Incidental Mutation 'R8954:Trpm1'
| ID |
681832 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trpm1
|
| Ensembl Gene |
ENSMUSG00000030523 |
| Gene Name |
transient receptor potential cation channel, subfamily M, member 1 |
| Synonyms |
Mlsn1, melastatin, 4732499L03Rik, LTRPC1 |
| MMRRC Submission |
068790-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8954 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
63803583-63919523 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 63858089 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 177
(V177I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000146265
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000085222]
[ENSMUST00000177102]
[ENSMUST00000205348]
[ENSMUST00000205731]
[ENSMUST00000205994]
[ENSMUST00000206263]
[ENSMUST00000206277]
[ENSMUST00000206314]
[ENSMUST00000206706]
|
| AlphaFold |
Q2TV84 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000085222
AA Change: V310I
PolyPhen 2
Score 0.626 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000082318
Gene: ENSMUSG00000030523
AA Change: V310I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
183 |
195 |
N/A |
INTRINSIC |
|
low complexity region
|
289 |
307 |
N/A |
INTRINSIC |
|
low complexity region
|
456 |
491 |
N/A |
INTRINSIC |
|
Blast:ANK
|
505 |
533 |
1e-5 |
BLAST |
|
low complexity region
|
621 |
650 |
N/A |
INTRINSIC |
|
low complexity region
|
823 |
835 |
N/A |
INTRINSIC |
|
transmembrane domain
|
876 |
895 |
N/A |
INTRINSIC |
|
Pfam:Ion_trans
|
907 |
1120 |
6e-16 |
PFAM |
|
transmembrane domain
|
1150 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1216 |
1225 |
N/A |
INTRINSIC |
|
PDB:3E7K|H
|
1228 |
1279 |
1e-7 |
PDB |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177102
AA Change: V194I
PolyPhen 2
Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000134947
Gene: ENSMUSG00000030523
AA Change: V194I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
67 |
79 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
191 |
N/A |
INTRINSIC |
|
low complexity region
|
340 |
375 |
N/A |
INTRINSIC |
|
Blast:ANK
|
389 |
417 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000205348
AA Change: V310I
PolyPhen 2
Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205684
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000205731
AA Change: V194I
PolyPhen 2
Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205994
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000206263
AA Change: V194I
PolyPhen 2
Score 0.626 (Sensitivity: 0.87; Specificity: 0.91)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000206277
AA Change: V310I
PolyPhen 2
Score 0.518 (Sensitivity: 0.88; Specificity: 0.90)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206314
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000206706
AA Change: V177I
PolyPhen 2
Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the transient receptor potential melastatin subfamily of transient receptor potential ion channels. The encoded protein is a calcium permeable cation channel that is expressed in melanocytes and may play a role in melanin synthesis. Specific mutations in this gene are the cause autosomal recessive complete congenital stationary night blindness-1C. The expression of this protein is inversely correlated with melanoma aggressiveness and as such it is used as a prognostic marker for melanoma metastasis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
PHENOTYPE: Homozygous mutants have defects in rod and cone electrophysiology affecting the photoresponses. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Accsl |
T |
A |
2: 93,688,299 (GRCm39) |
Y445F |
probably benign |
Het |
| Actn4 |
T |
C |
7: 28,594,583 (GRCm39) |
D815G |
probably damaging |
Het |
| Adam4 |
T |
C |
12: 81,467,146 (GRCm39) |
S492G |
possibly damaging |
Het |
| Anapc2 |
A |
G |
2: 25,170,490 (GRCm39) |
K643E |
probably benign |
Het |
| Ankfy1 |
T |
A |
11: 72,641,317 (GRCm39) |
I630K |
possibly damaging |
Het |
| Arhgap24 |
A |
G |
5: 103,040,136 (GRCm39) |
T361A |
probably benign |
Het |
| Arhgef28 |
T |
C |
13: 98,066,141 (GRCm39) |
M1571V |
probably benign |
Het |
| Arid5b |
A |
C |
10: 67,937,810 (GRCm39) |
V196G |
possibly damaging |
Het |
| Art2b |
C |
A |
7: 101,229,110 (GRCm39) |
|
probably null |
Het |
| Asxl3 |
G |
A |
18: 22,650,807 (GRCm39) |
R932H |
probably damaging |
Het |
| B3galnt1 |
T |
C |
3: 69,482,673 (GRCm39) |
N196S |
possibly damaging |
Het |
| Brd10 |
A |
T |
19: 29,696,126 (GRCm39) |
N1122K |
possibly damaging |
Het |
| C5ar2 |
C |
A |
7: 15,971,733 (GRCm39) |
V65F |
possibly damaging |
Het |
| Cfap54 |
A |
T |
10: 92,879,255 (GRCm39) |
L403Q |
probably damaging |
Het |
| Cfap74 |
G |
A |
4: 155,521,187 (GRCm39) |
E620K |
|
Het |
| Chac1 |
C |
T |
2: 119,183,836 (GRCm39) |
A146V |
probably damaging |
Het |
| Cpne2 |
T |
A |
8: 95,284,774 (GRCm39) |
S317T |
probably damaging |
Het |
| Cux1 |
T |
A |
5: 136,402,203 (GRCm39) |
K138* |
probably null |
Het |
| Cwc22 |
T |
A |
2: 77,754,937 (GRCm39) |
Y214F |
probably damaging |
Het |
| Cyp2c39 |
A |
T |
19: 39,525,197 (GRCm39) |
T167S |
probably benign |
Het |
| Cyp4a12a |
T |
A |
4: 115,185,935 (GRCm39) |
Y414* |
probably null |
Het |
| Dap3 |
A |
T |
3: 88,835,570 (GRCm39) |
D256E |
probably damaging |
Het |
| Dmxl2 |
C |
T |
9: 54,381,156 (GRCm39) |
S110N |
probably benign |
Het |
| Dnhd1 |
A |
T |
7: 105,343,986 (GRCm39) |
I1777L |
probably benign |
Het |
| Ecel1 |
G |
A |
1: 87,076,349 (GRCm39) |
Q717* |
probably null |
Het |
| Efcab3 |
T |
G |
11: 104,909,525 (GRCm39) |
|
probably null |
Het |
| Eif3j2 |
G |
A |
18: 43,610,699 (GRCm39) |
T38M |
possibly damaging |
Het |
| Fat3 |
T |
C |
9: 16,287,864 (GRCm39) |
H553R |
probably benign |
Het |
| Fcho2 |
T |
C |
13: 98,913,985 (GRCm39) |
D204G |
probably benign |
Het |
| Frmpd1 |
A |
T |
4: 45,284,702 (GRCm39) |
E1174D |
probably benign |
Het |
| Gabra6 |
T |
A |
11: 42,205,959 (GRCm39) |
Y299F |
probably damaging |
Het |
| Gak |
G |
A |
5: 108,777,518 (GRCm39) |
|
probably benign |
Het |
| Gapdhs |
T |
A |
7: 30,432,591 (GRCm39) |
H214L |
probably damaging |
Het |
| Gapvd1 |
T |
C |
2: 34,568,110 (GRCm39) |
Y1418C |
probably damaging |
Het |
| Gk5 |
C |
A |
9: 96,059,562 (GRCm39) |
D471E |
probably benign |
Het |
| Glg1 |
A |
G |
8: 111,914,527 (GRCm39) |
M419T |
probably damaging |
Het |
| H2ac25 |
T |
A |
11: 58,845,785 (GRCm39) |
N74K |
possibly damaging |
Het |
| Ice1 |
T |
C |
13: 70,758,697 (GRCm39) |
N215S |
probably damaging |
Het |
| Idh2 |
TCCCAGG |
T |
7: 79,748,079 (GRCm39) |
|
probably benign |
Het |
| Ifitm10 |
T |
C |
7: 141,882,300 (GRCm39) |
N157D |
probably benign |
Het |
| Itga11 |
A |
G |
9: 62,676,545 (GRCm39) |
D911G |
possibly damaging |
Het |
| Kcnt1 |
A |
G |
2: 25,784,338 (GRCm39) |
N247S |
probably benign |
Het |
| Kirrel1 |
T |
C |
3: 86,997,173 (GRCm39) |
T265A |
probably benign |
Het |
| Klhl29 |
A |
T |
12: 5,187,542 (GRCm39) |
L274H |
possibly damaging |
Het |
| Kmt2b |
T |
G |
7: 30,273,640 (GRCm39) |
T2326P |
probably damaging |
Het |
| Lcn11 |
A |
G |
2: 25,669,265 (GRCm39) |
S141G |
probably benign |
Het |
| Ldb3 |
T |
C |
14: 34,277,301 (GRCm39) |
R358G |
probably null |
Het |
| Ldlr |
G |
A |
9: 21,650,828 (GRCm39) |
D446N |
possibly damaging |
Het |
| Lipt2 |
T |
C |
7: 99,809,449 (GRCm39) |
F179L |
probably damaging |
Het |
| Lmbrd1 |
G |
T |
1: 24,745,121 (GRCm39) |
V154F |
possibly damaging |
Het |
| Malrd1 |
A |
G |
2: 15,556,178 (GRCm39) |
I99V |
|
Het |
| Map1b |
T |
A |
13: 99,570,735 (GRCm39) |
E662V |
unknown |
Het |
| Mfsd11 |
T |
C |
11: 116,750,162 (GRCm39) |
S100P |
probably damaging |
Het |
| Mgst1 |
C |
T |
6: 138,119,967 (GRCm39) |
|
probably benign |
Het |
| Mtf1 |
T |
A |
4: 124,698,649 (GRCm39) |
V49D |
probably damaging |
Het |
| Mtss1 |
T |
C |
15: 58,826,986 (GRCm39) |
D236G |
probably damaging |
Het |
| Myct1 |
C |
T |
10: 5,554,208 (GRCm39) |
T25I |
probably damaging |
Het |
| Myh4 |
T |
A |
11: 67,143,806 (GRCm39) |
F1089I |
possibly damaging |
Het |
| Nrxn1 |
A |
T |
17: 90,897,615 (GRCm39) |
I835K |
probably damaging |
Het |
| Nsd3 |
T |
A |
8: 26,163,394 (GRCm39) |
S595T |
probably damaging |
Het |
| Nt5c2 |
A |
T |
19: 46,877,361 (GRCm39) |
S527T |
probably damaging |
Het |
| Or52m1 |
T |
C |
7: 102,289,882 (GRCm39) |
V143A |
probably benign |
Het |
| Or56b2 |
T |
A |
7: 104,337,900 (GRCm39) |
L226* |
probably null |
Het |
| Or5k3 |
T |
A |
16: 58,969,319 (GRCm39) |
Y35* |
probably null |
Het |
| Or7e175 |
A |
T |
9: 20,048,664 (GRCm39) |
D84V |
probably damaging |
Het |
| Or8k28 |
C |
A |
2: 86,285,892 (GRCm39) |
C241F |
probably damaging |
Het |
| Osbpl8 |
A |
G |
10: 111,108,053 (GRCm39) |
S350G |
probably benign |
Het |
| Otoa |
G |
A |
7: 120,744,741 (GRCm39) |
W833* |
probably null |
Het |
| Pcdhga6 |
T |
G |
18: 37,841,540 (GRCm39) |
I420S |
probably damaging |
Het |
| Pmfbp1 |
A |
C |
8: 110,258,433 (GRCm39) |
M666L |
probably benign |
Het |
| Pola2 |
T |
G |
19: 5,998,452 (GRCm39) |
D370A |
probably damaging |
Het |
| Ppip5k1 |
C |
G |
2: 121,153,701 (GRCm39) |
|
probably benign |
Het |
| Ppp1r12b |
A |
T |
1: 134,762,200 (GRCm39) |
D815E |
probably benign |
Het |
| Ppp4r3b |
T |
A |
11: 29,155,669 (GRCm39) |
V545E |
possibly damaging |
Het |
| Ptpn23 |
A |
T |
9: 110,221,568 (GRCm39) |
N177K |
probably damaging |
Het |
| Rad9b |
A |
T |
5: 122,482,293 (GRCm39) |
S147R |
probably benign |
Het |
| Rps20 |
T |
A |
4: 3,834,617 (GRCm39) |
M82L |
probably benign |
Het |
| Samd9l |
C |
T |
6: 3,374,577 (GRCm39) |
V895I |
probably damaging |
Het |
| Sbf2 |
T |
A |
7: 110,038,118 (GRCm39) |
K396* |
probably null |
Het |
| Sbno2 |
G |
T |
10: 79,893,796 (GRCm39) |
Q1198K |
probably damaging |
Het |
| Scp2d1 |
C |
T |
2: 144,665,886 (GRCm39) |
T75I |
probably damaging |
Het |
| Shank3 |
T |
A |
15: 89,433,431 (GRCm39) |
I1392N |
possibly damaging |
Het |
| Sidt1 |
A |
G |
16: 44,082,390 (GRCm39) |
F532L |
probably benign |
Het |
| Smchd1 |
A |
T |
17: 71,755,752 (GRCm39) |
V243D |
probably damaging |
Het |
| Smg1 |
T |
C |
7: 117,806,215 (GRCm39) |
R185G |
probably damaging |
Het |
| Spag16 |
C |
T |
1: 70,036,004 (GRCm39) |
S344F |
|
Het |
| Spata31f3 |
G |
T |
4: 42,871,753 (GRCm39) |
D207E |
probably damaging |
Het |
| Spsb3 |
A |
G |
17: 25,110,493 (GRCm39) |
D440G |
probably damaging |
Het |
| Themis |
A |
C |
10: 28,665,709 (GRCm39) |
S591R |
probably benign |
Het |
| Usp37 |
A |
G |
1: 74,514,143 (GRCm39) |
|
probably null |
Het |
| Vmn1r171 |
C |
T |
7: 23,332,525 (GRCm39) |
T238I |
probably damaging |
Het |
| Vmn2r33 |
T |
C |
7: 7,554,655 (GRCm39) |
M633V |
probably benign |
Het |
| Vmn2r93 |
T |
A |
17: 18,546,252 (GRCm39) |
L708H |
probably damaging |
Het |
| Vps35l |
A |
T |
7: 118,393,801 (GRCm39) |
T450S |
possibly damaging |
Het |
| Wdr53 |
T |
A |
16: 32,075,473 (GRCm39) |
V226E |
probably damaging |
Het |
| Wdr62 |
T |
A |
7: 29,953,454 (GRCm39) |
I193F |
probably damaging |
Het |
| Zfp607b |
T |
A |
7: 27,403,387 (GRCm39) |
D614E |
probably benign |
Het |
|
| Other mutations in Trpm1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00093:Trpm1
|
APN |
7 |
63,893,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00465:Trpm1
|
APN |
7 |
63,897,215 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01118:Trpm1
|
APN |
7 |
63,885,572 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01148:Trpm1
|
APN |
7 |
63,893,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01303:Trpm1
|
APN |
7 |
63,860,578 (GRCm39) |
critical splice acceptor site |
probably benign |
0.00 |
|
IGL01432:Trpm1
|
APN |
7 |
63,884,767 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01433:Trpm1
|
APN |
7 |
63,854,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01506:Trpm1
|
APN |
7 |
63,893,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01626:Trpm1
|
APN |
7 |
63,918,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01640:Trpm1
|
APN |
7 |
63,876,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Trpm1
|
APN |
7 |
63,884,742 (GRCm39) |
missense |
probably benign |
0.24 |
|
IGL01959:Trpm1
|
APN |
7 |
63,858,723 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02210:Trpm1
|
APN |
7 |
63,860,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02268:Trpm1
|
APN |
7 |
63,867,362 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02331:Trpm1
|
APN |
7 |
63,884,800 (GRCm39) |
missense |
probably benign |
0.30 |
|
IGL02334:Trpm1
|
APN |
7 |
63,895,690 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02407:Trpm1
|
APN |
7 |
63,868,869 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02425:Trpm1
|
APN |
7 |
63,890,175 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02485:Trpm1
|
APN |
7 |
63,918,862 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
IGL02635:Trpm1
|
APN |
7 |
63,848,972 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02640:Trpm1
|
APN |
7 |
63,868,881 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02827:Trpm1
|
APN |
7 |
63,868,908 (GRCm39) |
missense |
probably null |
1.00 |
|
PIT4458001:Trpm1
|
UTSW |
7 |
63,918,309 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
PIT4544001:Trpm1
|
UTSW |
7 |
63,848,998 (GRCm39) |
intron |
probably benign |
|
|
R0012:Trpm1
|
UTSW |
7 |
63,918,339 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0014:Trpm1
|
UTSW |
7 |
63,897,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0056:Trpm1
|
UTSW |
7 |
63,893,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0445:Trpm1
|
UTSW |
7 |
63,894,590 (GRCm39) |
unclassified |
probably benign |
|
|
R0463:Trpm1
|
UTSW |
7 |
63,870,002 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0469:Trpm1
|
UTSW |
7 |
63,873,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0510:Trpm1
|
UTSW |
7 |
63,873,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1301:Trpm1
|
UTSW |
7 |
63,852,801 (GRCm39) |
splice site |
probably null |
|
|
R1397:Trpm1
|
UTSW |
7 |
63,867,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1588:Trpm1
|
UTSW |
7 |
63,873,565 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1618:Trpm1
|
UTSW |
7 |
63,890,283 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1724:Trpm1
|
UTSW |
7 |
63,885,569 (GRCm39) |
nonsense |
probably null |
|
|
R1827:Trpm1
|
UTSW |
7 |
63,884,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1829:Trpm1
|
UTSW |
7 |
63,876,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1835:Trpm1
|
UTSW |
7 |
63,880,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Trpm1
|
UTSW |
7 |
63,917,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1895:Trpm1
|
UTSW |
7 |
63,873,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1946:Trpm1
|
UTSW |
7 |
63,873,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1959:Trpm1
|
UTSW |
7 |
63,879,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1960:Trpm1
|
UTSW |
7 |
63,879,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Trpm1
|
UTSW |
7 |
63,858,182 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1989:Trpm1
|
UTSW |
7 |
63,858,780 (GRCm39) |
intron |
probably null |
|
|
R2054:Trpm1
|
UTSW |
7 |
63,890,303 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2156:Trpm1
|
UTSW |
7 |
63,884,736 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2251:Trpm1
|
UTSW |
7 |
63,859,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3051:Trpm1
|
UTSW |
7 |
63,918,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3148:Trpm1
|
UTSW |
7 |
63,884,760 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3195:Trpm1
|
UTSW |
7 |
63,849,061 (GRCm39) |
nonsense |
probably null |
|
|
R3615:Trpm1
|
UTSW |
7 |
63,893,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3616:Trpm1
|
UTSW |
7 |
63,893,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3623:Trpm1
|
UTSW |
7 |
63,894,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3624:Trpm1
|
UTSW |
7 |
63,894,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3721:Trpm1
|
UTSW |
7 |
63,867,475 (GRCm39) |
intron |
probably benign |
|
|
R3822:Trpm1
|
UTSW |
7 |
63,867,451 (GRCm39) |
intron |
probably benign |
|
|
R4441:Trpm1
|
UTSW |
7 |
63,851,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4490:Trpm1
|
UTSW |
7 |
63,858,660 (GRCm39) |
nonsense |
probably null |
|
|
R4666:Trpm1
|
UTSW |
7 |
63,852,782 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4701:Trpm1
|
UTSW |
7 |
63,893,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4781:Trpm1
|
UTSW |
7 |
63,884,800 (GRCm39) |
missense |
probably benign |
0.30 |
|
R4811:Trpm1
|
UTSW |
7 |
63,858,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5017:Trpm1
|
UTSW |
7 |
63,894,580 (GRCm39) |
unclassified |
probably benign |
|
|
R5030:Trpm1
|
UTSW |
7 |
63,885,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5195:Trpm1
|
UTSW |
7 |
63,887,441 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5238:Trpm1
|
UTSW |
7 |
63,918,702 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5304:Trpm1
|
UTSW |
7 |
63,858,694 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5575:Trpm1
|
UTSW |
7 |
63,870,018 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5613:Trpm1
|
UTSW |
7 |
63,858,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5855:Trpm1
|
UTSW |
7 |
63,918,710 (GRCm39) |
nonsense |
probably null |
|
|
R5947:Trpm1
|
UTSW |
7 |
63,873,547 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5988:Trpm1
|
UTSW |
7 |
63,876,553 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6054:Trpm1
|
UTSW |
7 |
63,918,450 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6088:Trpm1
|
UTSW |
7 |
63,917,724 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6259:Trpm1
|
UTSW |
7 |
63,918,226 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6379:Trpm1
|
UTSW |
7 |
63,848,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6380:Trpm1
|
UTSW |
7 |
63,918,045 (GRCm39) |
missense |
probably benign |
0.24 |
|
R6429:Trpm1
|
UTSW |
7 |
63,918,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6600:Trpm1
|
UTSW |
7 |
63,803,781 (GRCm39) |
start codon destroyed |
probably null |
0.56 |
|
R6622:Trpm1
|
UTSW |
7 |
63,890,343 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6939:Trpm1
|
UTSW |
7 |
63,918,045 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6944:Trpm1
|
UTSW |
7 |
63,893,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7025:Trpm1
|
UTSW |
7 |
63,876,462 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7112:Trpm1
|
UTSW |
7 |
63,885,593 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7168:Trpm1
|
UTSW |
7 |
63,918,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7219:Trpm1
|
UTSW |
7 |
63,854,333 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7224:Trpm1
|
UTSW |
7 |
63,868,854 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7285:Trpm1
|
UTSW |
7 |
63,859,729 (GRCm39) |
nonsense |
probably null |
|
|
R7367:Trpm1
|
UTSW |
7 |
63,918,549 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7449:Trpm1
|
UTSW |
7 |
63,858,723 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7466:Trpm1
|
UTSW |
7 |
63,890,330 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7498:Trpm1
|
UTSW |
7 |
63,858,657 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7581:Trpm1
|
UTSW |
7 |
63,854,303 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7776:Trpm1
|
UTSW |
7 |
63,897,939 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8062:Trpm1
|
UTSW |
7 |
63,851,689 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8069:Trpm1
|
UTSW |
7 |
63,858,718 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R8157:Trpm1
|
UTSW |
7 |
63,849,017 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8219:Trpm1
|
UTSW |
7 |
63,851,699 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8258:Trpm1
|
UTSW |
7 |
63,918,777 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8259:Trpm1
|
UTSW |
7 |
63,918,777 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8320:Trpm1
|
UTSW |
7 |
63,918,541 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8536:Trpm1
|
UTSW |
7 |
63,897,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8544:Trpm1
|
UTSW |
7 |
63,874,356 (GRCm39) |
splice site |
probably null |
|
|
R8813:Trpm1
|
UTSW |
7 |
63,851,756 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8912:Trpm1
|
UTSW |
7 |
63,918,628 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9139:Trpm1
|
UTSW |
7 |
63,848,943 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9205:Trpm1
|
UTSW |
7 |
63,890,319 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9258:Trpm1
|
UTSW |
7 |
63,884,713 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9283:Trpm1
|
UTSW |
7 |
63,873,623 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9394:Trpm1
|
UTSW |
7 |
63,918,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9430:Trpm1
|
UTSW |
7 |
63,873,446 (GRCm39) |
missense |
probably benign |
0.38 |
|
R9537:Trpm1
|
UTSW |
7 |
63,803,616 (GRCm39) |
unclassified |
probably benign |
|
|
R9616:Trpm1
|
UTSW |
7 |
63,858,132 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9774:Trpm1
|
UTSW |
7 |
63,898,041 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
X0026:Trpm1
|
UTSW |
7 |
63,918,658 (GRCm39) |
missense |
probably benign |
0.05 |
|
Z1176:Trpm1
|
UTSW |
7 |
63,854,342 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Trpm1
|
UTSW |
7 |
63,852,879 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Trpm1
|
UTSW |
7 |
63,867,439 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGTCACCCTTCGCTTGAC -3'
(R):5'- GTCAGATGTTTTCCCCAGTCTG -3'
Sequencing Primer
(F):5'- GACTTAGTCGAAGCATTGGTCAAC -3'
(R):5'- TGTTTTCCCCAGTCTGACAAAAAGC -3'
|
| Posted On |
2021-08-31 |
Incidental Mutation