|Institutional Source||Beutler Lab|
|Gene Name||StAR-related lipid transfer (START) domain containing 13|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R8939 (G1)|
|Chromosomal Location||151037510-151233836 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to T at 151045109 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000053232 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000062015] [ENSMUST00000110483] [ENSMUST00000202111]|
|Meta Mutation Damage Score||0.9492|
|Coding Region Coverage||
|Validation Efficiency||100% (71/71)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit small body size, decreased weight, and reduced adipose tissue. Mice homozygous for another knock-out allele exhibit increased angiogenesis in matrigel plugs and implanted tumors. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Stard13||
(F):5'- ACCTAATCAACTGTGCACCTTG -3'
(R):5'- GAAGCTGTGGAAAGCATCTG -3'
(F):5'- CTAATCAACTGTGCACCTTGAGGAG -3'
(R):5'- CTGTGGAAAGCATCTGTGGAG -3'