Incidental Mutation 'R8941:Zfp729b'
ID 681003
Institutional Source Beutler Lab
Gene Symbol Zfp729b
Ensembl Gene ENSMUSG00000058093
Gene Name zinc finger protein 729b
Synonyms AA987161
MMRRC Submission 068781-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.143) question?
Stock # R8941 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 67737558-67757767 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 67741218 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 349 (M349T)
Ref Sequence ENSEMBL: ENSMUSP00000012873 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012873] [ENSMUST00000138725] [ENSMUST00000224814] [ENSMUST00000225627]
AlphaFold Q80VN4
Predicted Effect possibly damaging
Transcript: ENSMUST00000012873
AA Change: M349T

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000012873
Gene: ENSMUSG00000058093
AA Change: M349T

DomainStartEndE-ValueType
KRAB 5 65 1.63e-28 SMART
ZnF_C2H2 132 154 3.58e-2 SMART
PHD 133 194 1e1 SMART
ZnF_C2H2 160 182 3.21e-4 SMART
ZnF_C2H2 188 210 6.78e-3 SMART
ZnF_C2H2 216 238 3.16e-3 SMART
PHD 217 278 7.77e0 SMART
ZnF_C2H2 244 266 6.67e-2 SMART
ZnF_C2H2 272 294 1.12e-3 SMART
ZnF_C2H2 300 322 1.79e-2 SMART
PHD 301 362 1.65e1 SMART
ZnF_C2H2 328 350 2.57e-3 SMART
ZnF_C2H2 356 378 2.43e-4 SMART
ZnF_C2H2 412 434 1.67e-2 SMART
ZnF_C2H2 440 462 1.28e-3 SMART
PHD 441 502 4.46e0 SMART
ZnF_C2H2 468 490 1.58e-3 SMART
ZnF_C2H2 496 518 2.95e-3 SMART
ZnF_C2H2 524 546 4.47e-3 SMART
PHD 525 586 5.77e0 SMART
ZnF_C2H2 552 574 5.42e-2 SMART
ZnF_C2H2 580 602 1.03e-2 SMART
ZnF_C2H2 608 630 5.5e-3 SMART
PHD 609 670 1.52e1 SMART
ZnF_C2H2 636 658 6.99e-5 SMART
ZnF_C2H2 664 686 3.34e-2 SMART
ZnF_C2H2 720 742 3.63e-3 SMART
PHD 721 782 2.67e0 SMART
ZnF_C2H2 748 770 5.42e-2 SMART
ZnF_C2H2 776 798 5.14e-3 SMART
ZnF_C2H2 804 826 4.17e-3 SMART
ZnF_C2H2 832 854 1.47e-3 SMART
PHD 833 894 4.93e0 SMART
ZnF_C2H2 860 882 3.83e-2 SMART
ZnF_C2H2 888 910 4.4e-2 SMART
ZnF_C2H2 916 938 7.78e-3 SMART
ZnF_C2H2 944 966 4.17e-3 SMART
ZnF_C2H2 972 994 1.38e-3 SMART
ZnF_C2H2 1000 1022 1.69e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000138725
SMART Domains Protein: ENSMUSP00000115783
Gene: ENSMUSG00000058093

DomainStartEndE-ValueType
KRAB 15 75 1.63e-28 SMART
ZnF_C2H2 142 164 3.58e-2 SMART
ZnF_C2H2 170 192 3.21e-4 SMART
ZnF_C2H2 198 220 6.78e-3 SMART
ZnF_C2H2 226 248 3.16e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000224814
AA Change: M359T

PolyPhen 2 Score 0.024 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000225627
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (59/59)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T A 9: 124,056,679 (GRCm39) T103S probably benign Het
Aadacl2fm3 A G 3: 59,784,400 (GRCm39) Y291C probably damaging Het
Aass A T 6: 23,075,261 (GRCm39) probably benign Het
Adgrb3 A T 1: 25,133,235 (GRCm39) C1284S probably damaging Het
Adora2a G A 10: 75,169,559 (GRCm39) W341* probably null Het
Afg2a T A 3: 37,486,142 (GRCm39) L288H probably damaging Het
Arap1 G A 7: 101,057,324 (GRCm39) R1355Q possibly damaging Het
Asic5 A T 3: 81,913,915 (GRCm39) probably benign Het
Canx T C 11: 50,195,270 (GRCm39) D266G possibly damaging Het
Cfap57 A T 4: 118,426,799 (GRCm39) Y1080N probably damaging Het
Chat C T 14: 32,130,963 (GRCm39) M559I probably benign Het
Chd5 G A 4: 152,463,305 (GRCm39) S1425N possibly damaging Het
Cog8 T C 8: 107,783,202 (GRCm39) D29G probably damaging Het
Cox15 A G 19: 43,732,172 (GRCm39) S215P probably benign Het
Cramp1 C T 17: 25,202,114 (GRCm39) G456D probably damaging Het
Dbt T C 3: 116,339,698 (GRCm39) V362A probably damaging Het
Dio1 C A 4: 107,164,147 (GRCm39) A57S probably benign Het
F5 C A 1: 164,026,440 (GRCm39) H1671N probably benign Het
Gm6309 A G 5: 146,107,155 (GRCm39) Y64H probably damaging Het
Hipk1 A G 3: 103,660,743 (GRCm39) C731R probably damaging Het
Hmgcl G A 4: 135,683,015 (GRCm39) A156T probably damaging Het
Il15ra A T 2: 11,737,995 (GRCm39) T210S possibly damaging Het
Kat8 T C 7: 127,524,400 (GRCm39) L426P probably damaging Het
Lrrc39 G T 3: 116,359,496 (GRCm39) V14L probably damaging Het
Lrrc7 T C 3: 157,869,593 (GRCm39) M709V probably benign Het
Mdm4 T C 1: 132,919,671 (GRCm39) H398R probably benign Het
Mroh2b A T 15: 4,991,606 (GRCm39) Q1568L possibly damaging Het
Myo18b G A 5: 113,022,795 (GRCm39) probably benign Het
Nr4a3 C A 4: 48,051,756 (GRCm39) P170Q possibly damaging Het
Ntrk2 A G 13: 59,208,109 (GRCm39) M652V probably damaging Het
Or10n7-ps1 A T 9: 39,597,812 (GRCm39) *143K probably null Het
Or5b95 G A 19: 12,657,471 (GRCm39) probably benign Het
Paxbp1 T C 16: 90,832,815 (GRCm39) I325V possibly damaging Het
Pcare T C 17: 72,059,137 (GRCm39) H180R probably benign Het
Pi4ka G T 16: 17,114,807 (GRCm39) probably benign Het
Pira13 A G 7: 3,825,380 (GRCm39) S421P probably damaging Het
Pou6f1 T A 15: 100,489,742 (GRCm39) D74V probably damaging Het
Prpsap2 C A 11: 61,627,870 (GRCm39) R202L probably damaging Het
Ptprn A T 1: 75,228,407 (GRCm39) L890Q probably damaging Het
Ramp1 C G 1: 91,134,137 (GRCm39) P97A probably benign Het
Rapgefl1 A G 11: 98,731,101 (GRCm39) D179G probably damaging Het
Rbp3 T A 14: 33,678,486 (GRCm39) F811L possibly damaging Het
Rnf213 C A 11: 119,305,250 (GRCm39) L494M probably damaging Het
Rpl4 A G 9: 64,082,245 (GRCm39) N48S probably benign Het
Rsbn1l A G 5: 21,110,841 (GRCm39) V499A probably damaging Het
Sacs A G 14: 61,430,022 (GRCm39) T691A probably benign Het
Sass6 T C 3: 116,407,709 (GRCm39) V275A probably benign Het
Sdcbp T C 4: 6,393,661 (GRCm39) S259P probably benign Het
Sephs2 A G 7: 126,872,206 (GRCm39) F296L probably benign Het
Slc12a4 C T 8: 106,673,322 (GRCm39) probably null Het
Snrk G A 9: 121,989,597 (GRCm39) V314I probably benign Het
Tas1r3 C T 4: 155,947,600 (GRCm39) probably null Het
Tle3 T A 9: 61,320,195 (GRCm39) V560E probably damaging Het
Trdmt1 A G 2: 13,526,918 (GRCm39) Y144H probably benign Het
Trim42 T C 9: 97,245,100 (GRCm39) T567A probably benign Het
Tsbp1 A C 17: 34,678,973 (GRCm39) R228S possibly damaging Het
Tuba4a T C 1: 75,193,945 (GRCm39) D74G probably benign Het
Ube3c G A 5: 29,842,769 (GRCm39) probably null Het
Vwa3a A G 7: 120,375,311 (GRCm39) D375G probably benign Het
Other mutations in Zfp729b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02083:Zfp729b APN 13 67,743,349 (GRCm39) missense probably benign 0.09
IGL02852:Zfp729b APN 13 67,740,942 (GRCm39) missense probably damaging 0.99
PIT4449001:Zfp729b UTSW 13 67,739,542 (GRCm39) missense probably benign 0.01
R0238:Zfp729b UTSW 13 67,740,022 (GRCm39) missense probably damaging 0.98
R0238:Zfp729b UTSW 13 67,740,022 (GRCm39) missense probably damaging 0.98
R0450:Zfp729b UTSW 13 67,739,253 (GRCm39) missense probably benign
R0510:Zfp729b UTSW 13 67,739,253 (GRCm39) missense probably benign
R1122:Zfp729b UTSW 13 67,743,403 (GRCm39) missense possibly damaging 0.75
R1400:Zfp729b UTSW 13 67,740,913 (GRCm39) missense possibly damaging 0.63
R1915:Zfp729b UTSW 13 67,741,339 (GRCm39) missense probably damaging 1.00
R1929:Zfp729b UTSW 13 67,740,352 (GRCm39) missense probably damaging 1.00
R2229:Zfp729b UTSW 13 67,743,384 (GRCm39) missense probably damaging 0.99
R2270:Zfp729b UTSW 13 67,740,352 (GRCm39) missense probably damaging 1.00
R2271:Zfp729b UTSW 13 67,740,352 (GRCm39) missense probably damaging 1.00
R2344:Zfp729b UTSW 13 67,740,352 (GRCm39) missense probably damaging 1.00
R2377:Zfp729b UTSW 13 67,739,820 (GRCm39) missense possibly damaging 0.70
R2930:Zfp729b UTSW 13 67,739,973 (GRCm39) missense probably benign
R3053:Zfp729b UTSW 13 67,741,585 (GRCm39) missense probably damaging 1.00
R3404:Zfp729b UTSW 13 67,739,283 (GRCm39) missense probably damaging 0.98
R4118:Zfp729b UTSW 13 67,740,829 (GRCm39) missense possibly damaging 0.91
R4947:Zfp729b UTSW 13 67,744,791 (GRCm39) missense probably damaging 1.00
R5408:Zfp729b UTSW 13 67,739,563 (GRCm39) missense probably benign 0.18
R5511:Zfp729b UTSW 13 67,740,499 (GRCm39) missense probably damaging 1.00
R5542:Zfp729b UTSW 13 67,739,140 (GRCm39) missense probably benign
R5908:Zfp729b UTSW 13 67,739,374 (GRCm39) missense probably benign 0.00
R5977:Zfp729b UTSW 13 67,739,740 (GRCm39) missense probably benign 0.03
R5996:Zfp729b UTSW 13 67,741,977 (GRCm39) missense probably benign 0.18
R7086:Zfp729b UTSW 13 67,741,056 (GRCm39) missense probably damaging 0.99
R7146:Zfp729b UTSW 13 67,741,495 (GRCm39) missense probably damaging 1.00
R7217:Zfp729b UTSW 13 67,743,367 (GRCm39) missense probably damaging 0.96
R7332:Zfp729b UTSW 13 67,757,755 (GRCm39) splice site probably null
R7472:Zfp729b UTSW 13 67,742,002 (GRCm39) missense probably benign 0.00
R7615:Zfp729b UTSW 13 67,739,617 (GRCm39) missense possibly damaging 0.77
R7639:Zfp729b UTSW 13 67,739,971 (GRCm39) missense probably benign 0.02
R7652:Zfp729b UTSW 13 67,739,371 (GRCm39) missense probably benign 0.00
R7738:Zfp729b UTSW 13 67,740,194 (GRCm39) missense probably benign 0.00
R8137:Zfp729b UTSW 13 67,740,861 (GRCm39) missense probably damaging 1.00
R8381:Zfp729b UTSW 13 67,739,617 (GRCm39) missense possibly damaging 0.77
R8402:Zfp729b UTSW 13 67,740,696 (GRCm39) missense probably damaging 1.00
R9014:Zfp729b UTSW 13 67,740,274 (GRCm39) missense probably damaging 1.00
R9091:Zfp729b UTSW 13 67,740,480 (GRCm39) missense probably damaging 1.00
R9168:Zfp729b UTSW 13 67,741,942 (GRCm39) nonsense probably null
R9270:Zfp729b UTSW 13 67,740,480 (GRCm39) missense probably damaging 1.00
R9390:Zfp729b UTSW 13 67,742,014 (GRCm39) missense possibly damaging 0.95
R9390:Zfp729b UTSW 13 67,739,182 (GRCm39) missense probably benign 0.00
R9442:Zfp729b UTSW 13 67,739,337 (GRCm39) missense probably benign 0.25
R9620:Zfp729b UTSW 13 67,739,787 (GRCm39) missense probably damaging 1.00
X0023:Zfp729b UTSW 13 67,740,578 (GRCm39) missense possibly damaging 0.95
X0028:Zfp729b UTSW 13 67,740,313 (GRCm39) missense probably damaging 1.00
Z1088:Zfp729b UTSW 13 67,741,189 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- AGAAGGCCTTCCCACATACT -3'
(R):5'- GCAAGGCCTTCCACATTTCATC -3'

Sequencing Primer
(F):5'- GCCACATACTTCACATTTGTAGGG -3'
(R):5'- ACCCTACAAGTGTGAGGTATGTG -3'
Posted On 2021-08-31