Incidental Mutation 'R8954:Cux1'
| ID |
681821 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cux1
|
| Ensembl Gene |
ENSMUSG00000029705 |
| Gene Name |
cut-like homeobox 1 |
| Synonyms |
CDP, Cutl1, Cux, Cux-1 |
| MMRRC Submission |
068790-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.892)
|
| Stock # |
R8954 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
136276989-136596344 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 136402203 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Stop codon
at position 138
(K138*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000134819
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000004097]
[ENSMUST00000175918]
[ENSMUST00000175975]
[ENSMUST00000176172]
[ENSMUST00000176216]
[ENSMUST00000176745]
[ENSMUST00000176778]
[ENSMUST00000177297]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000004097
AA Change: K138*
|
| SMART Domains |
Protein: ENSMUSP00000004097
Gene: ENSMUSG00000029705
AA Change: K138*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
436 |
N/A |
INTRINSIC |
|
CUT
|
452 |
538 |
5.06e-39 |
SMART |
|
low complexity region
|
602 |
608 |
N/A |
INTRINSIC |
|
low complexity region
|
620 |
642 |
N/A |
INTRINSIC |
|
CUT
|
841 |
929 |
3.31e-43 |
SMART |
|
low complexity region
|
956 |
972 |
N/A |
INTRINSIC |
|
low complexity region
|
990 |
1011 |
N/A |
INTRINSIC |
|
CUT
|
1024 |
1110 |
3.78e-38 |
SMART |
|
HOX
|
1150 |
1212 |
6.32e-15 |
SMART |
|
low complexity region
|
1224 |
1239 |
N/A |
INTRINSIC |
|
low complexity region
|
1317 |
1379 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000175918
AA Change: K101*
|
| SMART Domains |
Protein: ENSMUSP00000135606
Gene: ENSMUSG00000029705
AA Change: K101*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
73 |
328 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000175975
AA Change: K138*
|
| SMART Domains |
Protein: ENSMUSP00000135223
Gene: ENSMUSG00000029705
AA Change: K138*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
169 |
N/A |
INTRINSIC |
|
low complexity region
|
235 |
251 |
N/A |
INTRINSIC |
|
low complexity region
|
277 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
331 |
342 |
N/A |
INTRINSIC |
|
CUT
|
358 |
444 |
5.06e-39 |
SMART |
|
low complexity region
|
508 |
514 |
N/A |
INTRINSIC |
|
low complexity region
|
526 |
548 |
N/A |
INTRINSIC |
|
CUT
|
747 |
835 |
3.31e-43 |
SMART |
|
low complexity region
|
862 |
878 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
917 |
N/A |
INTRINSIC |
|
CUT
|
930 |
1016 |
3.78e-38 |
SMART |
|
HOX
|
1056 |
1118 |
6.32e-15 |
SMART |
|
low complexity region
|
1130 |
1145 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1285 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176172
AA Change: K127*
|
| SMART Domains |
Protein: ENSMUSP00000135086
Gene: ENSMUSG00000029705
AA Change: K127*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
99 |
354 |
N/A |
INTRINSIC |
|
low complexity region
|
420 |
436 |
N/A |
INTRINSIC |
|
low complexity region
|
462 |
474 |
N/A |
INTRINSIC |
|
low complexity region
|
516 |
527 |
N/A |
INTRINSIC |
|
CUT
|
543 |
629 |
5.06e-39 |
SMART |
|
low complexity region
|
693 |
699 |
N/A |
INTRINSIC |
|
low complexity region
|
711 |
733 |
N/A |
INTRINSIC |
|
CUT
|
932 |
1020 |
3.31e-43 |
SMART |
|
low complexity region
|
1047 |
1063 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1102 |
N/A |
INTRINSIC |
|
CUT
|
1115 |
1201 |
3.78e-38 |
SMART |
|
HOX
|
1241 |
1303 |
6.32e-15 |
SMART |
|
low complexity region
|
1315 |
1330 |
N/A |
INTRINSIC |
|
low complexity region
|
1408 |
1470 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176216
AA Change: K138*
|
| SMART Domains |
Protein: ENSMUSP00000135054
Gene: ENSMUSG00000029705
AA Change: K138*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
9.35e-5 |
PROSPERO |
|
Pfam:CASP_C
|
421 |
647 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176486
|
| SMART Domains |
Protein: ENSMUSP00000135370
Gene: ENSMUSG00000029705
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
low complexity region
|
429 |
445 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
483 |
N/A |
INTRINSIC |
|
low complexity region
|
525 |
536 |
N/A |
INTRINSIC |
|
CUT
|
552 |
638 |
5.06e-39 |
SMART |
|
Blast:CUT
|
641 |
840 |
3e-50 |
BLAST |
|
CUT
|
919 |
1007 |
3.31e-43 |
SMART |
|
low complexity region
|
1034 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1068 |
1089 |
N/A |
INTRINSIC |
|
CUT
|
1102 |
1188 |
3.78e-38 |
SMART |
|
HOX
|
1228 |
1290 |
6.32e-15 |
SMART |
|
low complexity region
|
1302 |
1317 |
N/A |
INTRINSIC |
|
low complexity region
|
1395 |
1457 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176745
AA Change: K138*
|
| SMART Domains |
Protein: ENSMUSP00000135512
Gene: ENSMUSG00000029705
AA Change: K138*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
363 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
367 |
388 |
8.95e-5 |
PROSPERO |
|
Pfam:CASP_C
|
419 |
645 |
1.2e-71 |
PFAM |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000176778
AA Change: K223*
|
| SMART Domains |
Protein: ENSMUSP00000135892
Gene: ENSMUSG00000029705
AA Change: K223*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
86 |
N/A |
INTRINSIC |
|
coiled coil region
|
195 |
448 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
519 |
N/A |
INTRINSIC |
|
CUT
|
535 |
621 |
5.06e-39 |
SMART |
|
low complexity region
|
685 |
691 |
N/A |
INTRINSIC |
|
low complexity region
|
703 |
725 |
N/A |
INTRINSIC |
|
CUT
|
924 |
1012 |
3.31e-43 |
SMART |
|
low complexity region
|
1039 |
1055 |
N/A |
INTRINSIC |
|
low complexity region
|
1073 |
1094 |
N/A |
INTRINSIC |
|
CUT
|
1107 |
1193 |
3.78e-38 |
SMART |
|
HOX
|
1233 |
1295 |
6.32e-15 |
SMART |
|
low complexity region
|
1307 |
1322 |
N/A |
INTRINSIC |
|
low complexity region
|
1400 |
1462 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000177297
AA Change: K138*
|
| SMART Domains |
Protein: ENSMUSP00000134819
Gene: ENSMUSG00000029705
AA Change: K138*
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
16 |
45 |
N/A |
INTRINSIC |
|
coiled coil region
|
110 |
365 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
369 |
390 |
8.99e-6 |
PROSPERO |
|
Pfam:CASP_C
|
422 |
527 |
1.8e-17 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygotes for a targeted null mutation exhibit delayed lung development and neonatal mortality. Survivors show growth retardation and hair defects. Homozygotes for a partially deleted protein have curly hair, and females tend to lose their litters. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Accsl |
T |
A |
2: 93,688,299 (GRCm39) |
Y445F |
probably benign |
Het |
| Actn4 |
T |
C |
7: 28,594,583 (GRCm39) |
D815G |
probably damaging |
Het |
| Adam4 |
T |
C |
12: 81,467,146 (GRCm39) |
S492G |
possibly damaging |
Het |
| Anapc2 |
A |
G |
2: 25,170,490 (GRCm39) |
K643E |
probably benign |
Het |
| Ankfy1 |
T |
A |
11: 72,641,317 (GRCm39) |
I630K |
possibly damaging |
Het |
| Arhgap24 |
A |
G |
5: 103,040,136 (GRCm39) |
T361A |
probably benign |
Het |
| Arhgef28 |
T |
C |
13: 98,066,141 (GRCm39) |
M1571V |
probably benign |
Het |
| Arid5b |
A |
C |
10: 67,937,810 (GRCm39) |
V196G |
possibly damaging |
Het |
| Art2b |
C |
A |
7: 101,229,110 (GRCm39) |
|
probably null |
Het |
| Asxl3 |
G |
A |
18: 22,650,807 (GRCm39) |
R932H |
probably damaging |
Het |
| B3galnt1 |
T |
C |
3: 69,482,673 (GRCm39) |
N196S |
possibly damaging |
Het |
| Brd10 |
A |
T |
19: 29,696,126 (GRCm39) |
N1122K |
possibly damaging |
Het |
| C5ar2 |
C |
A |
7: 15,971,733 (GRCm39) |
V65F |
possibly damaging |
Het |
| Cfap54 |
A |
T |
10: 92,879,255 (GRCm39) |
L403Q |
probably damaging |
Het |
| Cfap74 |
G |
A |
4: 155,521,187 (GRCm39) |
E620K |
|
Het |
| Chac1 |
C |
T |
2: 119,183,836 (GRCm39) |
A146V |
probably damaging |
Het |
| Cpne2 |
T |
A |
8: 95,284,774 (GRCm39) |
S317T |
probably damaging |
Het |
| Cwc22 |
T |
A |
2: 77,754,937 (GRCm39) |
Y214F |
probably damaging |
Het |
| Cyp2c39 |
A |
T |
19: 39,525,197 (GRCm39) |
T167S |
probably benign |
Het |
| Cyp4a12a |
T |
A |
4: 115,185,935 (GRCm39) |
Y414* |
probably null |
Het |
| Dap3 |
A |
T |
3: 88,835,570 (GRCm39) |
D256E |
probably damaging |
Het |
| Dmxl2 |
C |
T |
9: 54,381,156 (GRCm39) |
S110N |
probably benign |
Het |
| Dnhd1 |
A |
T |
7: 105,343,986 (GRCm39) |
I1777L |
probably benign |
Het |
| Ecel1 |
G |
A |
1: 87,076,349 (GRCm39) |
Q717* |
probably null |
Het |
| Efcab3 |
T |
G |
11: 104,909,525 (GRCm39) |
|
probably null |
Het |
| Eif3j2 |
G |
A |
18: 43,610,699 (GRCm39) |
T38M |
possibly damaging |
Het |
| Fat3 |
T |
C |
9: 16,287,864 (GRCm39) |
H553R |
probably benign |
Het |
| Fcho2 |
T |
C |
13: 98,913,985 (GRCm39) |
D204G |
probably benign |
Het |
| Frmpd1 |
A |
T |
4: 45,284,702 (GRCm39) |
E1174D |
probably benign |
Het |
| Gabra6 |
T |
A |
11: 42,205,959 (GRCm39) |
Y299F |
probably damaging |
Het |
| Gak |
G |
A |
5: 108,777,518 (GRCm39) |
|
probably benign |
Het |
| Gapdhs |
T |
A |
7: 30,432,591 (GRCm39) |
H214L |
probably damaging |
Het |
| Gapvd1 |
T |
C |
2: 34,568,110 (GRCm39) |
Y1418C |
probably damaging |
Het |
| Gk5 |
C |
A |
9: 96,059,562 (GRCm39) |
D471E |
probably benign |
Het |
| Glg1 |
A |
G |
8: 111,914,527 (GRCm39) |
M419T |
probably damaging |
Het |
| H2ac25 |
T |
A |
11: 58,845,785 (GRCm39) |
N74K |
possibly damaging |
Het |
| Ice1 |
T |
C |
13: 70,758,697 (GRCm39) |
N215S |
probably damaging |
Het |
| Idh2 |
TCCCAGG |
T |
7: 79,748,079 (GRCm39) |
|
probably benign |
Het |
| Ifitm10 |
T |
C |
7: 141,882,300 (GRCm39) |
N157D |
probably benign |
Het |
| Itga11 |
A |
G |
9: 62,676,545 (GRCm39) |
D911G |
possibly damaging |
Het |
| Kcnt1 |
A |
G |
2: 25,784,338 (GRCm39) |
N247S |
probably benign |
Het |
| Kirrel1 |
T |
C |
3: 86,997,173 (GRCm39) |
T265A |
probably benign |
Het |
| Klhl29 |
A |
T |
12: 5,187,542 (GRCm39) |
L274H |
possibly damaging |
Het |
| Kmt2b |
T |
G |
7: 30,273,640 (GRCm39) |
T2326P |
probably damaging |
Het |
| Lcn11 |
A |
G |
2: 25,669,265 (GRCm39) |
S141G |
probably benign |
Het |
| Ldb3 |
T |
C |
14: 34,277,301 (GRCm39) |
R358G |
probably null |
Het |
| Ldlr |
G |
A |
9: 21,650,828 (GRCm39) |
D446N |
possibly damaging |
Het |
| Lipt2 |
T |
C |
7: 99,809,449 (GRCm39) |
F179L |
probably damaging |
Het |
| Lmbrd1 |
G |
T |
1: 24,745,121 (GRCm39) |
V154F |
possibly damaging |
Het |
| Malrd1 |
A |
G |
2: 15,556,178 (GRCm39) |
I99V |
|
Het |
| Map1b |
T |
A |
13: 99,570,735 (GRCm39) |
E662V |
unknown |
Het |
| Mfsd11 |
T |
C |
11: 116,750,162 (GRCm39) |
S100P |
probably damaging |
Het |
| Mgst1 |
C |
T |
6: 138,119,967 (GRCm39) |
|
probably benign |
Het |
| Mtf1 |
T |
A |
4: 124,698,649 (GRCm39) |
V49D |
probably damaging |
Het |
| Mtss1 |
T |
C |
15: 58,826,986 (GRCm39) |
D236G |
probably damaging |
Het |
| Myct1 |
C |
T |
10: 5,554,208 (GRCm39) |
T25I |
probably damaging |
Het |
| Myh4 |
T |
A |
11: 67,143,806 (GRCm39) |
F1089I |
possibly damaging |
Het |
| Nrxn1 |
A |
T |
17: 90,897,615 (GRCm39) |
I835K |
probably damaging |
Het |
| Nsd3 |
T |
A |
8: 26,163,394 (GRCm39) |
S595T |
probably damaging |
Het |
| Nt5c2 |
A |
T |
19: 46,877,361 (GRCm39) |
S527T |
probably damaging |
Het |
| Or52m1 |
T |
C |
7: 102,289,882 (GRCm39) |
V143A |
probably benign |
Het |
| Or56b2 |
T |
A |
7: 104,337,900 (GRCm39) |
L226* |
probably null |
Het |
| Or5k3 |
T |
A |
16: 58,969,319 (GRCm39) |
Y35* |
probably null |
Het |
| Or7e175 |
A |
T |
9: 20,048,664 (GRCm39) |
D84V |
probably damaging |
Het |
| Or8k28 |
C |
A |
2: 86,285,892 (GRCm39) |
C241F |
probably damaging |
Het |
| Osbpl8 |
A |
G |
10: 111,108,053 (GRCm39) |
S350G |
probably benign |
Het |
| Otoa |
G |
A |
7: 120,744,741 (GRCm39) |
W833* |
probably null |
Het |
| Pcdhga6 |
T |
G |
18: 37,841,540 (GRCm39) |
I420S |
probably damaging |
Het |
| Pmfbp1 |
A |
C |
8: 110,258,433 (GRCm39) |
M666L |
probably benign |
Het |
| Pola2 |
T |
G |
19: 5,998,452 (GRCm39) |
D370A |
probably damaging |
Het |
| Ppip5k1 |
C |
G |
2: 121,153,701 (GRCm39) |
|
probably benign |
Het |
| Ppp1r12b |
A |
T |
1: 134,762,200 (GRCm39) |
D815E |
probably benign |
Het |
| Ppp4r3b |
T |
A |
11: 29,155,669 (GRCm39) |
V545E |
possibly damaging |
Het |
| Ptpn23 |
A |
T |
9: 110,221,568 (GRCm39) |
N177K |
probably damaging |
Het |
| Rad9b |
A |
T |
5: 122,482,293 (GRCm39) |
S147R |
probably benign |
Het |
| Rps20 |
T |
A |
4: 3,834,617 (GRCm39) |
M82L |
probably benign |
Het |
| Samd9l |
C |
T |
6: 3,374,577 (GRCm39) |
V895I |
probably damaging |
Het |
| Sbf2 |
T |
A |
7: 110,038,118 (GRCm39) |
K396* |
probably null |
Het |
| Sbno2 |
G |
T |
10: 79,893,796 (GRCm39) |
Q1198K |
probably damaging |
Het |
| Scp2d1 |
C |
T |
2: 144,665,886 (GRCm39) |
T75I |
probably damaging |
Het |
| Shank3 |
T |
A |
15: 89,433,431 (GRCm39) |
I1392N |
possibly damaging |
Het |
| Sidt1 |
A |
G |
16: 44,082,390 (GRCm39) |
F532L |
probably benign |
Het |
| Smchd1 |
A |
T |
17: 71,755,752 (GRCm39) |
V243D |
probably damaging |
Het |
| Smg1 |
T |
C |
7: 117,806,215 (GRCm39) |
R185G |
probably damaging |
Het |
| Spag16 |
C |
T |
1: 70,036,004 (GRCm39) |
S344F |
|
Het |
| Spata31f3 |
G |
T |
4: 42,871,753 (GRCm39) |
D207E |
probably damaging |
Het |
| Spsb3 |
A |
G |
17: 25,110,493 (GRCm39) |
D440G |
probably damaging |
Het |
| Themis |
A |
C |
10: 28,665,709 (GRCm39) |
S591R |
probably benign |
Het |
| Trpm1 |
G |
A |
7: 63,858,089 (GRCm39) |
V177I |
probably damaging |
Het |
| Usp37 |
A |
G |
1: 74,514,143 (GRCm39) |
|
probably null |
Het |
| Vmn1r171 |
C |
T |
7: 23,332,525 (GRCm39) |
T238I |
probably damaging |
Het |
| Vmn2r33 |
T |
C |
7: 7,554,655 (GRCm39) |
M633V |
probably benign |
Het |
| Vmn2r93 |
T |
A |
17: 18,546,252 (GRCm39) |
L708H |
probably damaging |
Het |
| Vps35l |
A |
T |
7: 118,393,801 (GRCm39) |
T450S |
possibly damaging |
Het |
| Wdr53 |
T |
A |
16: 32,075,473 (GRCm39) |
V226E |
probably damaging |
Het |
| Wdr62 |
T |
A |
7: 29,953,454 (GRCm39) |
I193F |
probably damaging |
Het |
| Zfp607b |
T |
A |
7: 27,403,387 (GRCm39) |
D614E |
probably benign |
Het |
|
| Other mutations in Cux1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00846:Cux1
|
APN |
5 |
136,355,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00966:Cux1
|
APN |
5 |
136,340,345 (GRCm39) |
intron |
probably benign |
|
|
IGL01129:Cux1
|
APN |
5 |
136,333,572 (GRCm39) |
intron |
probably benign |
|
|
IGL01885:Cux1
|
APN |
5 |
136,337,301 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01947:Cux1
|
APN |
5 |
136,303,979 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02259:Cux1
|
APN |
5 |
136,355,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02666:Cux1
|
APN |
5 |
136,304,169 (GRCm39) |
nonsense |
probably null |
|
|
IGL02826:Cux1
|
APN |
5 |
136,336,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03014:Cux1
|
UTSW |
5 |
136,594,379 (GRCm39) |
intron |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0047:Cux1
|
UTSW |
5 |
136,392,107 (GRCm39) |
splice site |
probably benign |
|
|
R0057:Cux1
|
UTSW |
5 |
136,285,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0295:Cux1
|
UTSW |
5 |
136,342,066 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0361:Cux1
|
UTSW |
5 |
136,308,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0533:Cux1
|
UTSW |
5 |
136,336,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Cux1
|
UTSW |
5 |
136,315,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0801:Cux1
|
UTSW |
5 |
136,355,783 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0884:Cux1
|
UTSW |
5 |
136,336,689 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0976:Cux1
|
UTSW |
5 |
136,342,144 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1073:Cux1
|
UTSW |
5 |
136,281,395 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1222:Cux1
|
UTSW |
5 |
136,304,003 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1518:Cux1
|
UTSW |
5 |
136,337,133 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1686:Cux1
|
UTSW |
5 |
136,304,235 (GRCm39) |
nonsense |
probably null |
|
|
R1687:Cux1
|
UTSW |
5 |
136,341,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Cux1
|
UTSW |
5 |
136,421,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1797:Cux1
|
UTSW |
5 |
136,304,169 (GRCm39) |
missense |
probably benign |
0.22 |
|
R1919:Cux1
|
UTSW |
5 |
136,392,173 (GRCm39) |
nonsense |
probably null |
|
|
R2051:Cux1
|
UTSW |
5 |
136,361,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2339:Cux1
|
UTSW |
5 |
136,315,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3438:Cux1
|
UTSW |
5 |
136,340,414 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3713:Cux1
|
UTSW |
5 |
136,594,397 (GRCm39) |
intron |
probably benign |
|
|
R3800:Cux1
|
UTSW |
5 |
136,344,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3964:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4135:Cux1
|
UTSW |
5 |
136,336,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4198:Cux1
|
UTSW |
5 |
136,315,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4467:Cux1
|
UTSW |
5 |
136,341,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4498:Cux1
|
UTSW |
5 |
136,341,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4622:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4623:Cux1
|
UTSW |
5 |
136,337,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4651:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4652:Cux1
|
UTSW |
5 |
136,596,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4658:Cux1
|
UTSW |
5 |
136,279,448 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4665:Cux1
|
UTSW |
5 |
136,315,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4704:Cux1
|
UTSW |
5 |
136,278,055 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4867:Cux1
|
UTSW |
5 |
136,303,815 (GRCm39) |
intron |
probably benign |
|
|
R4965:Cux1
|
UTSW |
5 |
136,340,410 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R5090:Cux1
|
UTSW |
5 |
136,342,054 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5155:Cux1
|
UTSW |
5 |
136,594,295 (GRCm39) |
intron |
probably benign |
|
|
R5226:Cux1
|
UTSW |
5 |
136,399,027 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5252:Cux1
|
UTSW |
5 |
136,337,151 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5266:Cux1
|
UTSW |
5 |
136,341,548 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5399:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5509:Cux1
|
UTSW |
5 |
136,304,171 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5609:Cux1
|
UTSW |
5 |
136,421,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5681:Cux1
|
UTSW |
5 |
136,337,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5993:Cux1
|
UTSW |
5 |
136,392,125 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6049:Cux1
|
UTSW |
5 |
136,361,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6290:Cux1
|
UTSW |
5 |
136,340,412 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6310:Cux1
|
UTSW |
5 |
136,304,018 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6351:Cux1
|
UTSW |
5 |
136,338,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6531:Cux1
|
UTSW |
5 |
136,303,973 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6590:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6663:Cux1
|
UTSW |
5 |
136,514,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6690:Cux1
|
UTSW |
5 |
136,368,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6777:Cux1
|
UTSW |
5 |
136,594,422 (GRCm39) |
intron |
probably benign |
|
|
R6786:Cux1
|
UTSW |
5 |
136,596,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6817:Cux1
|
UTSW |
5 |
136,402,027 (GRCm39) |
splice site |
probably null |
|
|
R6989:Cux1
|
UTSW |
5 |
136,308,502 (GRCm39) |
nonsense |
probably null |
|
|
R7011:Cux1
|
UTSW |
5 |
136,388,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Cux1
|
UTSW |
5 |
136,338,895 (GRCm39) |
splice site |
probably null |
|
|
R7699:Cux1
|
UTSW |
5 |
136,514,593 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7861:Cux1
|
UTSW |
5 |
136,281,458 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7876:Cux1
|
UTSW |
5 |
136,392,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7916:Cux1
|
UTSW |
5 |
136,311,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8023:Cux1
|
UTSW |
5 |
136,402,251 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8154:Cux1
|
UTSW |
5 |
136,281,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8267:Cux1
|
UTSW |
5 |
136,311,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8289:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8305:Cux1
|
UTSW |
5 |
136,388,863 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8319:Cux1
|
UTSW |
5 |
136,594,251 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8405:Cux1
|
UTSW |
5 |
136,304,241 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8483:Cux1
|
UTSW |
5 |
136,303,944 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8506:Cux1
|
UTSW |
5 |
136,337,358 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8671:Cux1
|
UTSW |
5 |
136,279,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8680:Cux1
|
UTSW |
5 |
136,336,710 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8737:Cux1
|
UTSW |
5 |
136,311,796 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8738:Cux1
|
UTSW |
5 |
136,402,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8793:Cux1
|
UTSW |
5 |
136,594,539 (GRCm39) |
missense |
unknown |
|
|
R8897:Cux1
|
UTSW |
5 |
136,315,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8926:Cux1
|
UTSW |
5 |
136,338,404 (GRCm39) |
intron |
probably benign |
|
|
R9092:Cux1
|
UTSW |
5 |
136,514,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9205:Cux1
|
UTSW |
5 |
136,398,989 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Cux1
|
UTSW |
5 |
136,340,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9578:Cux1
|
UTSW |
5 |
136,282,919 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9682:Cux1
|
UTSW |
5 |
136,337,116 (GRCm39) |
missense |
probably benign |
|
|
R9701:Cux1
|
UTSW |
5 |
136,343,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9712:Cux1
|
UTSW |
5 |
136,338,673 (GRCm39) |
missense |
probably benign |
0.35 |
|
| Predicted Primers |
PCR Primer
(F):5'- TAAGAGATTCGGCTGCTTGC -3'
(R):5'- ATCTCCAGGAGATGACTTCTGTATAC -3'
Sequencing Primer
(F):5'- CCCCACCCTGGCTTCATGAG -3'
(R):5'- AGGGCTTGCCTAGAATTCAC -3'
|
| Posted On |
2021-08-31 |
Incidental Mutation