Incidental Mutation 'R8940:Nlrp3'
| ID |
680929 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nlrp3
|
| Ensembl Gene |
ENSMUSG00000032691 |
| Gene Name |
NLR family, pyrin domain containing 3 |
| Synonyms |
Mmig1, Cias1, NALP3, cryopyrin, Pypaf1 |
| MMRRC Submission |
068780-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.076)
|
| Stock # |
R8940 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
59432395-59457781 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 59455870 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 889
(V889M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000098707
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079476]
[ENSMUST00000101148]
|
| AlphaFold |
Q8R4B8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079476
AA Change: V889M
PolyPhen 2
Score 0.263 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000078440
Gene: ENSMUSG00000032691
AA Change: V889M
| Domain | Start | End | E-Value | Type |
|---|
|
PYRIN
|
4 |
87 |
6.39e-33 |
SMART |
|
FISNA
|
135 |
206 |
1.45e-22 |
SMART |
|
Pfam:NACHT
|
216 |
385 |
6.7e-52 |
PFAM |
|
low complexity region
|
533 |
539 |
N/A |
INTRINSIC |
|
low complexity region
|
688 |
697 |
N/A |
INTRINSIC |
|
LRR_RI
|
737 |
764 |
1.07e-9 |
SMART |
|
LRR
|
766 |
793 |
5.13e1 |
SMART |
|
LRR
|
794 |
821 |
3.86e-7 |
SMART |
|
LRR
|
823 |
850 |
1.62e0 |
SMART |
|
LRR
|
851 |
878 |
3.39e-3 |
SMART |
|
LRR
|
880 |
907 |
1.2e2 |
SMART |
|
LRR
|
908 |
935 |
2.24e-3 |
SMART |
|
LRR
|
937 |
964 |
2.16e2 |
SMART |
|
LRR
|
965 |
992 |
8.73e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000101148
AA Change: V889M
PolyPhen 2
Score 0.263 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000098707
Gene: ENSMUSG00000032691
AA Change: V889M
| Domain | Start | End | E-Value | Type |
|---|
|
PYRIN
|
4 |
87 |
6.39e-33 |
SMART |
|
FISNA
|
135 |
206 |
1.45e-22 |
SMART |
|
Pfam:NACHT
|
216 |
385 |
6.7e-52 |
PFAM |
|
low complexity region
|
533 |
539 |
N/A |
INTRINSIC |
|
low complexity region
|
688 |
697 |
N/A |
INTRINSIC |
|
LRR_RI
|
737 |
764 |
1.07e-9 |
SMART |
|
LRR
|
766 |
793 |
5.13e1 |
SMART |
|
LRR
|
794 |
821 |
3.86e-7 |
SMART |
|
LRR
|
823 |
850 |
1.62e0 |
SMART |
|
LRR
|
851 |
878 |
3.39e-3 |
SMART |
|
LRR
|
880 |
907 |
1.2e2 |
SMART |
|
LRR
|
908 |
935 |
2.24e-3 |
SMART |
|
LRR
|
937 |
964 |
2.16e2 |
SMART |
|
LRR
|
965 |
992 |
8.73e-6 |
SMART |
|
| Meta Mutation Damage Score |
0.0944 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
99% (73/74) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for null mutations exhibit attenuated inflammatory responses related to decrease secretion of IL-1beta and IL-18. Mice heterozygous for activating mutations suffer from autoinflammatory attacks that lead to organ failure and death before weaning. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(13) : Targeted(9) Chemically induced(4)
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2900026A02Rik |
A |
T |
5: 113,241,068 (GRCm39) |
S1709T |
probably benign |
Het |
| Abcc12 |
A |
G |
8: 87,287,440 (GRCm39) |
V135A |
probably benign |
Het |
| Alkbh3 |
G |
T |
2: 93,838,391 (GRCm39) |
P60H |
probably damaging |
Het |
| Armc3 |
A |
C |
2: 19,240,393 (GRCm39) |
Y50S |
probably damaging |
Het |
| Arpc4 |
T |
C |
6: 113,362,599 (GRCm39) |
V70A |
probably benign |
Het |
| Atp13a4 |
A |
G |
16: 29,273,508 (GRCm39) |
|
probably null |
Het |
| Bco1 |
A |
T |
8: 117,857,347 (GRCm39) |
Y438F |
probably benign |
Het |
| Cacna1b |
C |
A |
2: 24,653,084 (GRCm39) |
|
probably benign |
Het |
| Cdh17 |
C |
T |
4: 11,783,226 (GRCm39) |
S189L |
probably damaging |
Het |
| Cltc |
T |
C |
11: 86,621,072 (GRCm39) |
T312A |
probably benign |
Het |
| Crym |
T |
A |
7: 119,794,703 (GRCm39) |
N172I |
probably benign |
Het |
| Depdc7 |
A |
G |
2: 104,554,913 (GRCm39) |
|
probably null |
Het |
| Dnhd1 |
T |
A |
7: 105,363,854 (GRCm39) |
|
probably benign |
Het |
| Dntt |
T |
A |
19: 41,046,990 (GRCm39) |
|
probably benign |
Het |
| Elovl5 |
T |
A |
9: 77,890,007 (GRCm39) |
S273T |
possibly damaging |
Het |
| Fat2 |
A |
T |
11: 55,147,636 (GRCm39) |
L3869M |
possibly damaging |
Het |
| Garnl3 |
T |
C |
2: 32,895,241 (GRCm39) |
|
probably null |
Het |
| Gldc |
C |
T |
19: 30,128,884 (GRCm39) |
M196I |
probably benign |
Het |
| Gm17078 |
C |
T |
14: 51,846,342 (GRCm39) |
V120M |
probably damaging |
Het |
| Gm5157 |
G |
A |
7: 20,918,685 (GRCm39) |
S286F |
probably damaging |
Het |
| Gm6337 |
C |
T |
14: 6,055,308 (GRCm38) |
C187Y |
probably damaging |
Het |
| Golgb1 |
A |
G |
16: 36,736,759 (GRCm39) |
D2002G |
probably damaging |
Het |
| Gpr179 |
T |
C |
11: 97,228,675 (GRCm39) |
N1160S |
probably damaging |
Het |
| Gulo |
A |
G |
14: 66,235,040 (GRCm39) |
V227A |
probably benign |
Het |
| Hlcs |
G |
A |
16: 94,032,085 (GRCm39) |
A31V |
probably benign |
Het |
| Hs1bp3 |
T |
C |
12: 8,391,980 (GRCm39) |
S361P |
probably benign |
Het |
| Ifi44 |
G |
A |
3: 151,454,946 (GRCm39) |
P93L |
probably benign |
Het |
| Izumo2 |
T |
A |
7: 44,362,470 (GRCm39) |
M78K |
probably benign |
Het |
| Lin54 |
T |
C |
5: 100,594,530 (GRCm39) |
E545G |
probably damaging |
Het |
| Map3k13 |
A |
T |
16: 21,727,454 (GRCm39) |
I439F |
possibly damaging |
Het |
| Matr3 |
T |
G |
18: 35,705,640 (GRCm39) |
S188R |
probably damaging |
Het |
| Mug1 |
A |
T |
6: 121,858,642 (GRCm39) |
H1120L |
|
Het |
| Myef2l |
A |
T |
3: 10,153,406 (GRCm39) |
L58F |
probably benign |
Het |
| Ndst4 |
A |
G |
3: 125,474,802 (GRCm39) |
|
probably benign |
Het |
| Or1x6 |
A |
G |
11: 50,939,455 (GRCm39) |
I174V |
probably benign |
Het |
| Or2r2 |
A |
G |
6: 42,463,212 (GRCm39) |
M305T |
probably benign |
Het |
| Or5g29 |
A |
G |
2: 85,421,528 (GRCm39) |
I215V |
probably benign |
Het |
| Or5m5 |
A |
T |
2: 85,814,543 (GRCm39) |
M120L |
probably benign |
Het |
| Or8d4 |
T |
A |
9: 40,038,480 (GRCm39) |
Y259F |
probably damaging |
Het |
| P4hb |
A |
T |
11: 120,458,828 (GRCm39) |
D182E |
probably benign |
Het |
| Pcdh10 |
A |
G |
3: 45,338,620 (GRCm39) |
T926A |
possibly damaging |
Het |
| Pikfyve |
T |
C |
1: 65,286,129 (GRCm39) |
S1078P |
probably benign |
Het |
| Plcl2 |
A |
T |
17: 50,915,790 (GRCm39) |
D933V |
probably damaging |
Het |
| Pramel7 |
G |
A |
2: 87,321,612 (GRCm39) |
T141I |
probably benign |
Het |
| Prepl |
A |
T |
17: 85,376,354 (GRCm39) |
C567S |
probably damaging |
Het |
| Prpsap1 |
A |
T |
11: 116,370,615 (GRCm39) |
M114K |
probably damaging |
Het |
| Ptk2b |
A |
C |
14: 66,407,685 (GRCm39) |
|
probably null |
Het |
| Rest |
T |
C |
5: 77,430,715 (GRCm39) |
F1045L |
possibly damaging |
Het |
| Rnf19a |
A |
G |
15: 36,260,284 (GRCm39) |
C254R |
probably damaging |
Het |
| Rrad |
C |
T |
8: 105,355,222 (GRCm39) |
R262Q |
possibly damaging |
Het |
| Rsf1 |
GGCG |
GGCGACTGCCGCG |
7: 97,229,113 (GRCm39) |
|
probably benign |
Het |
| Setdb1 |
T |
A |
3: 95,263,483 (GRCm39) |
M8L |
probably benign |
Het |
| Setdb2 |
A |
G |
14: 59,646,956 (GRCm39) |
S536P |
probably damaging |
Het |
| Sipa1l1 |
T |
C |
12: 82,404,040 (GRCm39) |
L511P |
probably damaging |
Het |
| Slc12a9 |
T |
A |
5: 137,326,755 (GRCm39) |
H234L |
probably benign |
Het |
| Slc35e2 |
G |
T |
4: 155,694,542 (GRCm39) |
G30W |
probably damaging |
Het |
| Slc6a15 |
T |
C |
10: 103,229,357 (GRCm39) |
V132A |
probably damaging |
Het |
| Slc7a10 |
A |
G |
7: 34,899,875 (GRCm39) |
T486A |
probably benign |
Het |
| Smc5 |
T |
C |
19: 23,237,126 (GRCm39) |
Y235C |
probably benign |
Het |
| Sorcs3 |
T |
C |
19: 48,784,908 (GRCm39) |
|
probably null |
Het |
| Spata21 |
T |
C |
4: 140,832,216 (GRCm39) |
L459P |
probably damaging |
Het |
| Tbc1d9 |
A |
G |
8: 83,981,452 (GRCm39) |
I706M |
probably damaging |
Het |
| Tcp11 |
T |
A |
17: 28,299,204 (GRCm39) |
E17V |
probably damaging |
Het |
| Tiparp |
A |
G |
3: 65,439,299 (GRCm39) |
D23G |
probably benign |
Het |
| Tmem108 |
A |
G |
9: 103,377,156 (GRCm39) |
S98P |
possibly damaging |
Het |
| Tmem35b |
A |
G |
4: 127,021,673 (GRCm39) |
D56G |
probably damaging |
Het |
| Tnr |
G |
C |
1: 159,685,867 (GRCm39) |
G366A |
probably damaging |
Het |
| Ttc3 |
A |
G |
16: 94,230,358 (GRCm39) |
S852G |
possibly damaging |
Het |
| Ttn |
G |
A |
2: 76,596,938 (GRCm39) |
L19992F |
probably damaging |
Het |
| Ush2a |
T |
A |
1: 188,132,505 (GRCm39) |
M909K |
probably benign |
Het |
| Wdr90 |
G |
A |
17: 26,076,146 (GRCm39) |
R104C |
|
Het |
| Wif1 |
A |
G |
10: 120,935,684 (GRCm39) |
H333R |
probably benign |
Het |
| Zfp119a |
A |
G |
17: 56,172,551 (GRCm39) |
C431R |
probably damaging |
Het |
| Zfp345 |
G |
A |
2: 150,314,277 (GRCm39) |
P420L |
probably benign |
Het |
| Zfp608 |
C |
T |
18: 55,033,301 (GRCm39) |
D411N |
possibly damaging |
Het |
| Zfp609 |
C |
T |
9: 65,610,561 (GRCm39) |
A801T |
possibly damaging |
Het |
| Zfp74 |
A |
G |
7: 29,634,772 (GRCm39) |
V312A |
possibly damaging |
Het |
|
| Other mutations in Nlrp3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00421:Nlrp3
|
APN |
11 |
59,456,769 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00573:Nlrp3
|
APN |
11 |
59,455,942 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01025:Nlrp3
|
APN |
11 |
59,442,713 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL01637:Nlrp3
|
APN |
11 |
59,440,204 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02010:Nlrp3
|
APN |
11 |
59,440,361 (GRCm39) |
missense |
probably benign |
|
|
IGL02334:Nlrp3
|
APN |
11 |
59,455,909 (GRCm39) |
missense |
probably benign |
|
|
IGL02417:Nlrp3
|
APN |
11 |
59,456,849 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02578:Nlrp3
|
APN |
11 |
59,439,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02710:Nlrp3
|
APN |
11 |
59,456,802 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02816:Nlrp3
|
APN |
11 |
59,446,608 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03157:Nlrp3
|
APN |
11 |
59,440,372 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03334:Nlrp3
|
APN |
11 |
59,439,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Flogiston
|
UTSW |
11 |
59,449,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
nd1
|
UTSW |
11 |
59,456,800 (GRCm39) |
missense |
probably benign |
0.45 |
|
Nd14
|
UTSW |
11 |
59,446,701 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
Nd3
|
UTSW |
11 |
59,456,800 (GRCm39) |
missense |
probably benign |
0.45 |
|
nd5
|
UTSW |
11 |
59,456,705 (GRCm39) |
missense |
probably benign |
0.01 |
|
nd6
|
UTSW |
11 |
59,440,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
nd7
|
UTSW |
11 |
59,446,701 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
Nd9
|
UTSW |
11 |
59,440,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Park2
|
UTSW |
11 |
59,455,954 (GRCm39) |
nonsense |
probably null |
|
|
Park3
|
UTSW |
11 |
59,456,676 (GRCm39) |
missense |
probably benign |
0.02 |
|
Park4
|
UTSW |
11 |
59,440,357 (GRCm39) |
missense |
probably benign |
0.19 |
|
Park5
|
UTSW |
11 |
59,439,302 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Park6
|
UTSW |
11 |
59,439,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Park7
|
UTSW |
11 |
59,438,836 (GRCm39) |
nonsense |
probably null |
|
|
Park8
|
UTSW |
11 |
59,457,025 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0008:Nlrp3
|
UTSW |
11 |
59,449,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0008:Nlrp3
|
UTSW |
11 |
59,449,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0052:Nlrp3
|
UTSW |
11 |
59,455,954 (GRCm39) |
nonsense |
probably null |
|
|
R0362:Nlrp3
|
UTSW |
11 |
59,439,623 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0416:Nlrp3
|
UTSW |
11 |
59,446,750 (GRCm39) |
splice site |
probably benign |
|
|
R0649:Nlrp3
|
UTSW |
11 |
59,439,368 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R0740:Nlrp3
|
UTSW |
11 |
59,439,082 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0863:Nlrp3
|
UTSW |
11 |
59,456,676 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1300:Nlrp3
|
UTSW |
11 |
59,446,594 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1414:Nlrp3
|
UTSW |
11 |
59,440,357 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1622:Nlrp3
|
UTSW |
11 |
59,439,302 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1654:Nlrp3
|
UTSW |
11 |
59,433,949 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1715:Nlrp3
|
UTSW |
11 |
59,434,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1754:Nlrp3
|
UTSW |
11 |
59,449,228 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1837:Nlrp3
|
UTSW |
11 |
59,439,742 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1905:Nlrp3
|
UTSW |
11 |
59,439,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2281:Nlrp3
|
UTSW |
11 |
59,439,962 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R4296:Nlrp3
|
UTSW |
11 |
59,440,487 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4305:Nlrp3
|
UTSW |
11 |
59,438,836 (GRCm39) |
nonsense |
probably null |
|
|
R4540:Nlrp3
|
UTSW |
11 |
59,442,725 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4591:Nlrp3
|
UTSW |
11 |
59,440,048 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4816:Nlrp3
|
UTSW |
11 |
59,439,127 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4913:Nlrp3
|
UTSW |
11 |
59,440,064 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4970:Nlrp3
|
UTSW |
11 |
59,439,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5051:Nlrp3
|
UTSW |
11 |
59,457,025 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5112:Nlrp3
|
UTSW |
11 |
59,439,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5185:Nlrp3
|
UTSW |
11 |
59,455,910 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5417:Nlrp3
|
UTSW |
11 |
59,439,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5709:Nlrp3
|
UTSW |
11 |
59,446,574 (GRCm39) |
nonsense |
probably null |
|
|
R5869:Nlrp3
|
UTSW |
11 |
59,438,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5898:Nlrp3
|
UTSW |
11 |
59,437,678 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5953:Nlrp3
|
UTSW |
11 |
59,437,617 (GRCm39) |
missense |
probably benign |
|
|
R5979:Nlrp3
|
UTSW |
11 |
59,439,797 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6359:Nlrp3
|
UTSW |
11 |
59,439,392 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6723:Nlrp3
|
UTSW |
11 |
59,456,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7261:Nlrp3
|
UTSW |
11 |
59,439,272 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7349:Nlrp3
|
UTSW |
11 |
59,438,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7388:Nlrp3
|
UTSW |
11 |
59,455,892 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7715:Nlrp3
|
UTSW |
11 |
59,433,829 (GRCm39) |
splice site |
probably null |
|
|
R7916:Nlrp3
|
UTSW |
11 |
59,442,689 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8222:Nlrp3
|
UTSW |
11 |
59,439,614 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8360:Nlrp3
|
UTSW |
11 |
59,440,229 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8390:Nlrp3
|
UTSW |
11 |
59,442,616 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R8550:Nlrp3
|
UTSW |
11 |
59,440,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8738:Nlrp3
|
UTSW |
11 |
59,440,216 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8990:Nlrp3
|
UTSW |
11 |
59,439,584 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9324:Nlrp3
|
UTSW |
11 |
59,434,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Nlrp3
|
UTSW |
11 |
59,440,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF031:Nlrp3
|
UTSW |
11 |
59,449,378 (GRCm39) |
frame shift |
probably null |
|
|
RF040:Nlrp3
|
UTSW |
11 |
59,449,378 (GRCm39) |
frame shift |
probably null |
|
|
Z1088:Nlrp3
|
UTSW |
11 |
59,442,686 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGCTGAGACCATTGTCCATC -3'
(R):5'- CATGTTCCCATCACCTCAGG -3'
Sequencing Primer
(F):5'- ATCTCTCCTGTGGGATCCAGAGAC -3'
(R):5'- TCAGGCAGCCCATGAACTC -3'
|
| Posted On |
2021-08-31 |
Incidental Mutation