,164,356 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3077:Shprh
|
UTSW |
10 |
11,170,413 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3150:Shprh
|
UTSW |
10 |
11,170,030 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3796:Shprh
|
UTSW |
10 |
11,178,757 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R4196:Shprh
|
UTSW |
10 |
11,207,860 (GRCm38) |
utr 3 prime |
probably benign |
|
|
R4423:Shprh
|
UTSW |
10 |
11,186,518 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R4488:Shprh
|
UTSW |
10 |
11,160,471 (GRCm38) |
missense |
probably benign |
0.17 |
|
R4748:Shprh
|
UTSW |
10 |
11,170,476 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4768:Shprh
|
UTSW |
10 |
11,181,540 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4867:Shprh
|
UTSW |
10 |
11,164,557 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4937:Shprh
|
UTSW |
10 |
11,157,119 (GRCm38) |
missense |
probably benign |
|
|
R5140:Shprh
|
UTSW |
10 |
11,154,705 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5318:Shprh
|
UTSW |
10 |
11,166,557 (GRCm38) |
missense |
probably benign |
0.04 |
|
R5323:Shprh
|
UTSW |
10 |
11,170,297 (GRCm38) |
splice site |
probably null |
|
|
R5450:Shprh
|
UTSW |
10 |
11,212,330 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R5872:Shprh
|
UTSW |
10 |
11,188,073 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6030:Shprh
|
UTSW |
10 |
11,151,991 (GRCm38) |
missense |
probably benign |
0.37 |
|
R6030:Shprh
|
UTSW |
10 |
11,151,991 (GRCm38) |
missense |
probably benign |
0.37 |
|
R6392:Shprh
|
UTSW |
10 |
11,178,741 (GRCm38) |
nonsense |
probably null |
|
|
R6416:Shprh
|
UTSW |
10 |
11,167,873 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6470:Shprh
|
UTSW |
10 |
11,171,937 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6513:Shprh
|
UTSW |
10 |
11,186,893 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6530:Shprh
|
UTSW |
10 |
11,194,267 (GRCm38) |
missense |
probably benign |
0.02 |
|
R6678:Shprh
|
UTSW |
10 |
11,166,545 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6757:Shprh
|
UTSW |
10 |
11,181,508 (GRCm38) |
splice site |
probably null |
|
|
R6971:Shprh
|
UTSW |
10 |
11,166,693 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7158:Shprh
|
UTSW |
10 |
11,166,730 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7582:Shprh
|
UTSW |
10 |
11,164,705 (GRCm38) |
missense |
probably benign |
|
|
R7757:Shprh
|
UTSW |
10 |
11,162,180 (GRCm38) |
missense |
probably benign |
0.30 |
|
R7812:Shprh
|
UTSW |
10 |
11,151,991 (GRCm38) |
missense |
probably benign |
|
|
R7998:Shprh
|
UTSW |
10 |
11,185,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8061:Shprh
|
UTSW |
10 |
11,212,333 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R8082:Shprh
|
UTSW |
10 |
11,151,811 (GRCm38) |
missense |
probably benign |
0.22 |
|
R8116:Shprh
|
UTSW |
10 |
11,213,461 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8390:Shprh
|
UTSW |
10 |
11,187,983 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8445:Shprh
|
UTSW |
10 |
11,181,569 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8530:Shprh
|
UTSW |
10 |
11,151,934 (GRCm38) |
missense |
probably benign |
0.37 |
|
R8759:Shprh
|
UTSW |
10 |
11,157,164 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8995:Shprh
|
UTSW |
10 |
11,164,830 (GRCm38) |
nonsense |
probably null |
|
|
R9053:Shprh
|
UTSW |
10 |
11,154,702 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9131:Shprh
|
UTSW |
10 |
11,162,845 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R9176:Shprh
|
UTSW |
10 |
11,160,576 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9391:Shprh
|
UTSW |
10 |
11,162,889 (GRCm38) |
missense |
probably benign |
0.05 |
|
R9423:Shprh
|
UTSW |
10 |
11,205,263 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9563:Shprh
|
UTSW |
10 |
11,166,491 (GRCm38) |
nonsense |
probably null |
|
|
R9668:Shprh
|
UTSW |
10 |
11,206,332 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9709:Shprh
|
UTSW |
10 |
11,162,830 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R9718:Shprh
|
UTSW |
10 |
11,213,504 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9750:Shprh
|
UTSW |
10 |
11,164,460 (GRCm38) |
missense |
probably damaging |
0.98 |
|
RF012:Shprh
|
UTSW |
10 |
11,164,841 (GRCm38) |
missense |
probably benign |
0.02 |
|
V8831:Shprh
|
UTSW |
10 |
11,186,862 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,186,447 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,164,553 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Shprh
|
UTSW |
10 |
11,151,762 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGGTATTTGCCCAATACACACAG -3'
(R):5'- GGAGAACATTTCAAATGGCTAACAG -3'
Sequencing Primer
(F):5'- TGTATCTCTTTTCCCATTGAATGC -3'
(R):5'- ATGTCCCTAAGTCCATGG -3'
|
| Posted On |
2021-08-31 |
Incidental Mutation