Incidental Mutation 'IGL00421:Gpr89'
ID6814
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr89
Ensembl Gene ENSMUSG00000028096
Gene NameG protein-coupled receptor 89
Synonyms4933412D19Rik, SH120
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.326) question?
Stock #IGL00421
Quality Score
Status
Chromosome3
Chromosomal Location96868281-96905346 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 96898523 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Serine at position 24 (F24S)
Ref Sequence ENSEMBL: ENSMUSP00000116016 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029738] [ENSMUST00000154750]
Predicted Effect probably damaging
Transcript: ENSMUST00000029738
AA Change: F24S

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000029738
Gene: ENSMUSG00000028096
AA Change: F24S

DomainStartEndE-ValueType
transmembrane domain 4 26 N/A INTRINSIC
transmembrane domain 38 60 N/A INTRINSIC
transmembrane domain 75 97 N/A INTRINSIC
transmembrane domain 110 127 N/A INTRINSIC
Pfam:GPHR_N 140 207 1.1e-31 PFAM
Pfam:ABA_GPCR 276 446 4.9e-46 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139599
Predicted Effect probably damaging
Transcript: ENSMUST00000154750
AA Change: F24S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000116016
Gene: ENSMUSG00000028096
AA Change: F24S

DomainStartEndE-ValueType
transmembrane domain 4 26 N/A INTRINSIC
transmembrane domain 38 60 N/A INTRINSIC
transmembrane domain 75 97 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199586
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap8 T C 17: 32,317,280 Y53C probably damaging Het
Ampd3 C T 7: 110,803,147 R453C probably benign Het
Apob A C 12: 8,010,197 D2860A probably damaging Het
Arhgef1 C A 7: 24,908,359 R52S possibly damaging Het
Barhl2 C T 5: 106,455,499 A265T possibly damaging Het
Cacna1i A T 15: 80,382,019 D1569V probably damaging Het
Clic6 A T 16: 92,499,308 E285D probably damaging Het
Dok5 T G 2: 170,829,956 probably null Het
Gm10436 A T 12: 88,177,112 D310E probably benign Het
Grsf1 T C 5: 88,670,278 D84G probably damaging Het
Kif27 T C 13: 58,343,889 K479E probably damaging Het
Mx2 A T 16: 97,544,478 N32I probably damaging Het
Myo16 G T 8: 10,438,889 V687F probably damaging Het
Nlrp3 A G 11: 59,565,943 D977G probably damaging Het
Nol6 A T 4: 41,123,374 V97E possibly damaging Het
Pcdh15 T A 10: 74,185,345 Y130* probably null Het
Pnpla7 T A 2: 24,976,315 probably null Het
Prcc A T 3: 87,872,208 probably null Het
Sbf2 A C 7: 110,375,832 probably benign Het
Secisbp2l C A 2: 125,743,856 V859F probably damaging Het
Sptbn2 C A 19: 4,724,705 Q129K possibly damaging Het
Srrm2 G A 17: 23,812,478 S295N probably benign Het
Tacr3 A C 3: 134,854,821 I174L probably benign Het
Tchp A C 5: 114,708,733 D27A probably benign Het
Usp31 A T 7: 121,648,650 V1190D probably damaging Het
Zfp462 A G 4: 55,023,576 T2122A probably benign Het
Other mutations in Gpr89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00757:Gpr89 APN 3 96871534 missense probably benign 0.00
IGL01114:Gpr89 APN 3 96893549 missense probably damaging 0.98
IGL02417:Gpr89 APN 3 96897425 nonsense probably null
explorer UTSW 3 96880069 splice site probably null
R0207:Gpr89 UTSW 3 96871480 missense probably damaging 0.99
R0650:Gpr89 UTSW 3 96897324 splice site probably benign
R0704:Gpr89 UTSW 3 96880168 critical splice acceptor site probably null
R1496:Gpr89 UTSW 3 96905210 missense probably benign 0.00
R1869:Gpr89 UTSW 3 96875659 missense probably benign 0.16
R1913:Gpr89 UTSW 3 96875633 missense possibly damaging 0.91
R2264:Gpr89 UTSW 3 96872515 missense probably damaging 0.99
R2276:Gpr89 UTSW 3 96897427 missense probably damaging 1.00
R3822:Gpr89 UTSW 3 96892944 missense probably benign 0.03
R3922:Gpr89 UTSW 3 96890899 missense probably damaging 1.00
R4984:Gpr89 UTSW 3 96905196 missense probably benign 0.02
R5761:Gpr89 UTSW 3 96892880 missense probably damaging 1.00
R6185:Gpr89 UTSW 3 96890833 missense probably damaging 0.99
R7063:Gpr89 UTSW 3 96875698 missense probably damaging 1.00
R7164:Gpr89 UTSW 3 96871398 missense probably benign 0.04
R7172:Gpr89 UTSW 3 96880069 splice site probably null
R7215:Gpr89 UTSW 3 96880088 missense probably damaging 1.00
R7536:Gpr89 UTSW 3 96890893 missense probably damaging 0.96
R7708:Gpr89 UTSW 3 96880625 missense possibly damaging 0.81
R7849:Gpr89 UTSW 3 96871490 nonsense probably null
R7932:Gpr89 UTSW 3 96871490 nonsense probably null
RF019:Gpr89 UTSW 3 96905193 missense probably benign
Posted On2012-04-20