Incidental Mutation 'R8943:Cct6b'
ID 681111
Institutional Source Beutler Lab
Gene Symbol Cct6b
Ensembl Gene ENSMUSG00000020698
Gene Name chaperonin containing TCP1 subunit 6B
Synonyms CCTzeta-2, Cctz-2
MMRRC Submission 068782-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.384) question?
Stock # R8943 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 82610076-82655147 bp(-) (GRCm39)
Type of Mutation utr 5 prime
DNA Base Change (assembly) T to C at 82654959 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000098288 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021040] [ENSMUST00000056677] [ENSMUST00000100722]
AlphaFold Q61390
Predicted Effect
SMART Domains Protein: ENSMUSP00000021040
Gene: ENSMUSG00000020698
AA Change: D32G

DomainStartEndE-ValueType
Pfam:Cpn60_TCP1 30 526 1.1e-161 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000056677
SMART Domains Protein: ENSMUSP00000056154
Gene: ENSMUSG00000046010

DomainStartEndE-ValueType
coiled coil region 13 40 N/A INTRINSIC
Blast:ZnF_U1 48 82 4e-10 BLAST
low complexity region 129 143 N/A INTRINSIC
low complexity region 156 167 N/A INTRINSIC
coiled coil region 303 331 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000100722
SMART Domains Protein: ENSMUSP00000098288
Gene: ENSMUSG00000020698

DomainStartEndE-ValueType
Pfam:Cpn60_TCP1 4 486 9.7e-140 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency 98% (50/51)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik T C 7: 41,275,667 (GRCm39) S457P probably damaging Het
Aak1 A G 6: 86,964,234 (GRCm39) N945S unknown Het
Actr1a C A 19: 46,369,438 (GRCm39) R192L possibly damaging Het
Adgrl2 T A 3: 148,534,119 (GRCm39) N1036I probably damaging Het
Ak5 A G 3: 152,361,511 (GRCm39) V137A probably damaging Het
Aldh1a2 T C 9: 71,169,055 (GRCm39) V179A probably damaging Het
Ap2b1 A T 11: 83,237,579 (GRCm39) I548F probably damaging Het
Arhgef10l A G 4: 140,292,550 (GRCm39) Y352H probably damaging Het
Atad5 C T 11: 79,986,524 (GRCm39) T537M possibly damaging Het
Atoh7 A G 10: 62,935,938 (GRCm39) K2E possibly damaging Het
BC061237 A G 14: 44,741,658 (GRCm39) I134V probably benign Het
Cadm1 T C 9: 47,701,136 (GRCm39) I141T probably damaging Het
Capn10 T C 1: 92,871,454 (GRCm39) S351P probably damaging Het
Cd19 T C 7: 126,011,330 (GRCm39) T284A probably benign Het
Cfap53 A G 18: 74,432,253 (GRCm39) Y47C probably damaging Het
Cldn18 T C 9: 99,578,162 (GRCm39) M194V probably benign Het
Dgkb T A 12: 38,652,777 (GRCm39) Y721N probably damaging Het
Dmbt1 A G 7: 130,721,372 (GRCm39) Q1880R possibly damaging Het
Dock2 T C 11: 34,599,646 (GRCm39) N311S possibly damaging Het
Dpysl5 G T 5: 30,935,375 (GRCm39) M159I probably benign Het
Eif2b3 G A 4: 116,901,778 (GRCm39) G147E probably damaging Het
Fam193a A G 5: 34,597,796 (GRCm39) D531G probably benign Het
Fndc3b T C 3: 27,555,329 (GRCm39) probably benign Het
Foxe3 C A 4: 114,782,523 (GRCm39) A230S unknown Het
Gm5591 A T 7: 38,219,727 (GRCm39) V382E probably benign Het
Gm7995 A T 14: 42,132,228 (GRCm39) N21I probably damaging Het
Ipo8 G A 6: 148,676,547 (GRCm39) P981S probably benign Het
Kcnh8 A G 17: 53,104,486 (GRCm39) D161G probably benign Het
Krt71 A G 15: 101,645,180 (GRCm39) I377T possibly damaging Het
Krt75 A T 15: 101,476,767 (GRCm39) M374K probably benign Het
Krt9 TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC TCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCCCCCACTTCCTCCTCCATAGCTGCC 11: 100,079,903 (GRCm39) probably benign Het
Lpcat1 A G 13: 73,662,029 (GRCm39) T409A probably benign Het
Lrch1 A T 14: 75,032,808 (GRCm39) I514K probably benign Het
Mc4r A C 18: 66,993,110 (GRCm39) M1R probably null Het
Mthfd1l A T 10: 3,978,466 (GRCm39) H442L probably damaging Het
Or5d38 T A 2: 87,954,718 (GRCm39) I204F probably damaging Het
Pdcd1lg2 T C 19: 29,423,553 (GRCm39) M199T probably benign Het
Pigg G A 5: 108,484,066 (GRCm39) V438M probably damaging Het
Pira12 T C 7: 3,898,365 (GRCm39) E319G probably benign Het
Ppfibp1 T A 6: 146,920,681 (GRCm39) probably null Het
Rbm15 T A 3: 107,239,372 (GRCm39) Y342F possibly damaging Het
Rhbdl1 A T 17: 26,054,116 (GRCm39) V278E probably damaging Het
Ryr3 T C 2: 112,465,669 (GRCm39) N4781S probably damaging Het
Scn7a A T 2: 66,525,206 (GRCm39) silent Het
Sfswap A G 5: 129,581,168 (GRCm39) R114G probably damaging Het
Sohlh2 C A 3: 55,104,282 (GRCm39) A258D possibly damaging Het
Sstr4 T A 2: 148,237,782 (GRCm39) V131D possibly damaging Het
Tenm2 T C 11: 36,834,861 (GRCm39) T45A probably damaging Het
Tmem131l A T 3: 83,831,479 (GRCm39) F818I probably damaging Het
Trappc6b A G 12: 59,097,149 (GRCm39) F58L probably damaging Het
Vmn1r229 A T 17: 21,035,418 (GRCm39) H221L possibly damaging Het
Vmn1r33 T A 6: 66,588,783 (GRCm39) Y257F probably damaging Het
Wdfy3 T C 5: 101,993,231 (GRCm39) probably benign Het
Zfp446 C T 7: 12,713,564 (GRCm39) Q177* probably null Het
Zup1 A G 10: 33,795,301 (GRCm39) *552Q probably null Het
Other mutations in Cct6b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02227:Cct6b APN 11 82,632,217 (GRCm39) missense probably damaging 1.00
IGL02606:Cct6b APN 11 82,627,271 (GRCm39) missense probably damaging 1.00
IGL02707:Cct6b APN 11 82,645,780 (GRCm39) splice site probably benign
IGL03081:Cct6b APN 11 82,654,995 (GRCm39) nonsense probably null
R0032:Cct6b UTSW 11 82,644,469 (GRCm39) missense possibly damaging 0.87
R0395:Cct6b UTSW 11 82,630,506 (GRCm39) missense probably benign
R0556:Cct6b UTSW 11 82,610,270 (GRCm39) splice site probably benign
R0631:Cct6b UTSW 11 82,627,914 (GRCm39) splice site probably null
R1456:Cct6b UTSW 11 82,644,446 (GRCm39) splice site probably benign
R3713:Cct6b UTSW 11 82,651,183 (GRCm39) missense probably damaging 1.00
R4791:Cct6b UTSW 11 82,632,830 (GRCm39) splice site probably null
R5154:Cct6b UTSW 11 82,630,521 (GRCm39) missense probably damaging 1.00
R5256:Cct6b UTSW 11 82,655,046 (GRCm39) missense probably damaging 0.98
R5338:Cct6b UTSW 11 82,653,015 (GRCm39) missense possibly damaging 0.94
R5455:Cct6b UTSW 11 82,645,943 (GRCm39) missense probably benign 0.04
R5560:Cct6b UTSW 11 82,632,239 (GRCm39) missense probably damaging 1.00
R5616:Cct6b UTSW 11 82,632,175 (GRCm39) missense probably damaging 1.00
R5644:Cct6b UTSW 11 82,613,281 (GRCm39) missense probably benign 0.02
R6862:Cct6b UTSW 11 82,610,785 (GRCm39) missense probably damaging 1.00
R7960:Cct6b UTSW 11 82,632,221 (GRCm39) missense possibly damaging 0.94
R8240:Cct6b UTSW 11 82,614,650 (GRCm39) missense probably damaging 1.00
R8785:Cct6b UTSW 11 82,632,157 (GRCm39) missense probably damaging 1.00
R9527:Cct6b UTSW 11 82,630,447 (GRCm39) critical splice donor site probably null
R9674:Cct6b UTSW 11 82,645,838 (GRCm39) missense probably damaging 1.00
X0060:Cct6b UTSW 11 82,632,136 (GRCm39) missense probably benign 0.00
Z1176:Cct6b UTSW 11 82,654,891 (GRCm39) start gained probably benign
Z1176:Cct6b UTSW 11 82,614,765 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCTAACAGTTTCTATTGACGG -3'
(R):5'- GTCACTTCCTGTTATGGCGC -3'

Sequencing Primer
(F):5'- TCGGCTAGAGAATCCTAAGAGC -3'
(R):5'- CCTGTTATGGCGCCGATTG -3'
Posted On 2021-08-31