Incidental Mutation 'R8945:Dusp26'
ID 681242
Institutional Source Beutler Lab
Gene Symbol Dusp26
Ensembl Gene ENSMUSG00000039661
Gene Name dual specificity phosphatase 26
Synonyms 2310043K02Rik
MMRRC Submission 068713-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8945 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 31579555-31587074 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 31586367 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Lysine at position 196 (R196K)
Ref Sequence ENSEMBL: ENSMUSP00000126397 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036631] [ENSMUST00000161713] [ENSMUST00000170204]
AlphaFold Q9D700
Predicted Effect unknown
Transcript: ENSMUST00000036631
AA Change: R196K
SMART Domains Protein: ENSMUSP00000046794
Gene: ENSMUSG00000039661
AA Change: R196K

DomainStartEndE-ValueType
DSPc 61 204 3.1e-39 SMART
Predicted Effect unknown
Transcript: ENSMUST00000161713
AA Change: R196K
SMART Domains Protein: ENSMUSP00000124949
Gene: ENSMUSG00000039661
AA Change: R196K

DomainStartEndE-ValueType
DSPc 61 204 3.1e-39 SMART
Predicted Effect unknown
Transcript: ENSMUST00000170204
AA Change: R196K
SMART Domains Protein: ENSMUSP00000126397
Gene: ENSMUSG00000039661
AA Change: R196K

DomainStartEndE-ValueType
DSPc 61 204 3.1e-39 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aopep G T 13: 63,388,145 (GRCm39) K709N probably null Het
Aste1 G A 9: 105,273,880 (GRCm39) C40Y probably benign Het
Atp6v0a2 G T 5: 124,784,589 (GRCm39) A291S probably damaging Het
Bcl9l G T 9: 44,412,238 (GRCm39) V38L possibly damaging Het
Bmp1 T C 14: 70,727,630 (GRCm39) Y651C probably damaging Het
Btnl9 T C 11: 49,065,661 (GRCm39) E398G probably benign Het
C2cd3 A T 7: 100,040,286 (GRCm39) N285I possibly damaging Het
Cavin1 T C 11: 100,849,659 (GRCm39) T324A probably damaging Het
Ccdc73 A G 2: 104,821,712 (GRCm39) T554A probably benign Het
Clcn1 A T 6: 42,263,701 (GRCm39) M1L possibly damaging Het
Clec18a A T 8: 111,808,201 (GRCm39) S77T possibly damaging Het
Dhx32 A G 7: 133,323,876 (GRCm39) probably null Het
Dmxl1 C G 18: 50,072,639 (GRCm39) N2744K probably damaging Het
Dnah10 A C 5: 124,891,006 (GRCm39) E3199A probably damaging Het
Dnah11 G T 12: 117,987,718 (GRCm39) L2395I probably benign Het
Dthd1 A T 5: 63,007,096 (GRCm39) Y599F probably benign Het
Dyrk1a A G 16: 94,466,866 (GRCm39) Y140C probably damaging Het
Elmo1 T A 13: 20,766,438 (GRCm39) Y588* probably null Het
Eml6 T A 11: 29,703,110 (GRCm39) T1603S probably damaging Het
Fam162b T C 10: 51,466,469 (GRCm39) T17A probably benign Het
Fnbp1 T A 2: 30,995,346 (GRCm39) K29N probably damaging Het
Fzd4 A T 7: 89,056,792 (GRCm39) I280L possibly damaging Het
G3bp2 G A 5: 92,216,281 (GRCm39) T85I probably damaging Het
Gm13283 C T 4: 88,679,123 (GRCm39) A38V probably benign Het
Hps3 T A 3: 20,068,224 (GRCm39) H610L probably damaging Het
Ifnlr1 T G 4: 135,431,609 (GRCm39) L266R probably damaging Het
Jak1 A T 4: 101,020,109 (GRCm39) D683E probably benign Het
Lrrc1 G A 9: 77,342,373 (GRCm39) T412M probably damaging Het
Mdga1 G T 17: 30,058,959 (GRCm39) probably benign Het
Med26 T C 8: 73,250,934 (GRCm39) K55R probably benign Het
Mturn C A 6: 54,666,017 (GRCm39) C63* probably null Het
Myo1h A C 5: 114,470,784 (GRCm39) D381A probably damaging Het
Nectin1 A G 9: 43,703,237 (GRCm39) D165G probably benign Het
Nktr T A 9: 121,575,558 (GRCm39) D330E possibly damaging Het
Oprm1 A T 10: 6,782,644 (GRCm39) probably benign Het
Papola T A 12: 105,775,946 (GRCm39) probably benign Het
Pdcl2 A T 5: 76,465,675 (GRCm39) C134S probably damaging Het
Plch1 T C 3: 63,639,039 (GRCm39) Y478C probably benign Het
Rev1 A T 1: 38,122,824 (GRCm39) W465R probably damaging Het
Rp1 T A 1: 4,419,817 (GRCm39) I432F probably benign Het
Samd14 A C 11: 94,912,027 (GRCm39) D168A probably damaging Het
Sdk1 G T 5: 141,598,935 (GRCm39) C200F probably benign Het
Spmip2 A G 3: 79,252,812 (GRCm39) H9R probably benign Het
Spsb1 T C 4: 149,991,475 (GRCm39) Y31C possibly damaging Het
Spz1 T C 13: 92,711,499 (GRCm39) K326E possibly damaging Het
Tcaf1 C T 6: 42,663,307 (GRCm39) S191N probably benign Het
Tex15 A G 8: 34,064,724 (GRCm39) S1385G probably benign Het
Tmem38a C T 8: 73,338,570 (GRCm39) A194V probably damaging Het
Trappc9 T C 15: 72,929,945 (GRCm39) N137S probably benign Het
Tshr T C 12: 91,504,997 (GRCm39) L645P probably damaging Het
Tspyl4 T A 10: 34,173,461 (GRCm39) probably benign Het
Unc13a T A 8: 72,100,597 (GRCm39) I1064F probably damaging Het
Utp20 G A 10: 88,628,532 (GRCm39) Q921* probably null Het
Vps13a A T 19: 16,642,114 (GRCm39) I2171N probably damaging Het
Zfp40 A G 17: 23,401,201 (GRCm39) V14A probably benign Het
Other mutations in Dusp26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00964:Dusp26 APN 8 31,584,136 (GRCm39) missense probably benign 0.01
R0037:Dusp26 UTSW 8 31,586,388 (GRCm39) missense unknown
R0394:Dusp26 UTSW 8 31,581,987 (GRCm39) missense probably benign 0.16
R1792:Dusp26 UTSW 8 31,581,963 (GRCm39) missense probably benign 0.01
R4454:Dusp26 UTSW 8 31,584,172 (GRCm39) missense probably damaging 0.99
R4854:Dusp26 UTSW 8 31,584,165 (GRCm39) missense probably damaging 1.00
R5638:Dusp26 UTSW 8 31,584,169 (GRCm39) missense probably damaging 1.00
R6212:Dusp26 UTSW 8 31,584,252 (GRCm39) missense probably damaging 1.00
R6337:Dusp26 UTSW 8 31,586,325 (GRCm39) missense probably damaging 1.00
R7083:Dusp26 UTSW 8 31,581,747 (GRCm39) intron probably benign
R8754:Dusp26 UTSW 8 31,581,805 (GRCm39) intron probably benign
R8970:Dusp26 UTSW 8 31,584,232 (GRCm39) missense probably damaging 1.00
R9742:Dusp26 UTSW 8 31,584,198 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TAGTGGACCATGCTGAGCTC -3'
(R):5'- AAGAGCCACAGTGGTCTTG -3'

Sequencing Primer
(F):5'- GACCATGCTGAGCTCTCCCTAG -3'
(R):5'- CACAGTGGTCTTGGGGCTC -3'
Posted On 2021-08-31