Incidental Mutation 'R8944:Ncam1'
ID 681172
Institutional Source Beutler Lab
Gene Symbol Ncam1
Ensembl Gene ENSMUSG00000039542
Gene Name neural cell adhesion molecule 1
Synonyms NCAM, NCAM-1, NCAM-120, E-NCAM, CD56, NCAM-140, NCAM-180
MMRRC Submission 068783-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.928) question?
Stock # R8944 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 49413436-49710225 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 49431493 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 648 (P648L)
Ref Sequence ENSEMBL: ENSMUSP00000142275 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114476] [ENSMUST00000166811] [ENSMUST00000193547]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000114476
AA Change: P648L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110120
Gene: ENSMUSG00000039542
AA Change: P648L

DomainStartEndE-ValueType
IGc2 32 103 2.88e-4 SMART
IGc2 130 196 6.35e-6 SMART
IGc2 226 295 6.38e-20 SMART
IGc2 321 393 4.12e-14 SMART
IGc2 418 487 9.7e-11 SMART
FN3 501 586 4.77e-8 SMART
FN3 602 683 6.97e-1 SMART
low complexity region 711 725 N/A INTRINSIC
Predicted Effect
SMART Domains Protein: ENSMUSP00000130668
Gene: ENSMUSG00000039542
AA Change: P649L

DomainStartEndE-ValueType
IGc2 32 103 2.88e-4 SMART
IGc2 130 196 6.35e-6 SMART
IGc2 226 295 6.38e-20 SMART
IGc2 321 393 4.12e-14 SMART
IGc2 418 487 9.7e-11 SMART
FN3 501 586 4.77e-8 SMART
FN3 602 683 6.97e-1 SMART
transmembrane domain 706 728 N/A INTRINSIC
low complexity region 797 809 N/A INTRINSIC
low complexity region 814 830 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000193547
AA Change: P648L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000142275
Gene: ENSMUSG00000039542
AA Change: P648L

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IGc2 32 103 2.88e-4 SMART
IGc2 130 196 6.35e-6 SMART
IGc2 226 295 6.38e-20 SMART
IGc2 321 393 4.12e-14 SMART
IGc2 418 487 9.7e-11 SMART
FN3 501 586 4.77e-8 SMART
FN3 602 683 6.97e-1 SMART
transmembrane domain 706 728 N/A INTRINSIC
low complexity region 797 809 N/A INTRINSIC
low complexity region 814 830 N/A INTRINSIC
Predicted Effect
Predicted Effect probably benign
Transcript: ENSMUST00000194844
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (88/88)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
PHENOTYPE: Homozygous mutants show impairment in Morris water maze test, reduced brain and olfactory bulb size, hypoplasic corticospinal tract, abnormally distributed anterior pituitary cell types, and morphological and functional defects of neuromuscular junctions. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 90 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427D14Rik A T 11: 72,049,851 (GRCm39) probably benign Het
A830018L16Rik A T 1: 11,484,706 (GRCm39) probably benign Het
Acox1 C T 11: 116,066,040 (GRCm39) R454H probably damaging Het
Acte1 G T 7: 143,434,902 (GRCm39) probably null Het
Adam18 A G 8: 25,164,703 (GRCm39) L4P probably damaging Het
AI182371 A C 2: 34,990,622 (GRCm39) L25R probably damaging Het
Ankrd12 A C 17: 66,277,195 (GRCm39) Y2026* probably null Het
Atad5 C T 11: 79,986,524 (GRCm39) T537M possibly damaging Het
Atosa A G 9: 74,911,562 (GRCm39) Y11C probably damaging Het
Avil G T 10: 126,846,455 (GRCm39) G420V probably damaging Het
Bche A T 3: 73,608,008 (GRCm39) F473I probably damaging Het
Borcs5 T C 6: 134,621,437 (GRCm39) probably null Het
C4b T C 17: 34,961,913 (GRCm39) Q111R probably benign Het
Carmil2 T A 8: 106,417,437 (GRCm39) I565N probably damaging Het
Cd74 T C 18: 60,943,127 (GRCm39) M155T probably damaging Het
Chrnd G T 1: 87,119,997 (GRCm39) R105L probably damaging Het
Clpp G T 17: 57,300,553 (GRCm39) E217* probably null Het
Cpq T A 15: 33,594,269 (GRCm39) Y427N probably damaging Het
Crxos G A 7: 15,636,900 (GRCm39) E54K possibly damaging Het
Dcaf13 A G 15: 39,001,612 (GRCm39) R307G possibly damaging Het
Ddx55 A G 5: 124,706,788 (GRCm39) D595G probably damaging Het
Dld T A 12: 31,390,868 (GRCm39) I193F possibly damaging Het
Dnah11 T G 12: 118,091,381 (GRCm39) E917A possibly damaging Het
Dnai2 T A 11: 114,641,302 (GRCm39) Y376N possibly damaging Het
Dock7 A G 4: 98,829,243 (GRCm39) Y2078H probably damaging Het
Dusp4 A T 8: 35,274,941 (GRCm39) N20I probably benign Het
Dzank1 A G 2: 144,333,729 (GRCm39) L367P probably benign Het
Eea1 T A 10: 95,832,822 (GRCm39) D222E probably damaging Het
Erich3 G C 3: 154,462,692 (GRCm39) R742S Het
Erich6 C T 3: 58,537,275 (GRCm39) M246I probably benign Het
Galnt16 T G 12: 80,623,314 (GRCm39) I158S probably damaging Het
Gm28363 A G 1: 117,655,080 (GRCm39) T100A possibly damaging Het
Gm8257 A T 14: 44,893,849 (GRCm39) Y36N probably damaging Het
Gmpr2 T C 14: 55,913,149 (GRCm39) V142A possibly damaging Het
Grid2ip T C 5: 143,366,260 (GRCm39) probably null Het
Hamp2 A G 7: 30,622,001 (GRCm39) F63L possibly damaging Het
Hmga2 T C 10: 120,309,159 (GRCm39) K66E probably damaging Het
Hspa1a T C 17: 35,190,019 (GRCm39) T295A probably benign Het
Ift74 G A 4: 94,510,128 (GRCm39) G53D probably damaging Het
Ighv6-7 T C 12: 114,419,703 (GRCm39) M1V probably null Het
Ints4 T A 7: 97,183,593 (GRCm39) D769E probably benign Het
Kif7 G A 7: 79,360,005 (GRCm39) R411C probably damaging Het
Klhl30 T A 1: 91,287,174 (GRCm39) Y487N probably damaging Het
Kras T C 6: 145,170,853 (GRCm39) E174G probably benign Het
Krt84 T C 15: 101,437,183 (GRCm39) I327V probably benign Het
Lamb3 T A 1: 193,014,525 (GRCm39) C561* probably null Het
Lmbrd1 A G 1: 24,767,407 (GRCm39) probably benign Het
Lmnb1 T A 18: 56,876,331 (GRCm39) S480T probably benign Het
Lrp2 C T 2: 69,341,348 (GRCm39) G944D probably damaging Het
Mta3 G A 17: 84,083,146 (GRCm39) E280K probably damaging Het
Muc5b A T 7: 141,421,115 (GRCm39) I4236F Het
Myh9 T C 15: 77,655,432 (GRCm39) T1175A probably benign Het
Myt1l T A 12: 29,861,564 (GRCm39) D115E unknown Het
Naa25 A G 5: 121,552,573 (GRCm39) N167D probably benign Het
Or2t26 T C 11: 49,039,266 (GRCm39) Y61H probably damaging Het
Or2t44 A T 11: 58,677,519 (GRCm39) D153V probably damaging Het
P3h3 G T 6: 124,832,196 (GRCm39) A230E possibly damaging Het
Pacs2 A G 12: 113,020,476 (GRCm39) E253G probably damaging Het
Pbld1 A T 10: 62,901,648 (GRCm39) D57V probably benign Het
Pcsk5 T C 19: 17,452,275 (GRCm39) T1077A probably damaging Het
Pou4f2 T A 8: 79,161,932 (GRCm39) M224L Het
Ppcdc C T 9: 57,342,265 (GRCm39) R19H probably benign Het
Ppp1r10 T A 17: 36,241,018 (GRCm39) M640K probably benign Het
Prdx6 A T 1: 161,069,432 (GRCm39) probably benign Het
Rab40b A G 11: 121,250,384 (GRCm39) probably null Het
Rassf9 T A 10: 102,381,329 (GRCm39) M237K probably benign Het
Rbbp8nl G T 2: 179,919,769 (GRCm39) Y604* probably null Het
Reep2 G T 18: 34,975,929 (GRCm39) W42L possibly damaging Het
Serpinb6e A T 13: 34,017,261 (GRCm39) M253K probably damaging Het
Shank2 A G 7: 143,623,927 (GRCm39) Q304R probably damaging Het
Slk T C 19: 47,600,057 (GRCm39) M120T probably damaging Het
Spata31e5 T C 1: 28,816,155 (GRCm39) I626V probably benign Het
Sphkap T A 1: 83,256,927 (GRCm39) H274L probably benign Het
Stc1 T G 14: 69,269,884 (GRCm39) F155V possibly damaging Het
Tbc1d12 A G 19: 38,899,510 (GRCm39) T477A probably damaging Het
Tmem19 T A 10: 115,183,671 (GRCm39) I54F possibly damaging Het
Tmem62 G A 2: 120,817,316 (GRCm39) probably null Het
Ttc6 A T 12: 57,689,826 (GRCm39) R505S Het
Ttn G T 2: 76,623,184 (GRCm39) R15418S probably damaging Het
Ugt2a3 C A 5: 87,473,417 (GRCm39) C500F possibly damaging Het
Ugt2b35 T C 5: 87,149,310 (GRCm39) F187S probably benign Het
Ung T A 5: 114,269,456 (GRCm39) I56N probably damaging Het
Vmn1r17 G T 6: 57,338,142 (GRCm39) F25L probably benign Het
Vmn1r29 C A 6: 58,284,274 (GRCm39) probably benign Het
Vps26c T A 16: 94,302,481 (GRCm39) I242F probably benign Het
Wdhd1 T C 14: 47,504,470 (GRCm39) D368G probably benign Het
Wdr3 A T 3: 100,057,259 (GRCm39) I448N probably damaging Het
Wdr47 T A 3: 108,550,480 (GRCm39) M835K possibly damaging Het
Wt1 G A 2: 104,957,584 (GRCm39) G10D possibly damaging Het
Zdhhc19 G A 16: 32,316,500 (GRCm39) G85D probably damaging Het
Other mutations in Ncam1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00592:Ncam1 APN 9 49,434,865 (GRCm39) missense probably damaging 1.00
IGL01384:Ncam1 APN 9 49,421,152 (GRCm39) missense possibly damaging 0.76
IGL01798:Ncam1 APN 9 49,419,907 (GRCm39) missense probably damaging 1.00
IGL02239:Ncam1 APN 9 49,478,702 (GRCm39) missense probably damaging 1.00
IGL02368:Ncam1 APN 9 49,454,383 (GRCm39) nonsense probably null
IGL02616:Ncam1 APN 9 49,419,988 (GRCm39) missense probably benign 0.23
PIT4431001:Ncam1 UTSW 9 49,709,993 (GRCm39) missense probably benign 0.04
R0164:Ncam1 UTSW 9 49,479,709 (GRCm39) missense probably damaging 1.00
R0164:Ncam1 UTSW 9 49,479,709 (GRCm39) missense probably damaging 1.00
R0502:Ncam1 UTSW 9 49,481,118 (GRCm39) unclassified probably benign
R0924:Ncam1 UTSW 9 49,473,476 (GRCm39) intron probably benign
R1398:Ncam1 UTSW 9 49,428,889 (GRCm39) intron probably benign
R1440:Ncam1 UTSW 9 49,456,100 (GRCm39) missense probably damaging 1.00
R1491:Ncam1 UTSW 9 49,416,849 (GRCm39) missense probably benign 0.15
R1676:Ncam1 UTSW 9 49,468,472 (GRCm39) missense probably damaging 1.00
R1743:Ncam1 UTSW 9 49,468,445 (GRCm39) missense probably damaging 1.00
R1769:Ncam1 UTSW 9 49,456,556 (GRCm39) unclassified probably benign
R1951:Ncam1 UTSW 9 49,456,492 (GRCm39) missense probably benign 0.36
R2143:Ncam1 UTSW 9 49,454,319 (GRCm39) missense possibly damaging 0.87
R2167:Ncam1 UTSW 9 49,479,781 (GRCm39) missense probably benign 0.42
R2170:Ncam1 UTSW 9 49,709,981 (GRCm39) missense probably benign 0.06
R2290:Ncam1 UTSW 9 49,434,951 (GRCm39) splice site probably benign
R2321:Ncam1 UTSW 9 49,456,132 (GRCm39) unclassified probably benign
R3001:Ncam1 UTSW 9 49,468,526 (GRCm39) missense probably damaging 0.99
R3002:Ncam1 UTSW 9 49,468,526 (GRCm39) missense probably damaging 0.99
R4026:Ncam1 UTSW 9 49,476,295 (GRCm39) missense probably benign 0.00
R4279:Ncam1 UTSW 9 49,418,259 (GRCm39) intron probably benign
R4289:Ncam1 UTSW 9 49,468,472 (GRCm39) missense probably damaging 1.00
R4873:Ncam1 UTSW 9 49,418,921 (GRCm39) intron probably benign
R4875:Ncam1 UTSW 9 49,418,921 (GRCm39) intron probably benign
R4883:Ncam1 UTSW 9 49,453,183 (GRCm39) splice site probably null
R4899:Ncam1 UTSW 9 49,456,551 (GRCm39) critical splice acceptor site probably null
R4923:Ncam1 UTSW 9 49,416,779 (GRCm39) missense probably benign
R5041:Ncam1 UTSW 9 49,478,085 (GRCm39) missense probably damaging 1.00
R5058:Ncam1 UTSW 9 49,709,995 (GRCm39) missense probably benign 0.16
R5386:Ncam1 UTSW 9 49,476,174 (GRCm39) missense probably damaging 1.00
R5388:Ncam1 UTSW 9 49,456,054 (GRCm39) missense probably benign
R5512:Ncam1 UTSW 9 49,420,999 (GRCm39) splice site probably null
R5598:Ncam1 UTSW 9 49,457,051 (GRCm39) missense probably damaging 1.00
R5895:Ncam1 UTSW 9 49,418,343 (GRCm39) missense probably benign
R5972:Ncam1 UTSW 9 49,418,829 (GRCm39) missense possibly damaging 0.93
R6059:Ncam1 UTSW 9 49,455,966 (GRCm39) missense probably damaging 1.00
R6226:Ncam1 UTSW 9 49,476,304 (GRCm39) missense probably benign 0.00
R6392:Ncam1 UTSW 9 49,434,875 (GRCm39) missense probably damaging 0.99
R6750:Ncam1 UTSW 9 49,478,639 (GRCm39) missense probably damaging 1.00
R6799:Ncam1 UTSW 9 49,419,911 (GRCm39) missense probably damaging 0.99
R7230:Ncam1 UTSW 9 49,421,123 (GRCm39) missense probably benign 0.00
R7335:Ncam1 UTSW 9 49,418,211 (GRCm39) missense
R7561:Ncam1 UTSW 9 49,476,242 (GRCm39) missense probably damaging 1.00
R7645:Ncam1 UTSW 9 49,476,303 (GRCm39) missense probably benign 0.01
R8022:Ncam1 UTSW 9 49,476,192 (GRCm39) missense possibly damaging 0.72
R8023:Ncam1 UTSW 9 49,421,057 (GRCm39) missense probably benign 0.00
R8045:Ncam1 UTSW 9 49,418,736 (GRCm39) missense
R8234:Ncam1 UTSW 9 49,456,523 (GRCm39) missense probably damaging 0.99
R8308:Ncam1 UTSW 9 49,479,817 (GRCm39) missense probably damaging 0.99
R8370:Ncam1 UTSW 9 49,468,431 (GRCm39) nonsense probably null
R8500:Ncam1 UTSW 9 49,431,445 (GRCm39) missense probably damaging 1.00
R8542:Ncam1 UTSW 9 49,419,898 (GRCm39) missense probably damaging 1.00
R8977:Ncam1 UTSW 9 49,418,825 (GRCm39) missense probably damaging 1.00
R9028:Ncam1 UTSW 9 49,418,736 (GRCm39) missense
R9034:Ncam1 UTSW 9 49,481,198 (GRCm39) missense probably benign 0.42
R9106:Ncam1 UTSW 9 49,428,856 (GRCm39) missense probably damaging 0.99
R9224:Ncam1 UTSW 9 49,419,995 (GRCm39) missense probably damaging 1.00
R9330:Ncam1 UTSW 9 49,456,097 (GRCm39) missense probably benign
X0062:Ncam1 UTSW 9 49,456,901 (GRCm39) nonsense probably null
X0064:Ncam1 UTSW 9 49,477,980 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCATTAATTCAAAGCGGGG -3'
(R):5'- TTGGCACACATACTAGCCAG -3'

Sequencing Primer
(F):5'- GACAGAAAACAGACATGGCTGTACC -3'
(R):5'- GCACACATACTAGCCAGTTCCAC -3'
Posted On 2021-08-31